Details for: NTS

Gene ID: 4922

Symbol: NTS

Ensembl ID: ENSG00000133636

Description: neurotensin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 21.8717
    Cell Significance Index: -9.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.8921
    Cell Significance Index: 570.1200
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 3.0401
    Cell Significance Index: 31.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2717
    Cell Significance Index: 57.6400
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.2067
    Cell Significance Index: 8.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0864
    Cell Significance Index: 206.7600
  • Cell Name: dermis microvascular lymphatic vessel endothelial cell (CL2000041)
    Fold Change: 1.0226
    Cell Significance Index: 4.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7283
    Cell Significance Index: 15.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5589
    Cell Significance Index: 504.6100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4101
    Cell Significance Index: 44.6100
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.3906
    Cell Significance Index: 3.3600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3796
    Cell Significance Index: 61.7500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3648
    Cell Significance Index: 21.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2349
    Cell Significance Index: 23.2400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1535
    Cell Significance Index: 10.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1517
    Cell Significance Index: 4.3700
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.0923
    Cell Significance Index: 0.5500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0886
    Cell Significance Index: 1.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0701
    Cell Significance Index: 4.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0596
    Cell Significance Index: 2.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0222
    Cell Significance Index: 4.0000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0149
    Cell Significance Index: 0.2300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0125
    Cell Significance Index: 0.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0022
    Cell Significance Index: 1.5400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0010
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0017
    Cell Significance Index: -1.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0031
    Cell Significance Index: -5.8900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0037
    Cell Significance Index: -2.7400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0045
    Cell Significance Index: -2.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0056
    Cell Significance Index: -10.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0060
    Cell Significance Index: -3.3000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0066
    Cell Significance Index: -0.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0067
    Cell Significance Index: -10.3000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0080
    Cell Significance Index: -6.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0080
    Cell Significance Index: -10.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0092
    Cell Significance Index: -1.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0110
    Cell Significance Index: -3.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0118
    Cell Significance Index: -8.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0132
    Cell Significance Index: -8.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0178
    Cell Significance Index: -6.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0189
    Cell Significance Index: -3.2200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0198
    Cell Significance Index: -0.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0206
    Cell Significance Index: -9.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0247
    Cell Significance Index: -5.2100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0268
    Cell Significance Index: -0.7700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0316
    Cell Significance Index: -3.6100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0321
    Cell Significance Index: -0.7700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0323
    Cell Significance Index: -6.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0328
    Cell Significance Index: -6.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0333
    Cell Significance Index: -4.0900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0372
    Cell Significance Index: -1.1900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0524
    Cell Significance Index: -3.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0565
    Cell Significance Index: -8.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0589
    Cell Significance Index: -8.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0703
    Cell Significance Index: -9.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0753
    Cell Significance Index: -2.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0762
    Cell Significance Index: -7.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0763
    Cell Significance Index: -5.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0773
    Cell Significance Index: -8.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0932
    Cell Significance Index: -2.4000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1095
    Cell Significance Index: -1.6500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1183
    Cell Significance Index: -8.8200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1214
    Cell Significance Index: -1.8400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1294
    Cell Significance Index: -2.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1411
    Cell Significance Index: -7.3500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1440
    Cell Significance Index: -3.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1536
    Cell Significance Index: -7.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1566
    Cell Significance Index: -8.7900
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.1757
    Cell Significance Index: -1.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1764
    Cell Significance Index: -9.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1776
    Cell Significance Index: -7.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1811
    Cell Significance Index: -9.4100
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.1857
    Cell Significance Index: -1.3500
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.1863
    Cell Significance Index: -1.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1906
    Cell Significance Index: -8.9600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2001
    Cell Significance Index: -10.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2034
    Cell Significance Index: -5.4500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2044
    Cell Significance Index: -7.7400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2087
    Cell Significance Index: -7.6600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2091
    Cell Significance Index: -8.5700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.2112
    Cell Significance Index: -2.0900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2112
    Cell Significance Index: -5.6500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2125
    Cell Significance Index: -6.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2172
    Cell Significance Index: -7.1100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2209
    Cell Significance Index: -3.1000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2218
    Cell Significance Index: -7.7700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2305
    Cell Significance Index: -7.3400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2415
    Cell Significance Index: -3.9800
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.2415
    Cell Significance Index: -0.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2481
    Cell Significance Index: -8.6200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2553
    Cell Significance Index: -4.0500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2648
    Cell Significance Index: -6.6200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2734
    Cell Significance Index: -2.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2854
    Cell Significance Index: -7.6200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2914
    Cell Significance Index: -7.4500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2959
    Cell Significance Index: -7.7800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.3053
    Cell Significance Index: -4.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3115
    Cell Significance Index: -8.9300
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.3189
    Cell Significance Index: -1.6700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3195
    Cell Significance Index: -7.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure and Function:** NTS is a 13-amino acid peptide that belongs to the tachykinin family. It exhibits a unique structure, with a hydrophobic core and a C-terminal amidated sequence, which is essential for its biological activity. 2. **Receptor Binding:** NTS binds to GPCR family members, including class A/1 rhodopsin-like receptors, which are involved in various physiological processes, including vision, cognition, and immune response. 3. **Signaling Pathways:** NTS modulates signaling pathways, including Gαq signaling events, phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling, and NF-κB transcription factor activity, which are critical for immune and inflammatory responses. 4. **Cellular Expression:** NTS is expressed in a wide range of cell types, including respiratory basal cells, amacrine cells, GABAergic interneurons, and immune cells, such as granulocyte-monocyte progenitor cells and enterocytes. **Pathways and Functions:** 1. **Immune Response:** NTS modulates immune response by regulating the expression of genes involved in inflammation and immune cell activation. It also interacts with GPCR receptors, which are involved in the regulation of immune cell function and cytokine production. 2. **Neurological Functions:** NTS plays a crucial role in neuronal communication, including the regulation of neurotransmitter release and synaptic plasticity. It also modulates GABAergic transmission, which is essential for maintaining balance in the nervous system. 3. **Blood Vessel Diameter Maintenance:** NTS regulates blood vessel diameter through its interaction with GPCR receptors, which are involved in the regulation of vascular tone and blood pressure. 4. **Neurotensin Signaling Pathway:** The neurotensin signaling pathway involves the activation of GPCR receptors, which initiate a cascade of signaling events, including the activation of PI3K/Akt and NF-κB transcription factors. **Clinical Significance:** 1. **Cancer and Immune Response:** NTS has been implicated in cancer development and progression, particularly in lung and breast cancers. Its interaction with GPCR receptors modulates immune response and tumor growth. 2. **Neurological Disorders:** NTS has been linked to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. Its dysregulation may contribute to the pathogenesis of these conditions. 3. **Pain and Inflammation:** NTS has been shown to modulate pain and inflammation by regulating the expression of genes involved in pain signaling and immune response. 4. **Therapeutic Applications:** NTS and its receptors have been targeted for therapeutic applications, including the treatment of cancer, neurological disorders, and inflammatory diseases. In conclusion, neurotensin is a multifaceted neuropeptide hormone that plays a crucial role in immune and neurological processes. Its interaction with GPCR receptors modulates signaling pathways, including those involved in inflammation, immune response, and neuronal communication. Further research is necessary to fully understand the mechanisms of NTS signaling and its clinical significance in various diseases.

Genular Protein ID: 1622417429

Symbol: NEUT_HUMAN

Name: Neurotensin/neuromedin N

UniProtKB Accession Codes:

P30990

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9530155

Title: DNA methylation contributes to expression of the human neurotensin/neuromedin N gene.

PubMed ID: 9530155

DOI: 10.1152/ajpgi.1998.274.3.g535

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1436492

Title: Cloning of human neurotensin/neuromedin N genomic sequences and expression in the ventral mesencephalon of schizophrenics and age/sex matched controls.

PubMed ID: 1436492

DOI: 10.1016/0306-4522(92)90421-w

PubMed ID: 6208535

Title: Hydrolysis of substance p and neurotensin by converting enzyme and neutral endopeptidase.

PubMed ID: 6208535

DOI: 10.1016/0196-9781(84)90020-2

PubMed ID: 11294867

Title: Activation and functional characterization of the mosaic receptor SorLA/LR11.

PubMed ID: 11294867

DOI: 10.1074/jbc.m100857200

PubMed ID: 19122660

Title: Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain.

PubMed ID: 19122660

DOI: 10.1038/nsmb.1543

PubMed ID: 23140271

Title: Intermolecular interactions between the neurotensin and the third extracellular loop of human neurotensin 1 receptor.

PubMed ID: 23140271

DOI: 10.1080/07391102.2012.736776

Sequence Information:

  • Length: 170
  • Mass: 19795
  • Checksum: 66E2E146DA08E3C7
  • Sequence:
    • MMAGMKIQLV CMLLLAFSSW SLCSDSEEEM KALEADFLTN MHTSKISKAH VPSWKMTLLN 
VCSLVNNLNS PAEETGEVHE EELVARRKLP TALDGFSLEA MLTIYQLHKI CHSRAFQHWE 
LIQEDILDTG NDKNGKEEVI KRKIPYILKR QLYENKPRRP YILKRDSYYY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.