Details for: PHEX

Gene ID: 5251

Symbol: PHEX

Ensembl ID: ENSG00000102174

Description: phosphate regulating endopeptidase X-linked

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 25.2717
    Cell Significance Index: -6.4100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 5.7764
    Cell Significance Index: -5.5200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.1664
    Cell Significance Index: -6.3700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 4.8281
    Cell Significance Index: 29.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5366
    Cell Significance Index: 20.9700
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.7526
    Cell Significance Index: 6.8300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.3166
    Cell Significance Index: 4.0000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2251
    Cell Significance Index: 3.2100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1587
    Cell Significance Index: 2.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1541
    Cell Significance Index: 6.8200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1130
    Cell Significance Index: 22.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1104
    Cell Significance Index: 21.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1014
    Cell Significance Index: 3.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0990
    Cell Significance Index: 6.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0973
    Cell Significance Index: 19.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0827
    Cell Significance Index: 12.0200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0716
    Cell Significance Index: 49.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0524
    Cell Significance Index: 1.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0394
    Cell Significance Index: 5.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0334
    Cell Significance Index: 11.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0299
    Cell Significance Index: 3.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0257
    Cell Significance Index: 23.2000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0224
    Cell Significance Index: 0.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0207
    Cell Significance Index: 2.4100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0156
    Cell Significance Index: 28.7400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0137
    Cell Significance Index: 25.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0056
    Cell Significance Index: 8.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0040
    Cell Significance Index: 0.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0039
    Cell Significance Index: 5.3400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0008
    Cell Significance Index: 0.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0007
    Cell Significance Index: 0.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0006
    Cell Significance Index: -0.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0023
    Cell Significance Index: -0.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0034
    Cell Significance Index: -1.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0054
    Cell Significance Index: -0.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0075
    Cell Significance Index: -5.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0078
    Cell Significance Index: -5.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0082
    Cell Significance Index: -3.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0089
    Cell Significance Index: -6.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0092
    Cell Significance Index: -0.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0100
    Cell Significance Index: -0.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0102
    Cell Significance Index: -5.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0109
    Cell Significance Index: -6.7900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0135
    Cell Significance Index: -3.8900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0136
    Cell Significance Index: -0.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0152
    Cell Significance Index: -0.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0192
    Cell Significance Index: -1.1800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0205
    Cell Significance Index: -1.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0213
    Cell Significance Index: -3.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0217
    Cell Significance Index: -3.5400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0235
    Cell Significance Index: -2.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0279
    Cell Significance Index: -2.1400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0297
    Cell Significance Index: -0.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0312
    Cell Significance Index: -6.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0313
    Cell Significance Index: -2.3300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0368
    Cell Significance Index: -2.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0373
    Cell Significance Index: -1.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0383
    Cell Significance Index: -4.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0385
    Cell Significance Index: -4.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0396
    Cell Significance Index: -1.1400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0396
    Cell Significance Index: -0.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0465
    Cell Significance Index: -4.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0481
    Cell Significance Index: -4.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0484
    Cell Significance Index: -5.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0496
    Cell Significance Index: -2.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0544
    Cell Significance Index: -3.4300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0545
    Cell Significance Index: -1.4600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0550
    Cell Significance Index: -6.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0572
    Cell Significance Index: -2.6900
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0583
    Cell Significance Index: -0.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0623
    Cell Significance Index: -3.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0629
    Cell Significance Index: -4.4500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0638
    Cell Significance Index: -0.5200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0674
    Cell Significance Index: -1.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0722
    Cell Significance Index: -4.0500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0771
    Cell Significance Index: -6.1100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0810
    Cell Significance Index: -1.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0933
    Cell Significance Index: -4.8600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0995
    Cell Significance Index: -2.4100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1026
    Cell Significance Index: -6.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1082
    Cell Significance Index: -2.8900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1096
    Cell Significance Index: -3.8400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1115
    Cell Significance Index: -3.5500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1144
    Cell Significance Index: -1.7700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1173
    Cell Significance Index: -3.8400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1179
    Cell Significance Index: -3.1000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1209
    Cell Significance Index: -2.0900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1246
    Cell Significance Index: -6.5400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1347
    Cell Significance Index: -2.0300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1356
    Cell Significance Index: -4.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1419
    Cell Significance Index: -4.5500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1448
    Cell Significance Index: -3.0300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1493
    Cell Significance Index: -5.4800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1531
    Cell Significance Index: -4.3700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1542
    Cell Significance Index: -3.0500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.1595
    Cell Significance Index: -2.2300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1614
    Cell Significance Index: -3.8700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1668
    Cell Significance Index: -4.1600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1693
    Cell Significance Index: -2.7900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1809
    Cell Significance Index: -3.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PHEX is a transmembrane protein that belongs to the neutral endopeptidase family, which is involved in the degradation of various peptides, including those involved in bone and mineral metabolism. The PHEX gene is expressed in various tissues, including the kidneys, bones, and lungs, and its expression is tightly regulated to ensure proper phosphate homeostasis. The PHEX protein has a unique mechanism of action, where it regulates the activity of the sodium-phosphate cotransporter in the kidneys, thereby controlling phosphate reabsorption and excretion. **Pathways and Functions:** The PHEX gene is involved in several key pathways, including: 1. **Bone development and mineralization:** PHEX regulates the expression of genes involved in bone formation and mineralization, such as osteocalcin and alkaline phosphatase. 2. **Cell-cell signaling:** PHEX interacts with various signaling molecules, including parathyroid hormone (PTH) and vitamin D, to regulate phosphate homeostasis. 3. **Protein processing:** PHEX is involved in the degradation of various peptides, including those involved in bone and mineral metabolism. 4. **Cellular response to growth hormone and insulin-like growth factor:** PHEX regulates the expression of genes involved in growth and development in response to growth hormone and insulin-like growth factor. **Clinical Significance:** Mutations in the PHEX gene have been identified as the primary cause of X-linked hypophosphatemia, a rare genetic disorder characterized by low phosphate levels in the blood, leading to various complications such as: 1. **Rickets and osteomalacia:** Low phosphate levels can lead to softening of the bones and weakening of the skeletal system. 2. **Cardiovascular disease:** Low phosphate levels have been associated with an increased risk of cardiovascular disease, including atherosclerosis and heart failure. 3. **Neuropathy:** Low phosphate levels can lead to neuropathy, a condition characterized by nerve damage and numbness. In summary, the PHEX gene plays a critical role in regulating phosphate homeostasis and bone mineralization, and mutations in the PHEX gene can lead to various complications, including X-linked hypophosphatemia, rickets, osteomalacia, and cardiovascular disease. Further research is needed to fully understand the mechanisms by which PHEX regulates phosphate homeostasis and to develop effective treatments for individuals with PHEX-related disorders.

Genular Protein ID: 99115017

Symbol: PHEX_HUMAN

Name: Phosphate-regulating neutral endopeptidase PHEX

UniProtKB Accession Codes:

P78562 O00678 Q13646 Q2M325 Q93032 Q99827

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 32 Ensembl 1 GO 21 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9199930

Title: Genomic organization of the human PEX gene mutated in X-linked dominant hypophosphatemic rickets.

PubMed ID: 9199930

DOI: 10.1101/gr.7.6.573

PubMed ID: 9077527

Title: Pex/PEX tissue distribution and evidence for a deletion in the 3' region of the Pex gene in X-linked hypophosphatemic mice.

PubMed ID: 9077527

DOI: 10.1172/jci119276

PubMed ID: 9199999

Title: Cloning and sequencing of human PEX from a bone cDNA library: evidence for its developmental stage-specific regulation in osteoblasts.

PubMed ID: 9199999

DOI: 10.1359/jbmr.1997.12.7.1009

PubMed ID: 9070861

Title: Expression and cloning of the human X-linked hypophosphatemia gene cDNA.

PubMed ID: 9070861

DOI: 10.1006/bbrc.1997.6153

PubMed ID: 9593714

Title: Cloning of human PEX cDNA. Expression, subcellular localization, and endopeptidase activity.

PubMed ID: 9593714

DOI: 10.1074/jbc.273.22.13729

PubMed ID: 9106524

Title: Mutational analysis of the PEX gene in patients with X-linked hypophosphatemic rickets.

PubMed ID: 9106524

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7550339

Title: A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets.

PubMed ID: 7550339

DOI: 10.1038/ng1095-130

PubMed ID: 12220505

Title: Inhibition of MEPE cleavage by Phex.

PubMed ID: 12220505

DOI: 10.1016/s0006-291x(02)02125-3

PubMed ID: 15664000

Title: Surface plasmon resonance (SPR) confirms that MEPE binds to PHEX via the MEPE-ASARM motif: a model for impaired mineralization in X-linked rickets (HYP).

PubMed ID: 15664000

DOI: 10.1016/j.bone.2004.09.015

PubMed ID: 18162525

Title: Degradation of MEPE, DMP1, and release of SIBLING ASARM-peptides (minhibins): ASARM-peptide(s) are directly responsible for defective mineralization in HYP.

PubMed ID: 18162525

DOI: 10.1210/en.2007-1205

PubMed ID: 18597632

Title: MEPE-ASARM peptides control extracellular matrix mineralization by binding to hydroxyapatite: an inhibition regulated by PHEX cleavage of ASARM.

PubMed ID: 18597632

DOI: 10.1359/jbmr.080601

PubMed ID: 9097956

Title: Distribution of mutations in the PEX gene in families with X-linked hypophosphataemic rickets (HYP).

PubMed ID: 9097956

DOI: 10.1093/hmg/6.4.539

PubMed ID: 9768646

Title: A PHEX gene mutation is responsible for adult-onset vitamin D-resistant hypophosphatemic osteomalacia: evidence that the disorder is not a distinct entity from X-linked hypophosphatemic rickets.

PubMed ID: 9768646

DOI: 10.1210/jcem.83.10.5167

PubMed ID: 9768674

Title: Mutational analysis of PHEX gene in X-linked hypophosphatemia.

PubMed ID: 9768674

DOI: 10.1210/jcem.83.10.5180

PubMed ID: 10439971

Title: Non-random distribution of mutations in the PHEX gene, and under-detected missense mutations at non-conserved residues.

PubMed ID: 10439971

DOI: 10.1038/sj.ejhg.5200341

PubMed ID: 10737991

Title: Identification of fifteen novel PHEX gene mutations in Finnish patients with hypophosphatemic rickets.

PubMed ID: 10737991

DOI: 10.1002/(sici)1098-1004(200004)15:4<383::aid-humu18>3.0.co;2-#

PubMed ID: 11004247

Title: Three novel PHEX gene mutations in Japanese patients with X-linked hypophosphatemic rickets.

PubMed ID: 11004247

DOI: 10.1203/00006450-200010000-00019

Sequence Information:

  • Length: 749
  • Mass: 86474
  • Checksum: 7C4F9F3E2471C6A8
  • Sequence:
    • MEAETGSSVE TGKKANRGTR IALVVFVGGT LVLGTILFLV SQGLLSLQAK QEYCLKPECI 
EAAAAILSKV NLSVDPCDNF FRFACDGWIS NNPIPEDMPS YGVYPWLRHN VDLKLKELLE 
KSISRRRDTE AIQKAKILYS SCMNEKAIEK ADAKPLLHIL RHSPFRWPVL ESNIGPEGVW 
SERKFSLLQT LATFRGQYSN SVFIRLYVSP DDKASNEHIL KLDQATLSLA VREDYLDNST 
EAKSYRDALY KFMVDTAVLL GANSSRAEHD MKSVLRLEIK IAEIMIPHEN RTSEAMYNKM 
NISELSAMIP QFDWLGYIKK VIDTRLYPHL KDISPSENVV VRVPQYFKDL FRILGSERKK 
TIANYLVWRM VYSRIPNLSR RFQYRWLEFS RVIQGTTTLL PQWDKCVNFI ESALPYVVGK 
MFVDVYFQED KKEMMEELVE GVRWAFIDML EKENEWMDAG TKRKAKEKAR AVLAKVGYPE 
FIMNDTHVNE DLKAIKFSEA DYFGNVLQTR KYLAQSDFFW LRKAVPKTEW FTNPTTVNAF 
YSASTNQIRF PAGELQKPFF WGTEYPRSLS YGAIGVIVGH EFTHGFDNNG RKYDKNGNLD 
PWWSTESEEK FKEKTKCMIN QYSNYYWKKA GLNVKGKRTL GENIADNGGL REAFRAYRKW 
INDRRQGLEE PLLPGITFTN NQLFFLSYAH VRCNSYRPEA AREQVQIGAH SPPQFRVNGA 
ISNFEEFQKA FNCPPNSTMN RGMDSCRLW

Genular Protein ID: 614946849

Symbol: B4DNS0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DNS0

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 5 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 4 RefSeq 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 695
  • Mass: 80322
  • Checksum: 17A57586E188CDE7
  • Sequence:
    • MEAETGSSVE TGKKANRGTR IALVVFVGGT LVLGTILFLV SQGLLSLQAK QEYCLKPECI 
EAAAAILSKV NLSVDPCDNF FRFACDGWIS NNPIPEDMPS YGVYPWLRHN VDLKLKELLE 
KSISRRRDTE AIQKAKILYS SCMNEKAIEK ADAKPLLHIL RHSPFRWPVL ESNIGPEGVW 
SERKFSLLQT LATFRGQYSN SVFIRLYVSP DDKASNEHIL KLDQATLSLA VREDYLDNST 
EAKSYRDALY KFMVDTAVLL GANSSRAEHD MKSVLRLEIK IAEIMIPHEN RTSEAMYNKM 
NISELSAMIP QFDWLGYIKK VIDTRLYPHL KDISPSENVV VRVPQYFKDL FRILGSERKK 
TIANYLVWRM VYSRIPNLSR RFQYRWLEFS RVIQGTTTLL PQWDKCVNFI ESALPYVVGK 
MFVDVYFQED KKEMMEELVE GVRWAFIDML EKENEWMDAG TKRKAKEKAR AVLAKVGYPE 
FIMNDTHVNE DLKAIKFSEA DYFGNVLQTR KYLAQSDFFW LRKAVPKTEW FTNPTTVNAF 
YSASTNQIRF PAGELQKPFF WGTEYPRSLS YGAIGVIVGH EFTHGFDNNG RKYDKNGNLD 
PWWSTESEEK FKEKTKCMVN QYSNYYWKKA GLNVKGKRTL GENIADNGGL REAFRAYRKW 
INDRRQGLEE PLLPGITFTN NQLFFLSYAH GQWCN

Genular Protein ID: 3627800099

Symbol: B4DWG8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DWG8

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 5 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 4 ProteomicsDB 1 RefSeq 2 SUPFAM 1

Sequence Information:

  • Length: 652
  • Mass: 76100
  • Checksum: 7369FB60ED0365AF
  • Sequence:
    • MPSYGVYPWL RHNVDLKLKE LLEKSISRRR DTEAIQKAKI LYSSCMNEKA IEKADAKPLL 
HILRHSPFRW PVLESNIGPE GVWSERKFSL LQTLATFRGQ YSNSVFIRLY VSPDDKASNE 
HILKLDQATL SLAVREDYLD NSTEAKSYRD ALYKFMVDTA VLLGANSSRA EHDMKSVLRL 
EIKIAEIMIP HENRTSEAMY NKMNISELSA MIPQFDWLGY IKKVIDTRLY PHLKDISPSE 
NVVVRVPQYF KDLFRILGSE RKKTIANYLV WRMVYSRIPN LSRRFQYRWL EFSRVIQGTT 
TLLPQWDKCV NFIESALPYV VGKMFVDVYF QEDKKEMMEE LVEGVRWAFI DMLEKENEWM 
DAGTKRKAKE KARAVLAKVG YPEFIMNDTH VNEDLKAIKF SEADYFGNVL QTRKYLAQSD 
FFWLRKAVPK TEWFTNPTTV NAFYSASTNQ IRFPAGELQK PFFWGTEYPR SLSYGAIGVI 
VGHEFTHGFD NNGRKYDKNG NLDPWWSTES EEKFKEKTKC MINQYSNYYW KKAGLNVKGK 
RTLGENIADN GGLREAFRAY RKWINDRRQG LEEPLLPGIT FTNNQLFFLS YAHVRCNSYR 
PEAAREQVQI GAHSPPQFRV NGAISNFEEF QKAFNCPPNS TMNRGMDSCR LW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.