Details for: TCN1

Gene ID: 6947

Symbol: TCN1

Ensembl ID: ENSG00000134827

Description: transcobalamin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 12.7631
    Cell Significance Index: 71.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 12.1245
    Cell Significance Index: 565.3000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 8.4273
    Cell Significance Index: 138.8700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 7.4426
    Cell Significance Index: 155.2200
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 5.3552
    Cell Significance Index: 35.7600
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 4.0463
    Cell Significance Index: 17.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.9094
    Cell Significance Index: 239.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.7185
    Cell Significance Index: 55.0400
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: 1.4577
    Cell Significance Index: 10.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4138
    Cell Significance Index: 64.0900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.2933
    Cell Significance Index: 29.8800
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 1.0547
    Cell Significance Index: 7.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0456
    Cell Significance Index: 198.9800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.8361
    Cell Significance Index: 12.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7306
    Cell Significance Index: 72.2700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.7262
    Cell Significance Index: 18.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7112
    Cell Significance Index: 36.9500
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.7028
    Cell Significance Index: 7.2500
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.6853
    Cell Significance Index: 8.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6247
    Cell Significance Index: 564.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3873
    Cell Significance Index: 50.0400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3766
    Cell Significance Index: 61.2500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2745
    Cell Significance Index: 29.8600
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.2428
    Cell Significance Index: 2.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1736
    Cell Significance Index: 31.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1661
    Cell Significance Index: 7.8100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.1642
    Cell Significance Index: 1.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1507
    Cell Significance Index: 3.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1467
    Cell Significance Index: 10.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1196
    Cell Significance Index: 14.7100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0932
    Cell Significance Index: 15.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0559
    Cell Significance Index: 34.9000
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.0327
    Cell Significance Index: 0.2700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0207
    Cell Significance Index: 1.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0141
    Cell Significance Index: 1.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0001
    Cell Significance Index: 0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0004
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0005
    Cell Significance Index: -0.1100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0013
    Cell Significance Index: -0.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0033
    Cell Significance Index: -1.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0047
    Cell Significance Index: -6.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0059
    Cell Significance Index: -11.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0061
    Cell Significance Index: -0.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0062
    Cell Significance Index: -11.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0067
    Cell Significance Index: -10.3800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0083
    Cell Significance Index: -0.4200
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.0105
    Cell Significance Index: -0.0500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0124
    Cell Significance Index: -0.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0145
    Cell Significance Index: -9.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0147
    Cell Significance Index: -11.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0150
    Cell Significance Index: -1.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0205
    Cell Significance Index: -2.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0214
    Cell Significance Index: -7.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0255
    Cell Significance Index: -11.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0353
    Cell Significance Index: -1.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0383
    Cell Significance Index: -7.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0437
    Cell Significance Index: -12.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0540
    Cell Significance Index: -10.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0549
    Cell Significance Index: -5.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0575
    Cell Significance Index: -1.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0625
    Cell Significance Index: -9.0900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0652
    Cell Significance Index: -7.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0705
    Cell Significance Index: -1.9700
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.0736
    Cell Significance Index: -0.5600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0877
    Cell Significance Index: -1.8200
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.1049
    Cell Significance Index: -0.8400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1066
    Cell Significance Index: -1.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1130
    Cell Significance Index: -11.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1169
    Cell Significance Index: -8.7100
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1169
    Cell Significance Index: -1.0800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1173
    Cell Significance Index: -1.8200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1302
    Cell Significance Index: -1.8000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1536
    Cell Significance Index: -8.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1609
    Cell Significance Index: -10.8200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1659
    Cell Significance Index: -6.0900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1778
    Cell Significance Index: -11.2100
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1783
    Cell Significance Index: -1.5400
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.1811
    Cell Significance Index: -1.9400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1852
    Cell Significance Index: -4.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1866
    Cell Significance Index: -11.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1949
    Cell Significance Index: -14.9600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2108
    Cell Significance Index: -6.2100
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.2113
    Cell Significance Index: -1.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2230
    Cell Significance Index: -5.9800
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.2740
    Cell Significance Index: -1.9000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2904
    Cell Significance Index: -7.4000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3008
    Cell Significance Index: -5.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3022
    Cell Significance Index: -16.9600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3180
    Cell Significance Index: -11.1400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3327
    Cell Significance Index: -3.5100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3429
    Cell Significance Index: -10.9200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.3435
    Cell Significance Index: -4.4500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3461
    Cell Significance Index: -11.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3491
    Cell Significance Index: -15.4400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3616
    Cell Significance Index: -5.2500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3759
    Cell Significance Index: -11.8900
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.3869
    Cell Significance Index: -4.9000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3869
    Cell Significance Index: -11.0400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3871
    Cell Significance Index: -6.2700
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.3912
    Cell Significance Index: -3.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TCN1 is a small, secreted protein with a molecular weight of approximately 19 kDa. It is highly expressed in various tissues, including the gastrointestinal tract, retina, and immune cells. TCN1 has a high affinity for cobalamin, which is essential for its function. The protein exhibits a unique ability to bind to cobalamin and facilitate its uptake and transport within the body. **Pathways and Functions:** TCN1 is involved in several critical pathways, including: 1. **Cobalamin transport and metabolism:** TCN1 plays a crucial role in the transport of cobalamin from the gut lumen to the bloodstream, where it can be utilized by various tissues and cells. 2. **Immune system function:** TCN1 is expressed in immune cells, such as neutrophils and macrophages, where it helps regulate the immune response and prevent excessive inflammation. 3. **Neutrophil degranulation:** TCN1 has been shown to regulate the degranulation of neutrophils, which is essential for the elimination of pathogens and foreign substances. 4. **Molecular sequestering activity:** TCN1 has the ability to sequester cobalamin, preventing its oxidation and degradation, and ensuring its availability for cellular utilization. **Clinical Significance:** Dysregulation of TCN1 has been implicated in various diseases, including: 1. **Vitamin B12 deficiency:** TCN1 plays a critical role in the transport and metabolism of cobalamin, and its dysfunction can lead to vitamin B12 deficiency, which can cause a range of symptoms, including fatigue, weakness, and neurological impairment. 2. **Immune system disorders:** TCN1 has been shown to play a role in regulating the immune response, and its dysfunction can contribute to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Neurological disorders:** TCN1 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease, where cobalamin deficiency has been shown to contribute to disease progression. In conclusion, TCN1 is a critical protein involved in the transport and metabolism of cobalamin, and its dysfunction has significant clinical implications. Further research is needed to fully understand the role of TCN1 in maintaining immune homeostasis and preventing disease.

Genular Protein ID: 1136333446

Symbol: TCO1_HUMAN

Name: Transcobalamin-1

UniProtKB Accession Codes:

P20061 A8KAC5 Q8WV77

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 2 DrugCentral 1 EMBL 4 Ensembl 1 EvolutionaryTrace 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2777761

Title: Structure of the cDNA encoding transcobalamin I, a neutrophil granule protein.

PubMed ID: 2777761

DOI: 10.1016/s0021-9258(18)71539-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 23846701

Title: Structural basis for universal corrinoid recognition by the cobalamin transport protein haptocorrin.

PubMed ID: 23846701

DOI: 10.1074/jbc.m113.483271

Sequence Information:

  • Length: 433
  • Mass: 48207
  • Checksum: CF1052BE3DBA929A
  • Sequence:
    • MRQSHQLPLV GLLLFSFIPS QLCEICEVSE ENYIRLKPLL NTMIQSNYNR GTSAVNVVLS 
LKLVGIQIQT LMQKMIQQIK YNVKSRLSDV SSGELALIIL ALGVCRNAEE NLIYDYHLID 
KLENKFQAEI ENMEAHNGTP LTNYYQLSLD VLALCLFNGN YSTAEVVNHF TPENKNYYFG 
SQFSVDTGAM AVLALTCVKK SLINGQIKAD EGSLKNISIY TKSLVEKILS EKKENGLIGN 
TFSTGEAMQA LFVSSDYYNE NDWNCQQTLN TVLTEISQGA FSNPNAAAQV LPALMGKTFL 
DINKDSSCVS ASGNFNISAD EPITVTPPDS QSYISVNYSV RINETYFTNV TVLNGSVFLS 
VMEKAQKMND TIFGFTMEER SWGPYITCIQ GLCANNNDRT YWELLSGGEP LSQGAGSYVV 
RNGENLEVRW SKY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.