Details for: SERPINB3

Gene ID: 6317

Symbol: SERPINB3

Ensembl ID: ENSG00000057149

Description: serpin family B member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 8.6512
    Cell Significance Index: 74.3400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 7.2447
    Cell Significance Index: 76.9600
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 3.8302
    Cell Significance Index: 39.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.1864
    Cell Significance Index: 55.7600
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 1.1662
    Cell Significance Index: 9.6400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7727
    Cell Significance Index: 21.6000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.6247
    Cell Significance Index: 7.8900
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.5219
    Cell Significance Index: 4.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5111
    Cell Significance Index: 26.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.4574
    Cell Significance Index: 338.8000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.4059
    Cell Significance Index: 6.2800
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.3164
    Cell Significance Index: 2.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.2919
    Cell Significance Index: 164.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.2395
    Cell Significance Index: 50.4500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0700
    Cell Significance Index: 3.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0506
    Cell Significance Index: 9.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0220
    Cell Significance Index: 13.7500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0044
    Cell Significance Index: 0.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0023
    Cell Significance Index: 0.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0320
    Cell Significance Index: -24.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0478
    Cell Significance Index: -26.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.1047
    Cell Significance Index: -46.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1254
    Cell Significance Index: -14.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1750
    Cell Significance Index: -29.8900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1911
    Cell Significance Index: -26.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2022
    Cell Significance Index: -23.1600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2163
    Cell Significance Index: -2.4600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2170
    Cell Significance Index: -5.4200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2505
    Cell Significance Index: -28.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2565
    Cell Significance Index: -51.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2819
    Cell Significance Index: -36.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3766
    Cell Significance Index: -25.3200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4132
    Cell Significance Index: -15.1700
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.4624
    Cell Significance Index: -3.4400
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.5076
    Cell Significance Index: -3.5200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5155
    Cell Significance Index: -38.4200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5172
    Cell Significance Index: -15.2400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5829
    Cell Significance Index: -8.3700
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.6387
    Cell Significance Index: -1.4400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.6539
    Cell Significance Index: -15.8400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6553
    Cell Significance Index: -46.3400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6997
    Cell Significance Index: -15.3200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.7555
    Cell Significance Index: -7.9700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.7936
    Cell Significance Index: -19.7900
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.8383
    Cell Significance Index: -8.5500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8876
    Cell Significance Index: -25.3300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.9009
    Cell Significance Index: -15.4000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9232
    Cell Significance Index: -32.3400
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.9344
    Cell Significance Index: -10.1800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.9495
    Cell Significance Index: -17.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.9624
    Cell Significance Index: -44.8700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.9897
    Cell Significance Index: -16.0300
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -1.0988
    Cell Significance Index: -10.8400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.1405
    Cell Significance Index: -15.5600
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -1.1559
    Cell Significance Index: -8.8000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1756
    Cell Significance Index: -37.4400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -1.1822
    Cell Significance Index: -14.3800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -1.2151
    Cell Significance Index: -14.4600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.2838
    Cell Significance Index: -25.1000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.3361
    Cell Significance Index: -38.3000
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -1.3682
    Cell Significance Index: -16.3200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.3706
    Cell Significance Index: -34.9200
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: -1.3869
    Cell Significance Index: -13.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.3889
    Cell Significance Index: -37.0900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.4021
    Cell Significance Index: -34.2100
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -1.4203
    Cell Significance Index: -17.8400
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -1.4310
    Cell Significance Index: -15.4300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -1.4408
    Cell Significance Index: -24.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.4684
    Cell Significance Index: -39.9700
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -1.4722
    Cell Significance Index: -18.6300
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -1.4773
    Cell Significance Index: -14.9800
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -1.4800
    Cell Significance Index: -16.4600
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -1.5449
    Cell Significance Index: -14.1900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.5768
    Cell Significance Index: -14.5200
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: -1.5856
    Cell Significance Index: -15.2700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -1.5889
    Cell Significance Index: -21.9700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -1.5895
    Cell Significance Index: -16.0200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -1.6281
    Cell Significance Index: -20.5500
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -1.6429
    Cell Significance Index: -16.0200
  • Cell Name: basophil (CL0000767)
    Fold Change: -1.6431
    Cell Significance Index: -15.1200
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: -1.6438
    Cell Significance Index: -15.3200
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -1.6541
    Cell Significance Index: -15.4100
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -1.6814
    Cell Significance Index: -16.4500
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -1.7115
    Cell Significance Index: -16.2500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -1.7425
    Cell Significance Index: -22.4400
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -1.7676
    Cell Significance Index: -16.3500
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -1.8082
    Cell Significance Index: -17.9500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -1.8095
    Cell Significance Index: -15.3800
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: -1.8103
    Cell Significance Index: -17.9600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -1.8114
    Cell Significance Index: -25.3300
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -1.8144
    Cell Significance Index: -19.6400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -1.8156
    Cell Significance Index: -20.4600
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -1.8187
    Cell Significance Index: -15.3900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -1.8276
    Cell Significance Index: -15.9900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.8360
    Cell Significance Index: -46.9100
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: -1.8474
    Cell Significance Index: -12.9700
  • Cell Name: respiratory suprabasal cell (CL4033048)
    Fold Change: -1.8671
    Cell Significance Index: -16.8900
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -1.8849
    Cell Significance Index: -22.4100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -1.9067
    Cell Significance Index: -21.9400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -1.9089
    Cell Significance Index: -25.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SERPINB3 is a member of the serpin family, which consists of a conserved domain that inhibits proteolytic enzymes. SERPINB3 is specifically expressed in various cell types, including oligodendrocyte precursor cells, progenitor cells, nasal mucosa goblet cells, keratinocytes, basal cells of epithelial trachea, bronchial goblet cells, stratified epithelial cells, microglial cells, and epithelial cells of the esophagus. The expression of SERPINB3 is tightly regulated, suggesting its importance in maintaining cellular homeostasis. **Pathways and Functions:** SERPINB3 is involved in multiple signaling pathways, including autocrine signaling, paracrine signaling, and cytosolic pathways. It inhibits various proteases, such as cysteine-type endopeptidases, serine-type endopeptidases, and aspartic-type endopeptidases, thereby regulating cellular processes such as: 1. **Immune response:** SERPINB3 negatively regulates the activity of various proteases involved in immune cell activation, including neutrophil degranulation and cytokine production. 2. **Cell migration and proliferation:** SERPINB3 positively regulates cell migration and proliferation by inhibiting proteases that regulate these processes. 3. **Proteolysis:** SERPINB3 inhibits proteases involved in proteolysis, which is essential for maintaining cellular homeostasis. 4. **Epithelial-to-mesenchymal transition (EMT):** SERPINB3 positively regulates EMT by inhibiting proteases that regulate this process. **Clinical Significance:** SERPINB3 has been implicated in various diseases, including: 1. **Inflammatory disorders:** Alterations in SERPINB3 expression have been observed in inflammatory disorders, such as asthma and chronic obstructive pulmonary disease (COPD). 2. **Cancer:** SERPINB3 has been shown to have anti-tumor properties and is involved in regulating cancer cell proliferation and metastasis. 3. **Neurological disorders:** SERPINB3 has been implicated in neurological disorders, such as multiple sclerosis and Alzheimer's disease. In conclusion, SERPINB3 is a critical regulator of immune response, cell migration, proliferation, and proteolysis. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the mechanisms of SERPINB3 in maintaining cellular homeostasis. Further research is needed to elucidate the full range of SERPINB3's functions and its potential as a therapeutic target for various diseases. **References:** * [Insert references to relevant studies] **Note:** This article is a summary of the gene SERPINB3 and its characteristics, pathways, and functions, as well as its clinical significance. The references provided are not included in this response.

Genular Protein ID: 590713371

Symbol: SPB3_HUMAN

Name: Serpin B3

UniProtKB Accession Codes:

P29508 A6NDM2 B2RBT5 B3W5Y6 Q53H28 Q53YB5 Q86VF3 Q86W04 Q8IWL4 Q8IXI3 Q96J21 Q9BYF8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 25 Ensembl 2 EvolutionaryTrace 1 GO 25 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1958219

Title: Squamous cell carcinoma antigen is a new member of the serine protease inhibitors.

PubMed ID: 1958219

DOI: 10.1016/s0006-291x(05)81380-4

PubMed ID: 7724531

Title: A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene.

PubMed ID: 7724531

DOI: 10.1073/pnas.92.8.3147

PubMed ID: 12975381

Title: Squamous cell carcinoma antigen 1-mediated binding of hepatitis B virus to hepatocytes does not involve the hepatic serpin clearance system.

PubMed ID: 12975381

DOI: 10.1074/jbc.m302842200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14970861

Title: Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma.

PubMed ID: 14970861

DOI: 10.1038/sj.bjc.6601543

PubMed ID: 10956412

Title: Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells.

PubMed ID: 10956412

DOI: 10.1002/1097-0215(20000720)89:4<368::aid-ijc9>3.0.co;2-6

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 19166818

Title: Crystal structure of SCCA1 and insight about the interaction with JNK1.

PubMed ID: 19166818

DOI: 10.1016/j.bbrc.2009.01.057

PubMed ID: 21383048

Title: Increased antiprotease activity of the SERPINB3 polymorphic variant SCCA-PD.

PubMed ID: 21383048

DOI: 10.1258/ebm.2011.010229

Sequence Information:

  • Length: 390
  • Mass: 44565
  • Checksum: E5F27F986C752CFA
  • Sequence:
    • MNSLSEANTK FMFDLFQQFR KSKENNIFYS PISITSALGM VLLGAKDNTA QQIKKVLHFD 
QVTENTTGKA ATYHVDRSGN VHHQFQKLLT EFNKSTDAYE LKIANKLFGE KTYLFLQEYL 
DAIKKFYQTS VESVDFANAP EESRKKINSW VESQTNEKIK NLIPEGNIGS NTTLVLVNAI 
YFKGQWEKKF NKEDTKEEKF WPNKNTYKSI QMMRQYTSFH FASLEDVQAK VLEIPYKGKD 
LSMIVLLPNE IDGLQKLEEK LTAEKLMEWT SLQNMRETRV DLHLPRFKVE ESYDLKDTLR 
TMGMVDIFNG DADLSGMTGS RGLVLSGVLH KAFVEVTEEG AEAAAATAVV GFGSSPTSTN 
EEFHCNHPFL FFIRQNKTNS ILFYGRFSSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.