Details for: SERPINB3

Gene ID: 6317

Symbol: SERPINB3

Ensembl ID: ENSG00000057149

Description: serpin family B member 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.68
    Marker Score: 8266
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 5.15
    Marker Score: 33186
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 3.32
    Marker Score: 2219
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 3.29
    Marker Score: 2744
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.23
    Marker Score: 24073
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 3.03
    Marker Score: 1493
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.98
    Marker Score: 23257
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.79
    Marker Score: 5077
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.72
    Marker Score: 23456
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.68
    Marker Score: 3130
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.98
    Marker Score: 925
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.71
    Marker Score: 3116
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.44
    Marker Score: 1861
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.34
    Marker Score: 386
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.24
    Marker Score: 7546
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3640.5
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 1.18
    Marker Score: 323
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32712
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71819
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2390
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5331
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.92
    Marker Score: 2853
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.92
    Marker Score: 822
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.84
    Marker Score: 7338
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.82
    Marker Score: 576.5
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.81
    Marker Score: 635
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.8
    Marker Score: 728
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1252
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.71
    Marker Score: 2435
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.68
    Marker Score: 165
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.66
    Marker Score: 648
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.63
    Marker Score: 429
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.59
    Marker Score: 7965.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 430
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.51
    Marker Score: 311
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.49
    Marker Score: 126
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 273
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.45
    Marker Score: 508
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.43
    Marker Score: 639
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.43
    Marker Score: 430
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.42
    Marker Score: 265
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.35
    Marker Score: 154
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.34
    Marker Score: 104
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.34
    Marker Score: 358.5
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.34
    Marker Score: 957
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.31
    Marker Score: 644
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.29
    Marker Score: 559
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.26
    Marker Score: 224
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.26
    Marker Score: 92
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 88
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.25
    Marker Score: 73
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.25
    Marker Score: 153
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.25
    Marker Score: 143
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.24
    Marker Score: 67
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.23
    Marker Score: 445
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.22
    Marker Score: 395
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.22
    Marker Score: 230
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.22
    Marker Score: 361
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.22
    Marker Score: 1452
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.21
    Marker Score: 505.5
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.2
    Marker Score: 64
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.2
    Marker Score: 140
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.2
    Marker Score: 959
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.2
    Marker Score: 58
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.19
    Marker Score: 99
  • Cell Name: brush cell of trachebronchial tree (CL0002075)
    Fold Change: 0.19
    Marker Score: 58
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.17
    Marker Score: 55
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.16
    Marker Score: 331
  • Cell Name: primary cultured cell (CL0000001)
    Fold Change: 0.15
    Marker Score: 57
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.15
    Marker Score: 133
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.14
    Marker Score: 126
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.14
    Marker Score: 157
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.14
    Marker Score: 201
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.14
    Marker Score: 50
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.13
    Marker Score: 34
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.13
    Marker Score: 81
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.12
    Marker Score: 71
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.12
    Marker Score: 1874
  • Cell Name: phagocyte (CL0000234)
    Fold Change: 0.11
    Marker Score: 37
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.11
    Marker Score: 46
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.11
    Marker Score: 639
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.11
    Marker Score: 49
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.11
    Marker Score: 48
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.1
    Marker Score: 163
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.1
    Marker Score: 60
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.1
    Marker Score: 137
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.1
    Marker Score: 47
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.1
    Marker Score: 34
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.1
    Marker Score: 92
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.09
    Marker Score: 19
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.09
    Marker Score: 79
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.09
    Marker Score: 32

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Other Information

**Key characteristics:** * SerpinB3 is a serine endopeptidase inhibitor with a conserved catalytic domain. * It is expressed in high levels in oligodendrocyte precursor cells, progenitor cells, and epithelial cells. * It is also expressed in immune cells, including neutrophils, macrophages, and dendritic cells. * SERPINB3 is a key regulator of epithelial to mesenchymal transition. **Pathways and functions:** * SERPINB3 inhibits the activity of cysteine-type endopeptidases, which are enzymes that break down proteins. * It does this by binding to the active site of these enzymes and blocking their catalytic activity. * SERPINB3 also regulates the activity of other endopeptidases, including SPP1 and ADAM. * It plays a role in immune responses by inhibiting the activation of immune cells. * It is involved in the regulation of epithelial cell migration and proliferation. * SERPINB3 also regulates the epithelial-mesenchymal transition, which is a process by which epithelial cells lose their epithelial characteristics and acquire mesenchymal characteristics. **Clinical significance:** * Mutations in SERPINB3 have been linked to several human diseases, including autism, schizophrenia, and cancer. * SERPINB3 inhibitors are being investigated as potential therapeutic agents for these diseases. **Conclusion:** SERPINB3 is a key regulator of various cellular processes, including autocrine signaling, immune responses, and epithelial to mesenchymal transition. Its mutations have been linked to several human diseases, making it an important target for therapeutic development.

Genular Protein ID: 590713371

Symbol: SPB3_HUMAN

Name: Serpin B3

UniProtKB Accession Codes:

P29508 A6NDM2 B2RBT5 B3W5Y6 Q53H28 Q53YB5 Q86VF3 Q86W04 Q8IWL4 Q8IXI3 Q96J21 Q9BYF8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 25 EPD 1 Ensembl 2 EvolutionaryTrace 1 GO 25 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCD-2DPAGE 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1958219

Title: Squamous cell carcinoma antigen is a new member of the serine protease inhibitors.

PubMed ID: 1958219

DOI: 10.1016/s0006-291x(05)81380-4

PubMed ID: 7724531

Title: A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene.

PubMed ID: 7724531

DOI: 10.1073/pnas.92.8.3147

PubMed ID: 12975381

Title: Squamous cell carcinoma antigen 1-mediated binding of hepatitis B virus to hepatocytes does not involve the hepatic serpin clearance system.

PubMed ID: 12975381

DOI: 10.1074/jbc.m302842200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14970861

Title: Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma.

PubMed ID: 14970861

DOI: 10.1038/sj.bjc.6601543

PubMed ID: 10956412

Title: Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells.

PubMed ID: 10956412

DOI: 10.1002/1097-0215(20000720)89:4<368::aid-ijc9>3.0.co;2-6

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 19166818

Title: Crystal structure of SCCA1 and insight about the interaction with JNK1.

PubMed ID: 19166818

DOI: 10.1016/j.bbrc.2009.01.057

PubMed ID: 21383048

Title: Increased antiprotease activity of the SERPINB3 polymorphic variant SCCA-PD.

PubMed ID: 21383048

DOI: 10.1258/ebm.2011.010229

Sequence Information:

  • Length: 390
  • Mass: 44565
  • Checksum: E5F27F986C752CFA
  • Sequence:
    • MNSLSEANTK FMFDLFQQFR KSKENNIFYS PISITSALGM VLLGAKDNTA QQIKKVLHFD 
QVTENTTGKA ATYHVDRSGN VHHQFQKLLT EFNKSTDAYE LKIANKLFGE KTYLFLQEYL 
DAIKKFYQTS VESVDFANAP EESRKKINSW VESQTNEKIK NLIPEGNIGS NTTLVLVNAI 
YFKGQWEKKF NKEDTKEEKF WPNKNTYKSI QMMRQYTSFH FASLEDVQAK VLEIPYKGKD 
LSMIVLLPNE IDGLQKLEEK LTAEKLMEWT SLQNMRETRV DLHLPRFKVE ESYDLKDTLR 
TMGMVDIFNG DADLSGMTGS RGLVLSGVLH KAFVEVTEEG AEAAAATAVV GFGSSPTSTN 
EEFHCNHPFL FFIRQNKTNS ILFYGRFSSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.