Details for: SPRR3

Gene ID: 6707

Symbol: SPRR3

Ensembl ID: ENSG00000163209

Description: small proline rich protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 5.1216
    Cell Significance Index: 82.9500
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 3.6201
    Cell Significance Index: 24.0300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.1448
    Cell Significance Index: 59.9400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.2423
    Cell Significance Index: 11.4400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.1900
    Cell Significance Index: 2.6100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0851
    Cell Significance Index: 1.0400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0731
    Cell Significance Index: 0.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0541
    Cell Significance Index: 2.8100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0037
    Cell Significance Index: 0.1600
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.0017
    Cell Significance Index: 0.0200
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: -0.0037
    Cell Significance Index: -0.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0053
    Cell Significance Index: -0.9600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0071
    Cell Significance Index: -5.3500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0083
    Cell Significance Index: -0.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0261
    Cell Significance Index: -19.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0318
    Cell Significance Index: -3.9100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0353
    Cell Significance Index: -19.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0513
    Cell Significance Index: -6.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0972
    Cell Significance Index: -11.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1222
    Cell Significance Index: -20.8600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1250
    Cell Significance Index: -14.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1432
    Cell Significance Index: -14.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1522
    Cell Significance Index: -20.9000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1564
    Cell Significance Index: -2.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1667
    Cell Significance Index: -21.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1743
    Cell Significance Index: -19.9700
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.2519
    Cell Significance Index: -1.9200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2587
    Cell Significance Index: -7.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2623
    Cell Significance Index: -7.0100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2852
    Cell Significance Index: -10.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2908
    Cell Significance Index: -21.6700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3029
    Cell Significance Index: -7.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3102
    Cell Significance Index: -19.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4483
    Cell Significance Index: -20.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4631
    Cell Significance Index: -21.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4686
    Cell Significance Index: -21.2400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4757
    Cell Significance Index: -12.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5270
    Cell Significance Index: -7.1900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.5359
    Cell Significance Index: -9.1600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.6144
    Cell Significance Index: -7.9500
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.6233
    Cell Significance Index: -5.3700
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.6796
    Cell Significance Index: -7.9000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6823
    Cell Significance Index: -14.9400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.7299
    Cell Significance Index: -7.7000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7333
    Cell Significance Index: -19.6500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7629
    Cell Significance Index: -21.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7642
    Cell Significance Index: -20.8000
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.8450
    Cell Significance Index: -9.0500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.8665
    Cell Significance Index: -16.0200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.9043
    Cell Significance Index: -13.1800
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.9210
    Cell Significance Index: -9.5000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.9481
    Cell Significance Index: -9.6700
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -1.0108
    Cell Significance Index: -5.3200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -1.0281
    Cell Significance Index: -12.9900
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -1.0523
    Cell Significance Index: -10.6700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.0654
    Cell Significance Index: -20.8300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -1.0726
    Cell Significance Index: -14.7300
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -1.0981
    Cell Significance Index: -8.3600
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -1.1729
    Cell Significance Index: -14.8400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.1729
    Cell Significance Index: -24.5500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.1859
    Cell Significance Index: -19.8500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.1937
    Cell Significance Index: -16.9900
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -1.2162
    Cell Significance Index: -14.6700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.2188
    Cell Significance Index: -24.3100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -1.2204
    Cell Significance Index: -20.1100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -1.2246
    Cell Significance Index: -17.7800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.2246
    Cell Significance Index: -21.1100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -1.2781
    Cell Significance Index: -16.6900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -1.3022
    Cell Significance Index: -11.1900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -1.3045
    Cell Significance Index: -16.3900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -1.3068
    Cell Significance Index: -17.3700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -1.3118
    Cell Significance Index: -15.6100
  • Cell Name: granule cell (CL0000120)
    Fold Change: -1.3211
    Cell Significance Index: -15.0400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -1.3427
    Cell Significance Index: -17.6700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.3506
    Cell Significance Index: -19.9400
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -1.3623
    Cell Significance Index: -15.1500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -1.3631
    Cell Significance Index: -14.9100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -1.3810
    Cell Significance Index: -16.4000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -1.3823
    Cell Significance Index: -21.9300
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -1.3915
    Cell Significance Index: -13.7800
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -1.3923
    Cell Significance Index: -15.1100
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -1.3936
    Cell Significance Index: -15.1100
  • Cell Name: club cell (CL0000158)
    Fold Change: -1.4016
    Cell Significance Index: -15.2700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -1.4029
    Cell Significance Index: -16.6800
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -1.4061
    Cell Significance Index: -15.1600
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -1.4071
    Cell Significance Index: -14.9200
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -1.4241
    Cell Significance Index: -14.6900
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -1.4337
    Cell Significance Index: -14.3100
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: -1.4609
    Cell Significance Index: -15.0400
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -1.4619
    Cell Significance Index: -22.2400
  • Cell Name: platelet (CL0000233)
    Fold Change: -1.4736
    Cell Significance Index: -15.1600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -1.4859
    Cell Significance Index: -19.5000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -1.4882
    Cell Significance Index: -20.6400
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -1.4896
    Cell Significance Index: -16.2700
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -1.5018
    Cell Significance Index: -18.2700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -1.5065
    Cell Significance Index: -18.8200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -1.5137
    Cell Significance Index: -20.9300
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: -1.5143
    Cell Significance Index: -15.0200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -1.5164
    Cell Significance Index: -19.4800
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -1.5206
    Cell Significance Index: -16.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Proline-rich protein**: SPRR3 belongs to the small proline-rich protein family, which is characterized by the presence of proline-rich sequences in its protein structure. 2. **Widespread expression**: SPRR3 is expressed in various cell types, including keratinocytes, squamous epithelial cells, and leukocytes, highlighting its importance in epithelial homeostasis. 3. **Structural molecule activity**: SPRR3 is involved in maintaining the structural integrity of epithelial cells, particularly during keratinization and wound healing processes. 4. **Protein binding**: SPRR3 interacts with other proteins, including keratins and other structural molecules, to regulate cellular processes. **Pathways and Functions:** 1. **Keratinization**: SPRR3 plays a crucial role in the process of keratinization, which is essential for the development and maintenance of stratified epithelial tissues. 2. **Wound healing**: SPRR3 is involved in the wound healing process, where it helps to regulate the migration and differentiation of keratinocytes. 3. **Developmental biology**: SPRR3 is expressed during embryonic development and plays a role in the formation of the cornified envelope, a critical component of stratified epithelial tissues. 4. **Epithelial cell differentiation**: SPRR3 helps to regulate the differentiation of epithelial cells, particularly during keratinocyte differentiation. **Clinical Significance:** 1. **Skin disorders**: Mutations in the SPRR3 gene have been associated with skin disorders, including ichthyosis and epidermolysis bullosa simplex. 2. **Wound healing disorders**: SPRR3 dysfunction has been linked to impaired wound healing, which can lead to chronic wounds and delayed recovery. 3. **Cancer**: Aberrant expression of SPRR3 has been observed in various types of cancer, including squamous cell carcinoma and basal cell carcinoma. 4. **Neurological disorders**: SPRR3 is expressed in the nervous system, where it may play a role in the development and maintenance of neural cells. In conclusion, SPRR3 is a critical protein that plays a vital role in maintaining epithelial homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of SPRR3 function and its clinical significance. As an expert immunologist, I believe that a deeper understanding of SPRR3 will lead to the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 335367779

Symbol: SPRR3_HUMAN

Name: Small proline-rich protein 3

UniProtKB Accession Codes:

Q9UBC9 A5YKK8 B2R4G8 D3DV32 O75597 Q4ZGI7 Q5T525 Q8NET7 Q9UDG3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PRIDE 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8325635

Title: Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins.

PubMed ID: 8325635

DOI: 10.1006/geno.1993.1240

PubMed ID: 8018055

Title: Differential expression of protease inhibitor and small proline-rich protein genes between normal human oral tissue and odontogenic keratocysts.

PubMed ID: 8018055

DOI: 10.1016/0003-9969(94)90051-5

PubMed ID: 8809402

Title: Esophagin cDNA cloning and characterization: a tissue-specific member of the small proline-rich protein family that is not expressed in esophageal tumors.

PubMed ID: 8809402

PubMed ID: 11230159

Title: Identification of human epidermal differentiation complex (EDC)-encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library.

PubMed ID: 11230159

DOI: 10.1101/gr.114801

PubMed ID: 20599699

Title: Characterization of two isoforms of human SPRR3 from saliva of preterm human newborn and autoptic fetal oral mucosa, parotid and submandibular gland samples.

PubMed ID: 20599699

DOI: 10.1016/j.bbrc.2010.06.103

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7829876

Title: The pancornulins: a group of small proline rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation.

PubMed ID: 7829876

DOI: 10.1111/1523-1747.ep12612759

Sequence Information:

  • Length: 169
  • Mass: 18154
  • Checksum: B8E522AF798F1ECB
  • Sequence:
    • MSSYQQKQTF TPPPQLQQQQ VKQPSQPPPQ EIFVPTTKEP CHSKVPQPGN TKIPEPGCTK 
VPEPGCTKVP EPGCTKVPEP GCTKVPEPGC TKVPEPGCTK VPEPGYTKVP EPGSIKVPDQ 
GFIKFPEPGA IKVPEQGYTK VPVPGYTKLP EPCPSTVTPG PAQQKTKQK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.