Details for: TMEM8B

Gene ID: 51754

Symbol: TMEM8B

Ensembl ID: ENSG00000137103

Description: transmembrane protein 8B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 104.9855
    Cell Significance Index: -16.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 65.5645
    Cell Significance Index: -16.6300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.4646
    Cell Significance Index: -13.8100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.3744
    Cell Significance Index: -16.4900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.3870
    Cell Significance Index: -17.1100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.2372
    Cell Significance Index: -16.7200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.4492
    Cell Significance Index: 23.8800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3409
    Cell Significance Index: 18.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3076
    Cell Significance Index: 129.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.0630
    Cell Significance Index: 123.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0404
    Cell Significance Index: 169.2200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7230
    Cell Significance Index: 19.0100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7128
    Cell Significance Index: 37.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6665
    Cell Significance Index: 72.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4931
    Cell Significance Index: 29.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4373
    Cell Significance Index: 20.3900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.3957
    Cell Significance Index: 5.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3716
    Cell Significance Index: 14.0700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3673
    Cell Significance Index: 254.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3667
    Cell Significance Index: 16.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3557
    Cell Significance Index: 127.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3444
    Cell Significance Index: 23.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3131
    Cell Significance Index: 14.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2968
    Cell Significance Index: 6.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2907
    Cell Significance Index: 8.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2894
    Cell Significance Index: 58.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2716
    Cell Significance Index: 53.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2658
    Cell Significance Index: 47.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2334
    Cell Significance Index: 15.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1945
    Cell Significance Index: 12.2600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1903
    Cell Significance Index: 13.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1900
    Cell Significance Index: 23.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1825
    Cell Significance Index: 164.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1782
    Cell Significance Index: 78.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1394
    Cell Significance Index: 19.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1375
    Cell Significance Index: 8.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0957
    Cell Significance Index: 52.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0937
    Cell Significance Index: 12.0100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0904
    Cell Significance Index: 2.4600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0824
    Cell Significance Index: 2.0600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0670
    Cell Significance Index: 1.8000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0613
    Cell Significance Index: 1.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0512
    Cell Significance Index: 1.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0446
    Cell Significance Index: 8.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0272
    Cell Significance Index: 2.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0215
    Cell Significance Index: 40.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0169
    Cell Significance Index: 0.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0139
    Cell Significance Index: 2.3800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0108
    Cell Significance Index: 0.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0039
    Cell Significance Index: 2.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0023
    Cell Significance Index: 1.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0004
    Cell Significance Index: 0.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0025
    Cell Significance Index: -0.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0029
    Cell Significance Index: -2.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0030
    Cell Significance Index: -5.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0047
    Cell Significance Index: -7.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0090
    Cell Significance Index: -12.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0110
    Cell Significance Index: -6.8700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0114
    Cell Significance Index: -6.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0180
    Cell Significance Index: -13.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0252
    Cell Significance Index: -3.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0364
    Cell Significance Index: -2.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0384
    Cell Significance Index: -8.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0482
    Cell Significance Index: -13.8700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0502
    Cell Significance Index: -6.4900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0536
    Cell Significance Index: -0.8500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0640
    Cell Significance Index: -0.8200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0709
    Cell Significance Index: -1.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0817
    Cell Significance Index: -8.3500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0825
    Cell Significance Index: -0.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0862
    Cell Significance Index: -2.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0891
    Cell Significance Index: -2.4900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0913
    Cell Significance Index: -0.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1169
    Cell Significance Index: -6.1400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1173
    Cell Significance Index: -1.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1214
    Cell Significance Index: -14.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1246
    Cell Significance Index: -6.9900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1270
    Cell Significance Index: -14.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1366
    Cell Significance Index: -8.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1378
    Cell Significance Index: -14.3500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1434
    Cell Significance Index: -2.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1606
    Cell Significance Index: -7.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1696
    Cell Significance Index: -13.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1899
    Cell Significance Index: -11.6500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2030
    Cell Significance Index: -5.4200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2160
    Cell Significance Index: -5.1800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2465
    Cell Significance Index: -7.2600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2469
    Cell Significance Index: -12.8600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2469
    Cell Significance Index: -5.2800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2630
    Cell Significance Index: -9.1400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2701
    Cell Significance Index: -6.2400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2752
    Cell Significance Index: -5.7600
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2895
    Cell Significance Index: -4.3300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2988
    Cell Significance Index: -7.6800
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.3091
    Cell Significance Index: -2.9900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3156
    Cell Significance Index: -6.9100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3205
    Cell Significance Index: -4.8300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3369
    Cell Significance Index: -10.7300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3427
    Cell Significance Index: -11.2200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3532
    Cell Significance Index: -5.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TMEM8B is a transmembrane protein with a characteristic structure consisting of four transmembrane domains. Its expression is highly specific, with significant levels observed in polychromatophilic erythroblast, hematopoietic oligopotent progenitor cells, ciliated cells of the bronchus, and epithelial cells of the pancreas and stomach. TMEM8B has been shown to interact with various proteins, including those involved in cell adhesion, signaling, and regulation of the mitotic cell cycle. **Pathways and Functions:** TMEM8B is involved in several signaling pathways, including: 1. **Cell-matrix adhesion**: TMEM8B interacts with integrins and other cell surface receptors to regulate cell adhesion to the extracellular matrix, thereby influencing cell migration, proliferation, and differentiation. 2. **Cell surface signaling**: TMEM8B is a member of the TMEM family, which is characterized by its ability to interact with various signaling molecules, including G-proteins and receptors. 3. **Protein binding**: TMEM8B has been shown to interact with other proteins, including those involved in protein degradation, lipid metabolism, and cell cycle regulation. 4. **Regulation of the mitotic cell cycle**: TMEM8B has been implicated in the regulation of the mitotic cell cycle, with its expression influencing cell proliferation and apoptosis. **Clinical Significance:** TMEM8B dysregulation has been associated with various diseases, including: 1. **Autoimmune disorders**: TMEM8B has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where its expression is altered in affected tissues. 2. **Cancer**: TMEM8B has been shown to be overexpressed in certain types of cancer, including breast cancer and colon cancer, where its expression correlates with tumor progression and metastasis. 3. **Neurological disorders**: TMEM8B has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where its expression is altered in affected tissues. 4. **Metabolic disorders**: TMEM8B has been shown to be involved in lipid metabolism, with its expression influencing glucose and lipid homeostasis. In conclusion, TMEM8B is a multifunctional protein with significant implications for cellular adhesion, signaling, and disease pathogenesis. Further research into its functions and potential therapeutic targets is necessary to fully understand its role in human health and disease.

Genular Protein ID: 2848664852

Symbol: TMM8B_HUMAN

Name: Transmembrane protein 8B

UniProtKB Accession Codes:

A6NDV4 B3KQF3 O75539 Q49AB1 Q4KMX5 Q5TCW5 Q9HBY2 Q9P0U7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 5 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 3 SMR 1 STRING 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11565907

Title: Proteomic detection of changes in protein synthesis induced by NGX6 transfected in human nasopharyngeal carcinoma cells.

PubMed ID: 11565907

DOI: 10.1023/a:1010912311564

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15498789

Title: Role of a novel EGF-like domain-containing gene NGX6 in cell adhesion modulation in nasopharyngeal carcinoma cells.

PubMed ID: 15498789

DOI: 10.1093/carcin/bgh312

PubMed ID: 15723283

Title: NGX6 gene inhibits cell proliferation and plays a negative role in EGFR pathway in nasopharyngeal carcinoma cells.

PubMed ID: 15723283

DOI: 10.1002/jcb.20393

PubMed ID: 17641538

Title: The role of NGX6 and its deletion mutants in the proliferation, adhesion and migration of nasopharyngeal carcinoma 5-8F cells.

PubMed ID: 17641538

DOI: 10.1159/000106073

PubMed ID: 17270023

Title: The expression of ezrin in NPC and its interaction with NGX6, a novel candidate suppressor.

PubMed ID: 17270023

DOI: 10.1111/j.1349-7006.2007.00410.x

Sequence Information:

  • Length: 472
  • Mass: 51941
  • Checksum: 3E5EA4495CF54389
  • Sequence:
    • MNMPQSLGNQ PLPPEPPSLG TPAEGPGTTS PPEHCWPVRP TLRNELDTFS VHFYIFFGPS 
VALPPERPAV FAMRLLPVLD SGGVLSLELQ LNASSVRQEN VTVFGCLTHE VPLSLGDAAV 
TCSKESLAGF LLSVSATTRV ARLRIPFPQT GTWFLALRSL CGVGPRFVRC RNATAEVRMR 
TFLSPCVDDC GPYGQCKLLR THNYLYAACE CKAGWRGWGC TDSADALTYG FQLLSTLLLC 
LSNLMFLPPV VLAIRSRYVL EAAVYTFTMF FSTFYHACDQ PGIVVFCIMD YDVLQFCDFL 
GSLMSVWVTV IAMARLQPVV KQVLYLLGAM LLSMALQLDR HGLWNLLGPS LFALGILATA 
WTVRSVRRRH CYPPTWRRWL FYLCPGSLIA GSAVLLYAFV ETRDNYFYIH SIWHMLIAGS 
VGFLLPPRAK TDHGVPSGAR ARGCGYQLCI NEQEELGLVG PGGATVSSIC AS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.