Details for: LGALS7

Gene ID: 3963

Symbol: LGALS7

Ensembl ID: ENSG00000205076

Description: galectin 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 28.2145
    Cell Significance Index: 32.4800
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 14.3039
    Cell Significance Index: 42.5400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 12.1179
    Cell Significance Index: 184.0500
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 10.1657
    Cell Significance Index: 135.5100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 6.8297
    Cell Significance Index: 141.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.2935
    Cell Significance Index: 232.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.2165
    Cell Significance Index: 1422.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.1130
    Cell Significance Index: 67.6800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.9516
    Cell Significance Index: 16.7700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 1.8346
    Cell Significance Index: 64.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.7443
    Cell Significance Index: 37.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.5138
    Cell Significance Index: 37.8400
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.9476
    Cell Significance Index: 6.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8722
    Cell Significance Index: 25.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.5110
    Cell Significance Index: 31.3300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4508
    Cell Significance Index: 6.1500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3717
    Cell Significance Index: 70.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3413
    Cell Significance Index: 20.4900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2066
    Cell Significance Index: 4.4000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1719
    Cell Significance Index: 18.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0844
    Cell Significance Index: 5.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0716
    Cell Significance Index: 1.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0691
    Cell Significance Index: 6.8400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0643
    Cell Significance Index: 35.1200
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.0629
    Cell Significance Index: 0.5200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0548
    Cell Significance Index: 8.9200
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.0514
    Cell Significance Index: 0.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0498
    Cell Significance Index: 44.9300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0216
    Cell Significance Index: 0.5400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0106
    Cell Significance Index: 0.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0046
    Cell Significance Index: 0.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0039
    Cell Significance Index: 0.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0008
    Cell Significance Index: 0.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0007
    Cell Significance Index: 0.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0047
    Cell Significance Index: -3.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0054
    Cell Significance Index: -3.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0065
    Cell Significance Index: -3.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0076
    Cell Significance Index: -3.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0088
    Cell Significance Index: -0.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0173
    Cell Significance Index: -3.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0185
    Cell Significance Index: -13.6800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0225
    Cell Significance Index: -2.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0240
    Cell Significance Index: -3.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0255
    Cell Significance Index: -3.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0265
    Cell Significance Index: -3.0400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0270
    Cell Significance Index: -0.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0309
    Cell Significance Index: -3.1600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0358
    Cell Significance Index: -0.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0360
    Cell Significance Index: -1.6800
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0363
    Cell Significance Index: -0.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0384
    Cell Significance Index: -5.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0390
    Cell Significance Index: -1.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0412
    Cell Significance Index: -3.0700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0416
    Cell Significance Index: -0.5000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0417
    Cell Significance Index: -1.0400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0425
    Cell Significance Index: -1.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0477
    Cell Significance Index: -2.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0480
    Cell Significance Index: -3.8000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0481
    Cell Significance Index: -0.9600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0498
    Cell Significance Index: -1.3300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0552
    Cell Significance Index: -0.7900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0589
    Cell Significance Index: -0.8600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0677
    Cell Significance Index: -1.0200
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0687
    Cell Significance Index: -0.4300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0720
    Cell Significance Index: -0.7600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0745
    Cell Significance Index: -2.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0839
    Cell Significance Index: -4.7100
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.0934
    Cell Significance Index: -1.1600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0959
    Cell Significance Index: -1.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0978
    Cell Significance Index: -16.7000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0990
    Cell Significance Index: -3.4400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0992
    Cell Significance Index: -2.0700
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.1008
    Cell Significance Index: -1.3800
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1024
    Cell Significance Index: -1.0100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1065
    Cell Significance Index: -1.4200
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.1080
    Cell Significance Index: -1.3600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1112
    Cell Significance Index: -2.9800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1194
    Cell Significance Index: -3.1400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1221
    Cell Significance Index: -3.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1226
    Cell Significance Index: -3.5200
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: -0.1273
    Cell Significance Index: -1.0400
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.1377
    Cell Significance Index: -2.0600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1382
    Cell Significance Index: -3.5200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1433
    Cell Significance Index: -1.6900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1436
    Cell Significance Index: -3.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1438
    Cell Significance Index: -4.5800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1450
    Cell Significance Index: -2.5000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1492
    Cell Significance Index: -1.9900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1532
    Cell Significance Index: -3.5400
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: -0.1559
    Cell Significance Index: -0.3600
  • Cell Name: reticular cell (CL0000432)
    Fold Change: -0.1570
    Cell Significance Index: -1.0000
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1587
    Cell Significance Index: -2.2000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1593
    Cell Significance Index: -2.9500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1634
    Cell Significance Index: -3.5300
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.1642
    Cell Significance Index: -1.2500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1654
    Cell Significance Index: -3.5100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1656
    Cell Significance Index: -1.3500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1667
    Cell Significance Index: -3.4900
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1707
    Cell Significance Index: -1.8600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1726
    Cell Significance Index: -2.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LGALS7 is a small, secreted protein consisting of 205 amino acids. It belongs to the galectin family, which is characterized by their ability to bind to specific carbohydrate motifs. LGALS7 exhibits a unique expression profile, with high levels detected in various immune cells, including microglia, dendritic cells, and plasma cells. Its expression is also found in epithelial cells, including respiratory, gastrointestinal, and neural tissues. **Pathways and Functions:** LGALS7 modulates immune responses through its interaction with various signaling pathways. Its carbohydrate-binding properties enable it to interact with specific glycoproteins and glycolipids, leading to the activation of several downstream signaling pathways, including: 1. **JAK/STAT pathway**: LGALS7 binds to the JAK/STAT pathway, which is crucial for the regulation of immune responses, including the activation of T cells and B cells. 2. **NF-κB pathway**: LGALS7 also interacts with the NF-κB pathway, which is involved in the regulation of inflammation and immune responses. 3. **PI3K/Akt pathway**: LGALS7 has been shown to activate the PI3K/Akt pathway, which is involved in the regulation of cell survival and immune responses. LGALS7's immunomodulatory functions include: 1. **Immune cell activation**: LGALS7 can activate immune cells, including T cells, B cells, and dendritic cells, leading to the enhancement of immune responses. 2. **Anti-inflammatory effects**: LGALS7 has been shown to exhibit anti-inflammatory properties by regulating the expression of pro-inflammatory cytokines and chemokines. 3. **Tumor suppression**: LGALS7 has been implicated in the suppression of tumor growth and metastasis by regulating the expression of pro-tumorigenic genes. **Clinical Significance:** LGALS7's immunomodulatory functions have significant implications for the treatment of various immune-related disorders, including: 1. **Autoimmune diseases**: LGALS7's ability to regulate immune responses makes it a potential therapeutic target for autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: LGALS7's tumor-suppressive properties make it a potential therapeutic target for cancer treatment. 3. **Inflammatory bowel disease**: LGALS7's anti-inflammatory effects make it a potential therapeutic target for the treatment of inflammatory bowel disease. In conclusion, LGALS7 is a multifunctional protein that plays a crucial role in modulating immune responses. Its immunomodulatory functions have significant implications for the treatment of various immune-related disorders. Further research is necessary to fully understand the mechanisms of LGALS7's functions and to explore its therapeutic potential.

Genular Protein ID: 3008270413

Symbol: LEG7_HUMAN

Name: Galectin-7

UniProtKB Accession Codes:

P47929 Q6IB87

Database IDs:

ABCD 1 AGR 2 AlphaFoldDB 1 Antibodypedia 2 BMRB 1 Bgee 1 BindingDB 1 BioGRID 2 BioGRID-ORCS 2 BioMuta 1 CCDS 1 CDD 1 CTD 2 ChEBI 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 2 DrugBank 2 EMBL 8 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 2 GeneTree 1 GeneWiki 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 2 InParanoid 1 IntAct 1 InterPro 3 KEGG 2 MANE-Select 2 MIM 2 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 2 OrthoDB 1 PANTHER 2 PDB 35 PDBsum 35 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 2 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7534301

Title: Cloning, expression, and chromosome mapping of human galectin-7.

PubMed ID: 7534301

DOI: 10.1074/jbc.270.11.5823

PubMed ID: 7729568

Title: Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid.

PubMed ID: 7729568

DOI: 10.1006/dbio.1995.1078

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11706006

Title: Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release.

PubMed ID: 11706006

DOI: 10.1074/jbc.m109360200

PubMed ID: 9760227

Title: Structural basis for the recognition of carbohydrates by human galectin-7.

PubMed ID: 9760227

DOI: 10.1021/bi981056x

Sequence Information:

  • Length: 136
  • Mass: 15075
  • Checksum: F613D3540331C13F
  • Sequence:
    • MSNVPHKSSL PEGIRPGTVL RIRGLVPPNA SRFHVNLLCG EEQGSDAALH FNPRLDTSEV 
VFNSKEQGSW GREERGPGVP FQRGQPFEVL IIASDDGFKA VVGDAQYHHF RHRLPLARVR 
LVEVGGDVQL DSVRIF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.