Details for: CFAP263

Gene ID: 29070

Symbol: CFAP263

Ensembl ID: ENSG00000103021

Description: cilia and flagella associated protein 263

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 56.7681
    Cell Significance Index: -8.8300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 34.4578
    Cell Significance Index: -8.7400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.2022
    Cell Significance Index: -8.8800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.9578
    Cell Significance Index: 48.7400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.3782
    Cell Significance Index: 19.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.3117
    Cell Significance Index: 82.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.2801
    Cell Significance Index: 78.4900
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.7649
    Cell Significance Index: 7.5800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7505
    Cell Significance Index: 17.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6307
    Cell Significance Index: 120.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6180
    Cell Significance Index: 337.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5881
    Cell Significance Index: 30.5500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3854
    Cell Significance Index: 23.1400
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.3690
    Cell Significance Index: 3.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3218
    Cell Significance Index: 64.5500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2718
    Cell Significance Index: 29.5700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2227
    Cell Significance Index: 201.0500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.2036
    Cell Significance Index: 2.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1962
    Cell Significance Index: 31.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1624
    Cell Significance Index: 16.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1604
    Cell Significance Index: 28.9100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1566
    Cell Significance Index: 3.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1385
    Cell Significance Index: 3.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1291
    Cell Significance Index: 46.3000
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.1265
    Cell Significance Index: 1.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1105
    Cell Significance Index: 7.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1011
    Cell Significance Index: 4.4700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0843
    Cell Significance Index: 1.0100
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.0773
    Cell Significance Index: 0.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0740
    Cell Significance Index: 4.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0739
    Cell Significance Index: 2.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0712
    Cell Significance Index: 2.0500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0578
    Cell Significance Index: 1.5500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0536
    Cell Significance Index: 37.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0523
    Cell Significance Index: 6.4300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0487
    Cell Significance Index: 21.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0272
    Cell Significance Index: 1.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0255
    Cell Significance Index: 1.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0254
    Cell Significance Index: 1.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0240
    Cell Significance Index: 4.7600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0100
    Cell Significance Index: 0.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0063
    Cell Significance Index: 0.2200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0051
    Cell Significance Index: 0.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0018
    Cell Significance Index: 3.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0004
    Cell Significance Index: 0.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0004
    Cell Significance Index: 0.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0004
    Cell Significance Index: -0.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0065
    Cell Significance Index: -4.7900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0072
    Cell Significance Index: -4.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0095
    Cell Significance Index: -7.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0098
    Cell Significance Index: -1.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0099
    Cell Significance Index: -7.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0117
    Cell Significance Index: -6.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0119
    Cell Significance Index: -1.3900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0130
    Cell Significance Index: -0.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0152
    Cell Significance Index: -6.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0225
    Cell Significance Index: -1.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0242
    Cell Significance Index: -1.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0251
    Cell Significance Index: -7.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0310
    Cell Significance Index: -3.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0359
    Cell Significance Index: -5.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0404
    Cell Significance Index: -1.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0408
    Cell Significance Index: -4.6800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0409
    Cell Significance Index: -0.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0426
    Cell Significance Index: -8.9700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0467
    Cell Significance Index: -0.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0468
    Cell Significance Index: -6.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0486
    Cell Significance Index: -4.9600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0501
    Cell Significance Index: -1.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0566
    Cell Significance Index: -6.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0667
    Cell Significance Index: -3.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0700
    Cell Significance Index: -5.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0771
    Cell Significance Index: -2.4700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0830
    Cell Significance Index: -1.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0832
    Cell Significance Index: -8.6600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0838
    Cell Significance Index: -1.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0866
    Cell Significance Index: -6.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0929
    Cell Significance Index: -4.3700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1197
    Cell Significance Index: -2.5400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1292
    Cell Significance Index: -1.1900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1353
    Cell Significance Index: -4.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1394
    Cell Significance Index: -4.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1400
    Cell Significance Index: -9.0300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1411
    Cell Significance Index: -1.9800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1433
    Cell Significance Index: -4.9800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1479
    Cell Significance Index: -3.8900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1574
    Cell Significance Index: -3.1600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1632
    Cell Significance Index: -3.5300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1653
    Cell Significance Index: -5.7900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1685
    Cell Significance Index: -4.3300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1814
    Cell Significance Index: -3.5400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1839
    Cell Significance Index: -2.9500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1855
    Cell Significance Index: -6.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1888
    Cell Significance Index: -5.1400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1921
    Cell Significance Index: -2.5600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1932
    Cell Significance Index: -3.8200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1955
    Cell Significance Index: -2.1300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1971
    Cell Significance Index: -2.9700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2157
    Cell Significance Index: -5.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CFAP263 is a protein-coding gene that belongs to the cilia and flagella associated protein family. It is primarily expressed in cells with cilia, such as ciliated columnar cells of the tracheobronchial tree, ciliated cells, and goblet cells in the colon. The gene's protein product, CC113_HUMAN, is characterized by a coiled-coil domain, which suggests a potential role in protein-protein interactions. **Pathways and Functions:** CFAP263 is involved in several cellular pathways, including: 1. **Axoneme formation:** CFAP263 is essential for the assembly and maintenance of the axoneme, the core structure of cilia and flagella. 2. **Ciliary basal body formation:** The gene product is also involved in the formation of the ciliary basal body, a critical component of the cilium. 3. **Protein-containing complex:** CFAP263 is part of a protein-containing complex that regulates various cellular processes, including cell signaling and transport. 4. **Protein binding:** The gene product exhibits high affinity for specific proteins, suggesting a role in protein-protein interactions. **Functions:** The functions of CFAP263 are multifaceted and critical for maintaining ciliary function and overall cellular health. Some of the key functions include: 1. **Cilia assembly and maintenance:** CFAP263 plays a crucial role in the assembly and maintenance of cilia, ensuring their proper structure and function. 2. **Cell signaling:** The gene product is involved in cell signaling pathways, regulating various cellular processes, including cell proliferation and differentiation. 3. **Transport and trafficking:** CFAP263 is also involved in the transport and trafficking of proteins and other molecules within the cell. **Clinical Significance:** Dysregulation of CFAP263 has been implicated in various diseases, including: 1. **Ciliary dyskinesia:** Mutations in CFAP263 have been associated with ciliary dyskinesia, a condition characterized by impaired ciliary function and respiratory problems. 2. **Neurological disorders:** CFAP263 has also been linked to neurological disorders, such as cerebral cortex GABAergic interneuron dysfunction and forebrain radial glial cell abnormalities. 3. **Gastrointestinal disorders:** The gene product has been implicated in gastrointestinal disorders, including colon goblet cell dysfunction and absorptive cell abnormalities. In conclusion, CFAP263 is a crucial gene involved in maintaining ciliary function and overall cellular health. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the gene's functions and significance.

Genular Protein ID: 2598937718

Symbol: CF263_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9H0I3 B2RAQ7 B4DR20 Q9NZX2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 1 Ensembl 2 ExpressionAtlas 1 GO 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 25074808

Title: Proteomic analysis of mammalian sperm cells identifies new components of the centrosome.

PubMed ID: 25074808

DOI: 10.1242/jcs.157008

Sequence Information:

  • Length: 377
  • Mass: 44220
  • Checksum: 6375CDF98733E33B
  • Sequence:
    • MTDDESESVL SDSHEGSELE LPVIQLCGLV EELSYVNSAL KTETEMFEKY YAKLEPRDQR 
PPRLSEIKIS AADYAQFRGR RRSKSRTGMD RGVGLTADQK LELVQKEVAD MKDDLRHTRA 
NAERDLQHHE AIIEEAEIRW SEVSREVHEF EKDILKAISK KKGSILATQK VMKYIEDMNR 
RRDNMKEKLR LKNVSLKVQR KKMLLQLRQK EEVSEALHDV DFQQLKIENA QFLETIEARN 
QELTQLKLSS GNTLQVLNAY KSKLHKAMEI YLNLDKEILL RKELLEKIEK ETLQVEEDRA 
KAEAVNKRLR KQLAEFRAPQ VMTYVREKIL NADLEKSIRM WERKVEIAEM SLKGHRKAWN 
RMKITNEQLQ ADYLAGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.