Details for: BPIFA1

Gene ID: 51297

Symbol: BPIFA1

Ensembl ID: ENSG00000198183

Description: BPI fold containing family A member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 3.5898
    Cell Significance Index: 37.0300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.8646
    Cell Significance Index: 46.4000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.9843
    Cell Significance Index: 33.9200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.6625
    Cell Significance Index: 9.0900
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.5432
    Cell Significance Index: 4.4900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0116
    Cell Significance Index: 0.1500
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0006
    Cell Significance Index: 0.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0002
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0003
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.0048
    Cell Significance Index: -0.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0092
    Cell Significance Index: -6.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0280
    Cell Significance Index: -15.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0374
    Cell Significance Index: -6.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0560
    Cell Significance Index: -16.1000
  • Cell Name: serous cell of epithelium of trachea (CL1000330)
    Fold Change: -0.0818
    Cell Significance Index: -0.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0833
    Cell Significance Index: -16.7100
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.1110
    Cell Significance Index: -0.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1127
    Cell Significance Index: -15.4800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2277
    Cell Significance Index: -8.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2360
    Cell Significance Index: -3.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2400
    Cell Significance Index: -16.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2601
    Cell Significance Index: -13.5100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2959
    Cell Significance Index: -7.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3075
    Cell Significance Index: -14.3400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.3631
    Cell Significance Index: -5.0200
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.3925
    Cell Significance Index: -8.1900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3972
    Cell Significance Index: -4.1900
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.4303
    Cell Significance Index: -5.1200
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.4474
    Cell Significance Index: -5.3400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.4743
    Cell Significance Index: -6.7400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4844
    Cell Significance Index: -12.0800
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.4906
    Cell Significance Index: -4.9100
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.4966
    Cell Significance Index: -4.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4998
    Cell Significance Index: -8.3700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.5031
    Cell Significance Index: -6.5000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5032
    Cell Significance Index: -9.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5169
    Cell Significance Index: -13.8500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5180
    Cell Significance Index: -16.9600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.5217
    Cell Significance Index: -10.2000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.5295
    Cell Significance Index: -8.4000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5331
    Cell Significance Index: -16.9800
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.5385
    Cell Significance Index: -4.1000
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.5425
    Cell Significance Index: -5.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5453
    Cell Significance Index: -14.5600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5656
    Cell Significance Index: -16.1400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.5689
    Cell Significance Index: -13.7800
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.5853
    Cell Significance Index: -5.9700
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: -0.5915
    Cell Significance Index: -3.9500
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.5971
    Cell Significance Index: -6.6400
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.6386
    Cell Significance Index: -6.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6469
    Cell Significance Index: -14.1700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.6552
    Cell Significance Index: -6.9600
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.6567
    Cell Significance Index: -5.9400
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.6680
    Cell Significance Index: -8.4600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.6711
    Cell Significance Index: -16.7400
  • Cell Name: lung interstitial macrophage (CL4033043)
    Fold Change: -0.6787
    Cell Significance Index: -6.5400
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.6806
    Cell Significance Index: -6.7400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.6841
    Cell Significance Index: -8.8100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.7066
    Cell Significance Index: -14.0900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7076
    Cell Significance Index: -16.9700
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: -0.7319
    Cell Significance Index: -7.1900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.7483
    Cell Significance Index: -10.1800
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.7557
    Cell Significance Index: -7.0400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.7628
    Cell Significance Index: -13.1500
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.7646
    Cell Significance Index: -8.1200
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.7697
    Cell Significance Index: -7.5300
  • Cell Name: basophil (CL0000767)
    Fold Change: -0.7737
    Cell Significance Index: -7.1200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.7804
    Cell Significance Index: -16.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7883
    Cell Significance Index: -16.7300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.7965
    Cell Significance Index: -9.9500
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.8013
    Cell Significance Index: -9.0900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.8017
    Cell Significance Index: -8.6800
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: -0.8078
    Cell Significance Index: -6.1200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.8093
    Cell Significance Index: -16.8900
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: -0.8122
    Cell Significance Index: -5.7000
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.8234
    Cell Significance Index: -8.7600
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.8277
    Cell Significance Index: -9.5400
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.8303
    Cell Significance Index: -8.7500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.8400
    Cell Significance Index: -16.8700
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.8415
    Cell Significance Index: -10.5700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.8466
    Cell Significance Index: -16.7400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.8470
    Cell Significance Index: -16.6700
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.8525
    Cell Significance Index: -7.8300
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.8603
    Cell Significance Index: -7.2800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.8655
    Cell Significance Index: -9.9600
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.8714
    Cell Significance Index: -8.0600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.8812
    Cell Significance Index: -12.6200
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.8887
    Cell Significance Index: -9.6200
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: -0.8993
    Cell Significance Index: -7.8800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.9003
    Cell Significance Index: -10.1500
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.9049
    Cell Significance Index: -10.2800
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.9086
    Cell Significance Index: -9.9600
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.9095
    Cell Significance Index: -9.6200
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.9226
    Cell Significance Index: -9.6700
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.9230
    Cell Significance Index: -8.4400
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.9312
    Cell Significance Index: -9.6500
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.9372
    Cell Significance Index: -11.1400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.9464
    Cell Significance Index: -9.9700
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.9505
    Cell Significance Index: -9.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BPIFA1 is a 23-kDa protein that belongs to the BPI fold-containing family A. Its structure consists of a single BPI fold, which is a characteristic domain known for its antimicrobial properties. The protein is highly expressed in cells that are involved in the innate immune response, such as respiratory goblet cells and megakaryocytes. BPIFA1 has been shown to interact with various proteins, including antimicrobial peptides, and modulate the activity of other proteins involved in immune responses. **Pathways and Functions:** BPIFA1 is involved in several biological pathways, including: 1. **Antibacterial humoral response:** BPIFA1 interacts with antimicrobial peptides, such as defensins, and enhances their antimicrobial activity against Gram-negative bacteria. 2. **Antimicrobial peptides:** BPIFA1 binds to and regulates the activity of antimicrobial peptides, such as cathelicidins, which are essential for innate immune defense. 3. **Defense response to virus:** BPIFA1 has been shown to inhibit the replication of certain viruses, such as influenza virus, by modulating the activity of immune cells. 4. **Surfactant homeostasis:** BPIFA1 regulates the surface tension of lung surfactant, which is essential for maintaining proper lung function and preventing respiratory distress syndrome. 5. **Regulation of sodium ion transmembrane transport:** BPIFA1 interacts with sodium channels and regulates the transport of sodium ions across cell membranes. **Clinical Significance:** Dysregulation of BPIFA1 has been implicated in various diseases, including: 1. **Respiratory disorders:** BPIFA1 deficiency has been associated with respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma. 2. **Metabolic disorders:** BPIFA1 has been shown to regulate lipid metabolism and insulin sensitivity, making it a potential target for the treatment of metabolic disorders, such as type 2 diabetes. 3. **Cancer:** BPIFA1 has been implicated in the regulation of cancer cell growth and invasion, making it a potential target for cancer therapy. In conclusion, BPIFA1 is a multifunctional protein that plays a critical role in the human immune system and homeostasis. Its dysregulation may have significant implications for the development of respiratory and metabolic disorders. Further research is needed to fully understand the mechanisms of BPIFA1 and its potential therapeutic applications.

Genular Protein ID: 814269290

Symbol: BPIA1_HUMAN

Name: BPI fold-containing family A member 1

UniProtKB Accession Codes:

Q9NP55 A6XMV5 A8K9R3 E1P5M9 Q9NZT0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 16 Ensembl 3 EvolutionaryTrace 1 GO 12 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11018263

Title: Characterization of the human plunc gene, a gene product with an upper airways and nasopharyngeal restricted expression pattern.

PubMed ID: 11018263

DOI: 10.1016/s0167-4781(00)00196-2

PubMed ID: 11251963

Title: Isolation of a novel human lung-specific gene, LUNX, a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer.

PubMed ID: 11251963

DOI: 10.1002/1097-0215(200002)9999:9999<::aid-ijc1059>3.0.co;2-b

PubMed ID: 12409287

Title: Molecular cloning and characterization of spurt, a human novel gene that is retinoic acid-inducible and encodes a secretory protein specific in upper respiratory tracts.

PubMed ID: 12409287

DOI: 10.1074/jbc.m210523200

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11425234

Title: Identification of a new potential airway irritation marker, palate lung nasal epithelial clone protein, in human nasal lavage fluid with two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-time of flight.

PubMed ID: 11425234

DOI: 10.1002/1522-2683(200105)22:9<1795::aid-elps1795>3.0.co;2-j

PubMed ID: 15158712

Title: PLUNC in human nasal lavage fluid: multiple isoforms that bind to lipopolysaccharide.

PubMed ID: 15158712

DOI: 10.1016/j.bbapap.2004.01.001

PubMed ID: 12920053

Title: Purification and characterization of PLUNC from human tracheobronchial secretions.

PubMed ID: 12920053

DOI: 10.1165/rcmb.2003-0142oc

PubMed ID: 23499554

Title: SPLUNC1/BPIFA1 contributes to pulmonary host defense against Klebsiella pneumoniae respiratory infection.

PubMed ID: 23499554

DOI: 10.1016/j.ajpath.2013.01.050

PubMed ID: 24124190

Title: Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures.

PubMed ID: 24124190

DOI: 10.1152/ajplung.00103.2013

PubMed ID: 23132494

Title: Multifunctional role of human SPLUNC1 in Pseudomonas aeruginosa infection.

PubMed ID: 23132494

DOI: 10.1128/iai.00500-12

PubMed ID: 26559477

Title: Palate Lung Nasal Clone (PLUNC), a Novel Protein of the Tear Film: Three-Dimensional Structure, Immune Activation, and Involvement in Dry Eye Disease (DED).

PubMed ID: 26559477

DOI: 10.1167/iovs.15-17560

PubMed ID: 24043776

Title: Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways.

PubMed ID: 24043776

DOI: 10.1073/pnas.1311999110

PubMed ID: 25223608

Title: Structural characterization of the pulmonary innate immune protein SPLUNC1 and identification of lipid ligands.

PubMed ID: 25223608

DOI: 10.1096/fj.14-259291

PubMed ID: 27145151

Title: Structural Features Essential to the Antimicrobial Functions of Human SPLUNC1.

PubMed ID: 27145151

DOI: 10.1021/acs.biochem.6b00271

Sequence Information:

  • Length: 256
  • Mass: 26713
  • Checksum: EDF152FBC35315BC
  • Sequence:
    • MFQTGGLIVF YGLLAQTMAQ FGGLPVPLDQ TLPLNVNPAL PLSPTGLAGS LTNALSNGLL 
SGGLLGILEN LPLLDILKPG GGTSGGLLGG LLGKVTSVIP GLNNIIDIKV TDPQLLELGL 
VQSPDGHRLY VTIPLGIKLQ VNTPLVGASL LRLAVKLDIT AEILAVRDKQ ERIHLVLGDC 
THSPGSLQIS LLDGLGPLPI QGLLDSLTGI LNKVLPELVQ GNVCPLVNEV LRGLDITLVH 
DIVNMLIHGL QFVIKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.