Details for: SPRR3

Gene ID: 6707

Symbol: SPRR3

Ensembl ID: ENSG00000163209

Description: small proline rich protein 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.98
    Marker Score: 162030.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.66
    Marker Score: 8233
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 4.16
    Marker Score: 3471
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 3.79
    Marker Score: 2581
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.59
    Marker Score: 28063
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 3.25
    Marker Score: 28013
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 3.01
    Marker Score: 1710
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.61
    Marker Score: 630
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 2.54
    Marker Score: 1460
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 2.54
    Marker Score: 3653
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.83
    Marker Score: 2529.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.24
    Marker Score: 7530
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.19
    Marker Score: 3575
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.1
    Marker Score: 734
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.05
    Marker Score: 32677
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71782
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48009
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.93
    Marker Score: 388.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5298
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.93
    Marker Score: 2355.5
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.85
    Marker Score: 751
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.83
    Marker Score: 437
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 704
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.74
    Marker Score: 1203
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 371
  • Cell Name: phagocyte (CL0000234)
    Fold Change: 0.68
    Marker Score: 227
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.66
    Marker Score: 751
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.56
    Marker Score: 635
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.51
    Marker Score: 407
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.49
    Marker Score: 155
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.47
    Marker Score: 850
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.43
    Marker Score: 258
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.38
    Marker Score: 252
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.36
    Marker Score: 384
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.36
    Marker Score: 73
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.36
    Marker Score: 683
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.36
    Marker Score: 70
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.35
    Marker Score: 215
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.35
    Marker Score: 313
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.32
    Marker Score: 211
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3
    Marker Score: 439
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.29
    Marker Score: 73
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.29
    Marker Score: 73
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.29
    Marker Score: 3840
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.28
    Marker Score: 72
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.27
    Marker Score: 71
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.27
    Marker Score: 72
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.26
    Marker Score: 1228.5
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.25
    Marker Score: 1624
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.25
    Marker Score: 517
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.25
    Marker Score: 270
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.25
    Marker Score: 180
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.25
    Marker Score: 69
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.25
    Marker Score: 72
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.25
    Marker Score: 59
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.24
    Marker Score: 99
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.23
    Marker Score: 206
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.23
    Marker Score: 73
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.23
    Marker Score: 80
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.23
    Marker Score: 104
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.23
    Marker Score: 117
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.22
    Marker Score: 83
  • Cell Name: brush cell of trachebronchial tree (CL0002075)
    Fold Change: 0.22
    Marker Score: 68
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.22
    Marker Score: 220
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.22
    Marker Score: 69.5
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.21
    Marker Score: 54
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.21
    Marker Score: 61
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.21
    Marker Score: 67
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.2
    Marker Score: 58
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.2
    Marker Score: 61
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.2
    Marker Score: 103
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.2
    Marker Score: 222
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.19
    Marker Score: 131
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.19
    Marker Score: 69
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.19
    Marker Score: 93
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.19
    Marker Score: 73
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.18
    Marker Score: 49
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.18
    Marker Score: 76
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.18
    Marker Score: 2863
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.18
    Marker Score: 172
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.18
    Marker Score: 64
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.18
    Marker Score: 55
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.17
    Marker Score: 80.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.17
    Marker Score: 70
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.16
    Marker Score: 464
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.16
    Marker Score: 384
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.16
    Marker Score: 94
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.16
    Marker Score: 108
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.16
    Marker Score: 959
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.16
    Marker Score: 88
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.16
    Marker Score: 80
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.15
    Marker Score: 82
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.15
    Marker Score: 90
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.14
    Marker Score: 41
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.14
    Marker Score: 155
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.13
    Marker Score: 62
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.13
    Marker Score: 105
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.13
    Marker Score: 154
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.13
    Marker Score: 57

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Other Information

**Key characteristics:** * Gene name: SPRR3 * Ensembl ID: ENSG00000163209 * Protein product: SPRR3_HUMAN * Molecular weight: 54.5 kDa * Tissue expression: High expression in the following cell types: * Glutamatergic neuron * Oligodendrocyte precursor cell * Keratinocyte * Squamous epithelial cell * Stratified epithelial cell * Epithelial cell of esophagus * Megakaryocyte * Epithelial cell of stratum germinativum of esophagus * Leukocyte * Respiratory basal cell **Pathways and functions:** * **Cornified envelope:** SPRR3 is a key component of the cornified envelope, a specialized structure that surrounds and protects the cell membrane in stratified squamous epithelial cells. * **Cytosol:** SPRR3 is expressed in the cytosol of various cell types, where it plays a role in cell migration and signaling. * **Developmental biology:** SPRR3 is involved in cell migration and differentiation during embryonic development. * **Epidermis development:** SPRR3 is expressed in the skin and hair follicles, where it contributes to the formation of the cornified envelope. * **Extracellular exosome:** SPRR3 is a component of extracellular vesicles (EVs) released by cells, and it is involved in intercellular communication. * **Formation of the cornified envelope:** SPRR3 is a key factor in the formation of the cornified envelope, a process that protects cells from their environment. * **Golgi apparatus:** SPRR3 is a protein that is targeted to the Golgi apparatus, where it is involved in protein sorting and trafficking. * **Keratinization:** SPRR3 is expressed in the skin and hair follicles, where it is involved in keratinization, the process by which the skin and hair acquire their protective barrier properties. * **Keratinocyte differentiation:** SPRR3 is a key factor in keratinocyte differentiation, the process by which skin and hair cells are formed. * **Perinuclear region of cytoplasm:** SPRR3 is expressed in the perinuclear region of cytoplasm, where it is involved in cell signaling and regulation. * **Protein binding:** SPRR3 can bind to various proteins, including cadherins, integrins, and fibronectin. These interactions are involved in cell adhesion, migration, and signaling. **Clinical significance:** * Mutations in the SPRR3 gene have been linked to several human diseases, including skin disorders, cancer, and cardiovascular diseases. * SPRR3 is a potential therapeutic target for these diseases, as it is involved in the pathogenesis of these conditions.

Genular Protein ID: 335367779

Symbol: SPRR3_HUMAN

Name: Small proline-rich protein 3

UniProtKB Accession Codes:

Q9UBC9 A5YKK8 B2R4G8 D3DV32 O75597 Q4ZGI7 Q5T525 Q8NET7 Q9UDG3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PRIDE 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8325635

Title: Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins.

PubMed ID: 8325635

DOI: 10.1006/geno.1993.1240

PubMed ID: 8018055

Title: Differential expression of protease inhibitor and small proline-rich protein genes between normal human oral tissue and odontogenic keratocysts.

PubMed ID: 8018055

DOI: 10.1016/0003-9969(94)90051-5

PubMed ID: 8809402

Title: Esophagin cDNA cloning and characterization: a tissue-specific member of the small proline-rich protein family that is not expressed in esophageal tumors.

PubMed ID: 8809402

PubMed ID: 11230159

Title: Identification of human epidermal differentiation complex (EDC)-encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library.

PubMed ID: 11230159

DOI: 10.1101/gr.114801

PubMed ID: 20599699

Title: Characterization of two isoforms of human SPRR3 from saliva of preterm human newborn and autoptic fetal oral mucosa, parotid and submandibular gland samples.

PubMed ID: 20599699

DOI: 10.1016/j.bbrc.2010.06.103

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7829876

Title: The pancornulins: a group of small proline rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation.

PubMed ID: 7829876

DOI: 10.1111/1523-1747.ep12612759

Sequence Information:

  • Length: 169
  • Mass: 18154
  • Checksum: B8E522AF798F1ECB
  • Sequence:
    • MSSYQQKQTF TPPPQLQQQQ VKQPSQPPPQ EIFVPTTKEP CHSKVPQPGN TKIPEPGCTK 
VPEPGCTKVP EPGCTKVPEP GCTKVPEPGC TKVPEPGCTK VPEPGYTKVP EPGSIKVPDQ 
GFIKFPEPGA IKVPEQGYTK VPVPGYTKLP EPCPSTVTPG PAQQKTKQK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.