Details for: GALNT4

Gene ID: 8693

Symbol: GALNT4

Ensembl ID: ENSG00000257594

Description: polypeptide N-acetylgalactosaminyltransferase 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 11.1590
    Cell Significance Index: -5.7400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 7.4333
    Cell Significance Index: 122.4900
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 4.5723
    Cell Significance Index: 45.1100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.5008
    Cell Significance Index: 80.8800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 2.7449
    Cell Significance Index: 27.6900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.8280
    Cell Significance Index: 109.7400
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 1.5230
    Cell Significance Index: 10.1700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1499
    Cell Significance Index: 125.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0416
    Cell Significance Index: 103.0400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.7380
    Cell Significance Index: 10.3600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6385
    Cell Significance Index: 44.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6089
    Cell Significance Index: 99.0400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5967
    Cell Significance Index: 5.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5026
    Cell Significance Index: 14.4800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.4434
    Cell Significance Index: 6.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4165
    Cell Significance Index: 75.0800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4056
    Cell Significance Index: 366.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3412
    Cell Significance Index: 8.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3372
    Cell Significance Index: 41.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3190
    Cell Significance Index: 6.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2888
    Cell Significance Index: 13.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2059
    Cell Significance Index: 39.1900
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.1932
    Cell Significance Index: 1.7000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1434
    Cell Significance Index: 1.9900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.1278
    Cell Significance Index: 2.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1110
    Cell Significance Index: 3.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0842
    Cell Significance Index: 16.8900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0797
    Cell Significance Index: 0.9100
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.0726
    Cell Significance Index: 0.5800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0682
    Cell Significance Index: 0.9300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0629
    Cell Significance Index: 3.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0540
    Cell Significance Index: 1.1500
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: 0.0356
    Cell Significance Index: 0.2500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0327
    Cell Significance Index: 0.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0310
    Cell Significance Index: 1.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0205
    Cell Significance Index: 7.3500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0152
    Cell Significance Index: 0.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0072
    Cell Significance Index: 0.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0026
    Cell Significance Index: 0.2000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0005
    Cell Significance Index: 0.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0025
    Cell Significance Index: -1.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0043
    Cell Significance Index: -2.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0054
    Cell Significance Index: -4.0000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0073
    Cell Significance Index: -0.2100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0076
    Cell Significance Index: -5.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0076
    Cell Significance Index: -5.7800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0096
    Cell Significance Index: -1.1200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0111
    Cell Significance Index: -0.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0112
    Cell Significance Index: -0.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0126
    Cell Significance Index: -1.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0269
    Cell Significance Index: -5.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0302
    Cell Significance Index: -0.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0329
    Cell Significance Index: -5.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0370
    Cell Significance Index: -3.7800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0374
    Cell Significance Index: -0.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0378
    Cell Significance Index: -4.3300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0385
    Cell Significance Index: -4.5400
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0404
    Cell Significance Index: -0.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0405
    Cell Significance Index: -2.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0414
    Cell Significance Index: -1.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0533
    Cell Significance Index: -3.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0579
    Cell Significance Index: -3.5500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0642
    Cell Significance Index: -1.6000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0647
    Cell Significance Index: -2.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0688
    Cell Significance Index: -3.2100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0804
    Cell Significance Index: -1.3600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0838
    Cell Significance Index: -1.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0890
    Cell Significance Index: -5.7400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0896
    Cell Significance Index: -1.3500
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0919
    Cell Significance Index: -1.3800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1015
    Cell Significance Index: -2.9800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1016
    Cell Significance Index: -3.5600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1048
    Cell Significance Index: -2.7600
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.1070
    Cell Significance Index: -1.1600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1107
    Cell Significance Index: -1.4200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1188
    Cell Significance Index: -3.8900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1231
    Cell Significance Index: -3.6300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1278
    Cell Significance Index: -4.0700
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1431
    Cell Significance Index: -1.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1433
    Cell Significance Index: -3.9000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1507
    Cell Significance Index: -4.0300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1515
    Cell Significance Index: -3.7800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1575
    Cell Significance Index: -2.0600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1630
    Cell Significance Index: -4.0700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1700
    Cell Significance Index: -6.2400
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.1711
    Cell Significance Index: -2.1700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1720
    Cell Significance Index: -2.4700
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1729
    Cell Significance Index: -1.0700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1800
    Cell Significance Index: -3.8900
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1886
    Cell Significance Index: -1.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1899
    Cell Significance Index: -3.5100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1915
    Cell Significance Index: -4.8800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1934
    Cell Significance Index: -2.7700
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.1936
    Cell Significance Index: -1.6000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1958
    Cell Significance Index: -2.6400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1965
    Cell Significance Index: -2.4900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1969
    Cell Significance Index: -4.1800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2036
    Cell Significance Index: -3.9800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2067
    Cell Significance Index: -4.1500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2156
    Cell Significance Index: -3.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GALNT4 is a type II transmembrane glycosyltransferase, which means it has a single transmembrane domain and is anchored to the cell surface. This enzyme is responsible for the transfer of N-acetylgalactosamine (GalNAc) units to serine or threonine residues on target proteins, resulting in the formation of O-linked glycan structures. GALNT4 is highly conserved across species and has been identified in various cell types, including endothelial cells, goblet cells, and immune cells. **Pathways and Functions:** GALNT4 plays a crucial role in the formation of O-glycans on mucins, which are key components of the mucus layer in epithelial tissues. This process is essential for maintaining mucin homeostasis and preventing excessive mucus production, which can lead to respiratory and gastrointestinal disorders. GALNT4 also regulates the glycosylation of proteins involved in immune responses, such as immunoglobulins and cytokines. The enzyme is involved in the following pathways: 1. **O-linked glycosylation**: GALNT4 is responsible for the transfer of GalNAc units to serine or threonine residues on target proteins, resulting in the formation of O-glycan structures. 2. **Mucin glycosylation**: GALNT4 regulates the glycosylation of mucins, which is essential for maintaining mucin homeostasis and preventing excessive mucus production. 3. **Immune response**: GALNT4 modulates the glycosylation of proteins involved in immune responses, such as immunoglobulins and cytokines. 4. **Cell signaling**: GALNT4 is involved in cell signaling pathways, including the regulation of cell proliferation, differentiation, and survival. **Clinical Significance:** Dysregulation of GALNT4 has been implicated in various immune-mediated disorders, including: 1. **Asthma**: Excessive mucus production in asthma is associated with altered GALNT4 expression and activity. 2. **Cancer**: GALNT4 is overexpressed in various types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis. 3. **Autoimmune diseases**: GALNT4 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus, where altered glycosylation of proteins contributes to immune dysregulation. 4. **Infectious diseases**: GALNT4 is involved in the regulation of glycosylation of proteins involved in immune responses, which is essential for host defense against infections. In conclusion, GALNT4 is a crucial enzyme involved in the post-translational modification of proteins, with significant implications for immune function and disease. Further research is needed to fully elucidate the mechanisms by which GALNT4 regulates O-glycosylation and its role in various immune-mediated disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.