Details for: FUT6

Gene ID: 2528

Symbol: FUT6

Ensembl ID: ENSG00000156413

Description: fucosyltransferase 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.35
    Marker Score: 921
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.34
    Marker Score: 661
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.33
    Marker Score: 890
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.11
    Marker Score: 2619
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.02
    Marker Score: 853
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.02
    Marker Score: 647
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48052.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5321
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.9
    Marker Score: 7635
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.89
    Marker Score: 3167.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.86
    Marker Score: 274
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.86
    Marker Score: 1321
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.82
    Marker Score: 238
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.77
    Marker Score: 3714
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 588
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 308
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 692
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.76
    Marker Score: 353
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.75
    Marker Score: 281
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.73
    Marker Score: 1662
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.72
    Marker Score: 690
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.71
    Marker Score: 6122
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2855
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.66
    Marker Score: 2079
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.65
    Marker Score: 178
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.58
    Marker Score: 578.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.54
    Marker Score: 358
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.52
    Marker Score: 218
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.51
    Marker Score: 8030
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.5
    Marker Score: 122
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.49
    Marker Score: 1167
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.41
    Marker Score: 365.5
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.39
    Marker Score: 96
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.37
    Marker Score: 2902
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.36
    Marker Score: 663
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.35
    Marker Score: 100
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.34
    Marker Score: 90
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.34
    Marker Score: 106
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.33
    Marker Score: 104
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.31
    Marker Score: 219
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.29
    Marker Score: 304
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.28
    Marker Score: 81
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.28
    Marker Score: 326
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.26
    Marker Score: 598
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.24
    Marker Score: 167
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.24
    Marker Score: 90
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.24
    Marker Score: 63
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.23
    Marker Score: 441
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.23
    Marker Score: 471
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.23
    Marker Score: 153.5
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.23
    Marker Score: 90
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.22
    Marker Score: 57
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.22
    Marker Score: 1427
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.21
    Marker Score: 122
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.21
    Marker Score: 2797
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.21
    Marker Score: 893
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.2
    Marker Score: 75
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.2
    Marker Score: 54
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.19
    Marker Score: 1666
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.19
    Marker Score: 652
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.19
    Marker Score: 120
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.19
    Marker Score: 111
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.18
    Marker Score: 1374
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.18
    Marker Score: 84
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.18
    Marker Score: 62
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.17
    Marker Score: 52
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.17
    Marker Score: 82
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.17
    Marker Score: 64
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.17
    Marker Score: 263
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.17
    Marker Score: 1079
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.17
    Marker Score: 180
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.16
    Marker Score: 173
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.16
    Marker Score: 1065
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.16
    Marker Score: 41
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.15
    Marker Score: 112
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.15
    Marker Score: 163
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.15
    Marker Score: 40
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.15
    Marker Score: 55
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.15
    Marker Score: 46
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.15
    Marker Score: 411
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.14
    Marker Score: 84
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.14
    Marker Score: 184
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.14
    Marker Score: 84
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.14
    Marker Score: 71
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.14
    Marker Score: 263
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.14
    Marker Score: 225.5

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Other Information

**Key characteristics:** - The FUT6 gene is located on chromosome 15q26.2. - It is a protein of 1104 amino acids. - It is expressed in a variety of cell types, including squamous epithelial cells, bronchial goblet cells, nasal mucosa goblet cells, kidney proximal straight tubule epithelial cells, keratinocytes, granulocyte monocyte progenitor cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, and tuft cells of the colon. **Pathways and functions:** - FUT6 is involved in the synthesis of Lewis blood group antigens. - It is also involved in the biosynthesis of glycoproteins, such as proteoglycans and glycoproteins of the extracellular matrix. - It is involved in the regulation of cell adhesion, migration, and differentiation. - It is involved in the maintenance of tissue integrity and the prevention of inflammation. **Clinical significance:** - Mutations in the FUT6 gene have been linked to the inheritance of human leukocyte antigen (HLA) blood types. - In individuals with the FUT6-A allele, the surface of red blood cells is coated with a Lewis A antigen, which is associated with blood type A. - In individuals with the FUT6-B allele, the surface of red blood cells is coated with a Lewis B antigen, which is associated with blood type B. - FUT6 mutations can also lead to the expression of alternative glycoproteins, which can result in blood types other than A or B. **Conclusion:** The FUT6 gene is an essential enzyme in the biosynthesis of fucosyl groups on glycoproteins. Its mutations can have significant clinical implications, as they can lead to the inheritance of human leukocyte antigen (HLA) blood types.

Genular Protein ID: 148463859

Symbol: FUT6_HUMAN

Name: Fucosyltransferase 6

UniProtKB Accession Codes:

P51993 A6NEX0 D6W637 Q9UND8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CTD 1 ChEBI 55 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 15 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 2 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 3 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 13 Rhea 21 SMR 1 STRING 1 SUPFAM 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1520296

Title: The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand.

PubMed ID: 1520296

DOI: 10.1016/s0006-291x(05)81472-x

PubMed ID: 1339443

Title: Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes.

PubMed ID: 1339443

DOI: 10.1016/s0021-9258(18)35803-4

PubMed ID: 7650030

Title: Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms.

PubMed ID: 7650030

DOI: 10.1074/jbc.270.34.20112

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 9451035

Title: Trafficking and localization studies of recombinant alpha1, 3-fucosyltransferase VI stably expressed in CHO cells.

PubMed ID: 9451035

DOI: 10.1093/glycob/8.3.259

PubMed ID: 9363434

Title: Acceptor specificity of GDP-Fuc:Gal beta 1-->4GlcNAc-R alpha 3-fucosyltransferase VI (FucT VI) expressed in insect cells as soluble, secreted enzyme.

PubMed ID: 9363434

DOI: 10.1093/glycob/7.7.921

PubMed ID: 10728707

Title: Expression of sialyl 6-sulfo Lewis X is inversely correlated with conventional sialyl Lewis X expression in human colorectal cancer.

PubMed ID: 10728707

PubMed ID: 17604274

Title: Site-specific fucosylation of sialylated polylactosamines by alpha1,3/4-fucosyltransferases-V and -VI Is defined by amino acids near the N terminus of the catalytic domain.

PubMed ID: 17604274

DOI: 10.1074/jbc.m702395200

PubMed ID: 29593094

Title: Distinct human alpha(1,3)-fucosyltransferases drive Lewis-X/sialyl Lewis-X assembly in human cells.

PubMed ID: 29593094

DOI: 10.1074/jbc.ra117.000775

PubMed ID: 8175676

Title: Molecular basis for plasma alpha(1,3)-fucosyltransferase gene deficiency (FUT6).

PubMed ID: 8175676

DOI: 10.1016/s0021-9258(18)99927-8

PubMed ID: 11102976

Title: Identification of two functionally deficient plasma alpha 3-fucosyltransferase (FUT6) alleles.

PubMed ID: 11102976

DOI: 10.1002/1098-1004(200012)16:6<473::aid-humu4>3.0.co;2-t

PubMed ID: 27535533

Title: Analysis of protein-coding genetic variation in 60,706 humans.

PubMed ID: 27535533

DOI: 10.1038/nature19057

Sequence Information:

  • Length: 359
  • Mass: 41860
  • Checksum: 67ABDF058F0999DA
  • Sequence:
    • MDPLGPAKPQ WSWRCCLTTL LFQLLMAVCF FSYLRVSQDD PTVYPNGSRF PDSTGTPAHS 
IPLILLWTWP FNKPIALPRC SEMVPGTADC NITADRKVYP QADAVIVHHR EVMYNPSAQL 
PRSPRRQGQR WIWFSMESPS HCWQLKAMDG YFNLTMSYRS DSDIFTPYGW LEPWSGQPAH 
PPLNLSAKTE LVAWAVSNWG PNSARVRYYQ SLQAHLKVDV YGRSHKPLPQ GTMMETLSRY 
KFYLAFENSL HPDYITEKLW RNALEAWAVP VVLGPSRSNY ERFLPPDAFI HVDDFQSPKD 
LARYLQELDK DHARYLSYFR WRETLRPRSF SWALAFCKAC WKLQEESRYQ TRGIAAWFT

Genular Protein ID: 1038591100

Symbol: Q6P7E6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6P7E6

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 IntAct 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 2 RuleBase 1 SUPFAM 1 UniPathway 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 359
  • Mass: 41858
  • Checksum: C77818F802A00674
  • Sequence:
    • MDPLGPAKPQ WSWRCCLTTL LFHLLMAVCF FSYLRVSQDD PTVYPNGSRF PDSTGTPAHS 
IPLILLWTWP FNKPIALPRC SEMVPGTADC NITADRKVYP QADAVIVHHR EVMYNPSAQL 
PRSSRRQGQR WIWFSMESPS HCWQLKAMDG YFNLTMSYRS DSDIFTPYGW LEPWSGQPAH 
PPLNLSAKTE LVAWAVSNWG PNSARVRYYQ SLQAHLKVDV YGRSHKPLPQ GTMMETLSRY 
KFYLAFKNSL HPDYITEKLW RNALEAWAVP VVLGPSRSNY ERFLPPDAFI HVDDFQSPKD 
LARYLQELDK DHARYLSYFR WRETLRPRSF SWALAFCKAC WKLQEESRYQ TRGIAAWFT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.