Details for: LGALS7

Gene ID: 3963

Symbol: LGALS7

Ensembl ID: ENSG00000205076

Description: galectin 7

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Other Information

## Summary LGALS7 is a cell surface protein that is expressed in a variety of cell types. It is involved in cell adhesion, migration, and signaling. LGALS7 is also expressed in the extracellular matrix, where it helps to regulate cell behavior. ## Key characteristics * **Protein type:** Cell surface protein * **Ensembl ID:** ENSG00000205076 * **Protein length:** 123 amino acids * **Expression:** Significantly expressed in respiratory basal cell, tracheal goblet cell, neuroendocrine cell, keratinocyte, microglial cell, conventional dendritic cell, basal cell of epithelium of trachea, enterocyte of epithelium of large intestine, plasma cell, colon goblet cell ## Pathways and functions LGALS7 is involved in a variety of cellular processes, including: * Cell adhesion: LGALS7 is a cell adhesion molecule that is expressed on the surface of many cell types. It is involved in cell adhesion to extracellular matrix proteins and to other cells. * Cell migration: LGALS7 is also involved in cell migration. It is expressed on the surface of epithelial cells and is thought to play a role in the migration of these cells. * Cell signaling: LGALS7 is a signaling molecule that is involved in cell signaling pathways. It is expressed in a variety of cell types, including epithelial cells, immune cells, and cancer cells. LGALS7 is thought to interact with a variety of other proteins to regulate cell signaling. ## Clinical significance LGALS7 is a promising target for cancer immunotherapy. Studies have shown that LGALS7 is expressed on the surface of cancer cells, and that blocking LGALS7 signaling can inhibit cancer cell growth. This has led to the development of a number of drugs that target LGALS7, which are being tested in clinical trials for the treatment of cancer.

Genular Protein ID: 3008270413

Symbol: LEG7_HUMAN

Name: Galectin-7

UniProtKB Accession Codes:

P47929 Q6IB87

Database IDs:

AGR 2 AlphaFoldDB 1 Antibodypedia 2 BMRB 1 Bgee 1 BindingDB 1 BioGRID 2 BioGRID-ORCS 2 BioMuta 1 CCDS 1 CDD 1 CTD 2 ChEBI 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 2 DrugBank 2 EMBL 8 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 2 GeneTree 1 GeneWiki 1 Genevisible 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 2 InParanoid 1 IntAct 1 InterPro 3 KEGG 2 MANE-Select 2 MIM 2 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 2 OrthoDB 1 PANTHER 2 PDB 36 PDBsum 35 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 2 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7534301

Title: Cloning, expression, and chromosome mapping of human galectin-7.

PubMed ID: 7534301

DOI: 10.1074/jbc.270.11.5823

PubMed ID: 7729568

Title: Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid.

PubMed ID: 7729568

DOI: 10.1006/dbio.1995.1078

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11706006

Title: Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release.

PubMed ID: 11706006

DOI: 10.1074/jbc.m109360200

PubMed ID: 9760227

Title: Structural basis for the recognition of carbohydrates by human galectin-7.

PubMed ID: 9760227

DOI: 10.1021/bi981056x

Sequence Information:

  • Length: 136
  • Mass: 15075
  • Checksum: F613D3540331C13F
  • Sequence:
    • MSNVPHKSSL PEGIRPGTVL RIRGLVPPNA SRFHVNLLCG EEQGSDAALH FNPRLDTSEV 
VFNSKEQGSW GREERGPGVP FQRGQPFEVL IIASDDGFKA VVGDAQYHHF RHRLPLARVR 
LVEVGGDVQL DSVRIF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.