Details for: MPO

Gene ID: 4353

Symbol: MPO

Ensembl ID: ENSG00000005381

Description: myeloperoxidase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 25.8346
    Cell Significance Index: 171.3900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 23.6540
    Cell Significance Index: 632.7300
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 22.7220
    Cell Significance Index: 145.0500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 3.1423
    Cell Significance Index: 80.2800
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.9218
    Cell Significance Index: 8.2400
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 0.7301
    Cell Significance Index: 0.3300
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.6872
    Cell Significance Index: 4.9400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 0.3370
    Cell Significance Index: -1.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3074
    Cell Significance Index: 19.8400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1868
    Cell Significance Index: 2.3600
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.1292
    Cell Significance Index: 1.3800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1107
    Cell Significance Index: 1.5900
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.1055
    Cell Significance Index: 0.8900
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.0891
    Cell Significance Index: 0.6800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0325
    Cell Significance Index: 0.6000
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0277
    Cell Significance Index: 0.3100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0274
    Cell Significance Index: 0.4700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0225
    Cell Significance Index: 1.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0161
    Cell Significance Index: 3.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0142
    Cell Significance Index: 7.7500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.0136
    Cell Significance Index: 0.1600
  • Cell Name: immature neutrophil (CL0000776)
    Fold Change: 0.0033
    Cell Significance Index: 0.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0002
    Cell Significance Index: 0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0001
    Cell Significance Index: 0.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0005
    Cell Significance Index: -0.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0005
    Cell Significance Index: -0.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0013
    Cell Significance Index: -0.2200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0014
    Cell Significance Index: -0.0300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0015
    Cell Significance Index: -0.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0019
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0021
    Cell Significance Index: -1.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0021
    Cell Significance Index: -1.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0022
    Cell Significance Index: -1.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0022
    Cell Significance Index: -1.2200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0023
    Cell Significance Index: -0.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0024
    Cell Significance Index: -1.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0026
    Cell Significance Index: -1.2000
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0026
    Cell Significance Index: -0.0300
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0027
    Cell Significance Index: -0.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0033
    Cell Significance Index: -0.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0045
    Cell Significance Index: -0.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0049
    Cell Significance Index: -0.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0077
    Cell Significance Index: -1.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0078
    Cell Significance Index: -1.6400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0081
    Cell Significance Index: -1.1800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0085
    Cell Significance Index: -0.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0090
    Cell Significance Index: -1.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0092
    Cell Significance Index: -0.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0109
    Cell Significance Index: -0.6100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0113
    Cell Significance Index: -0.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0127
    Cell Significance Index: -1.3000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0137
    Cell Significance Index: -1.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0138
    Cell Significance Index: -1.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0177
    Cell Significance Index: -0.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0180
    Cell Significance Index: -1.2100
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0184
    Cell Significance Index: -0.1700
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0213
    Cell Significance Index: -0.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0213
    Cell Significance Index: -0.9400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0237
    Cell Significance Index: -0.8300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0239
    Cell Significance Index: -0.7600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0242
    Cell Significance Index: -0.3000
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0253
    Cell Significance Index: -0.3200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0259
    Cell Significance Index: -0.5500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0267
    Cell Significance Index: -0.9800
  • Cell Name: CD14-positive, CD16-low monocyte (CL0001055)
    Fold Change: -0.0270
    Cell Significance Index: -0.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0277
    Cell Significance Index: -1.0500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0296
    Cell Significance Index: -0.9700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0300
    Cell Significance Index: -0.8800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0302
    Cell Significance Index: -0.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0317
    Cell Significance Index: -1.6500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0319
    Cell Significance Index: -1.0100
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.0324
    Cell Significance Index: -0.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0326
    Cell Significance Index: -0.9400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0330
    Cell Significance Index: -0.4400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0331
    Cell Significance Index: -0.4000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0332
    Cell Significance Index: -0.8100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0334
    Cell Significance Index: -0.9000
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0334
    Cell Significance Index: -0.5000
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0335
    Cell Significance Index: -0.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0345
    Cell Significance Index: -0.9900
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.0349
    Cell Significance Index: -0.2600
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.0350
    Cell Significance Index: -0.3500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0357
    Cell Significance Index: -0.5200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0358
    Cell Significance Index: -0.7500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0363
    Cell Significance Index: -0.5100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0388
    Cell Significance Index: -0.7900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0389
    Cell Significance Index: -0.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0389
    Cell Significance Index: -1.0600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0399
    Cell Significance Index: -0.5800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0401
    Cell Significance Index: -0.5500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0404
    Cell Significance Index: -1.0100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0405
    Cell Significance Index: -1.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0406
    Cell Significance Index: -1.4100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0411
    Cell Significance Index: -0.9500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0425
    Cell Significance Index: -0.8300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0432
    Cell Significance Index: -0.5900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0434
    Cell Significance Index: -1.1100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0438
    Cell Significance Index: -1.2500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0452
    Cell Significance Index: -1.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** MPO is a peroxidase enzyme that catalyzes the conversion of hydrogen peroxide (H2O2) into hypochlorous acid (HOCl), a potent antimicrobial agent. 2. **Cellular Localization:** MPO is predominantly expressed in azurophilic granules of neutrophils, where it is stored in close proximity to the cell membrane. 3. **Regulatory Mechanisms:** MPO expression is tightly regulated by various signals, including transcriptional and post-transcriptional mechanisms, to ensure proper immune function. 4. **Cellular Interactions:** MPO interacts with various proteins and lipids, influencing cellular adhesion, migration, and signaling pathways. **Pathways and Functions:** 1. **Antimicrobial Defense:** MPO's primary function is to produce ROS and HOCl, which are essential for eliminating pathogens, bacteria, and fungi. 2. **Apoptosis Regulation:** MPO has been shown to modulate the apoptotic process, influencing the survival and death of immune cells. 3. **Cell Signaling:** MPO interacts with various signaling molecules, including chemokines and cytokines, to regulate immune responses. 4. **Tissue Homeostasis:** MPO is involved in the remodeling of the extracellular matrix and the regulation of tissue homeostasis. **Clinical Significance:** 1. **Inflammatory Diseases:** MPO has been implicated in various inflammatory diseases, including atherosclerosis, arthritis, and cancer. 2. **Antimicrobial Resistance:** MPO's role in antimicrobial defense has led to its investigation as a potential target for the development of antimicrobial therapies. 3. **Neurological Disorders:** MPO's involvement in neuroinflammation and neurodegenerative diseases, such as Alzheimer's and Parkinson's, has sparked interest in its potential therapeutic applications. 4. **Cancer:** MPO's role in cancer progression and metastasis has led to its investigation as a potential biomarker and therapeutic target. In conclusion, MPO is a multifunctional enzyme that plays a crucial role in the innate immune system. Its involvement in various cellular processes and disease pathology highlights the need for further research into the mechanisms and therapeutic potential of MPO.

Genular Protein ID: 1348202236

Symbol: PERM_HUMAN

Name: Myeloperoxidase

UniProtKB Accession Codes:

P05164 A1L4B8 Q14862 Q4PJH5 Q9UCL7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTC 1 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 25 DrugCentral 1 EC 1 EMBL 18 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 31 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 20 PIR 3 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PeroxiBase 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 1 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3029127

Title: Molecular cloning and characterization of cDNA for human myeloperoxidase.

PubMed ID: 3029127

DOI: 10.1016/s0021-9258(18)61433-4

PubMed ID: 2444596

Title: Chromosomal gene structure of human myeloperoxidase and regulation of its expression by granulocyte colony-stimulating factor.

PubMed ID: 2444596

DOI: 10.1016/s0021-9258(18)48159-8

PubMed ID: 3654979

Title: Isolation of a complementary DNA clone for thyroid microsomal antigen. Homology with the gene for thyroid peroxidase.

PubMed ID: 3654979

DOI: 10.1172/jci113181

PubMed ID: 3031585

Title: Characterization of cDNA clones for human myeloperoxidase: predicted amino acid sequence and evidence for multiple mRNA species.

PubMed ID: 3031585

DOI: 10.1093/nar/15.5.2013

PubMed ID: 2903767

Title: Multiple species of myeloperoxidase messenger RNAs produced by alternative splicing and differential polyadenylation.

PubMed ID: 2903767

DOI: 10.1021/bi00416a013

PubMed ID: 2552418

Title: Complete nucleotide sequence of the human myeloperoxidase gene.

PubMed ID: 2552418

DOI: 10.1093/nar/17.19.7985

PubMed ID: 8383257

Title: Cloning and characterization of four types of cDNA encoding myeloperoxidase from human monocytic leukemia cell line, SKM-1.

PubMed ID: 8383257

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2154223

Title: Isolation and characterization of extracellular myeloperoxidase precursor in HL-60 cell cultures.

PubMed ID: 2154223

DOI: 10.1016/0006-291x(90)90888-t

PubMed ID: 20332087

Title: Glycosylation pattern of mature dimeric leukocyte and recombinant monomeric myeloperoxidase: glycosylation is required for optimal enzymatic activity.

PubMed ID: 20332087

DOI: 10.1074/jbc.m109.089748

PubMed ID: 1334087

Title: Unique autolytic cleavage of human myeloperoxidase. Implications for the involvement of active site MET409.

PubMed ID: 1334087

DOI: 10.1016/s0021-9258(19)74037-x

PubMed ID: 8390465

Title: Identification of transcriptional cis-elements in introns 7 and 9 of the myeloperoxidase gene.

PubMed ID: 8390465

DOI: 10.1016/s0021-9258(19)38674-0

PubMed ID: 2884926

Title: Isolation and characterization of a cDNA coding for human myeloperoxidase.

PubMed ID: 2884926

DOI: 10.1016/0003-9861(87)90304-3

PubMed ID: 9922160

Title: Reaction of myeloperoxidase compound I with chloride, bromide, iodide, and thiocyanate.

PubMed ID: 9922160

DOI: 10.1021/bi9818772

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25698971

Title: A1M/alpha1-microglobulin is proteolytically activated by myeloperoxidase, binds its heme group and inhibits low density lipoprotein oxidation.

PubMed ID: 25698971

DOI: 10.3389/fphys.2015.00011

PubMed ID: 7840679

Title: Structure of the green heme in myeloperoxidase.

PubMed ID: 7840679

DOI: 10.1006/abbi.1995.1086

PubMed ID: 10766826

Title: X-ray crystal structure and characterization of halide-binding sites of human myeloperoxidase at 1.8-A resolution.

PubMed ID: 10766826

DOI: 10.1074/jbc.275.16.11964

PubMed ID: 11705390

Title: Human myeloperoxidase: structure of a cyanide complex and its interaction with bromide and thiocyanate substrates at 1.9 A resolution.

PubMed ID: 11705390

DOI: 10.1021/bi0111808

PubMed ID: 23843990

Title: Ceruloplasmin: macromolecular assemblies with iron-containing acute phase proteins.

PubMed ID: 23843990

DOI: 10.1371/journal.pone.0067145

PubMed ID: 8142659

Title: Myeloperoxidase (MPO) gene mutation in hereditary MPO deficiency.

PubMed ID: 8142659

PubMed ID: 7904599

Title: Hereditary myeloperoxidase deficiency due to a missense mutation of arginine 569 to tryptophan.

PubMed ID: 7904599

DOI: 10.1016/s0021-9258(17)42244-7

PubMed ID: 8621627

Title: Effect of the R569W missense mutation on the biosynthesis of myeloperoxidase.

PubMed ID: 8621627

DOI: 10.1074/jbc.271.16.9546

PubMed ID: 9637725

Title: A novel form of hereditary myeloperoxidase deficiency linked to endoplasmic reticulum/proteasome degradation.

PubMed ID: 9637725

DOI: 10.1172/jci2649

PubMed ID: 9354683

Title: Biochemical and molecular characterization of hereditary myeloperoxidase deficiency.

PubMed ID: 9354683

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 37198333

Title: De novo MCM6 variants in neurodevelopmental disorders: a recognizable phenotype related to zinc binding residues.

PubMed ID: 37198333

DOI: 10.1007/s00439-023-02569-7

Sequence Information:

  • Length: 745
  • Mass: 83869
  • Checksum: 348B1CE0A11038B4
  • Sequence:
    • MGVPFFSSLR CMVDLGPCWA GGLTAEMKLL LALAGLLAIL ATPQPSEGAA PAVLGEVDTS 
LVLSSMEEAK QLVDKAYKER RESIKQRLRS GSASPMELLS YFKQPVAATR TAVRAADYLH 
VALDLLERKL RSLWRRPFNV TDVLTPAQLN VLSKSSGCAY QDVGVTCPEQ DKYRTITGMC 
NNRRSPTLGA SNRAFVRWLP AEYEDGFSLP YGWTPGVKRN GFPVALARAV SNEIVRFPTD 
QLTPDQERSL MFMQWGQLLD HDLDFTPEPA ARASFVTGVN CETSCVQQPP CFPLKIPPND 
PRIKNQADCI PFFRSCPACP GSNITIRNQI NALTSFVDAS MVYGSEEPLA RNLRNMSNQL 
GLLAVNQRFQ DNGRALLPFD NLHDDPCLLT NRSARIPCFL AGDTRSSEMP ELTSMHTLLL 
REHNRLATEL KSLNPRWDGE RLYQEARKIV GAMVQIITYR DYLPLVLGPT AMRKYLPTYR 
SYNDSVDPRI ANVFTNAFRY GHTLIQPFMF RLDNRYQPME PNPRVPLSRV FFASWRVVLE 
GGIDPILRGL MATPAKLNRQ NQIAVDEIRE RLFEQVMRIG LDLPALNMQR SRDHGLPGYN 
AWRRFCGLPQ PETVGQLGTV LRNLKLARKL MEQYGTPNNI DIWMGGVSEP LKRKGRVGPL 
LACIIGTQFR KLRDGDRFWW ENEGVFSMQQ RQALAQISLP RIICDNTGIT TVSKNNIFMS 
NSYPRDFVNC STLPALNLAS WREAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.