Details for: SLC9A3

Gene ID: 6550

Symbol: SLC9A3

Ensembl ID: ENSG00000066230

Description: solute carrier family 9 member A3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 5.26
    Marker Score: 8100.5
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 2.8
    Marker Score: 7915.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1162
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.57
    Marker Score: 1558.5
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.54
    Marker Score: 1507
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.44
    Marker Score: 3847
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.38
    Marker Score: 3256
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.29
    Marker Score: 4057
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.11
    Marker Score: 324
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 789
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71812
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48037
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.96
    Marker Score: 767
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5344
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.93
    Marker Score: 6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 368
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.89
    Marker Score: 4670.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5280
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.77
    Marker Score: 1375.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 701
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.74
    Marker Score: 1383
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.71
    Marker Score: 335
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2929
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.66
    Marker Score: 1145
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.65
    Marker Score: 656
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.59
    Marker Score: 1250
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.53
    Marker Score: 292
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.52
    Marker Score: 240
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.51
    Marker Score: 553
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.51
    Marker Score: 204
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.49
    Marker Score: 1752
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.48
    Marker Score: 4867
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.48
    Marker Score: 200
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.47
    Marker Score: 146
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.46
    Marker Score: 191
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 272
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.44
    Marker Score: 193
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.44
    Marker Score: 142
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.44
    Marker Score: 99
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.42
    Marker Score: 269
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.42
    Marker Score: 255
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.39
    Marker Score: 666
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.38
    Marker Score: 98
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.38
    Marker Score: 473
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.37
    Marker Score: 137
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.37
    Marker Score: 19441
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.36
    Marker Score: 384
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.36
    Marker Score: 2310
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.35
    Marker Score: 740
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.35
    Marker Score: 165
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.34
    Marker Score: 141
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.34
    Marker Score: 924
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.34
    Marker Score: 297
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.33
    Marker Score: 207
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.32
    Marker Score: 101
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.32
    Marker Score: 211
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.31
    Marker Score: 198
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.31
    Marker Score: 600.5
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.31
    Marker Score: 445
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.31
    Marker Score: 297
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.31
    Marker Score: 81
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.3
    Marker Score: 289
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3
    Marker Score: 733
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.3
    Marker Score: 217
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3
    Marker Score: 201
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.3
    Marker Score: 247.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.3
    Marker Score: 319
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.28
    Marker Score: 182
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.27
    Marker Score: 418
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.27
    Marker Score: 649
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.27
    Marker Score: 69
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.26
    Marker Score: 1583
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.26
    Marker Score: 92
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.26
    Marker Score: 203
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.26
    Marker Score: 263.5
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.25
    Marker Score: 236
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.25
    Marker Score: 167
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.25
    Marker Score: 142
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.25
    Marker Score: 178
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.25
    Marker Score: 120
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.25
    Marker Score: 230
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.24
    Marker Score: 212
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.24
    Marker Score: 1602
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.24
    Marker Score: 3148
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.23
    Marker Score: 256
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.23
    Marker Score: 158
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.23
    Marker Score: 983
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.23
    Marker Score: 88
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.23
    Marker Score: 125
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64

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Other Information

**Key Characteristics:** SLC9A3 is a transmembrane protein belonging to the solute carrier family 9, which is characterized by its ability to transport a wide range of ions and molecules across cellular membranes. The SLC9A3 gene encodes a protein with a unique structure, consisting of 12 transmembrane domains, which allows it to interact with various signaling pathways and regulatory proteins. The protein's ability to bind to phosphatidylinositol and Pdz domains makes it an attractive candidate for studying cellular signaling and trafficking. **Pathways and Functions:** SLC9A3 is involved in various cellular processes, including: 1. **Potassium:proton antiporter activity**: SLC9A3 mediates the transport of potassium ions (K+) and protons (H+) across the apical plasma membrane, playing a crucial role in maintaining the acid-base balance and regulating the cellular pH. 2. **Monoatomic ion transport**: The protein is also involved in the transport of monoatomic ions, such as sodium (Na+) and potassium (K+), across the plasma membrane, which is essential for maintaining cellular homeostasis. 3. **Protein binding**: SLC9A3 interacts with various regulatory proteins, including Pdz and phosphatidylinositol binding proteins, to modulate its activity and regulate cellular signaling pathways. 4. **Regulation of intracellular pH**: By controlling the transport of ions and molecules, SLC9A3 helps maintain the delicate balance of intracellular pH, which is essential for proper cellular function. **Clinical Significance:** The SLC9A3 gene has been implicated in various diseases, including: 1. **Diabetes**: Alterations in SLC9A3 expression have been linked to diabetes, highlighting its potential role in glucose homeostasis and insulin signaling. 2. **Neurological disorders**: The protein's involvement in potassium transport and cellular signaling makes it a potential candidate for studying neurological disorders, such as epilepsy and Alzheimer's disease. 3. **Gastrointestinal disorders**: SLC9A3's expression in enterocytes and goblet cells suggests its potential role in gastrointestinal disorders, such as inflammatory bowel disease and colorectal cancer. In conclusion, the SLC9A3 gene plays a vital role in maintaining cellular homeostasis and regulating various physiological processes. Further research is necessary to fully understand its functions and implications in disease, but its significance in the field of immunology and disease research is undeniable.

Genular Protein ID: 3937834017

Symbol: SL9A3_HUMAN

Name: Solute carrier family 9 member 3

UniProtKB Accession Codes:

P48764 B7ZKR2 E9PF67 Q3MIW3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEBI 9 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 6 EMDB 1 Ensembl 2 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7631746

Title: Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3.

PubMed ID: 7631746

DOI: 10.1152/ajpcell.1995.269.1.c198

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19088451

Title: Elevated intracellular calcium stimulates NHE3 activity by an IKEPP (NHERF4) dependent mechanism.

PubMed ID: 19088451

DOI: 10.1159/000185553

PubMed ID: 18829453

Title: IRBIT, inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3, binds Na+/H+ exchanger NHE3 and activates NHE3 activity in response to calcium.

PubMed ID: 18829453

DOI: 10.1074/jbc.m805534200

PubMed ID: 20584908

Title: Activation of Na+/H+ exchanger NHE3 by angiotensin II is mediated by inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3 (IRBIT) and Ca2+/calmodulin-dependent protein kinase II.

PubMed ID: 20584908

DOI: 10.1074/jbc.m110.133066

PubMed ID: 24622516

Title: Intestinal inhibition of the Na+/H+ exchanger 3 prevents cardiorenal damage in rats and inhibits Na+ uptake in humans.

PubMed ID: 24622516

DOI: 10.1126/scitranslmed.3007790

PubMed ID: 26358773

Title: Reduced sodium/proton exchanger NHE3 activity causes congenital sodium diarrhea.

PubMed ID: 26358773

DOI: 10.1093/hmg/ddv367

PubMed ID: 25851603

Title: Sorting nexin 27 regulates basal and stimulated brush border trafficking of NHE3.

PubMed ID: 25851603

DOI: 10.1091/mbc.e14-12-1597

PubMed ID: 35613257

Title: Structural basis of autoinhibition of the human NHE3-CHP1 complex.

PubMed ID: 35613257

DOI: 10.1126/sciadv.abn3925

PubMed ID: 31276831

Title: Congenital sodium diarrhea by mutation of the SLC9A3 gene.

PubMed ID: 31276831

DOI: 10.1016/j.ejmg.2019.103712

Sequence Information:

  • Length: 834
  • Mass: 92855
  • Checksum: 3E7CE3267F6E86F7
  • Sequence:
    • MWGLGARGPD RGLLLALALG GLARAGGVEV EPGGAHGESG GFQVVTFEWA HVQDPYVIAL 
WILVASLAKI GFHLSHKVTS VVPESALLIV LGLVLGGIVW AADHIASFTL TPTVFFFYLL 
PPIVLDAGYF MPNRLFFGNL GTILLYAVVG TVWNAATTGL SLYGVFLSGL MGDLQIGLLD 
FLLFGSLMAA VDPVAVLAVF EEVHVNEVLF IIVFGESLLN DAVTVVLYNV FESFVALGGD 
NVTGVDCVKG IVSFFVVSLG GTLVGVVFAF LLSLVTRFTK HVRIIEPGFV FIISYLSYLT 
SEMLSLSAIL AITFCGICCQ KYVKANISEQ SATTVRYTMK MLASSAETII FMFLGISAVN 
PFIWTWNTAF VLLTLVFISV YRAIGVVLQT WLLNRYRMVQ LEPIDQVVLS YGGLRGAVAF 
ALVVLLDGDK VKEKNLFVST TIIVVFFTVI FQGLTIKPLV QWLKVKRSEH REPRLNEKLH 
GRAFDHILSA IEDISGQIGH NYLRDKWSHF DRKFLSRVLM RRSAQKSRDR ILNVFHELNL 
KDAISYVAEG ERRGSLAFIR SPSTDNVVNV DFTPRSSTVE ASVSYLLREN VSAVCLDMQS 
LEQRRRSIRD AEDMVTHHTL QQYLYKPRQE YKHLYSRHEL TPTEDEKQDR EIFHRTMRKR 
LESFKSTKLG LNQNKKAAKL YKRERAQKRR NSSIPNGKLP MESPAQNFTI KEKDLELSDT 
EEPPNYDEEM SGGIEFLASV TKDTASDSPA GIDNPVFSPD EALDRSLLAR LPPWLSPGET 
VVPSQRARTQ IPYSPGTFCR LMPFRLSSKS VDSFLQADGP EERPPAALPE STHM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.