Details for: LY6D

Gene ID: 8581

Symbol: LY6D

Ensembl ID: ENSG00000167656

Description: lymphocyte antigen 6 family member D

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 11.18
    Marker Score: 16060.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.32
    Marker Score: 25915
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 3.01
    Marker Score: 25905
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.53
    Marker Score: 857
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.38
    Marker Score: 2692
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1991
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.82
    Marker Score: 1032
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.62
    Marker Score: 390
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1166
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.59
    Marker Score: 1330
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 1.57
    Marker Score: 431
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.35
    Marker Score: 1993
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 851
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7563
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3643
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 482
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4810
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.09
    Marker Score: 970
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.08
    Marker Score: 498
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32713
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71819
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48045
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2382
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.91
    Marker Score: 332
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.87
    Marker Score: 964
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.86
    Marker Score: 6385
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.84
    Marker Score: 11305
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.82
    Marker Score: 545
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.8
    Marker Score: 728
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.77
    Marker Score: 337
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.76
    Marker Score: 598
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1231
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 458
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.71
    Marker Score: 4045
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.68
    Marker Score: 797
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.66
    Marker Score: 282
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.65
    Marker Score: 319
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.62
    Marker Score: 655
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.61
    Marker Score: 1886
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.6
    Marker Score: 1135
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.56
    Marker Score: 261
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 430
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.52
    Marker Score: 146
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.51
    Marker Score: 8002
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.5
    Marker Score: 339
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 274
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.44
    Marker Score: 251
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.42
    Marker Score: 537
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.41
    Marker Score: 834.5
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.41
    Marker Score: 742
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.41
    Marker Score: 286
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.4
    Marker Score: 190
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.38
    Marker Score: 471
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.37
    Marker Score: 223
  • Cell Name: phagocyte (CL0000234)
    Fold Change: 0.37
    Marker Score: 121
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.35
    Marker Score: 580
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.3
    Marker Score: 532
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.28
    Marker Score: 1705
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.27
    Marker Score: 127
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.25
    Marker Score: 80
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.25
    Marker Score: 93
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.23
    Marker Score: 341
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.22
    Marker Score: 147
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.21
    Marker Score: 1823
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.2
    Marker Score: 141
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.19
    Marker Score: 910
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.18
    Marker Score: 53
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.15
    Marker Score: 435
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.14
    Marker Score: 29
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.14
    Marker Score: 349
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.14
    Marker Score: 63
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.14
    Marker Score: 122
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.13
    Marker Score: 115
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.12
    Marker Score: 24
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.12
    Marker Score: 769
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.12
    Marker Score: 63
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.12
    Marker Score: 29
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.12
    Marker Score: 29
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.11
    Marker Score: 59
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.11
    Marker Score: 31
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.11
    Marker Score: 57
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.11
    Marker Score: 114
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.11
    Marker Score: 685
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.11
    Marker Score: 362
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.1
    Marker Score: 116
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1
    Marker Score: 31
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.1
    Marker Score: 42
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.1
    Marker Score: 31

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Other Information

**Key characteristics:** - LY6D is a cell adhesion molecule that is expressed on various types of cells, including epithelial cells, immune cells, and cancer cells. - It is a transmembrane protein that is composed of a extracellular domain and a cytoplasmic domain. - The extracellular domain is responsible for binding to extracellular matrix proteins, while the cytoplasmic domain is involved in cell adhesion and signaling. - LY6D is a key regulator of epithelial cell migration and invasion. - It is also involved in the regulation of immune cell trafficking and inflammation. **Pathways and functions:** - LY6D is involved in cell adhesion by binding to extracellular matrix proteins, including collagen and fibronectin. - It is also involved in cell signaling pathways, including the MAPK pathway and the PI3K/AKT pathway. - LY6D is a key regulator of epithelial cell migration and invasion. - It is also involved in the regulation of immune cell trafficking and inflammation. **Clinical significance:** - LY6D gene mutations are associated with a number of human diseases, including cancer, autoimmune disorders, and inflammatory diseases. - Targeting LY6D has been shown to be a promising therapeutic strategy for these diseases. - LY6D is a promising target for the development of new cancer drugs.

Genular Protein ID: 4199462439

Symbol: LY6D_HUMAN

Name: Lymphocyte antigen 6D

UniProtKB Accession Codes:

Q14210 B2R5F1 D3DWJ0 O43783 Q6GTV9 Q8TBD4 Q92933

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7790363

Title: The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB, is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion.

PubMed ID: 7790363

DOI: 10.1083/jcb.129.6.1677

PubMed ID: 9366413

Title: A gain of novel tissue specificity in the human Ly-6 gene E48.

PubMed ID: 9366413

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9551972

Title: Characterization and mapping to human chromosome 8q24.3 of Ly-6-related gene 9804 encoding an apparent homologue of mouse TSA-1.

PubMed ID: 9551972

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

Sequence Information:

  • Length: 128
  • Mass: 13286
  • Checksum: 39618DF6AB5B0EBD
  • Sequence:
    • MRTALLLLAA LAVATGPALT LRCHVCTSSS NCKHSVVCPA SSRFCKTTNT VEPLRGNLVK 
KDCAESCTPS YTLQGQVSSG TSSTQCCQED LCNEKLHNAA PTRTALAHSA LSLGLALSLL 
AVILAPSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.