Details for: SPRR2A

Gene ID: 6700

Symbol: SPRR2A

Ensembl ID: ENSG00000241794

Description: small proline rich protein 2A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 18.9661
    Cell Significance Index: 307.1800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 8.8317
    Cell Significance Index: 114.2800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 8.2358
    Cell Significance Index: 112.9400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 7.2547
    Cell Significance Index: 62.3400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 4.7609
    Cell Significance Index: 60.1600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 3.0996
    Cell Significance Index: 20.5800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.3396
    Cell Significance Index: 4.9300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3344
    Cell Significance Index: 9.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0598
    Cell Significance Index: 10.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0508
    Cell Significance Index: 31.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0317
    Cell Significance Index: 4.0700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0228
    Cell Significance Index: 0.3900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0116
    Cell Significance Index: 0.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0158
    Cell Significance Index: -11.9800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0203
    Cell Significance Index: -15.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0220
    Cell Significance Index: -2.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0259
    Cell Significance Index: -14.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0270
    Cell Significance Index: -15.2200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0313
    Cell Significance Index: -0.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0533
    Cell Significance Index: -9.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0535
    Cell Significance Index: -6.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0744
    Cell Significance Index: -9.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0757
    Cell Significance Index: -15.9400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0793
    Cell Significance Index: -9.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0833
    Cell Significance Index: -9.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1055
    Cell Significance Index: -14.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1737
    Cell Significance Index: -2.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1923
    Cell Significance Index: -9.9900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2218
    Cell Significance Index: -5.5400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2292
    Cell Significance Index: -8.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2623
    Cell Significance Index: -16.1200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2745
    Cell Significance Index: -17.3000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3051
    Cell Significance Index: -4.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3501
    Cell Significance Index: -16.4600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3512
    Cell Significance Index: -5.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3736
    Cell Significance Index: -17.4200
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.3892
    Cell Significance Index: -2.9700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3898
    Cell Significance Index: -11.4800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.3942
    Cell Significance Index: -4.8000
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.4413
    Cell Significance Index: -3.3600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4510
    Cell Significance Index: -12.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4643
    Cell Significance Index: -12.2100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5089
    Cell Significance Index: -12.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5161
    Cell Significance Index: -13.7800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.5281
    Cell Significance Index: -5.6100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.5343
    Cell Significance Index: -5.4500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.5385
    Cell Significance Index: -13.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5759
    Cell Significance Index: -16.5100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6195
    Cell Significance Index: -11.4500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.6238
    Cell Significance Index: -6.5800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.6416
    Cell Significance Index: -6.9900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6846
    Cell Significance Index: -14.3300
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.6953
    Cell Significance Index: -7.0500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7038
    Cell Significance Index: -16.8800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.7074
    Cell Significance Index: -9.1400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.7330
    Cell Significance Index: -9.7400
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.7561
    Cell Significance Index: -6.2500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7588
    Cell Significance Index: -12.7000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.7612
    Cell Significance Index: -15.7900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.8091
    Cell Significance Index: -10.2100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.8161
    Cell Significance Index: -9.7000
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.8215
    Cell Significance Index: -7.8000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.8303
    Cell Significance Index: -9.8800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.8312
    Cell Significance Index: -10.4400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.8390
    Cell Significance Index: -14.2500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8491
    Cell Significance Index: -27.8000
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.8589
    Cell Significance Index: -9.0900
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.8631
    Cell Significance Index: -8.8800
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.8818
    Cell Significance Index: -15.1500
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.8886
    Cell Significance Index: -9.8700
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.9012
    Cell Significance Index: -6.6700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.9026
    Cell Significance Index: -12.6600
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.9045
    Cell Significance Index: -9.3300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.9277
    Cell Significance Index: -18.6300
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.9279
    Cell Significance Index: -9.8200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.9320
    Cell Significance Index: -18.1900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.9338
    Cell Significance Index: -18.4700
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.9647
    Cell Significance Index: -10.6800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.9831
    Cell Significance Index: -12.5900
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.9874
    Cell Significance Index: -10.5500
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: -0.9891
    Cell Significance Index: -9.8100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.9898
    Cell Significance Index: -12.3700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.9924
    Cell Significance Index: -19.7900
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: -0.9952
    Cell Significance Index: -9.7700
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -1.0116
    Cell Significance Index: -11.2500
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: -1.0161
    Cell Significance Index: -9.4700
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -1.0234
    Cell Significance Index: -12.1500
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -1.0236
    Cell Significance Index: -12.2100
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -1.0251
    Cell Significance Index: -9.8400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -1.0331
    Cell Significance Index: -16.3900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -1.0377
    Cell Significance Index: -11.9400
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -1.0378
    Cell Significance Index: -11.2100
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -1.0404
    Cell Significance Index: -10.3300
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -1.0447
    Cell Significance Index: -11.4100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -1.0495
    Cell Significance Index: -15.9400
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -1.0549
    Cell Significance Index: -11.3800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.0577
    Cell Significance Index: -9.7400
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -1.0674
    Cell Significance Index: -10.5300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -1.0759
    Cell Significance Index: -10.6500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.0763
    Cell Significance Index: -15.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Proline-rich domain:** SPRR2A contains a proline-rich domain, which is essential for its binding properties and interactions with other proteins. 2. **Cell-type specificity:** SPRR2A is expressed in various cell types, including hematopoietic stem cells, megakaryocytes, and keratinocytes, suggesting its involvement in different cellular processes. 3. **Multifaceted functions:** SPRR2A has been implicated in immune regulation, epithelial homeostasis, and development, highlighting its diverse roles in maintaining cellular and organismal homeostasis. **Pathways and Functions:** 1. **Antibacterial humoral response:** SPRR2A has been shown to be involved in the regulation of the antibacterial humoral response, which is crucial for defending against bacterial infections. 2. **Keratinization:** SPRR2A plays a role in the formation of the cornified envelope, a critical component of the skin's barrier function during keratinization. 3. **Host-mediated regulation of intestinal microbiota composition:** SPRR2A has been implicated in regulating the composition of the intestinal microbiota, which is essential for maintaining gut homeostasis and immune function. 4. **Defense response to gram-positive bacterium:** SPRR2A has been shown to be involved in the defense response to gram-positive bacteria, highlighting its role in regulating immune responses against bacterial infections. **Clinical Significance:** 1. **Skin disorders:** Mutations in SPRR2A have been associated with skin disorders, such as epidermolysis bullosa simplex, highlighting its importance in maintaining skin homeostasis. 2. **Immune system dysregulation:** Alterations in SPRR2A expression have been linked to immune system dysregulation, including autoimmune diseases and immunodeficiency disorders. 3. **Cancer:** SPRR2A has been implicated in cancer development and progression, particularly in epithelial cancers, where it may play a role in regulating cell growth and differentiation. In conclusion, SPRR2A is a multifaceted gene that plays a crucial role in regulating immune responses, epithelial homeostasis, and development. Its dysregulation has been implicated in various human diseases, including skin disorders, immune system dysregulation, and cancer. Further research is necessary to fully elucidate the mechanisms underlying SPRR2A's functions and to explore its therapeutic potential in human disease.

Genular Protein ID: 2264524135

Symbol: SPR2A_HUMAN

Name: N/A

UniProtKB Accession Codes:

P35326 B2R4T3 D3DV35 Q5T529

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PIR 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2388825

Title: Characterization of the human spr2 promoter: induction after UV irradiation or TPA treatment and regulation during differentiation of cultured primary keratinocytes.

PubMed ID: 2388825

DOI: 10.1093/nar/18.15.4401

PubMed ID: 8325635

Title: Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins.

PubMed ID: 8325635

DOI: 10.1006/geno.1993.1240

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 34735226

Title: Small proline-rich protein 2A is a gut bactericidal protein deployed during helminth infection.

PubMed ID: 34735226

DOI: 10.1126/science.abe6723

Sequence Information:

  • Length: 72
  • Mass: 7965
  • Checksum: 28B452D0F8B6344A
  • Sequence:
    • MSYQQQQCKQ PCQPPPVCPT PKCPEPCPPP KCPEPCPPPK CPQPCPPQQC QQKYPPVTPS 
PPCQSKYPPK SK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.