Details for: SPA17

Gene ID: 53340

Symbol: SPA17

Ensembl ID: ENSG00000064199

Description: sperm autoantigenic protein 17

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 46.9317
    Cell Significance Index: -7.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 42.5400
    Cell Significance Index: -10.7900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 30.7078
    Cell Significance Index: -12.6500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 22.7442
    Cell Significance Index: -9.2400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.5628
    Cell Significance Index: -9.1300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.6783
    Cell Significance Index: -10.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.8662
    Cell Significance Index: -11.3100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.3409
    Cell Significance Index: -7.1900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.7720
    Cell Significance Index: 40.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0812
    Cell Significance Index: 590.4600
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.8306
    Cell Significance Index: 8.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8152
    Cell Significance Index: 36.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7043
    Cell Significance Index: 69.6800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6689
    Cell Significance Index: 40.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6203
    Cell Significance Index: 560.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6095
    Cell Significance Index: 31.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5959
    Cell Significance Index: 64.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4636
    Cell Significance Index: 75.4000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3848
    Cell Significance Index: 5.2500
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.3271
    Cell Significance Index: 2.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3223
    Cell Significance Index: 22.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2609
    Cell Significance Index: 32.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2594
    Cell Significance Index: 46.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2290
    Cell Significance Index: 45.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2179
    Cell Significance Index: 4.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1964
    Cell Significance Index: 5.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1771
    Cell Significance Index: 33.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1615
    Cell Significance Index: 12.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1536
    Cell Significance Index: 10.8600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.1496
    Cell Significance Index: 1.6200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1331
    Cell Significance Index: 58.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1190
    Cell Significance Index: 4.1800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1079
    Cell Significance Index: 1.6700
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.0980
    Cell Significance Index: 0.9000
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.0828
    Cell Significance Index: 0.8100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0508
    Cell Significance Index: 2.3700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0402
    Cell Significance Index: 0.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0382
    Cell Significance Index: 13.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0359
    Cell Significance Index: 1.5900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0345
    Cell Significance Index: 0.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0338
    Cell Significance Index: 4.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0262
    Cell Significance Index: 3.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0193
    Cell Significance Index: 0.5400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0141
    Cell Significance Index: 9.7500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0114
    Cell Significance Index: 0.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0079
    Cell Significance Index: 1.0900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0069
    Cell Significance Index: 0.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0024
    Cell Significance Index: 1.8100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0004
    Cell Significance Index: 0.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0014
    Cell Significance Index: -0.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0032
    Cell Significance Index: -5.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0034
    Cell Significance Index: -6.3700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0047
    Cell Significance Index: -0.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0062
    Cell Significance Index: -9.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0105
    Cell Significance Index: -7.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0105
    Cell Significance Index: -14.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0113
    Cell Significance Index: -7.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0174
    Cell Significance Index: -9.8400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0204
    Cell Significance Index: -12.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0215
    Cell Significance Index: -6.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0243
    Cell Significance Index: -11.0200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0246
    Cell Significance Index: -1.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0248
    Cell Significance Index: -2.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0253
    Cell Significance Index: -4.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0314
    Cell Significance Index: -4.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0359
    Cell Significance Index: -4.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0412
    Cell Significance Index: -5.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0412
    Cell Significance Index: -4.7200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0551
    Cell Significance Index: -0.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0594
    Cell Significance Index: -12.5000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0709
    Cell Significance Index: -1.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0732
    Cell Significance Index: -4.9200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0745
    Cell Significance Index: -2.5900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0800
    Cell Significance Index: -6.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0903
    Cell Significance Index: -2.4100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1033
    Cell Significance Index: -6.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1054
    Cell Significance Index: -10.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1171
    Cell Significance Index: -6.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1201
    Cell Significance Index: -9.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1203
    Cell Significance Index: -5.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1231
    Cell Significance Index: -2.0600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1240
    Cell Significance Index: -1.7400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1255
    Cell Significance Index: -1.8800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1348
    Cell Significance Index: -0.8000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1354
    Cell Significance Index: -2.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1403
    Cell Significance Index: -9.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1424
    Cell Significance Index: -8.7300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1497
    Cell Significance Index: -1.5500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1595
    Cell Significance Index: -8.3100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1672
    Cell Significance Index: -10.5400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1766
    Cell Significance Index: -1.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1791
    Cell Significance Index: -4.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1804
    Cell Significance Index: -4.5100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1973
    Cell Significance Index: -5.6300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2092
    Cell Significance Index: -7.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2095
    Cell Significance Index: -6.1700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2105
    Cell Significance Index: -2.9200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2129
    Cell Significance Index: -5.4400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2150
    Cell Significance Index: -4.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The SPA17 protein is a small, secreted protein with a molecular weight of approximately 17 kDa. It is predominantly expressed on the surface of spermatozoa, where it plays a crucial role in sperm-zygote interactions. The protein has been shown to bind to the zona pellucida, a glycoprotein layer surrounding the egg, facilitating fertilization. Additionally, SPA17 has been implicated in the regulation of sperm motility and the maintenance of the sperm fibrous sheath, a structure essential for sperm movement. **Pathways and Functions:** The SPA17 protein is involved in several signaling pathways, including: 1. **Calmodulin binding:** SPA17 interacts with calmodulin, a calcium-binding protein, to regulate sperm motility and fertilization. 2. **Cilium movement:** SPA17 is involved in the regulation of ciliary movement, which is essential for the movement of spermatozoa through the female reproductive tract. 3. **Protein binding:** SPA17 interacts with various proteins, including the zona pellucida, to facilitate sperm-egg interactions. 4. **Single fertilization:** SPA17 has been implicated in the regulation of single fertilization, a process critical for embryonic development. **Clinical Significance:** The SPA17 gene has been implicated in several clinical conditions, including: 1. **Infertility:** Abnormalities in SPA17 expression have been linked to infertility in both males and females. 2. **Reproductive disorders:** SPA17 has been implicated in the regulation of sperm motility and fertilization, making it a potential target for the treatment of reproductive disorders. 3. **Autoimmune diseases:** SPA17 has been shown to interact with immune cells, suggesting a potential role in autoimmune diseases, such as rheumatoid arthritis. 4. **Cancer:** SPA17 has been implicated in the regulation of cell growth and apoptosis, making it a potential target for the treatment of certain types of cancer. In conclusion, the SPA17 gene is a multifunctional protein with a wide range of cellular processes, including sperm motility, fertilization, and immune responses. Further research is needed to fully elucidate the clinical significance of this gene and its potential applications in the treatment of various diseases.

Genular Protein ID: 987199792

Symbol: SP17_HUMAN

Name: Sperm surface protein Sp17

UniProtKB Accession Codes:

Q15506 B2R4F2 Q9BXF7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 1 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8688458

Title: Cloning and sequencing of cDNAs encoding the human sperm protein, Sp17.

PubMed ID: 8688458

DOI: 10.1016/0167-4781(96)00077-2

PubMed ID: 12393185

Title: Genomic organization of an intron-containing sperm protein 17 gene (Sp17-1) and an intronless pseudogene (Sp17-2) in humans: a new model.

PubMed ID: 12393185

DOI: 10.1016/s0167-4781(02)00478-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17551920

Title: A yeast two-hybrid system using Sp17 identified ropporin as a novel cancer-testis antigen in hematologic malignancies.

PubMed ID: 17551920

DOI: 10.1002/ijc.22842

Sequence Information:

  • Length: 151
  • Mass: 17406
  • Checksum: BC99EC310FA0E54A
  • Sequence:
    • MSIPFSNTHY RIPQGFGNLL EGLTREILRE QPDNIPAFAA AYFESLLEKR EKTNFDPAEW 
GSKVEDRFYN NHAFEEQEPP EKSDPKQEES QISGKEEETS VTILDSSEED KEKEEVAAVK 
IQAAFRGHIA REEAKKMKTN SLQNEEKEEN K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.