Details for: TCN1

Gene ID: 6947

Symbol: TCN1

Ensembl ID: ENSG00000134827

Description: transcobalamin 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 3.24
    Marker Score: 1293
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.58
    Marker Score: 819
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 2.55
    Marker Score: 3182.5
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.3
    Marker Score: 2053
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 2.28
    Marker Score: 834
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.26
    Marker Score: 5160
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 2.03
    Marker Score: 2909.5
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1994
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.69
    Marker Score: 790
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1168
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.39
    Marker Score: 688
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 855
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.2
    Marker Score: 845
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.17
    Marker Score: 507.5
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 487
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4812
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 503
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.08
    Marker Score: 685
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71824
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48048
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5332
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.89
    Marker Score: 1683
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.88
    Marker Score: 1995
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.81
    Marker Score: 794
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 612.5
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.78
    Marker Score: 916
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.72
    Marker Score: 484
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 462
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.7
    Marker Score: 170
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.64
    Marker Score: 423
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.6
    Marker Score: 1215
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.59
    Marker Score: 231
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 239
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 453
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.55
    Marker Score: 1003
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.55
    Marker Score: 158
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.54
    Marker Score: 8390
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.53
    Marker Score: 937
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.51
    Marker Score: 6788
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 475
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.46
    Marker Score: 256
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.45
    Marker Score: 254
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.43
    Marker Score: 264
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 183
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.41
    Marker Score: 321
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.39
    Marker Score: 202
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.38
    Marker Score: 97
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.38
    Marker Score: 3283
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.38
    Marker Score: 561
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.35
    Marker Score: 211
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.32
    Marker Score: 320
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.32
    Marker Score: 184
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.29
    Marker Score: 127
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.28
    Marker Score: 2192
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.28
    Marker Score: 74
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.27
    Marker Score: 187
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.25
    Marker Score: 120
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.25
    Marker Score: 517.5
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.24
    Marker Score: 1799
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.24
    Marker Score: 242
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.24
    Marker Score: 67
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: immature neutrophil (CL0000776)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.21
    Marker Score: 589
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.21
    Marker Score: 509
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: 0.2
    Marker Score: 57
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.2
    Marker Score: 255
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.18
    Marker Score: 82
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.18
    Marker Score: 85
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.18
    Marker Score: 244
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.18
    Marker Score: 174
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.17
    Marker Score: 1116
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.17
    Marker Score: 1072
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.16
    Marker Score: 183
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.16
    Marker Score: 81
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.16
    Marker Score: 168
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.16
    Marker Score: 40
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.16
    Marker Score: 338
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.16
    Marker Score: 66
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.16
    Marker Score: 173
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.15
    Marker Score: 140

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Other Information

**Key Characteristics:** TCN1 is a small, secreted protein with a molecular weight of approximately 19 kDa. It is highly expressed in various tissues, including the gastrointestinal tract, retina, and immune cells. TCN1 has a high affinity for cobalamin, which is essential for its function. The protein exhibits a unique ability to bind to cobalamin and facilitate its uptake and transport within the body. **Pathways and Functions:** TCN1 is involved in several critical pathways, including: 1. **Cobalamin transport and metabolism:** TCN1 plays a crucial role in the transport of cobalamin from the gut lumen to the bloodstream, where it can be utilized by various tissues and cells. 2. **Immune system function:** TCN1 is expressed in immune cells, such as neutrophils and macrophages, where it helps regulate the immune response and prevent excessive inflammation. 3. **Neutrophil degranulation:** TCN1 has been shown to regulate the degranulation of neutrophils, which is essential for the elimination of pathogens and foreign substances. 4. **Molecular sequestering activity:** TCN1 has the ability to sequester cobalamin, preventing its oxidation and degradation, and ensuring its availability for cellular utilization. **Clinical Significance:** Dysregulation of TCN1 has been implicated in various diseases, including: 1. **Vitamin B12 deficiency:** TCN1 plays a critical role in the transport and metabolism of cobalamin, and its dysfunction can lead to vitamin B12 deficiency, which can cause a range of symptoms, including fatigue, weakness, and neurological impairment. 2. **Immune system disorders:** TCN1 has been shown to play a role in regulating the immune response, and its dysfunction can contribute to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Neurological disorders:** TCN1 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease, where cobalamin deficiency has been shown to contribute to disease progression. In conclusion, TCN1 is a critical protein involved in the transport and metabolism of cobalamin, and its dysfunction has significant clinical implications. Further research is needed to fully understand the role of TCN1 in maintaining immune homeostasis and preventing disease.

Genular Protein ID: 1136333446

Symbol: TCO1_HUMAN

Name: Transcobalamin-1

UniProtKB Accession Codes:

P20061 A8KAC5 Q8WV77

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 4 Ensembl 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 2 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2777761

Title: Structure of the cDNA encoding transcobalamin I, a neutrophil granule protein.

PubMed ID: 2777761

DOI: 10.1016/s0021-9258(18)71539-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 23846701

Title: Structural basis for universal corrinoid recognition by the cobalamin transport protein haptocorrin.

PubMed ID: 23846701

DOI: 10.1074/jbc.m113.483271

Sequence Information:

  • Length: 433
  • Mass: 48207
  • Checksum: CF1052BE3DBA929A
  • Sequence:
    • MRQSHQLPLV GLLLFSFIPS QLCEICEVSE ENYIRLKPLL NTMIQSNYNR GTSAVNVVLS 
LKLVGIQIQT LMQKMIQQIK YNVKSRLSDV SSGELALIIL ALGVCRNAEE NLIYDYHLID 
KLENKFQAEI ENMEAHNGTP LTNYYQLSLD VLALCLFNGN YSTAEVVNHF TPENKNYYFG 
SQFSVDTGAM AVLALTCVKK SLINGQIKAD EGSLKNISIY TKSLVEKILS EKKENGLIGN 
TFSTGEAMQA LFVSSDYYNE NDWNCQQTLN TVLTEISQGA FSNPNAAAQV LPALMGKTFL 
DINKDSSCVS ASGNFNISAD EPITVTPPDS QSYISVNYSV RINETYFTNV TVLNGSVFLS 
VMEKAQKMND TIFGFTMEER SWGPYITCIQ GLCANNNDRT YWELLSGGEP LSQGAGSYVV 
RNGENLEVRW SKY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.