Details for: MARCHF1
Gene ID: 55016
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: MARCHF1
Ensembl ID: ENSG00000145416
Description: membrane associated ring-CH-type finger 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 57.28rCSI 68.42%PRS 91.82
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CSI 43.99rCSI 79.93%PRS 93.97
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CSI 42.58rCSI 68.48%PRS 92.18
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CSI 36.09rCSI 79.41%PRS 86.47
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CSI 33.58rCSI 30.83%PRS 98.84
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CSI 33.51rCSI 72.69%PRS 90.21
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CSI 31.63rCSI 82.41%PRS 93.19
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CSI 30.84rCSI 39.58%PRS 95.54
-
CSI 30.14rCSI 72.09%PRS 91.51
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CSI 29.15rCSI 70.85%PRS 90.4
-
CSI 28.88rCSI 51.01%PRS 91.7
-
CSI 28.27rCSI 40.07%PRS 96.37
-
CSI 26.5rCSI 34.17%PRS 92.41
-
CSI 26.01rCSI 48.72%PRS 93.14
-
CSI 25.51rCSI 67.94%PRS 89.39
-
CSI 25.47rCSI 21.85%PRS 98.44
-
CSI 24.44rCSI 18.15%PRS 98.94
-
CSI 23.85rCSI 70.47%PRS 90.71
-
CSI 23.26rCSI 72.68%PRS 92.42
-
CSI 23.16rCSI 51.15%PRS 92.08
-
CSI 22.55rCSI 39.75%PRS 94.73
-
CSI 22.43rCSI 25.9%PRS 93.37
-
CSI 22.34rCSI 17.21%PRS 98.63
-
CSI 21.89rCSI 21.62%PRS 98.38
-
CSI 21.37rCSI 49.34%PRS 92.81
-
CSI 21.29rCSI 36.82%PRS 95.2
-
CSI 21.13rCSI 69.45%PRS 90.55
-
CSI 21.06rCSI 26.2%PRS 90.41
-
CSI 20.72rCSI 42.04%PRS 87.41
-
CSI 20.64rCSI 37.1%PRS 94.56
-
CSI 19.67rCSI 17.1%PRS 99.02
-
CSI 19.3rCSI 44.15%PRS 97.66
-
CSI 18.4rCSI 80.85%PRS 94.29
-
CSI 18.26rCSI 52.92%PRS 92.89
-
CSI 17.85rCSI 61.15%PRS 89.9
-
CSI 17.33rCSI 15.99%PRS 98.04
-
CSI 17.28rCSI 24.01%PRS 96.79
-
CSI 16.82rCSI 34.57%PRS 90.08
-
CSI 16.71rCSI 22.36%PRS 95.31
-
CSI 16.52rCSI 26.59%PRS 92.92
-
CSI 16.39rCSI 20.42%PRS 99.26
-
CSI 15.69rCSI 25.03%PRS 93.49
-
CSI 15.64rCSI 40.78%PRS 98.15
-
CSI 15.62rCSI 12.34%PRS 95.04
-
CSI 15.55rCSI 58.77%PRS 91.7
-
CSI 15.29rCSI 10.67%PRS 98.52
-
CSI 15.24rCSI 26.72%PRS 95.59
-
CSI 15.14rCSI 12.63%PRS 91.78
-
CSI 15.02rCSI 19.28%PRS 93.15
-
CSI 14.43rCSI 47.82%PRS 97.39
-
CSI 13.72rCSI 55.91%PRS 92.56
-
CSI 13.61rCSI 71.58%PRS 90.68
-
CSI 13.01rCSI 19.12%PRS 94.5
-
CSI 12.99rCSI 19.6%PRS 98.85
-
CSI 12.9rCSI 25.89%PRS 94.85
-
CSI 12.77rCSI 20.91%PRS 94.39
-
CSI 12.68rCSI 18.36%PRS 99.47
-
CSI 12.18rCSI 19.53%PRS 98.13
-
CSI 12rCSI 25.52%PRS 93.57
-
CSI 11.94rCSI 48.06%PRS 95.58
-
CSI 11.39rCSI 20.59%PRS 97.81
-
CSI 11.05rCSI 13.89%PRS 99.23
-
CSI 10.84rCSI 24.29%PRS 92.08
-
CSI 10.78rCSI 17.76%PRS 97.62
-
CSI 10.78rCSI 16.46%PRS 96.48
-
CSI 10.68rCSI 13.16%PRS 96.31
-
CSI 10.57rCSI 62.44%PRS 91.43
-
CSI 10.54rCSI 23.66%PRS 99.43
-
CSI 10.31rCSI 17.61%PRS 99.62
-
CSI 10.18rCSI 59.96%PRS 91.88
-
CSI 9.81rCSI 70.16%PRS 91.11
-
CSI 9.57rCSI 7.53%PRS 97.44
-
CSI 9.51rCSI 16.3%PRS 97.99
-
CSI 9.49rCSI 17.26%PRS 96.37
-
CSI 9.36rCSI 20.92%PRS 98.94
-
CSI 9.08rCSI 15.25%PRS 91.98
-
CSI 9.08rCSI 34.02%PRS 95.92
-
CSI 8.74rCSI 29.28%PRS 89.61
-
CSI 8.66rCSI 10.46%PRS 98.73
-
CSI 8.66rCSI 58.92%PRS 91.78
-
CSI 8.62rCSI 27.59%PRS 96.62
-
CSI 8.33rCSI 14.91%PRS 95.77
-
CSI 8.17rCSI 10.7%PRS 99.19
-
CSI 7.95rCSI 9.98%PRS 98.87
-
CSI 7.92rCSI 66.68%PRS 88.32
-
CSI 7.82rCSI 11.94%PRS 99.01
-
CSI 7.8rCSI 14.73%PRS 98.76
-
CSI 7.53rCSI 29.45%PRS 89.76
-
CSI 7.51rCSI 11.53%PRS 98.96
-
CSI 7.5rCSI 37.31%PRS 93.74
-
CSI 7.44rCSI 16.37%PRS 98.25
-
CSI 7.35rCSI 54.02%PRS 93.52
-
CSI 7.22rCSI 16.48%PRS 94.26
-
CSI 6.94rCSI 32.64%PRS 90.29
-
CSI 6.64rCSI 30.69%PRS 99.34
-
CSI 6.51rCSI 36.8%PRS 91.34
-
CSI 6.51rCSI 27.05%PRS 95.65
-
CSI 6.49rCSI 46.36%PRS 94.52
-
CSI 6.18rCSI 23.54%PRS 93.77
-
CSI 6.07rCSI 26.71%PRS 90.37
-
CSI 0.6rCSI 5.5%PRS 92.8%
-
CSI 0.8rCSI 6.3%PRS 92.1%
-
CSI 0.9rCSI 5.7%PRS 92.9%
-
CSI 1.3rCSI 12.0%PRS 93.7%
-
CSI 2.1rCSI 12.0%PRS 99.2%
-
CSI 2.6rCSI 51.9%PRS 92.4%
-
CSI 2.8rCSI 68.0%PRS 89.5%
-
CSI 2.9rCSI 68.9%PRS 89.7%
-
CSI 2.9rCSI 59.9%PRS 92.2%
-
CSI 3.0rCSI 4.4%PRS 96.0%
-
CSI 3.1rCSI 23.5%PRS 90.1%
-
CSI 3.2rCSI 2.4%PRS 98.7%
-
CSI 3.6rCSI 13.2%PRS 99.1%
-
CSI 3.8rCSI 7.5%PRS 95.4%
-
CSI 3.8rCSI 5.8%PRS 95.5%
-
CSI 3.8rCSI 5.2%PRS 93.4%
-
CSI 4.1rCSI 24.9%PRS 98.9%
-
CSI 4.2rCSI 32.9%PRS 97.0%
-
CSI 4.3rCSI 19.3%PRS 98.9%
-
CSI 4.4rCSI 15.8%PRS 90.6%
-
CSI 4.7rCSI 67.3%PRS 92.6%
-
CSI 5.0rCSI 15.6%PRS 93.3%
-
CSI 5.6rCSI 19.4%PRS 96.8%
-
CSI 5.8rCSI 24.0%PRS 97.7%
-
CSI 6.1rCSI 26.7%PRS 90.4%
-
CSI 6.2rCSI 23.5%PRS 93.8%
-
CSI 6.5rCSI 46.4%PRS 94.5%
-
CSI 6.5rCSI 27.1%PRS 95.7%
-
CSI 6.5rCSI 36.8%PRS 91.3%
-
CSI 6.6rCSI 30.7%PRS 99.3%
-
CSI 6.9rCSI 32.6%PRS 90.3%
-
CSI 7.2rCSI 16.5%PRS 94.3%
-
CSI 7.4rCSI 54.0%PRS 93.5%
-
CSI 7.4rCSI 16.4%PRS 98.3%
-
CSI 7.5rCSI 37.3%PRS 93.7%
-
CSI 7.5rCSI 11.5%PRS 99.0%
-
CSI 7.5rCSI 29.5%PRS 89.8%
-
CSI 7.8rCSI 14.7%PRS 98.8%
-
CSI 7.8rCSI 11.9%PRS 99.0%
-
CSI 7.9rCSI 66.7%PRS 88.3%
-
CSI 8.0rCSI 10.0%PRS 98.9%
-
CSI 8.2rCSI 10.7%PRS 99.2%
-
CSI 8.3rCSI 14.9%PRS 95.8%
-
CSI 8.6rCSI 27.6%PRS 96.6%
-
CSI 8.7rCSI 58.9%PRS 91.8%
-
CSI 8.7rCSI 10.5%PRS 98.7%
-
CSI 8.7rCSI 29.3%PRS 89.6%
-
CSI 9.1rCSI 34.0%PRS 95.9%
-
CSI 9.1rCSI 15.3%PRS 92.0%
-
CSI 9.4rCSI 20.9%PRS 98.9%
-
CSI 9.5rCSI 17.3%PRS 96.4%
-
CSI 9.5rCSI 16.3%PRS 98.0%
-
CSI 9.6rCSI 7.5%PRS 97.4%
-
CSI 9.8rCSI 70.2%PRS 91.1%
-
CSI 10.2rCSI 60.0%PRS 91.9%
-
CSI 10.3rCSI 17.6%PRS 99.6%
-
CSI 10.5rCSI 23.7%PRS 99.4%
-
CSI 10.6rCSI 62.4%PRS 91.4%
-
CSI 10.7rCSI 13.2%PRS 96.3%
-
CSI 10.8rCSI 16.5%PRS 96.5%
-
CSI 10.8rCSI 17.8%PRS 97.6%
-
CSI 10.8rCSI 24.3%PRS 92.1%
-
CSI 11.1rCSI 13.9%PRS 99.2%
-
CSI 11.4rCSI 20.6%PRS 97.8%
-
CSI 11.9rCSI 48.1%PRS 95.6%
-
CSI 12.0rCSI 25.5%PRS 93.6%
-
CSI 12.2rCSI 19.5%PRS 98.1%
-
CSI 12.7rCSI 18.4%PRS 99.5%
-
CSI 12.8rCSI 20.9%PRS 94.4%
-
CSI 12.9rCSI 25.9%PRS 94.9%
-
CSI 13.0rCSI 19.6%PRS 98.9%
-
CSI 13.0rCSI 19.1%PRS 94.5%
-
CSI 13.6rCSI 71.6%PRS 90.7%
-
CSI 13.7rCSI 55.9%PRS 92.6%
-
CSI 14.4rCSI 47.8%PRS 97.4%
-
CSI 15.0rCSI 19.3%PRS 93.2%
-
CSI 15.1rCSI 12.6%PRS 91.8%
-
CSI 15.2rCSI 26.7%PRS 95.6%
-
CSI 15.3rCSI 10.7%PRS 98.5%
-
CSI 15.6rCSI 58.8%PRS 91.7%
-
CSI 15.6rCSI 12.3%PRS 95.0%
-
CSI 15.6rCSI 40.8%PRS 98.2%
-
CSI 15.7rCSI 25.0%PRS 93.5%
-
CSI 16.4rCSI 20.4%PRS 99.3%
-
CSI 16.5rCSI 26.6%PRS 92.9%
-
CSI 16.7rCSI 22.4%PRS 95.3%
-
CSI 16.8rCSI 34.6%PRS 90.1%
-
CSI 17.3rCSI 24.0%PRS 96.8%
-
CSI 17.3rCSI 16.0%PRS 98.0%
-
CSI 17.9rCSI 61.2%PRS 89.9%
-
CSI 18.3rCSI 52.9%PRS 92.9%
-
CSI 18.4rCSI 80.9%PRS 94.3%
-
CSI 19.3rCSI 44.2%PRS 97.7%
-
CSI 19.7rCSI 17.1%PRS 99.0%
-
CSI 20.6rCSI 37.1%PRS 94.6%
-
CSI 20.7rCSI 42.0%PRS 87.4%
-
CSI 21.1rCSI 26.2%PRS 90.4%
-
CSI 21.1rCSI 69.5%PRS 90.6%
-
CSI 21.3rCSI 36.8%PRS 95.2%
-
CSI 21.4rCSI 49.3%PRS 92.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1066002566
Symbol: MARH1_HUMAN
Name: E3 ubiquitin-protein ligase MARCHF1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 14722266
Title: Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins.
PubMed ID: 14722266
PubMed ID: 17255932
Title: Novel regulation of MHC class II function in B cells.
PubMed ID: 17255932
PubMed ID: 18389477
Title: Interleukin-10-induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes.
PubMed ID: 18389477
PubMed ID: 18305173
Title: MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation.
PubMed ID: 18305173
PubMed ID: 19117940
Title: The HLA-DRalpha chain is modified by polyubiquitination.
PubMed ID: 19117940
Sequence Information:
- Length: 289
- Mass: 32308
- Checksum: 923E1809AB3D7087
- Sequence:
MLGWCEAIAR NPHRIPNNTR TPEISGDLAD ASQTSTLNEK SPGRSASRSS NISKASSPTT GTAPRSQSRL SVCPSTQDIC RICHCEGDEE SPLITPCRCT GTLRFVHQSC LHQWIKSSDT RCCELCKYDF IMETKLKPLR KWEKLQMTTS ERRKIFCSVT FHVIAITCVV WSLYVLIDRT AEEIKQGNDN GVLEWPFWTK LVVVAIGFTG GLVFMYVQCK VYVQLWRRLK AYNRVIFVQN CPDTAKKLEK NFSCNVNTDI KDAVVVPVPQ TGANSLPSAE GGPPEVVSV
Genular Protein ID: 1553200359
Symbol: A8K0Z6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 289
- Mass: 32368
- Checksum: 9231F813AB3D709D
- Sequence:
MLGWCEAIAR NPHRIPNNTR TPEISGDLAD ASQTSTLNEK SPGRSASRSS NISKASSPTT GTAPRSQSRL SVCPSTQDIC RICHCEGDEE SPLITPCRCT GTLRFVHQSC LHQWIKSSDT RCCELCKYDF IMETKLKPLR KWEKLQMTTS ERRKIFCSVT FHVIAITYVV WSLYVLIDRT AEEIKQGNDN GVLEWPFWTK LVVVAIGFTG GLVFMYVQCK VYVQLWRRLK AYNRVIFVQN CPDTAKKLEK NFSCNVNTDI KDAVVVPVPQ TGANSLPSAE GGPPEVVSV