Details for: LY6D

Gene ID: 8581

Symbol: LY6D

Ensembl ID: ENSG00000167656

Description: lymphocyte antigen 6 family member D

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 30.2958
    Cell Significance Index: 90.1000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 16.5414
    Cell Significance Index: 142.1400
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 13.0895
    Cell Significance Index: 29.5100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 9.2340
    Cell Significance Index: 191.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 8.4437
    Cell Significance Index: 296.7000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.9484
    Cell Significance Index: -10.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 4.8470
    Cell Significance Index: 135.4600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.9902
    Cell Significance Index: 99.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.6854
    Cell Significance Index: 225.9500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 3.2510
    Cell Significance Index: 104.1300
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 3.1274
    Cell Significance Index: 20.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.8633
    Cell Significance Index: 148.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.3898
    Cell Significance Index: 51.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2646
    Cell Significance Index: 57.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0044
    Cell Significance Index: 191.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9363
    Cell Significance Index: 413.9800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.8494
    Cell Significance Index: 12.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7348
    Cell Significance Index: 72.6900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6136
    Cell Significance Index: 5.6500
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: 0.5987
    Cell Significance Index: 4.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5961
    Cell Significance Index: 538.2400
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.4702
    Cell Significance Index: 2.9100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4683
    Cell Significance Index: 6.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3846
    Cell Significance Index: 69.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3785
    Cell Significance Index: 61.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3309
    Cell Significance Index: 40.6900
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.2998
    Cell Significance Index: 1.9100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2195
    Cell Significance Index: 23.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0978
    Cell Significance Index: 6.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0855
    Cell Significance Index: 5.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0595
    Cell Significance Index: 7.6900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0185
    Cell Significance Index: 0.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0193
    Cell Significance Index: -14.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0270
    Cell Significance Index: -14.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0446
    Cell Significance Index: -16.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0585
    Cell Significance Index: -26.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0645
    Cell Significance Index: -12.9400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0777
    Cell Significance Index: -1.9400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0900
    Cell Significance Index: -5.4100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1017
    Cell Significance Index: -2.9300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1094
    Cell Significance Index: -12.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1115
    Cell Significance Index: -14.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1203
    Cell Significance Index: -20.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1335
    Cell Significance Index: -18.3300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1349
    Cell Significance Index: -1.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1491
    Cell Significance Index: -15.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1786
    Cell Significance Index: -20.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1906
    Cell Significance Index: -8.9600
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.1954
    Cell Significance Index: -1.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2127
    Cell Significance Index: -15.8500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2335
    Cell Significance Index: -14.7200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2401
    Cell Significance Index: -3.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2472
    Cell Significance Index: -16.6200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2943
    Cell Significance Index: -7.8900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3093
    Cell Significance Index: -7.9500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3500
    Cell Significance Index: -12.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3519
    Cell Significance Index: -7.5000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3519
    Cell Significance Index: -5.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4047
    Cell Significance Index: -18.8700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4463
    Cell Significance Index: -5.0700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4768
    Cell Significance Index: -12.7300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5015
    Cell Significance Index: -16.4200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5261
    Cell Significance Index: -18.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5298
    Cell Significance Index: -16.8800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5714
    Cell Significance Index: -14.2500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6264
    Cell Significance Index: -18.4500
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: -0.6304
    Cell Significance Index: -5.1500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.6413
    Cell Significance Index: -6.7700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6541
    Cell Significance Index: -18.7500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6876
    Cell Significance Index: -15.0600
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.6910
    Cell Significance Index: -7.3400
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.6986
    Cell Significance Index: -5.7800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.7021
    Cell Significance Index: -17.1300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.7424
    Cell Significance Index: -9.0300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.7511
    Cell Significance Index: -9.4900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7521
    Cell Significance Index: -18.7600
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.7876
    Cell Significance Index: -6.0100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7938
    Cell Significance Index: -18.3400
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.7964
    Cell Significance Index: -16.6100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.8050
    Cell Significance Index: -20.5100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.8262
    Cell Significance Index: -15.2700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8725
    Cell Significance Index: -22.2900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.8729
    Cell Significance Index: -18.8600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.8874
    Cell Significance Index: -10.5600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8889
    Cell Significance Index: -18.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.8966
    Cell Significance Index: -24.4100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.8989
    Cell Significance Index: -18.7600
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.9162
    Cell Significance Index: -15.7400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.9203
    Cell Significance Index: -10.5900
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.9253
    Cell Significance Index: -4.2600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.9374
    Cell Significance Index: -18.8200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.9410
    Cell Significance Index: -18.5200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.9473
    Cell Significance Index: -18.8900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.9538
    Cell Significance Index: -18.8600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.9719
    Cell Significance Index: -13.8100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.9794
    Cell Significance Index: -19.1500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.9893
    Cell Significance Index: -11.5000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -1.0049
    Cell Significance Index: -11.8800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.0393
    Cell Significance Index: -18.3700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.0668
    Cell Significance Index: -22.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell Surface Expression:** LY6D is primarily expressed on the surface of immune cells, including T cells and B cells, where it plays a crucial role in regulating their differentiation and adhesion. 2. **Cell Adhesion:** LY6D facilitates cell adhesion by interacting with other cell surface molecules, such as CD4 and CD8, which are essential for T cell activation and differentiation. 3. **Lymphocyte Differentiation:** LY6D regulates the differentiation of lymphocytes, including the development of T cells and B cells, which is essential for immune cell development and function. 4. **GPI-Anchored Protein Synthesis:** LY6D is involved in the synthesis of GPI-anchored proteins, which are essential for cell surface protein expression and function. **Pathways and Functions:** 1. **Cell Signaling:** LY6D regulates cell signaling pathways, including the PI3K/Akt and MAPK/ERK pathways, which are essential for immune cell activation and differentiation. 2. **Immune Cell Differentiation:** LY6D regulates the differentiation of immune cells, including the development of T cells and B cells, which is essential for immune cell development and function. 3. **Cell Adhesion:** LY6D facilitates cell adhesion by interacting with other cell surface molecules, such as CD4 and CD8, which are essential for T cell activation and differentiation. 4. **Protein Synthesis:** LY6D is involved in the synthesis of GPI-anchored proteins, which are essential for cell surface protein expression and function. **Clinical Significance:** 1. **Immunological Disorders:** LY6D has been implicated in various immunological disorders, including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer Immunotherapy:** LY6D has been identified as a potential target for cancer immunotherapy, where it can be used to enhance anti-tumor immune responses. 3. **Infectious Diseases:** LY6D has been implicated in the development of infectious diseases, such as HIV and tuberculosis, where it plays a crucial role in regulating immune cell differentiation and adhesion. 4. **Regenerative Medicine:** LY6D has been identified as a potential target for regenerative medicine, where it can be used to enhance tissue repair and regeneration. In conclusion, LY6D is a gene that plays a crucial role in regulating lymphocyte differentiation and adhesion, which are essential processes in immune cell development and activation. Its clinical significance extends to various immunological disorders, cancer immunotherapy, infectious diseases, and regenerative medicine, highlighting its potential as a therapeutic target and research tool.

Genular Protein ID: 4199462439

Symbol: LY6D_HUMAN

Name: Lymphocyte antigen 6D

UniProtKB Accession Codes:

Q14210 B2R5F1 D3DWJ0 O43783 Q6GTV9 Q8TBD4 Q92933

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7790363

Title: The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB, is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion.

PubMed ID: 7790363

DOI: 10.1083/jcb.129.6.1677

PubMed ID: 9366413

Title: A gain of novel tissue specificity in the human Ly-6 gene E48.

PubMed ID: 9366413

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9551972

Title: Characterization and mapping to human chromosome 8q24.3 of Ly-6-related gene 9804 encoding an apparent homologue of mouse TSA-1.

PubMed ID: 9551972

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

Sequence Information:

  • Length: 128
  • Mass: 13286
  • Checksum: 39618DF6AB5B0EBD
  • Sequence:
    • MRTALLLLAA LAVATGPALT LRCHVCTSSS NCKHSVVCPA SSRFCKTTNT VEPLRGNLVK 
KDCAESCTPS YTLQGQVSSG TSSTQCCQED LCNEKLHNAA PTRTALAHSA LSLGLALSLL 
AVILAPSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.