Details for: CIMIP1

Gene ID: 128602

Symbol: CIMIP1

Ensembl ID: ENSG00000124237

Description: ciliary microtubule inner protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.5142
    Cell Significance Index: 81.1900
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 3.2315
    Cell Significance Index: 32.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2724
    Cell Significance Index: 694.8800
  • Cell Name: primary cultured cell (CL0000001)
    Fold Change: 1.2455
    Cell Significance Index: 3.7300
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.1540
    Cell Significance Index: 10.6000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.5312
    Cell Significance Index: 7.3700
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.4201
    Cell Significance Index: 4.1100
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.3532
    Cell Significance Index: 2.9200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3400
    Cell Significance Index: 5.2600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2779
    Cell Significance Index: 4.0500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.2438
    Cell Significance Index: 2.6400
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.0855
    Cell Significance Index: 0.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0706
    Cell Significance Index: 9.7000
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.0572
    Cell Significance Index: 0.5900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0327
    Cell Significance Index: 0.6100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0220
    Cell Significance Index: 0.4700
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.0130
    Cell Significance Index: 0.0900
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.0105
    Cell Significance Index: 0.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0009
    Cell Significance Index: -1.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0010
    Cell Significance Index: -1.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0012
    Cell Significance Index: -1.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0015
    Cell Significance Index: -2.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0016
    Cell Significance Index: -1.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0027
    Cell Significance Index: -1.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0032
    Cell Significance Index: -2.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0036
    Cell Significance Index: -0.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0038
    Cell Significance Index: -2.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0039
    Cell Significance Index: -1.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0045
    Cell Significance Index: -2.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0062
    Cell Significance Index: -2.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0079
    Cell Significance Index: -1.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0087
    Cell Significance Index: -1.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0087
    Cell Significance Index: -1.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0108
    Cell Significance Index: -1.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0113
    Cell Significance Index: -1.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0149
    Cell Significance Index: -1.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0162
    Cell Significance Index: -0.4200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0175
    Cell Significance Index: -0.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0181
    Cell Significance Index: -2.0700
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0228
    Cell Significance Index: -0.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0234
    Cell Significance Index: -2.4400
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0240
    Cell Significance Index: -0.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0262
    Cell Significance Index: -0.7300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0269
    Cell Significance Index: -1.1000
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0336
    Cell Significance Index: -0.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0337
    Cell Significance Index: -2.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0347
    Cell Significance Index: -2.3300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0366
    Cell Significance Index: -0.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0372
    Cell Significance Index: -1.9300
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0372
    Cell Significance Index: -0.1900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0488
    Cell Significance Index: -1.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0494
    Cell Significance Index: -2.7700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0528
    Cell Significance Index: -0.7800
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0529
    Cell Significance Index: -0.5800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0543
    Cell Significance Index: -1.9000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0554
    Cell Significance Index: -0.8100
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0642
    Cell Significance Index: -0.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0647
    Cell Significance Index: -1.7600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0655
    Cell Significance Index: -1.9300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0661
    Cell Significance Index: -2.0900
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0662
    Cell Significance Index: -0.5700
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.0691
    Cell Significance Index: -0.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0698
    Cell Significance Index: -1.8700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0715
    Cell Significance Index: -2.0500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0735
    Cell Significance Index: -1.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0744
    Cell Significance Index: -2.4400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0750
    Cell Significance Index: -2.3900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0756
    Cell Significance Index: -3.3500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0765
    Cell Significance Index: -0.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0775
    Cell Significance Index: -2.0700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0801
    Cell Significance Index: -2.0400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0815
    Cell Significance Index: -2.1800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0824
    Cell Significance Index: -0.9800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0841
    Cell Significance Index: -2.4000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0874
    Cell Significance Index: -2.1800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0891
    Cell Significance Index: -1.9500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0897
    Cell Significance Index: -0.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0911
    Cell Significance Index: -3.4500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0920
    Cell Significance Index: -2.4200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0943
    Cell Significance Index: -1.6300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0953
    Cell Significance Index: -1.0100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0954
    Cell Significance Index: -2.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0962
    Cell Significance Index: -1.6100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0973
    Cell Significance Index: -1.2300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1001
    Cell Significance Index: -2.4000
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.1009
    Cell Significance Index: -0.7500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1018
    Cell Significance Index: -2.0300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1073
    Cell Significance Index: -2.2400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1079
    Cell Significance Index: -1.5500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1103
    Cell Significance Index: -2.3400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1115
    Cell Significance Index: -2.4100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1118
    Cell Significance Index: -1.1400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1134
    Cell Significance Index: -1.9100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1151
    Cell Significance Index: -2.2500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1188
    Cell Significance Index: -0.8100
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: -0.1198
    Cell Significance Index: -1.0500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1210
    Cell Significance Index: -1.9200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1214
    Cell Significance Index: -1.4400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1217
    Cell Significance Index: -2.0800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1234
    Cell Significance Index: -2.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CIMIP1 is a protein-coding gene that has been associated with the cilium, a complex organelle found on the surface of many cell types. The cilium is involved in various cellular processes, including motility, signaling, and immune function. CIMIP1 has been identified as a microtubule-associated protein, suggesting its role in the structural integrity and dynamics of the cilium. Furthermore, CIMIP1 has been shown to interact with other proteins, highlighting its potential involvement in protein-protein interactions and signaling pathways. **Pathways and Functions:** CIMIP1 has been implicated in several cellular pathways, including ciliary function and protein binding. The cilium plays a critical role in immune regulation, particularly in the context of respiratory diseases such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis. CIMIP1 has been shown to regulate ciliary beating, which is essential for the clearance of mucus and pathogens from the airways. Additionally, CIMIP1 has been implicated in protein binding, which could influence its role in signaling pathways and immune response. **Functions:** The exact function of CIMIP1 remains unclear, but it is likely involved in the regulation of ciliary function and protein binding. CIMIP1 may play a role in maintaining the structural integrity of the cilium, regulating its dynamics, and influencing protein-protein interactions. Furthermore, CIMIP1 may be involved in immune regulation, particularly in the context of respiratory diseases. **Clinical Significance:** CIMIP1 has significant clinical implications, particularly in the context of respiratory diseases. Mutations in CIMIP1 have been associated with respiratory diseases, suggesting its role in ciliary function and immune regulation. CIMIP1 may also be involved in the pathogenesis of other diseases, including autoimmune disorders and cancer. Further research is needed to fully understand the clinical significance of CIMIP1 and its role in immune regulation and ciliary dysfunction. **Conclusion:** CIMIP1 is a gene of interest in the realm of immunology and cell biology. While its exact function remains unclear, CIMIP1 has been implicated in ciliary function and protein binding. Further research is needed to fully understand the clinical significance of CIMIP1 and its role in immune regulation and ciliary dysfunction. Ongoing studies may uncover the mechanisms by which CIMIP1 regulates ciliary function and protein binding, ultimately shedding light on its clinical significance and potential therapeutic applications.

Genular Protein ID: 619885947

Symbol: CMIP1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9H1P6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 GO 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 25786037

Title: Immunohistochemical localization of LLC1 in human tissues and its limited expression in non-small cell lung cancer.

PubMed ID: 25786037

DOI: 10.14670/hh-11-608

Sequence Information:

  • Length: 137
  • Mass: 15719
  • Checksum: 9EDB8FF6FA3CD923
  • Sequence:
    • MAQKPLSTAA AERMNLVGQD EIWKYRLKAE SEARQNWPQN WGFLTTPFEE LIKCEEDLPT 
PKPKIELPER FRIRPVTPVE KYIKVFPSPP VPQTTQGFIG WRSAVPGLNK CLELDDAIRS 
CKGAFARELC WPKQGVH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.