Details for: AKR1C2

Gene ID: 1646

Symbol: AKR1C2

Ensembl ID: ENSG00000151632

Description: aldo-keto reductase family 1 member C2

Associated with

  • Bile acid and bile salt metabolism
    (R-HSA-194068)
  • Metabolism
    (R-HSA-1430728)
  • Metabolism of lipids
    (R-HSA-556833)
  • Metabolism of steroids
    (R-HSA-8957322)
  • Synthesis of bile acids and bile salts
    (R-HSA-192105)
  • Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
    (R-HSA-193368)
  • Synthesis of bile acids and bile salts via 24-hydroxycholesterol
    (R-HSA-193775)
  • Synthesis of bile acids and bile salts via 27-hydroxycholesterol
    (R-HSA-193807)
  • Aldose reductase (nadph) activity
    (GO:0004032)
  • Androstan-3-alpha,17-beta-diol dehydrogenase activity
    (GO:0047044)
  • Androsterone dehydrogenase activity
    (GO:0047023)
  • Bile acid binding
    (GO:0032052)
  • Carboxylic acid binding
    (GO:0031406)
  • Cellular response to jasmonic acid stimulus
    (GO:0071395)
  • Cellular response to prostaglandin d stimulus
    (GO:0071799)
  • Cytosol
    (GO:0005829)
  • Daunorubicin metabolic process
    (GO:0044597)
  • Digestion
    (GO:0007586)
  • Doxorubicin metabolic process
    (GO:0044598)
  • Epithelial cell differentiation
    (GO:0030855)
  • Estradiol 17-beta-dehydrogenase [nad(p)+] activity
    (GO:0004303)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Indanol dehydrogenase activity
    (GO:0047718)
  • Ketosteroid monooxygenase activity
    (GO:0047086)
  • Oxidoreductase activity, acting on nad(p)h, quinone or similar compound as acceptor
    (GO:0016655)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Progesterone metabolic process
    (GO:0042448)
  • Prostaglandin metabolic process
    (GO:0006693)
  • Steroid metabolic process
    (GO:0008202)
  • Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
    (GO:0047115)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 114.6451
    Cell Significance Index: -17.8300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 71.1235
    Cell Significance Index: -18.0400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 51.0016
    Cell Significance Index: -21.0100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.5828
    Cell Significance Index: -17.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 8.7888
    Cell Significance Index: 456.5500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 7.2808
    Cell Significance Index: 122.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 6.2728
    Cell Significance Index: 1130.7800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 6.1692
    Cell Significance Index: 56.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 5.9458
    Cell Significance Index: 731.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.5666
    Cell Significance Index: -18.0200
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 3.9071
    Cell Significance Index: 14.7200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.6698
    Cell Significance Index: 50.0700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.5822
    Cell Significance Index: -7.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.6232
    Cell Significance Index: 56.8300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.8119
    Cell Significance Index: 51.9400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.4451
    Cell Significance Index: 15.7100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.3704
    Cell Significance Index: 9.2900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.3318
    Cell Significance Index: 16.7700
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.9594
    Cell Significance Index: 5.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9303
    Cell Significance Index: 26.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8731
    Cell Significance Index: 166.1500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.7694
    Cell Significance Index: 12.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6852
    Cell Significance Index: 135.9800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.6013
    Cell Significance Index: 9.5400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.5135
    Cell Significance Index: 12.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4414
    Cell Significance Index: 51.4400
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.3469
    Cell Significance Index: 1.5100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3382
    Cell Significance Index: 36.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3146
    Cell Significance Index: 9.0700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.2229
    Cell Significance Index: 3.2900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2015
    Cell Significance Index: 4.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1797
    Cell Significance Index: 12.4300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1568
    Cell Significance Index: 3.0600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1336
    Cell Significance Index: 15.2500
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.1311
    Cell Significance Index: 2.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1199
    Cell Significance Index: 108.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1063
    Cell Significance Index: 4.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1023
    Cell Significance Index: 5.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0714
    Cell Significance Index: 3.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0644
    Cell Significance Index: 1.6100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0544
    Cell Significance Index: 33.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0532
    Cell Significance Index: 8.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0445
    Cell Significance Index: 19.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0274
    Cell Significance Index: 17.4200
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.0266
    Cell Significance Index: 0.2200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0165
    Cell Significance Index: 1.0200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0146
    Cell Significance Index: 0.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0118
    Cell Significance Index: 1.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0057
    Cell Significance Index: 0.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0034
    Cell Significance Index: 1.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0030
    Cell Significance Index: -0.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0033
    Cell Significance Index: -1.1900
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -0.0058
    Cell Significance Index: -0.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0066
    Cell Significance Index: -0.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0070
    Cell Significance Index: -13.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0075
    Cell Significance Index: -0.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0089
    Cell Significance Index: -6.5600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0119
    Cell Significance Index: -22.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0131
    Cell Significance Index: -9.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0135
    Cell Significance Index: -20.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0185
    Cell Significance Index: -10.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0207
    Cell Significance Index: -28.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0223
    Cell Significance Index: -16.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0320
    Cell Significance Index: -6.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0391
    Cell Significance Index: -17.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0438
    Cell Significance Index: -5.6100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0637
    Cell Significance Index: -0.9600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0740
    Cell Significance Index: -2.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0901
    Cell Significance Index: -12.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0993
    Cell Significance Index: -10.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1076
    Cell Significance Index: -15.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1114
    Cell Significance Index: -7.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1263
    Cell Significance Index: -4.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1337
    Cell Significance Index: -17.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1541
    Cell Significance Index: -9.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1560
    Cell Significance Index: -7.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1775
    Cell Significance Index: -18.4800
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.2094
    Cell Significance Index: -1.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2323
    Cell Significance Index: -17.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2366
    Cell Significance Index: -15.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2425
    Cell Significance Index: -18.0700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2468
    Cell Significance Index: -4.1300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2591
    Cell Significance Index: -9.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2645
    Cell Significance Index: -14.8400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2708
    Cell Significance Index: -6.5600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2718
    Cell Significance Index: -7.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2785
    Cell Significance Index: -17.9700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2854
    Cell Significance Index: -17.9900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2926
    Cell Significance Index: -4.4100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3048
    Cell Significance Index: -7.8400
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.3191
    Cell Significance Index: -1.9800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.3204
    Cell Significance Index: -2.6500
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.3250
    Cell Significance Index: -3.3500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3351
    Cell Significance Index: -8.3700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.3706
    Cell Significance Index: -5.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4343
    Cell Significance Index: -19.2100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4425
    Cell Significance Index: -9.6900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.4473
    Cell Significance Index: -6.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4481
    Cell Significance Index: -9.3800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4617
    Cell Significance Index: -16.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Aldo-Keto Reductase Family Member:** AKR1C2 is a member of the aldo-keto reductase family, which is characterized by its ability to catalyze the reduction of aldehydes and ketones. 2. **Steroid Metabolism:** AKR1C2 is involved in the reduction of various steroids, including androgens, estrogens, and progestins. 3. **Bile Acid Synthesis:** The gene is also involved in the synthesis of bile acids, which are essential for the digestion and absorption of fats. 4. **Cell Proliferation:** AKR1C2 has been shown to promote cell proliferation, which is a critical process in tissue development and repair. 5. **Expression in Various Cell Types:** The gene is significantly expressed in various cell types, including epicardial adipocytes, bladder urothelial cells, and malignant cells. **Pathways and Functions:** 1. **Steroid Metabolism:** AKR1C2 is involved in the reduction of various steroids, including androgens, estrogens, and progestins. This process is crucial for the regulation of hormone-dependent processes, such as cell growth and differentiation. 2. **Bile Acid Synthesis:** The gene is also involved in the synthesis of bile acids, which are essential for the digestion and absorption of fats. 3. **Cell Proliferation:** AKR1C2 has been shown to promote cell proliferation, which is a critical process in tissue development and repair. 4. **Jasmonic Acid and Prostaglandin Signaling:** The gene is involved in the signaling pathways of jasmonic acid and prostaglandin, which are critical for the regulation of plant defense responses and inflammation. 5. **Metabolism of Lipids and Steroids:** AKR1C2 is involved in the metabolism of lipids and steroids, including the reduction of fatty acids and the synthesis of bile acids. **Clinical Significance:** 1. **Cancer:** AKR1C2 has been shown to be overexpressed in various types of cancer, including breast, prostate, and lung cancer. Its expression is associated with tumor progression and metastasis. 2. **Metabolic Disorders:** The gene is also involved in the regulation of lipid metabolism, and its dysregulation has been linked to various metabolic disorders, including obesity and insulin resistance. 3. **Steroid-Dependent Diseases:** AKR1C2 is involved in the regulation of steroid metabolism, and its dysregulation has been linked to various steroid-dependent diseases, including hormone-sensitive cancers. 4. **Bile Acid Metabolism:** The gene is also involved in the regulation of bile acid metabolism, and its dysregulation has been linked to various liver diseases, including cholestasis and cirrhosis. In conclusion, the AKR1C2 gene is a crucial enzyme involved in various metabolic pathways, including steroid metabolism, bile acid synthesis, and cell proliferation. Its dysregulation has been linked to various diseases, including cancer, metabolic disorders, and steroid-dependent diseases. Further research is needed to fully understand the role of AKR1C2 in human health and disease.

Genular Protein ID: 4113031975

Symbol: AK1C2_HUMAN

Name: 3-alpha-HSD3

UniProtKB Accession Codes:

P52895 A8K2N9 B4DKR9 Q14133 Q5SR16 Q7M4N1 Q96A71

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 4 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTC 1 CTD 1 ChEBI 76 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 12 DrugCentral 1 EC 9 EMBL 13 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 16 PIR 3 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 Rhea 29 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8274401

Title: Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.

PubMed ID: 8274401

DOI: 10.1016/0960-0760(93)90308-j

PubMed ID: 8011662

Title: cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase.

PubMed ID: 8011662

DOI: 10.1016/0005-2728(94)90144-9

PubMed ID: 7959017

Title: Structure of a gene coding for human dihydrodiol dehydrogenase/bile acid-binding protein.

PubMed ID: 7959017

DOI: 10.1016/0378-1119(94)90176-7

PubMed ID: 8920937

Title: Molecular cloning of human type 3 3 alpha-hydroxysteroid dehydrogenase that differs from 20 alpha-hydroxysteroid dehydrogenase by seven amino acids.

PubMed ID: 8920937

DOI: 10.1006/bbrc.1996.1684

PubMed ID: 9716498

Title: Sequence of the cDNA of a human dihydrodiol dehydrogenase isoform (AKR1C2) and tissue distribution of its mRNA.

PubMed ID: 9716498

DOI: 10.1042/bj3340399

PubMed ID: 10672042

Title: Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes.

PubMed ID: 10672042

DOI: 10.1046/j.1365-2443.2000.00310.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8573067

Title: Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells.

PubMed ID: 8573067

DOI: 10.1042/bj3130373

PubMed ID: 8486699

Title: cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family.

PubMed ID: 8486699

DOI: 10.1016/s0021-9258(18)82220-7

PubMed ID: 10998348

Title: Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones.

PubMed ID: 10998348

DOI: 10.1042/0264-6021:3510067

PubMed ID: 14672942

Title: Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action.

PubMed ID: 14672942

DOI: 10.1074/jbc.m313308200

PubMed ID: 19218247

Title: Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism.

PubMed ID: 19218247

DOI: 10.1074/jbc.m809465200

PubMed ID: 21802064

Title: Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation.

PubMed ID: 21802064

DOI: 10.1016/j.ajhg.2011.06.009

PubMed ID: 11513593

Title: Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate.

PubMed ID: 11513593

DOI: 10.1021/bi010919a

PubMed ID: 11514561

Title: Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution.

PubMed ID: 11514561

DOI: 10.1074/jbc.m105610200

PubMed ID: 15929998

Title: Comparison of crystal structures of human type 3 3alpha-hydroxysteroid dehydrogenase reveals an 'induced-fit' mechanism and a conserved basic motif involved in the binding of androgen.

PubMed ID: 15929998

DOI: 10.1110/ps.051353205

PubMed ID: 17034817

Title: Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme.

PubMed ID: 17034817

DOI: 10.1016/j.jmb.2006.09.030

PubMed ID: 17442338

Title: Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding.

PubMed ID: 17442338

DOI: 10.1016/j.jmb.2007.03.058

Sequence Information:

  • Length: 323
  • Mass: 36735
  • Checksum: 0D7B6F983FCE85E1
  • Sequence:
    • MDSKYQCVKL NDGHFMPVLG FGTYAPAEVP KSKALEAVKL AIEAGFHHID SAHVYNNEEQ 
VGLAIRSKIA DGSVKREDIF YTSKLWSNSH RPELVRPALE RSLKNLQLDY VDLYLIHFPV 
SVKPGEEVIP KDENGKILFD TVDLCATWEA MEKCKDAGLA KSIGVSNFNH RLLEMILNKP 
GLKYKPVCNQ VECHPYFNQR KLLDFCKSKD IVLVAYSALG SHREEPWVDP NSPVLLEDPV 
LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTS EEMKAIDGLN 
RNVRYLTLDI FAGPPNYPFS DEY

Genular Protein ID: 3542026281

Symbol: B4DK69_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DK69

Database IDs:

ARBA 12 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 45 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 7 EMBL 4 Ensembl 2 GO 1 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 3 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 17 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 297
  • Mass: 33834
  • Checksum: AF427C98DEED9F78
  • Sequence:
    • MDSKYQCVKL NDGHFMPVLG FGTYAPAEVP KSKALEAVKL AIEAGFHHID SAHVYNNEEQ 
VGLAIRSKIA DGSVKREDIF YTSKLWSNSH RPELVRPALE RSLKNLQLDY VDLYLIHFPV 
SVKAMEKCKD AGLAKSIGVS NFNHRLLEMI LNKPGLKYKP VCNQVECHPY FNQRKLLDFC 
KSKDIVLVAY SALGSHREEP WVDPNSPVLL EDPVLCALAK KHKRTPALIA LRYQLQRGVV 
VLAKSYNEQR IRQNVQVFEF QLTSEEMKAI DGLNRNVRYL TLDIFAGPPN YPFSDEY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.