Details for: CFP

Gene ID: 5199

Symbol: CFP

Ensembl ID: ENSG00000126759

Description: complement factor properdin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 29.0269
    Cell Significance Index: -4.5200
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 23.7609
    Cell Significance Index: 62.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 16.8366
    Cell Significance Index: -6.8400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 13.5307
    Cell Significance Index: -6.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 9.8564
    Cell Significance Index: -2.5000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.3842
    Cell Significance Index: -7.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.4957
    Cell Significance Index: -4.3100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.3887
    Cell Significance Index: 44.1500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.8828
    Cell Significance Index: 29.1300
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 1.3498
    Cell Significance Index: 23.1900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.2291
    Cell Significance Index: -4.8500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.8757
    Cell Significance Index: 12.2900
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.4884
    Cell Significance Index: 3.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3828
    Cell Significance Index: 10.2400
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.2839
    Cell Significance Index: 2.3000
  • Cell Name: CD14-positive, CD16-low monocyte (CL0001055)
    Fold Change: 0.2578
    Cell Significance Index: 2.4800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2317
    Cell Significance Index: 12.0700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1894
    Cell Significance Index: 4.7400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1569
    Cell Significance Index: 10.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0855
    Cell Significance Index: 2.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0570
    Cell Significance Index: 10.8500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.0566
    Cell Significance Index: 1.3700
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0558
    Cell Significance Index: 0.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0522
    Cell Significance Index: 10.4800
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.0272
    Cell Significance Index: 0.2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0261
    Cell Significance Index: 2.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0195
    Cell Significance Index: 7.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0165
    Cell Significance Index: 9.0100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.0054
    Cell Significance Index: 0.0500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0012
    Cell Significance Index: 0.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0018
    Cell Significance Index: -1.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0024
    Cell Significance Index: -4.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0054
    Cell Significance Index: -4.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0057
    Cell Significance Index: -2.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0073
    Cell Significance Index: -5.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0097
    Cell Significance Index: -7.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0097
    Cell Significance Index: -5.4600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0113
    Cell Significance Index: -7.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0124
    Cell Significance Index: -3.5700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0128
    Cell Significance Index: -0.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0161
    Cell Significance Index: -2.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0197
    Cell Significance Index: -8.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0199
    Cell Significance Index: -3.9500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0220
    Cell Significance Index: -0.2500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0221
    Cell Significance Index: -2.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0243
    Cell Significance Index: -4.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0254
    Cell Significance Index: -2.5900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0256
    Cell Significance Index: -2.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0263
    Cell Significance Index: -1.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0264
    Cell Significance Index: -3.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0266
    Cell Significance Index: -4.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0277
    Cell Significance Index: -5.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0289
    Cell Significance Index: -1.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0313
    Cell Significance Index: -5.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0373
    Cell Significance Index: -1.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0392
    Cell Significance Index: -2.7700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0398
    Cell Significance Index: -0.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0447
    Cell Significance Index: -5.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0450
    Cell Significance Index: -5.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0459
    Cell Significance Index: -5.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0477
    Cell Significance Index: -5.6200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0487
    Cell Significance Index: -1.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0488
    Cell Significance Index: -7.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0488
    Cell Significance Index: -3.2800
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.0492
    Cell Significance Index: -0.4800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0540
    Cell Significance Index: -0.7900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0550
    Cell Significance Index: -2.3900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0556
    Cell Significance Index: -2.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0585
    Cell Significance Index: -2.6500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0620
    Cell Significance Index: -3.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0632
    Cell Significance Index: -4.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0643
    Cell Significance Index: -4.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0643
    Cell Significance Index: -3.3400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0645
    Cell Significance Index: -2.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0660
    Cell Significance Index: -1.4300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0667
    Cell Significance Index: -1.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0704
    Cell Significance Index: -3.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0708
    Cell Significance Index: -1.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0744
    Cell Significance Index: -4.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0758
    Cell Significance Index: -3.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0759
    Cell Significance Index: -5.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0771
    Cell Significance Index: -2.9200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0810
    Cell Significance Index: -2.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0825
    Cell Significance Index: -5.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0845
    Cell Significance Index: -3.9400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0916
    Cell Significance Index: -3.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0920
    Cell Significance Index: -5.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0937
    Cell Significance Index: -3.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0996
    Cell Significance Index: -2.6700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1024
    Cell Significance Index: -3.2600
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.1084
    Cell Significance Index: -0.6400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1121
    Cell Significance Index: -3.2000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1130
    Cell Significance Index: -3.7000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1159
    Cell Significance Index: -2.9800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1228
    Cell Significance Index: -3.2300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1287
    Cell Significance Index: -1.7100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1321
    Cell Significance Index: -4.8500
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.1367
    Cell Significance Index: -1.4600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1385
    Cell Significance Index: -2.9000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1391
    Cell Significance Index: -3.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Properdin is a glycoprotein that contains a tandem repeat of two kringle domains, which are responsible for its binding to the alternative pathway C3 convertase. The protein is synthesized in the endoplasmic reticulum and secreted into the extracellular space, where it associates with the alternative pathway C3 convertase, preventing its hydrolysis and maintaining its activity. Properdin is also involved in the regulation of opsonization and the immune response to bacterial infections. **Pathways and Functions** Properdin is involved in several key pathways, including: 1. **Activation of C3 and C5**: Properdin associates with the alternative pathway C3 convertase, stabilizing it and preventing its premature inactivation. This ensures that the complement cascade is activated in a controlled manner, preventing excessive inflammation. 2. **Alternative Complement Activation**: Properdin is essential for maintaining the alternative pathway C3 convertase, which is responsible for the activation of C3 and subsequent opsonization and phagocytosis of pathogens. 3. **Regulation of Complement Cascade**: Properdin regulates the activity of the complement cascade by preventing the premature inactivation of the alternative pathway C3 convertase. 4. **Opsonization**: Properdin is involved in the regulation of opsonization, which is the process by which pathogens are marked for destruction by the immune system. **Clinical Significance** Deficiencies in properdin have been linked to various autoimmune and inflammatory disorders, including: 1. **Atypical Hemolytic Uremic Syndrome (aHUS)**: A rare disorder characterized by the formation of blood clots in small blood vessels, leading to kidney failure and hemolytic anemia. 2. **Membranoproliferative Glomerulonephritis (MPGN)**: A type of kidney disease characterized by the deposition of immune complexes in the glomeruli. 3. **Autoimmune Diseases**: Deficiencies in properdin have been linked to various autoimmune diseases, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). In conclusion, properdin is a critical component of the innate immune system that plays a pivotal role in regulating the complement cascade. Deficiencies in properdin have significant clinical implications, highlighting the importance of this gene in maintaining immune homeostasis. Further research is needed to fully understand the mechanisms by which properdin regulates the complement cascade and to develop effective therapeutic strategies for the treatment of autoimmune and inflammatory disorders.

Genular Protein ID: 864548476

Symbol: PROP_HUMAN

Name: Properdin

UniProtKB Accession Codes:

P27918 O15134 O15135 O15136 O75826

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EMDB 2 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 2 SASBDB 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2009915

Title: Molecular cloning of the cDNA coding for properdin, a positive regulator of the alternative pathway of human complement.

PubMed ID: 2009915

DOI: 10.1002/eji.1830210333

PubMed ID: 1417780

Title: Characterization of the human properdin gene.

PubMed ID: 1417780

DOI: 10.1042/bj2870291

PubMed ID: 1431505

Title: Detection of properdin mRNA in human peripheral blood monocytes and spleen.

PubMed ID: 1431505

PubMed ID: 8530058

Title: Sequence-based analysis of properdin deficiency: identification of point mutations in two phenotypic forms of an X-linked immunodeficiency.

PubMed ID: 8530058

DOI: 10.1006/geno.1995.1208

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10878002

Title: Properdin, the positive regulator of complement, is highly C-mannosylated.

PubMed ID: 10878002

DOI: 10.1074/jbc.m001732200

PubMed ID: 12096136

Title: C-mannosylation and O-fucosylation of thrombospondin type 1 repeats.

PubMed ID: 12096136

DOI: 10.1074/mcp.m100011-mcp200

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 20382442

Title: Native polymeric forms of properdin selectively bind to targets and promote activation of the alternative pathway of complement.

PubMed ID: 20382442

DOI: 10.1016/j.imbio.2010.02.002

PubMed ID: 15491616

Title: The dimeric and trimeric solution structures of the multidomain complement protein properdin by X-ray scattering, analytical ultracentrifugation and constrained modelling.

PubMed ID: 15491616

DOI: 10.1016/j.jmb.2004.09.001

PubMed ID: 28264884

Title: Functional and structural insight into properdin control of complement alternative pathway amplification.

PubMed ID: 28264884

DOI: 10.15252/embj.201696173

PubMed ID: 31507604

Title: Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System.

PubMed ID: 31507604

DOI: 10.3389/fimmu.2019.02007

PubMed ID: 8871668

Title: Molecular characterization of properdin deficiency type III: dysfunction produced by a single point mutation in exon 9 of the structural gene causing a tyrosine to aspartic acid interchange.

PubMed ID: 8871668

PubMed ID: 9710744

Title: Expression of properdin in complete and incomplete deficiency: normal in vitro synthesis by monocytes in two cases with properdin deficiency type II due to distinct mutations.

PubMed ID: 9710744

DOI: 10.1023/a:1027385806871

PubMed ID: 10909851

Title: Molecular characterisation of 10 Dutch properdin type I deficient families: mutation analysis and X-inactivation studies.

PubMed ID: 10909851

DOI: 10.1038/sj.ejhg.5200496

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 469
  • Mass: 51276
  • Checksum: 5EB42B63F0283917
  • Sequence:
    • MITEGAQAPR LLLPPLLLLL TLPATGSDPV LCFTQYEESS GKCKGLLGGG VSVEDCCLNT 
AFAYQKRSGG LCQPCRSPRW SLWSTWAPCS VTCSEGSQLR YRRCVGWNGQ CSGKVAPGTL 
EWQLQACEDQ QCCPEMGGWS GWGPWEPCSV TCSKGTRTRR RACNHPAPKC GGHCPGQAQE 
SEACDTQQVC PTHGAWATWG PWTPCSASCH GGPHEPKETR SRKCSAPEPS QKPPGKPCPG 
LAYEQRRCTG LPPCPVAGGW GPWGPVSPCP VTCGLGQTME QRTCNHPVPQ HGGPFCAGDA 
TRTHICNTAV PCPVDGEWDS WGEWSPCIRR NMKSISCQEI PGQQSRGRTC RGRKFDGHRC 
AGQQQDIRHC YSIQHCPLKG SWSEWSTWGL CMPPCGPNPT RARQRLCTPL LPKYPPTVSM 
VEGQGEKNVT FWGRPLPRCE ELQGQKLVVE EKRPCLHVPA CKDPEEEEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.