Details for: FUT6

Gene ID: 2528

Symbol: FUT6

Ensembl ID: ENSG00000156413

Description: fucosyltransferase 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 26.0696
    Cell Significance Index: -4.0600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 15.6519
    Cell Significance Index: -3.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.5876
    Cell Significance Index: 74.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.4925
    Cell Significance Index: 172.3700
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 2.4318
    Cell Significance Index: 18.4400
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 2.2440
    Cell Significance Index: 24.3200
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.0445
    Cell Significance Index: 21.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.0279
    Cell Significance Index: 91.9200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.6761
    Cell Significance Index: -4.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.4706
    Cell Significance Index: 31.8600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4497
    Cell Significance Index: 1309.0100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3569
    Cell Significance Index: 81.4600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.3368
    Cell Significance Index: 20.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1721
    Cell Significance Index: 127.4900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.0940
    Cell Significance Index: 26.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9099
    Cell Significance Index: 147.9900
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 0.8386
    Cell Significance Index: 5.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7204
    Cell Significance Index: 25.3200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.6612
    Cell Significance Index: 6.6700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5888
    Cell Significance Index: 12.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5722
    Cell Significance Index: 26.6800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.5091
    Cell Significance Index: 10.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4494
    Cell Significance Index: 44.4600
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.4095
    Cell Significance Index: 3.5800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2257
    Cell Significance Index: 3.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2173
    Cell Significance Index: 6.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2172
    Cell Significance Index: 5.4300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.2093
    Cell Significance Index: 3.5200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.2015
    Cell Significance Index: 1.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1609
    Cell Significance Index: 10.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1183
    Cell Significance Index: 22.5200
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.0945
    Cell Significance Index: 1.9700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0864
    Cell Significance Index: 1.0300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0760
    Cell Significance Index: 2.1200
  • Cell Name: duodenum glandular cell (CL1001589)
    Fold Change: 0.0558
    Cell Significance Index: 0.4000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0440
    Cell Significance Index: 0.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0436
    Cell Significance Index: 2.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0394
    Cell Significance Index: 1.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0305
    Cell Significance Index: 6.0600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0249
    Cell Significance Index: 0.4200
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.0242
    Cell Significance Index: 0.2000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0111
    Cell Significance Index: 0.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0105
    Cell Significance Index: 1.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0094
    Cell Significance Index: 1.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0093
    Cell Significance Index: 1.0700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.0082
    Cell Significance Index: 0.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0052
    Cell Significance Index: 1.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0040
    Cell Significance Index: 1.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0018
    Cell Significance Index: 0.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0002
    Cell Significance Index: -0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0010
    Cell Significance Index: -1.8000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0018
    Cell Significance Index: -3.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0019
    Cell Significance Index: -2.8900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0025
    Cell Significance Index: -3.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0043
    Cell Significance Index: -3.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0047
    Cell Significance Index: -0.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0050
    Cell Significance Index: -3.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0052
    Cell Significance Index: -3.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0061
    Cell Significance Index: -3.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0070
    Cell Significance Index: -0.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0070
    Cell Significance Index: -3.9500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0083
    Cell Significance Index: -0.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0084
    Cell Significance Index: -3.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0106
    Cell Significance Index: -3.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0154
    Cell Significance Index: -1.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0159
    Cell Significance Index: -1.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0169
    Cell Significance Index: -2.8900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0169
    Cell Significance Index: -0.1100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0185
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0192
    Cell Significance Index: -4.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0232
    Cell Significance Index: -3.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0238
    Cell Significance Index: -3.2700
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.0242
    Cell Significance Index: -0.1700
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.0290
    Cell Significance Index: -0.2900
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0379
    Cell Significance Index: -0.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0389
    Cell Significance Index: -4.0600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0390
    Cell Significance Index: -4.6000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0431
    Cell Significance Index: -2.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0434
    Cell Significance Index: -3.4400
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0482
    Cell Significance Index: -0.3500
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0514
    Cell Significance Index: -0.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0533
    Cell Significance Index: -4.0900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0543
    Cell Significance Index: -2.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0547
    Cell Significance Index: -3.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0553
    Cell Significance Index: -3.3900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0572
    Cell Significance Index: -2.1000
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.0596
    Cell Significance Index: -0.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0605
    Cell Significance Index: -4.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0656
    Cell Significance Index: -3.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0657
    Cell Significance Index: -4.2400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0657
    Cell Significance Index: -0.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0678
    Cell Significance Index: -4.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0680
    Cell Significance Index: -3.5700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0750
    Cell Significance Index: -1.0400
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.0773
    Cell Significance Index: -0.6800
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0774
    Cell Significance Index: -0.7000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0777
    Cell Significance Index: -1.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0860
    Cell Significance Index: -2.9900
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.0876
    Cell Significance Index: -0.3300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0900
    Cell Significance Index: -1.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FUT6 is a type II transmembrane glycosyltransferase, exhibiting high specificity for the addition of fucose to specific glycosidic bonds. The enzyme is primarily expressed in epithelial cells, including squamous epithelial cells, bronchial goblet cells, and nasal mucosa goblet cells, as well as in immune cells, such as granulocyte monocyte progenitor cells. FUT6 is also found in the Golgi apparatus, where it is involved in the biosynthesis of glycosphingolipids and glycoproteins. **Pathways and Functions:** FUT6 is involved in several biological pathways, including: 1. **Glycosphingolipid biosynthesis:** FUT6 catalyzes the addition of fucose to ceramide, resulting in the formation of fucosylceramide, a key component of glycosphingolipids. 2. **Glycoprotein biosynthesis:** FUT6 is involved in the addition of fucose to glycoproteins, including those involved in immune response and cell signaling. 3. **Blood group antigen expression:** FUT6 is responsible for the synthesis of Lewis blood group antigens, which are important for the identification of blood groups. 4. **Immune response:** FUT6 plays a role in the regulation of immune responses, including the activation of immune cells and the production of cytokines. 5. **Cell signaling:** FUT6 is involved in the modulation of cell signaling pathways, including those involved in the regulation of cell growth, differentiation, and survival. **Clinical Significance:** FUT6 has been implicated in various diseases and disorders, including: 1. **Blood group disorders:** Abnormalities in FUT6 expression or function have been linked to blood group disorders, such as hemolytic disease of the newborn. 2. **Immune system disorders:** FUT6 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where dysregulation of immune responses is a key feature. 3. **Cancer:** FUT6 has been found to be overexpressed in several types of cancer, including breast, lung, and colon cancer, suggesting its potential role in tumorigenesis. 4. **Neurological disorders:** FUT6 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where dysregulation of glycosylation and cell signaling pathways is a key feature. In conclusion, FUT6 is a crucial enzyme involved in various biological processes, including glycosphingolipid biosynthesis, glycoprotein biosynthesis, and immune response. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of understanding its function and clinical significance.

Genular Protein ID: 148463859

Symbol: FUT6_HUMAN

Name: Fucosyltransferase 6

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1520296

Title: The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand.

PubMed ID: 1520296

DOI: 10.1016/s0006-291x(05)81472-x

PubMed ID: 1339443

Title: Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes.

PubMed ID: 1339443

DOI: 10.1016/s0021-9258(18)35803-4

PubMed ID: 7650030

Title: Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms.

PubMed ID: 7650030

DOI: 10.1074/jbc.270.34.20112

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 9451035

Title: Trafficking and localization studies of recombinant alpha1, 3-fucosyltransferase VI stably expressed in CHO cells.

PubMed ID: 9451035

DOI: 10.1093/glycob/8.3.259

PubMed ID: 9363434

Title: Acceptor specificity of GDP-Fuc:Gal beta 1-->4GlcNAc-R alpha 3-fucosyltransferase VI (FucT VI) expressed in insect cells as soluble, secreted enzyme.

PubMed ID: 9363434

DOI: 10.1093/glycob/7.7.921

PubMed ID: 10728707

Title: Expression of sialyl 6-sulfo Lewis X is inversely correlated with conventional sialyl Lewis X expression in human colorectal cancer.

PubMed ID: 10728707

PubMed ID: 17604274

Title: Site-specific fucosylation of sialylated polylactosamines by alpha1,3/4-fucosyltransferases-V and -VI Is defined by amino acids near the N terminus of the catalytic domain.

PubMed ID: 17604274

DOI: 10.1074/jbc.m702395200

PubMed ID: 29593094

Title: Distinct human alpha(1,3)-fucosyltransferases drive Lewis-X/sialyl Lewis-X assembly in human cells.

PubMed ID: 29593094

DOI: 10.1074/jbc.ra117.000775

PubMed ID: 8175676

Title: Molecular basis for plasma alpha(1,3)-fucosyltransferase gene deficiency (FUT6).

PubMed ID: 8175676

DOI: 10.1016/s0021-9258(18)99927-8

PubMed ID: 11102976

Title: Identification of two functionally deficient plasma alpha 3-fucosyltransferase (FUT6) alleles.

PubMed ID: 11102976

DOI: 10.1002/1098-1004(200012)16:6<473::aid-humu4>3.0.co;2-t

PubMed ID: 27535533

Title: Analysis of protein-coding genetic variation in 60,706 humans.

PubMed ID: 27535533

DOI: 10.1038/nature19057

Sequence Information:

  • Length: 359
  • Mass: 41860
  • Checksum: 67ABDF058F0999DA
  • Sequence:
  • MDPLGPAKPQ WSWRCCLTTL LFQLLMAVCF FSYLRVSQDD PTVYPNGSRF PDSTGTPAHS 
    IPLILLWTWP FNKPIALPRC SEMVPGTADC NITADRKVYP QADAVIVHHR EVMYNPSAQL 
    PRSPRRQGQR WIWFSMESPS HCWQLKAMDG YFNLTMSYRS DSDIFTPYGW LEPWSGQPAH 
    PPLNLSAKTE LVAWAVSNWG PNSARVRYYQ SLQAHLKVDV YGRSHKPLPQ GTMMETLSRY 
    KFYLAFENSL HPDYITEKLW RNALEAWAVP VVLGPSRSNY ERFLPPDAFI HVDDFQSPKD 
    LARYLQELDK DHARYLSYFR WRETLRPRSF SWALAFCKAC WKLQEESRYQ TRGIAAWFT

Genular Protein ID: 1038591100

Symbol: Q6P7E6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 359
  • Mass: 41858
  • Checksum: C77818F802A00674
  • Sequence:
  • MDPLGPAKPQ WSWRCCLTTL LFHLLMAVCF FSYLRVSQDD PTVYPNGSRF PDSTGTPAHS 
    IPLILLWTWP FNKPIALPRC SEMVPGTADC NITADRKVYP QADAVIVHHR EVMYNPSAQL 
    PRSSRRQGQR WIWFSMESPS HCWQLKAMDG YFNLTMSYRS DSDIFTPYGW LEPWSGQPAH 
    PPLNLSAKTE LVAWAVSNWG PNSARVRYYQ SLQAHLKVDV YGRSHKPLPQ GTMMETLSRY 
    KFYLAFKNSL HPDYITEKLW RNALEAWAVP VVLGPSRSNY ERFLPPDAFI HVDDFQSPKD 
    LARYLQELDK DHARYLSYFR WRETLRPRSF SWALAFCKAC WKLQEESRYQ TRGIAAWFT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.