IGLV1 44 | ENSG00000211651 | NCBI 28823

Details for: IGLV1 44

Gene ID: 28823

Symbol: IGLV1 44

Ensembl ID: ENSG00000211651

Description: immunoglobulin lambda variable 1-44

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Antigen binding
(GO:0003823)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.9223
Cell Significance Index: 13.3900
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.5597
Cell Significance Index: 8.6600
Cell Name: blood cell (CL0000081)
Fold Change: 0.1543
Cell Significance Index: 1.3200
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0024
Cell Significance Index: 0.3000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0041
Cell Significance Index: -3.1300
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0307
Cell Significance Index: -0.8200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0480
Cell Significance Index: -4.9000
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0566
Cell Significance Index: -1.3700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0674
Cell Significance Index: -3.5000
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0826
Cell Significance Index: -5.3300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0848
Cell Significance Index: -2.3100
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0892
Cell Significance Index: -2.2300
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0967
Cell Significance Index: -12.4900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1115
Cell Significance Index: -8.5600
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1147
Cell Significance Index: -7.0300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1190
Cell Significance Index: -20.3200
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.1226
Cell Significance Index: -1.3700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1336
Cell Significance Index: -26.8000
Cell Name: melanocyte (CL0000148)
Fold Change: -0.1391
Cell Significance Index: -1.3000
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.1404
Cell Significance Index: -3.5000
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1435
Cell Significance Index: -6.6900
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.1637
Cell Significance Index: -1.0900
Cell Name: MHC-II-positive classical monocyte (CL0002470)
Fold Change: -0.1679
Cell Significance Index: -0.8900
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1699
Cell Significance Index: -12.6600
Cell Name: plasma cell (CL0000786)
Fold Change: -0.1710
Cell Significance Index: -1.9100
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1757
Cell Significance Index: -6.4500
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1817
Cell Significance Index: -4.6300
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: -0.1832
Cell Significance Index: -2.3200
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.1989
Cell Significance Index: -2.3400
Cell Name: leukocyte (CL0000738)
Fold Change: -0.2055
Cell Significance Index: -3.4900
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.2086
Cell Significance Index: -2.5800
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.2102
Cell Significance Index: -2.8600
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2153
Cell Significance Index: -3.9800
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.2348
Cell Significance Index: -4.5900
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.2479
Cell Significance Index: -2.9300
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.2487
Cell Significance Index: -3.2200
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.2538
Cell Significance Index: -4.1100
Cell Name: myoepithelial cell (CL0000185)
Fold Change: -0.2583
Cell Significance Index: -2.9300
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.2693
Cell Significance Index: -2.9300
Cell Name: promonocyte (CL0000559)
Fold Change: -0.2757
Cell Significance Index: -2.9500
Cell Name: enterocyte (CL0000584)
Fold Change: -0.2805
Cell Significance Index: -1.7400
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.2834
Cell Significance Index: -4.1300
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.2855
Cell Significance Index: -4.8800
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.2919
Cell Significance Index: -3.3100
Cell Name: plasmablast (CL0000980)
Fold Change: -0.2952
Cell Significance Index: -2.7400
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: -0.3036
Cell Significance Index: -3.3100
Cell Name: B cell (CL0000236)
Fold Change: -0.3055
Cell Significance Index: -3.6100
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.3057
Cell Significance Index: -5.1500
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.3093
Cell Significance Index: -4.2900
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.3097
Cell Significance Index: -4.5300
Cell Name: IgA plasmablast (CL0000984)
Fold Change: -0.3111
Cell Significance Index: -2.5000
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.3216
Cell Significance Index: -4.4100
Cell Name: stromal cell (CL0000499)
Fold Change: -0.3264
Cell Significance Index: -3.3400
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.3303
Cell Significance Index: -4.3200
Cell Name: monocyte (CL0000576)
Fold Change: -0.3311
Cell Significance Index: -3.8100
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: -0.3402
Cell Significance Index: -3.5400
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.3421
Cell Significance Index: -5.0500
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.3440
Cell Significance Index: -2.8400
Cell Name: osteoclast (CL0000092)
Fold Change: -0.3477
Cell Significance Index: -3.5500
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: -0.3526
Cell Significance Index: -3.5800
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: -0.3548
Cell Significance Index: -4.1200
Cell Name: naive B cell (CL0000788)
Fold Change: -0.3581
Cell Significance Index: -3.7700
Cell Name: acinar cell (CL0000622)
Fold Change: -0.3583
Cell Significance Index: -4.5000
Cell Name: goblet cell (CL0000160)
Fold Change: -0.3604
Cell Significance Index: -3.2600
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: -0.3621
Cell Significance Index: -3.3600
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.3626
Cell Significance Index: -4.4100
Cell Name: neutrophil (CL0000775)
Fold Change: -0.3650
Cell Significance Index: -4.5600
Cell Name: lung ciliated cell (CL1000271)
Fold Change: -0.3669
Cell Significance Index: -3.5900
Cell Name: memory B cell (CL0000787)
Fold Change: -0.3678
Cell Significance Index: -3.9100
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: -0.3687
Cell Significance Index: -4.1000
Cell Name: podocyte (CL0000653)
Fold Change: -0.3690
Cell Significance Index: -4.2300
Cell Name: osteoblast (CL0000062)
Fold Change: -0.3690
Cell Significance Index: -3.5800
Cell Name: mature B cell (CL0000785)
Fold Change: -0.3702
Cell Significance Index: -2.4100
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: -0.3703
Cell Significance Index: -3.8200
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.3723
Cell Significance Index: -4.4000
Cell Name: club cell (CL0000158)
Fold Change: -0.3726
Cell Significance Index: -4.0600
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.3728
Cell Significance Index: -3.3300
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.3771
Cell Significance Index: -3.6200
Cell Name: mast cell (CL0000097)
Fold Change: -0.3853
Cell Significance Index: -5.0700
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.3894
Cell Significance Index: -5.1100
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.3902
Cell Significance Index: -4.3200
Cell Name: B-1b B cell (CL0000821)
Fold Change: -0.3928
Cell Significance Index: -1.9700
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: -0.3972
Cell Significance Index: -4.0300
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: -0.3977
Cell Significance Index: -4.3900
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: -0.3990
Cell Significance Index: -4.0700
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -0.3991
Cell Significance Index: -3.6500
Cell Name: immature B cell (CL0000816)
Fold Change: -0.4027
Cell Significance Index: -3.8100
Cell Name: endocrine cell (CL0000163)
Fold Change: -0.4029
Cell Significance Index: -4.8700
Cell Name: epithelial cell (CL0000066)
Fold Change: -0.4105
Cell Significance Index: -4.3300
Cell Name: respiratory basal cell (CL0002633)
Fold Change: -0.4136
Cell Significance Index: -4.0800
Cell Name: glial cell (CL0000125)
Fold Change: -0.4153
Cell Significance Index: -4.5500
Cell Name: alveolar type 1 fibroblast cell (CL4028004)
Fold Change: -0.4153
Cell Significance Index: -4.4000
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.4158
Cell Significance Index: -4.6100
Cell Name: mesothelial cell (CL0000077)
Fold Change: -0.4179
Cell Significance Index: -5.0800
Cell Name: fibroblast of lung (CL0002553)
Fold Change: -0.4206
Cell Significance Index: -5.0000
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: -0.4220
Cell Significance Index: -2.9700
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.4267
Cell Significance Index: -5.5700
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: -0.4274
Cell Significance Index: -4.4000
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: -0.4287
Cell Significance Index: -4.6400
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: -0.4305
Cell Significance Index: -4.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** IGLV1 44 is a lambda light chain gene that is part of the immunoglobulin variable region. It is characterized by its unique structure and function, which enables it to interact with various ligands and receptors on the surface of immune cells. The gene is highly conserved across different species, suggesting its importance in immune function. IGLV1 44 has been implicated in various immune-related processes, including antigen activation, complement activation, and phagocytosis. **Pathways and Functions:** IGLV1 44 is involved in several key pathways, including: 1. **Adaptive Immune Response:** IGLV1 44 plays a crucial role in the adaptive immune response by interacting with antigen receptors on B cells and T cells, leading to the activation of immune cells and the production of antibodies. 2. **Complement Activation:** IGLV1 44 is involved in the activation of the complement cascade, which is a critical component of the innate immune response. The gene helps to regulate the activation of complement proteins, which ultimately leads to the elimination of pathogens. 3. **Antigen Binding:** IGLV1 44 is involved in the binding of antigens to immune cells, which is essential for the activation of immune cells and the production of antibodies. 4. **Phagocytosis:** IGLV1 44 is involved in the phagocytic process, which is critical for the clearance of pathogens and dead cells from the body. 5. **Regulation of Actin Dynamics:** IGLV1 44 helps regulate actin dynamics, which is essential for the formation of phagocytic cups and the movement of immune cells. **Clinical Significance:** IGLV1 44 has significant implications in various diseases, including: 1. **Leishmaniasis:** IGLV1 44 has been implicated in the regulation of Leishmania parasite growth and survival, highlighting its potential as a therapeutic target for the treatment of this disease. 2. **SARS-CoV:** IGLV1 44 has been shown to play a role in the regulation of SARS-CoV infections, suggesting its potential as a therapeutic target for the treatment of this disease. 3. **Cancer:** IGLV1 44 has been implicated in the regulation of immune responses in cancer, highlighting its potential as a therapeutic target for the treatment of this disease. 4. **Autoimmune Diseases:** IGLV1 44 has been implicated in the regulation of immune responses in autoimmune diseases, highlighting its potential as a therapeutic target for the treatment of these diseases. In conclusion, IGLV1 44 is a complex gene with diverse implications in immune response and disease. Further research is needed to fully understand the mechanisms by which this gene regulates immune responses and to explore its potential as a therapeutic target for the treatment of various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.