DEFB4A | ENSG00000171711 | NCBI 1673

Details for: DEFB4A

Gene ID: 1673

Symbol: DEFB4A

Ensembl ID: ENSG00000171711

Description: defensin beta 4A

Associated with

Antimicrobial peptides
(R-HSA-6803157)
Beta defensins
(R-HSA-1461957)
Defensins
(R-HSA-1461973)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Antifungal innate immune response
(GO:0061760)
Antimicrobial humoral immune response mediated by antimicrobial peptide
(GO:0061844)
Ccr6 chemokine receptor binding
(GO:0031731)
Cell chemotaxis
(GO:0060326)
Chemoattractant activity
(GO:0042056)
Chemotaxis
(GO:0006935)
Defense response to bacterium
(GO:0042742)
Defense response to fungus
(GO:0050832)
Defense response to gram-negative bacterium
(GO:0050829)
Defense response to gram-positive bacterium
(GO:0050830)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Golgi lumen
(GO:0005796)
G protein-coupled receptor signaling pathway
(GO:0007186)
Immune response
(GO:0006955)
Killing of cells of another organism
(GO:0031640)
Phosphatidylinositol-4,5-bisphosphate binding
(GO:0005546)
Positive chemotaxis
(GO:0050918)
Protein binding
(GO:0005515)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0099
Cell Significance Index: -5.3900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0139
Cell Significance Index: -10.4900
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0212
Cell Significance Index: -15.6800
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0219
Cell Significance Index: -0.6100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0291
Cell Significance Index: -16.4400
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.0542
Cell Significance Index: -0.8900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0695
Cell Significance Index: -11.8700
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0750
Cell Significance Index: -0.8500
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0755
Cell Significance Index: -3.2800
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0791
Cell Significance Index: -16.6500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0819
Cell Significance Index: -11.2500
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0877
Cell Significance Index: -10.2200
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1078
Cell Significance Index: -13.9300
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1163
Cell Significance Index: -13.3200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1171
Cell Significance Index: -23.5000
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.1266
Cell Significance Index: -2.3400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1425
Cell Significance Index: -7.4000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1453
Cell Significance Index: -6.8300
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1852
Cell Significance Index: -6.8000
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.1956
Cell Significance Index: -2.3400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1978
Cell Significance Index: -14.7400
Cell Name: thymocyte (CL0000893)
Fold Change: -0.2022
Cell Significance Index: -2.5500
Cell Name: erythroblast (CL0000765)
Fold Change: -0.2029
Cell Significance Index: -2.4200
Cell Name: lung secretory cell (CL1000272)
Fold Change: -0.2141
Cell Significance Index: -1.6300
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.2387
Cell Significance Index: -2.4700
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: -0.2622
Cell Significance Index: -2.5600
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: -0.2670
Cell Significance Index: -2.0500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.3108
Cell Significance Index: -4.2400
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.3445
Cell Significance Index: -8.5900
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: -0.3829
Cell Significance Index: -3.1700
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.4304
Cell Significance Index: -10.7500
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -0.4384
Cell Significance Index: -2.9100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.5030
Cell Significance Index: -23.4500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.5118
Cell Significance Index: -13.6700
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.5121
Cell Significance Index: -14.6800
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.5356
Cell Significance Index: -5.6900
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: -0.5716
Cell Significance Index: -5.8300
Cell Name: peg cell (CL4033014)
Fold Change: -0.5783
Cell Significance Index: -13.3600
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: -0.5954
Cell Significance Index: -6.4200
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.6092
Cell Significance Index: -7.4100
Cell Name: leukocyte (CL0000738)
Fold Change: -0.6147
Cell Significance Index: -10.4400
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: -0.6177
Cell Significance Index: -6.4900
Cell Name: neutrophil (CL0000775)
Fold Change: -0.6252
Cell Significance Index: -7.8100
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: -0.6322
Cell Significance Index: -5.0300
Cell Name: smooth muscle cell (CL0000192)
Fold Change: -0.6378
Cell Significance Index: -7.4100
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: -0.6495
Cell Significance Index: -6.7000
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: -0.6519
Cell Significance Index: -6.4700
Cell Name: mucus secreting cell (CL0000319)
Fold Change: -0.6637
Cell Significance Index: -6.7800
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.6844
Cell Significance Index: -6.5700
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.6873
Cell Significance Index: -17.5100
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: -0.6901
Cell Significance Index: -7.8400
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: -0.6938
Cell Significance Index: -6.9900
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: -0.6987
Cell Significance Index: -7.7700
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: -0.7202
Cell Significance Index: -6.4900
Cell Name: lung goblet cell (CL1000143)
Fold Change: -0.7212
Cell Significance Index: -7.0800
Cell Name: fibroblast of lung (CL0002553)
Fold Change: -0.7277
Cell Significance Index: -8.6500
Cell Name: alveolar type 1 fibroblast cell (CL4028004)
Fold Change: -0.7427
Cell Significance Index: -7.8600
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: -0.7557
Cell Significance Index: -6.9900
Cell Name: T cell (CL0000084)
Fold Change: -0.7597
Cell Significance Index: -8.9700
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.7601
Cell Significance Index: -11.7600
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.7623
Cell Significance Index: -13.0300
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.7786
Cell Significance Index: -8.6200
Cell Name: neuron (CL0000540)
Fold Change: -0.7828
Cell Significance Index: -7.4200
Cell Name: M cell of gut (CL0000682)
Fold Change: -0.7969
Cell Significance Index: -6.6400
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.7977
Cell Significance Index: -12.9200
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.8137
Cell Significance Index: -11.2900
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: -0.8301
Cell Significance Index: -8.8600
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.8370
Cell Significance Index: -14.7900
Cell Name: acinar cell (CL0000622)
Fold Change: -0.8431
Cell Significance Index: -10.5900
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: -0.8451
Cell Significance Index: -9.0300
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -0.8464
Cell Significance Index: -6.4700
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: -0.8506
Cell Significance Index: -6.8900
Cell Name: epithelial cell (CL0000066)
Fold Change: -0.8532
Cell Significance Index: -9.0000
Cell Name: respiratory basal cell (CL0002633)
Fold Change: -0.8616
Cell Significance Index: -8.5000
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.8627
Cell Significance Index: -12.2800
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: -0.8660
Cell Significance Index: -8.9700
Cell Name: respiratory hillock cell (CL4030023)
Fold Change: -0.8742
Cell Significance Index: -8.3000
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: -0.8771
Cell Significance Index: -9.0300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.8832
Cell Significance Index: -24.0400
Cell Name: alveolar macrophage (CL0000583)
Fold Change: -0.8944
Cell Significance Index: -7.8800
Cell Name: pulmonary alveolar type 2 cell (CL0002063)
Fold Change: -0.8971
Cell Significance Index: -7.4200
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: -0.8985
Cell Significance Index: -6.9900
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.9076
Cell Significance Index: -12.0600
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: -0.9217
Cell Significance Index: -8.6700
Cell Name: classical monocyte (CL0000860)
Fold Change: -0.9323
Cell Significance Index: -8.6800
Cell Name: pulmonary alveolar type 1 cell (CL0002062)
Fold Change: -0.9392
Cell Significance Index: -10.3100
Cell Name: alveolar adventitial fibroblast (CL4028006)
Fold Change: -0.9399
Cell Significance Index: -10.4400
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: -0.9524
Cell Significance Index: -9.0300
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: -0.9603
Cell Significance Index: -8.8200
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.9735
Cell Significance Index: -13.3500
Cell Name: club cell (CL0000158)
Fold Change: -0.9738
Cell Significance Index: -10.6100
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: -0.9765
Cell Significance Index: -10.5700
Cell Name: elicited macrophage (CL0000861)
Fold Change: -0.9895
Cell Significance Index: -8.6500
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: -1.0016
Cell Significance Index: -8.6800
Cell Name: precursor B cell (CL0000817)
Fold Change: -1.0224
Cell Significance Index: -13.2300
Cell Name: lung ciliated cell (CL1000271)
Fold Change: -1.0334
Cell Significance Index: -10.1100
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: -1.0352
Cell Significance Index: -13.1100
Cell Name: obsolete animal cell (CL0000548)
Fold Change: -1.0355
Cell Significance Index: -10.5000
Cell Name: bronchial smooth muscle cell (CL0002598)
Fold Change: -1.0565
Cell Significance Index: -7.0600
Cell Name: astrocyte (CL0000127)
Fold Change: -1.0599
Cell Significance Index: -12.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** DEFB4A is a small, cationic peptide with a molecular weight of approximately 4 kDa. It is structurally similar to other defensins, but has distinct differences in its amino acid sequence. DEF4A is primarily expressed in the extracellular space, particularly in the Golgi lumen, where it is secreted by various cell types. Its expression is induced in response to infection or inflammation, and it is also present in normal tissues, suggesting a role in maintaining tissue homeostasis. **Pathways and Functions** DEFB4A is involved in several signaling pathways that regulate immune cell function and chemotaxis. These pathways include: 1. **Antifungal innate immune response**: DEF4A is expressed in response to fungal infections and is thought to play a role in the defense against fungal pathogens. 2. **Antimicrobial humoral immune response mediated by antimicrobial peptide**: DEF4A is secreted by plasma cells and other immune cells, where it acts as an antimicrobial agent, killing or inhibiting the growth of microorganisms. 3. **G protein-coupled receptor signaling pathway**: DEF4A interacts with G protein-coupled receptors, which are essential for immune cell function and chemotaxis. 4. **Cell chemotaxis**: DEF4A is involved in the chemotaxis of immune cells, guiding them towards sites of infection or inflammation. **Clinical Significance** The expression of DEF4A in neoplastic cells has been observed in various types of cancer, including breast, lung, and colon cancer. This suggests that DEF4A may play a role in cancer progression and metastasis. Additionally, DEF4A has been implicated in the defense against bacterial and fungal infections, making it a potential therapeutic target for the treatment of infectious diseases. Furthermore, the expression of DEF4A in mast cells has been linked to allergic responses and asthma, suggesting that DEF4A may play a role in the regulation of immune responses and inflammation. In conclusion, DEF4A is a key player in the innate immune response, particularly in the defense against fungal and bacterial infections. Its expression in neoplastic cells and its involvement in various signaling pathways make it a potential target for the treatment of cancer and infectious diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.