Details for: MMP10

Gene ID: 4319

Symbol: MMP10

Ensembl ID: ENSG00000166670

Description: matrix metallopeptidase 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.9821
    Cell Significance Index: 54.3300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.5862
    Cell Significance Index: 13.6300
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 1.5508
    Cell Significance Index: 11.1600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.0515
    Cell Significance Index: 16.8700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.9640
    Cell Significance Index: 12.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7734
    Cell Significance Index: 422.3900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4041
    Cell Significance Index: 11.5900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.2321
    Cell Significance Index: 3.8300
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.1711
    Cell Significance Index: 0.7900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.1219
    Cell Significance Index: 2.0500
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.0798
    Cell Significance Index: 0.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0698
    Cell Significance Index: 43.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0600
    Cell Significance Index: 7.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0408
    Cell Significance Index: 4.7600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0002
    Cell Significance Index: 0.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0009
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0018
    Cell Significance Index: -1.3000
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0026
    Cell Significance Index: -0.0300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0027
    Cell Significance Index: -0.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0028
    Cell Significance Index: -0.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0036
    Cell Significance Index: -2.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0040
    Cell Significance Index: -0.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0043
    Cell Significance Index: -8.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0043
    Cell Significance Index: -7.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0044
    Cell Significance Index: -3.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0058
    Cell Significance Index: -8.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0068
    Cell Significance Index: -9.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0101
    Cell Significance Index: -1.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0106
    Cell Significance Index: -1.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0195
    Cell Significance Index: -8.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0212
    Cell Significance Index: -3.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0267
    Cell Significance Index: -3.4200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0298
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0300
    Cell Significance Index: -3.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0338
    Cell Significance Index: -6.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0360
    Cell Significance Index: -4.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0366
    Cell Significance Index: -5.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0427
    Cell Significance Index: -8.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0508
    Cell Significance Index: -5.0300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0542
    Cell Significance Index: -0.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0562
    Cell Significance Index: -4.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0588
    Cell Significance Index: -6.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0605
    Cell Significance Index: -7.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0821
    Cell Significance Index: -2.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0891
    Cell Significance Index: -5.6200
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -0.0930
    Cell Significance Index: -0.8000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0976
    Cell Significance Index: -1.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0986
    Cell Significance Index: -5.1200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1076
    Cell Significance Index: -2.6800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1089
    Cell Significance Index: -5.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1222
    Cell Significance Index: -8.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1256
    Cell Significance Index: -7.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1350
    Cell Significance Index: -6.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1371
    Cell Significance Index: -3.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1401
    Cell Significance Index: -6.5300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1423
    Cell Significance Index: -1.1600
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.1435
    Cell Significance Index: -1.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1477
    Cell Significance Index: -5.1900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1506
    Cell Significance Index: -3.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1626
    Cell Significance Index: -7.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1695
    Cell Significance Index: -9.5100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1701
    Cell Significance Index: -6.2500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1790
    Cell Significance Index: -9.4000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1997
    Cell Significance Index: -3.0900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2000
    Cell Significance Index: -5.8900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2007
    Cell Significance Index: -5.3600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2024
    Cell Significance Index: -2.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2280
    Cell Significance Index: -6.1100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2414
    Cell Significance Index: -4.0400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2449
    Cell Significance Index: -8.5800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2498
    Cell Significance Index: -6.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2572
    Cell Significance Index: -8.4200
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.2656
    Cell Significance Index: -3.2100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2691
    Cell Significance Index: -8.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2738
    Cell Significance Index: -7.2000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2744
    Cell Significance Index: -7.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2812
    Cell Significance Index: -7.0300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2874
    Cell Significance Index: -3.4200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2877
    Cell Significance Index: -8.2100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2936
    Cell Significance Index: -4.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3123
    Cell Significance Index: -6.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3141
    Cell Significance Index: -6.6900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3181
    Cell Significance Index: -4.5600
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.3225
    Cell Significance Index: -3.8900
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.3233
    Cell Significance Index: -3.8100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3272
    Cell Significance Index: -6.5300
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.3350
    Cell Significance Index: -3.2300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3352
    Cell Significance Index: -8.1200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3381
    Cell Significance Index: -3.8400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3387
    Cell Significance Index: -6.2600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3388
    Cell Significance Index: -8.1300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3462
    Cell Significance Index: -7.5800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3703
    Cell Significance Index: -6.3300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3718
    Cell Significance Index: -8.5900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3935
    Cell Significance Index: -17.1100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3936
    Cell Significance Index: -5.6400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3960
    Cell Significance Index: -8.5600
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.3990
    Cell Significance Index: -4.0700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.3996
    Cell Significance Index: -2.8700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.4030
    Cell Significance Index: -7.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MMP10 is a serine-type endopeptidase that belongs to the zinc-dependent metalloproteinase family. It is primarily expressed in various cell types, including oligodendrocyte precursor cells, conjunctival epithelial cells, colon goblet cells, and granulocyte monocyte progenitor cells. MMP10 is characterized by its ability to degrade collagen, elastin, and other ECM components, as well as its involvement in signaling pathways that regulate cell proliferation, migration, and differentiation. **Pathways and Functions:** MMP10 is involved in several signaling pathways that regulate ECM organization and remodeling. These pathways include: 1. **Activation of matrix metalloproteinases:** MMP10 can activate other members of the matrix metalloproteinase family, leading to a cascade of ECM degradation and remodeling. 2. **Collagen catabolic process:** MMP10 can degrade collagen, leading to the breakdown of ECM components and the regulation of tissue remodeling. 3. **Degradation of the extracellular matrix:** MMP10 can degrade ECM components, including collagen, elastin, and proteoglycans, leading to changes in tissue structure and function. 4. **Extracellular matrix disassembly:** MMP10 can disassemble the ECM, leading to the release of growth factors and other signaling molecules that regulate cell behavior. 5. **Extracellular matrix organization:** MMP10 can also regulate ECM organization by degrading components that inhibit ECM assembly, such as collagenases. **Clinical Significance:** MMP10 has been implicated in various diseases, including: 1. **Arthritis:** MMP10 has been shown to contribute to joint destruction and inflammation in rheumatoid arthritis. 2. **Cancer:** MMP10 has been implicated in tumor progression and metastasis, as it can degrade ECM components and facilitate cell migration and invasion. 3. **Neurodegenerative diseases:** MMP10 has been shown to play a role in the degradation of ECM components in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 4. **Inflammatory diseases:** MMP10 has been implicated in the pathogenesis of inflammatory diseases, such as asthma and inflammatory bowel disease. In conclusion, MMP10 is a key enzyme involved in ECM regulation and immune response. Its dysregulation has been implicated in various diseases, highlighting the importance of MMP10 in maintaining tissue homeostasis and preventing disease. Further research is needed to fully understand the role of MMP10 in disease pathology and to develop therapeutic strategies that target this enzyme.

Genular Protein ID: 3033418934

Symbol: MMP10_HUMAN

Name: Stromelysin-2

UniProtKB Accession Codes:

P09238 B2R9X9 Q53HH9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 2 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2844164

Title: The collagenase gene family in humans consists of at least four members.

PubMed ID: 2844164

DOI: 10.1042/bj2530187

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15095982

Title: Crystal structure of the catalytic domain of human matrix metalloproteinase 10.

PubMed ID: 15095982

DOI: 10.1016/j.jmb.2003.12.033

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 476
  • Mass: 54151
  • Checksum: 516DCDDFEF92A0D6
  • Sequence:
    • MMHLAFLVLL CLPVCSAYPL SGAAKEEDSN KDLAQQYLEK YYNLEKDVKQ FRRKDSNLIV 
KKIQGMQKFL GLEVTGKLDT DTLEVMRKPR CGVPDVGHFS SFPGMPKWRK THLTYRIVNY 
TPDLPRDAVD SAIEKALKVW EEVTPLTFSR LYEGEADIMI SFAVKEHGDF YSFDGPGHSL 
AHAYPPGPGL YGDIHFDDDE KWTEDASGTN LFLVAAHELG HSLGLFHSAN TEALMYPLYN 
SFTELAQFRL SQDDVNGIQS LYGPPPASTE EPLVPTKSVP SGSEMPAKCD PALSFDAIST 
LRGEYLFFKD RYFWRRSHWN PEPEFHLISA FWPSLPSYLD AAYEVNSRDT VFIFKGNEFW 
AIRGNEVQAG YPRGIHTLGF PPTIRKIDAA VSDKEKKKTY FFAADKYWRF DENSQSMEQG 
FPRLIADDFP GVEPKVDAVL QAFGFFYFFS GSSQFEFDPN ARMVTHILKS NSWLHC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.