Details for: UPK1B

Gene ID: 7348

Symbol: UPK1B

Ensembl ID: ENSG00000114638

Description: uroplakin 1B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 57.6038
    Cell Significance Index: -8.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 35.4040
    Cell Significance Index: -8.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 13.1900
    Cell Significance Index: 685.1800
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 6.5698
    Cell Significance Index: 67.9700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 5.3326
    Cell Significance Index: 75.9100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 5.2950
    Cell Significance Index: 48.7600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 3.8144
    Cell Significance Index: 44.3400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.5966
    Cell Significance Index: 26.3100
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.9476
    Cell Significance Index: 9.7800
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7259
    Cell Significance Index: 6.6600
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.6351
    Cell Significance Index: 5.2500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4696
    Cell Significance Index: 10.8500
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 0.4349
    Cell Significance Index: 3.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4069
    Cell Significance Index: 73.3600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.4039
    Cell Significance Index: 46.1100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.3351
    Cell Significance Index: 2.1900
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.2825
    Cell Significance Index: 2.4300
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.2788
    Cell Significance Index: 3.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.2695
    Cell Significance Index: 30.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.2471
    Cell Significance Index: 154.2900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1184
    Cell Significance Index: 64.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0816
    Cell Significance Index: 10.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0715
    Cell Significance Index: 49.4600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0662
    Cell Significance Index: 1.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0662
    Cell Significance Index: 13.2800
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.0647
    Cell Significance Index: 0.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0355
    Cell Significance Index: 1.5700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0335
    Cell Significance Index: 1.2700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0036
    Cell Significance Index: 0.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0028
    Cell Significance Index: 1.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0008
    Cell Significance Index: 0.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0023
    Cell Significance Index: -1.7400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0028
    Cell Significance Index: -5.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0033
    Cell Significance Index: -1.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0042
    Cell Significance Index: -0.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0054
    Cell Significance Index: -10.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0059
    Cell Significance Index: -1.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0065
    Cell Significance Index: -10.0500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0073
    Cell Significance Index: -0.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0087
    Cell Significance Index: -11.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0093
    Cell Significance Index: -1.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0113
    Cell Significance Index: -8.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0123
    Cell Significance Index: -9.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0125
    Cell Significance Index: -7.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0156
    Cell Significance Index: -1.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0163
    Cell Significance Index: -7.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0186
    Cell Significance Index: -5.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0291
    Cell Significance Index: -1.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0309
    Cell Significance Index: -6.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0440
    Cell Significance Index: -3.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0452
    Cell Significance Index: -6.5700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0533
    Cell Significance Index: -1.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0677
    Cell Significance Index: -1.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0734
    Cell Significance Index: -9.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0751
    Cell Significance Index: -7.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0825
    Cell Significance Index: -8.6000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1034
    Cell Significance Index: -1.5700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1037
    Cell Significance Index: -8.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1166
    Cell Significance Index: -7.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1282
    Cell Significance Index: -9.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1331
    Cell Significance Index: -8.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1393
    Cell Significance Index: -8.9900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1593
    Cell Significance Index: -2.1500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1635
    Cell Significance Index: -1.3900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1640
    Cell Significance Index: -2.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1682
    Cell Significance Index: -9.4400
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.1870
    Cell Significance Index: -1.8300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1894
    Cell Significance Index: -6.6400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1915
    Cell Significance Index: -9.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1940
    Cell Significance Index: -9.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1949
    Cell Significance Index: -5.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2110
    Cell Significance Index: -9.5700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2126
    Cell Significance Index: -6.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2137
    Cell Significance Index: -11.2200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2163
    Cell Significance Index: -8.8600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2175
    Cell Significance Index: -7.9900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2193
    Cell Significance Index: -7.1800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2348
    Cell Significance Index: -8.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2389
    Cell Significance Index: -11.1400
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.2578
    Cell Significance Index: -1.3500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2603
    Cell Significance Index: -4.4600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2762
    Cell Significance Index: -5.6200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2766
    Cell Significance Index: -9.7200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.2817
    Cell Significance Index: -3.6400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2858
    Cell Significance Index: -4.2200
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.2884
    Cell Significance Index: -2.0000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2902
    Cell Significance Index: -6.9600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2916
    Cell Significance Index: -6.3000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2945
    Cell Significance Index: -2.0000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2975
    Cell Significance Index: -8.4900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2991
    Cell Significance Index: -6.2600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2991
    Cell Significance Index: -4.2500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3139
    Cell Significance Index: -9.2200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3181
    Cell Significance Index: -5.3500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3187
    Cell Significance Index: -7.9600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3202
    Cell Significance Index: -9.1800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3243
    Cell Significance Index: -8.0900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3269
    Cell Significance Index: -8.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3316
    Cell Significance Index: -8.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** UPK1B is a type II transmembrane protein that localizes to the apical plasma membrane of epithelial cells, where it forms urothelial plaques that provide a physical barrier against external insults. This protein possesses a characteristic rod-like structure, which allows it to interact with other proteins and cellular structures, thereby regulating cell-cell adhesion and signaling. UPK1B is highly expressed in various epithelial tissues, including the bladder, conjunctiva, retina, colon, and small intestine, where it plays a critical role in maintaining tissue homeostasis and preventing disease. **Pathways and Functions** UPK1B is involved in several key pathways, including: 1. **Apical plasma membrane urothelial plaque formation**: UPK1B interacts with other proteins to form urothelial plaques, which provide a physical barrier against external insults, such as bacterial invasion and oxidative stress. 2. **Epithelial cell differentiation**: UPK1B regulates the differentiation of epithelial cells, ensuring the proper formation of urothelial plaques and maintaining tissue homeostasis. 3. **Extracellular exosome formation**: UPK1B is involved in the formation of extracellular exosomes, which are small vesicles that contain proteins and lipids, and play a role in intercellular communication. 4. **Protein binding**: UPK1B interacts with various proteins, including integrins, cadherins, and E-cadherin, to regulate cell-cell adhesion and signaling. **Clinical Significance** UPK1B's role in maintaining epithelial barrier function and preventing disease makes it a potential target for the prevention and treatment of various disorders, including: 1. **Cancer**: UPK1B's involvement in epithelial cell differentiation and tumor suppression makes it a potential target for cancer prevention and treatment. 2. **Inflammatory bowel disease**: UPK1B's role in maintaining the integrity of the intestinal epithelium makes it a potential target for the prevention and treatment of inflammatory bowel disease. 3. **Bladder cancer**: UPK1B's involvement in urothelial plaque formation and tumor suppression makes it a potential target for bladder cancer prevention and treatment. In conclusion, UPK1B is a multifaceted protein that plays a critical role in maintaining epithelial cell biology and preventing disease. Further research is needed to fully elucidate the mechanisms underlying UPK1B's functions and to explore its potential applications in disease prevention and treatment.

Genular Protein ID: 2098989269

Symbol: UPK1B_HUMAN

Name: Uroplakin-1b

UniProtKB Accession Codes:

O75841 O60753 Q9UIM2 Q9UNX6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9818021

Title: Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma.

PubMed ID: 9818021

DOI: 10.1111/j.1349-7006.1998.tb00643.x

PubMed ID: 9935153

Title: Cloning of the human uroplakin 1B cDNA and analysis of its expression in urothelial-tumor cell lines and bladder-carcinoma tissue.

PubMed ID: 9935153

DOI: 10.1002/(sici)1097-0215(19990209)80:4<533::aid-ijc9>3.0.co;2-5

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9846985

Title: Uroplakin gene expression by normal and neoplastic human urothelium.

PubMed ID: 9846985

DOI: 10.1016/s0002-9440(10)65709-4

PubMed ID: 9073521

Title: Chromosomal localization of the human urothelial 'tetraspan' gene, UPK1B, to 3q13.3-q21 and detection of a TaqI polymorphism.

PubMed ID: 9073521

DOI: 10.1006/geno.1996.4589

Sequence Information:

  • Length: 260
  • Mass: 29643
  • Checksum: 0512AF8D33884C0F
  • Sequence:
    • MAKDNSTVRC FQGLLIFGNV IIGCCGIALT AECIFFVSDQ HSLYPLLEAT DNDDIYGAAW 
IGIFVGICLF CLSVLGIVGI MKSSRKILLA YFILMFIVYA FEVASCITAA TQQDFFTPNL 
FLKQMLERYQ NNSPPNNDDQ WKNNGVTKTW DRLMLQDNCC GVNGPSDWQK YTSAFRTENN 
DADYPWPRQC CVMNNLKEPL NLEACKLGVP GFYHNQGCYE LISGPMNRHA WGVAWFGFAI 
LCWTFWVLLG TMFYWSRIEY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.