CXCL8 | ENSG00000169429 | NCBI 3576

Details for: CXCL8

Gene ID: 3576

Symbol: CXCL8

Ensembl ID: ENSG00000169429

Description: C-X-C motif chemokine ligand 8

Associated with

Atf4 activates genes in response to endoplasmic reticulum stress
(R-HSA-380994)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chemokine receptors bind chemokines
(R-HSA-380108)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
Cytokine signaling in immune system
(R-HSA-1280215)
G alpha (i) signalling events
(R-HSA-418594)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Immune system
(R-HSA-168256)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Interleukin-10 signaling
(R-HSA-6783783)
Peptide ligand-binding receptors
(R-HSA-375276)
Perk regulates gene expression
(R-HSA-381042)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by gpcr
(R-HSA-372790)
Signaling by interleukins
(R-HSA-449147)
Unfolded protein response (upr)
(R-HSA-381119)
Angiogenesis
(GO:0001525)
Antimicrobial humoral immune response mediated by antimicrobial peptide
(GO:0061844)
Calcium-mediated signaling
(GO:0019722)
Cellular response to fibroblast growth factor stimulus
(GO:0044344)
Cellular response to interleukin-1
(GO:0071347)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to tumor necrosis factor
(GO:0071356)
Chemokine-mediated signaling pathway
(GO:0070098)
Chemokine activity
(GO:0008009)
Chemotaxis
(GO:0006935)
Cxcr chemokine receptor binding
(GO:0045236)
Embryonic digestive tract development
(GO:0048566)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
G protein-coupled receptor signaling pathway
(GO:0007186)
Heparin binding
(GO:0008201)
Induction of positive chemotaxis
(GO:0050930)
Inflammatory response
(GO:0006954)
Interleukin-8 receptor binding
(GO:0005153)
Intracellular signal transduction
(GO:0035556)
Killing of cells of another organism
(GO:0031640)
Negative regulation of cell adhesion molecule production
(GO:0060354)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of g protein-coupled receptor signaling pathway
(GO:0045744)
Neutrophil activation
(GO:0042119)
Neutrophil chemotaxis
(GO:0030593)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of cellular biosynthetic process
(GO:0031328)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of neutrophil chemotaxis
(GO:0090023)
Protein binding
(GO:0005515)
Receptor internalization
(GO:0031623)
Regulation of cell adhesion
(GO:0030155)
Regulation of entry of bacterium into host cell
(GO:2000535)
Regulation of single stranded viral rna replication via double stranded dna intermediate
(GO:0045091)
Response to endoplasmic reticulum stress
(GO:0034976)
Response to molecule of bacterial origin
(GO:0002237)
Signal transduction
(GO:0007165)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 77.8211
Cell Significance Index: -40.0300
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 66.4360
Cell Significance Index: -44.5800
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 19.8245
Cell Significance Index: -60.8900
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 18.9240
Cell Significance Index: 135.9100
Cell Name: mononuclear cell (CL0000842)
Fold Change: 17.3836
Cell Significance Index: 72.3500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 11.7024
Cell Significance Index: 335.4600
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 6.0327
Cell Significance Index: 37.3400
Cell Name: monocyte-derived dendritic cell (CL0011031)
Fold Change: 4.8109
Cell Significance Index: 82.6500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 3.7214
Cell Significance Index: 174.9000
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.2842
Cell Significance Index: 60.7000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 2.8270
Cell Significance Index: 329.4600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.3000
Cell Significance Index: 119.4800
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.1498
Cell Significance Index: 58.5200
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.8521
Cell Significance Index: 1011.4500
Cell Name: lactocyte (CL0002325)
Fold Change: 1.3524
Cell Significance Index: 174.7300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.2152
Cell Significance Index: 90.5700
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.3657
Cell Significance Index: 4.9900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3110
Cell Significance Index: 38.2500
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.2614
Cell Significance Index: 4.6200
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1429
Cell Significance Index: 129.0200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0771
Cell Significance Index: 58.3900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0686
Cell Significance Index: 3.2000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0415
Cell Significance Index: 7.4800
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0304
Cell Significance Index: 5.7800
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0204
Cell Significance Index: 2.6200
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0084
Cell Significance Index: 0.1300
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.0049
Cell Significance Index: 0.0300
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0011
Cell Significance Index: 0.0500
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0010
Cell Significance Index: -0.0400
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0082
Cell Significance Index: -0.2900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0120
Cell Significance Index: -2.0500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0231
Cell Significance Index: -0.8100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0231
Cell Significance Index: -43.5100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0232
Cell Significance Index: -3.1800
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0338
Cell Significance Index: -62.3900
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0407
Cell Significance Index: -62.6500
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0463
Cell Significance Index: -0.2800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0568
Cell Significance Index: -36.1000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0667
Cell Significance Index: -49.4100
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0782
Cell Significance Index: -7.9900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0826
Cell Significance Index: -36.5400
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0894
Cell Significance Index: -50.4200
Cell Name: perivascular cell (CL4033054)
Fold Change: -0.1018
Cell Significance Index: -0.4700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1047
Cell Significance Index: -47.5300
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1059
Cell Significance Index: -12.1300
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1075
Cell Significance Index: -67.1500
Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.1114
Cell Significance Index: -11.0200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.1413
Cell Significance Index: -22.9800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1416
Cell Significance Index: -3.7800
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1429
Cell Significance Index: -41.1200
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.2172
Cell Significance Index: -2.0000
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.2182
Cell Significance Index: -43.3100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.2444
Cell Significance Index: -49.0300
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2475
Cell Significance Index: -35.9700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3055
Cell Significance Index: -64.3500
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.3182
Cell Significance Index: -34.6100
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.3384
Cell Significance Index: -39.9100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.3390
Cell Significance Index: -15.3700
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.3600
Cell Significance Index: -4.0900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4346
Cell Significance Index: -45.2500
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.4680
Cell Significance Index: -13.0800
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.5007
Cell Significance Index: -32.3100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5277
Cell Significance Index: -32.3500
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.5611
Cell Significance Index: -15.0100
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.5737
Cell Significance Index: -14.3400
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.5901
Cell Significance Index: -40.8100
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.6997
Cell Significance Index: -47.0500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.7019
Cell Significance Index: -53.8600
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.7096
Cell Significance Index: -26.0500
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.7461
Cell Significance Index: -52.7700
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.7630
Cell Significance Index: -46.9000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.7709
Cell Significance Index: -22.2100
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: -0.8308
Cell Significance Index: -6.6100
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.8726
Cell Significance Index: -14.3800
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.8936
Cell Significance Index: -26.3200
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.9835
Cell Significance Index: -8.0200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.0289
Cell Significance Index: -54.0200
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.0786
Cell Significance Index: -34.5500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.0909
Cell Significance Index: -37.9100
Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
Fold Change: -1.2007
Cell Significance Index: -13.1600
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -1.2255
Cell Significance Index: -23.9600
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -1.2476
Cell Significance Index: -36.6400
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -1.4129
Cell Significance Index: -29.3100
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -1.4200
Cell Significance Index: -35.4100
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -1.4744
Cell Significance Index: -35.7200
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.4790
Cell Significance Index: -56.0100
Cell Name: hepatoblast (CL0005026)
Fold Change: -1.5042
Cell Significance Index: -25.3000
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.5165
Cell Significance Index: -49.6500
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: -1.5226
Cell Significance Index: -13.1700
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.5426
Cell Significance Index: -49.1300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.5495
Cell Significance Index: -33.5700
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: -1.5501
Cell Significance Index: -4.6100
Cell Name: classical monocyte (CL0000860)
Fold Change: -1.5627
Cell Significance Index: -14.5500
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -1.5641
Cell Significance Index: -13.4400
Cell Name: granulosa cell (CL0000501)
Fold Change: -1.6205
Cell Significance Index: -42.6100
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -1.6477
Cell Significance Index: -47.0200
Cell Name: myeloid cell (CL0000763)
Fold Change: -1.6537
Cell Significance Index: -21.9800
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: -1.6685
Cell Significance Index: -18.4300
Cell Name: pro-T cell (CL0000827)
Fold Change: -1.6781
Cell Significance Index: -42.8700
Cell Name: urothelial cell (CL0000731)
Fold Change: -1.7495
Cell Significance Index: -12.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** CXCL8 is a C-X-C motif chemokine that belongs to the IL-8 family of chemokines. It is a small, secreted protein that binds to specific receptors on the surface of target cells, triggering a signaling cascade that regulates various cellular responses. Key characteristics of CXCL8 include: * High expression in immune cells, such as neutrophils and monocytes * Strong chemoattractant activity for neutrophils * Ability to regulate angiogenesis, cellular responses to stress, and positive chemotaxis * Involvement in the regulation of pro-inflammatory cytokines and chemokines * Ability to bind to G-protein coupled receptors, triggering signaling pathways **Pathways and Functions** CXCL8 is involved in various signaling pathways that regulate immune responses, inflammation, and tissue repair. Key pathways and functions of CXCL8 include: * Angiogenesis: CXCL8 promotes the formation of new blood vessels by regulating the expression of pro-angiogenic factors. * Cellular responses to stress: CXCL8 regulates the expression of genes involved in cellular stress responses, including the unfolded protein response (UPR) and the endoplasmic reticulum stress response. * Chemotaxis: CXCL8 is a potent chemoattractant for neutrophils, which are essential for the clearance of pathogens and dead cells from infected tissues. * Inflammation: CXCL8 regulates the production of pro-inflammatory cytokines and chemokines, promoting the recruitment of immune cells to sites of inflammation. * Tissue repair: CXCL8 is involved in the regulation of the expression of genes involved in tissue repair, including the regulation of angiogenesis and the induction of positive chemotaxis. **Clinical Significance** CXCL8 has significant clinical implications in various diseases, including: * Inflammatory disorders: CXCL8 is involved in the regulation of inflammation, and its dysregulation has been implicated in various inflammatory disorders, including rheumatoid arthritis, asthma, and chronic obstructive pulmonary disease (COPD). * Cancer: CXCL8 is involved in the regulation of angiogenesis and the induction of positive chemotaxis, making it a potential target for cancer therapy. * Infectious diseases: CXCL8 is a potent chemoattractant for neutrophils, which are essential for the clearance of pathogens from infected tissues. * Neurological disorders: CXCL8 has been implicated in the regulation of inflammation and tissue repair in various neurological disorders, including multiple sclerosis and Alzheimer's disease. Overall, CXCL8 is a critical regulator of immune responses, inflammation, and tissue repair, and its dysregulation has significant clinical implications in various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Interleukin-8

Genular Protein ID: 1982771349

Symbol: IL8_HUMAN

Name: Interleukin-8

UniProtKB Accession Codes:

P10145 B2R4L8 Q6FGF6 Q6LAE6 Q96RG6 Q9C077 Q9UCE1 Q9UCR8 Q9UCR9 Q9UCS0

Database IDs:

Citations:

PubMed ID: 2953813

Title: Induction of mRNA for a serine protease and a beta-thromboglobulin-like protein in mitogen-stimulated human leukocytes.

PubMed ID: 2953813

PubMed ID: 3260265

Title: Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor.

PubMed ID: 3260265

DOI: 10.1084/jem.167.6.1883

PubMed ID: 2663993

Title: Genomic structure of the human monocyte-derived neutrophil chemotactic factor IL-8.

PubMed ID: 2663993

PubMed ID: 2664463

Title: Regulation of the mRNA for monocyte-derived neutrophil-activating peptide in differentiating HL60 promyelocytes.

PubMed ID: 2664463

DOI: 10.1128/mcb.9.5.1946-1957.1989

PubMed ID: 2200751

Title: Coding region structure of interleukin-8 gene of human lung giant cell carcinoma LU65C cells that produce LUCT/interleukin-8: homogeneity in interleukin-8 genes.

PubMed ID: 2200751

DOI: 10.1016/0165-2478(90)90043-p

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2523801

Title: Purification of granulocyte chemotactic peptide/interleukin-8 reveals N-terminal sequence heterogeneity similar to that of beta-thromboglobulin.

PubMed ID: 2523801

DOI: 10.1111/j.1432-1033.1989.tb14729.x

PubMed ID: 2145175

Title: The neutrophil-activating proteins interleukin 8 and beta-thromboglobulin: in vitro and in vivo comparison of NH2-terminally processed forms.

PubMed ID: 2145175

DOI: 10.1002/eji.1830200933

PubMed ID: 2648135

Title: Three forms of monocyte-derived neutrophil chemotactic factor (MDNCF) distinguished by different lengths of the amino-terminal sequence.

PubMed ID: 2648135

DOI: 10.1016/0161-5890(89)90024-2

PubMed ID: 2659722

Title: Purification and partial primary sequence of a chemotactic protein for polymorphonuclear leukocytes derived from human lung giant cell carcinoma LU65C cells.

PubMed ID: 2659722

DOI: 10.1084/jem.169.6.1895

PubMed ID: 1755384

Title: Biochemical and biological characterization of NAP-1/IL-8-related cytokines in lesional psoriatic scale.

PubMed ID: 1755384

DOI: 10.1007/978-1-4684-6009-4_12

PubMed ID: 2655583

Title: Inflammatory cytokines induce synthesis and secretion of gro protein and a neutrophil chemotactic factor but not beta 2-microglobulin in human synovial cells and fibroblasts.

PubMed ID: 2655583

DOI: 10.1042/bj2590585

PubMed ID: 8344717

Title: Isolation and amino acid sequence of a chemotactic protein, LECT/interleukin 8, from a human myeloid leukemia cell line, ML-1.

PubMed ID: 8344717

DOI: 10.1016/0165-2478(93)90071-9

PubMed ID: 3279957

Title: Structure determination of a human lymphocyte derived neutrophil activating peptide (LYNAP).

PubMed ID: 3279957

DOI: 10.1016/s0006-291x(88)80364-4

PubMed ID: 3480540

Title: Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines.

PubMed ID: 3480540

DOI: 10.1073/pnas.84.24.9233

PubMed ID: 3322281

Title: Purification and amino acid sequencing of NAF, a novel neutrophil-activating factor produced by monocytes.

PubMed ID: 3322281

DOI: 10.1016/0006-291x(87)90432-3

PubMed ID: 2212672

Title: Endothelial and leukocyte forms of IL-8. Conversion by thrombin and interactions with neutrophils.

PubMed ID: 2212672

PubMed ID: 2007144

Title: Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide.

PubMed ID: 2007144

DOI: 10.1021/bi00226a021

PubMed ID: 1840701

Title: Structure and functional expression of a human interleukin-8 receptor.

PubMed ID: 1840701

DOI: 10.1126/science.1840701

PubMed ID: 1891716

Title: Cloning of complementary DNA encoding a functional human interleukin-8 receptor.

PubMed ID: 1891716

DOI: 10.1126/science.1891716

PubMed ID: 7636208

Title: IL-8 induces neutrophil chemotaxis predominantly via type I IL-8 receptors.

PubMed ID: 7636208

PubMed ID: 8662698

Title: Physical association of Gi2alpha with interleukin-8 receptors.

PubMed ID: 8662698

DOI: 10.1074/jbc.271.22.12783

PubMed ID: 9623510

Title: IL-8 and the activation of eosinophils and neutrophils following nasal allergen challenge.

PubMed ID: 9623510

DOI: 10.1159/000023925

PubMed ID: 11023497

Title: Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-alpha and leaves RANTES and MCP-2 intact.

PubMed ID: 11023497

PubMed ID: 11978786

Title: Identification of biologically active chemokine isoforms from ascitic fluid and elevated levels of CCL18/pulmonary and activation-regulated chemokine in ovarian carcinoma.

PubMed ID: 11978786

DOI: 10.1074/jbc.m112275200

PubMed ID: 11971003

Title: Signaling pathways involved in IL-8-dependent activation of adhesion through Mac-1.

PubMed ID: 11971003

DOI: 10.4049/jimmunol.168.9.4559

PubMed ID: 1639201

Title: Interleukin-8, a chemotactic and inflammatory cytokine.

PubMed ID: 1639201

DOI: 10.1016/0014-5793(92)80909-z

PubMed ID: 14711052

Title: Regulation of the immune response by the interaction of chemokines and proteases.

PubMed ID: 14711052

DOI: 10.1016/s0065-2776(03)81001-5

PubMed ID: 18710930

Title: Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation.

PubMed ID: 18710930

DOI: 10.1084/jem.20080305

PubMed ID: 18692776

Title: The IL-8 protease SpyCEP/ScpC of group A Streptococcus promotes resistance to neutrophil killing.

PubMed ID: 18692776

DOI: 10.1016/j.chom.2008.07.002

PubMed ID: 19608678

Title: Citrullination of CXCL8 increases this chemokine's ability to mobilize neutrophils into the blood circulation.

PubMed ID: 19608678

DOI: 10.3324/haematol.2009.006973

PubMed ID: 20829347

Title: Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma.

PubMed ID: 20829347

DOI: 10.1074/jbc.m110.136259

PubMed ID: 24501198

Title: TSG-6 inhibits neutrophil migration via direct interaction with the chemokine CXCL8.

PubMed ID: 24501198

DOI: 10.4049/jimmunol.1300194

PubMed ID: 31235521

Title: Tick saliva protein Evasin-3 modulates chemotaxis by disrupting CXCL8 interactions with glycosaminoglycans and CXCR2.

PubMed ID: 31235521

DOI: 10.1074/jbc.ra119.008902

PubMed ID: 2681204

Title: Determination of the secondary structure of interleukin-8 by nuclear magnetic resonance spectroscopy.

PubMed ID: 2681204

DOI: 10.1016/s0021-9258(19)47243-8

PubMed ID: 2184886

Title: Three-dimensional structure of interleukin 8 in solution.

PubMed ID: 2184886

DOI: 10.1021/bi00459a004

PubMed ID: 8631339

Title: Structure and activity of a chimeric interleukin-8-melanoma-growth-stimulatory-activity protein.

PubMed ID: 8631339

DOI: 10.1111/j.1432-1033.1996.00026.x

PubMed ID: 10368283

Title: Structure of a CXC chemokine-receptor fragment in complex with interleukin-8.

PubMed ID: 10368283

DOI: 10.1016/s0969-2126(99)80022-7

PubMed ID: 2182630

Title: Crystallization of human interleukin-8. A protein chemotactic for neutrophils and T-lymphocytes.

PubMed ID: 2182630

DOI: 10.1016/s0021-9258(19)39226-9

PubMed ID: 2005614

Title: Comparison of the solution nuclear magnetic resonance and crystal structures of interleukin-8. Possible implications for the mechanism of receptor binding.

PubMed ID: 2005614

DOI: 10.1016/0022-2836(91)90518-b

PubMed ID: 1988949

Title: Crystal structure of interleukin 8: symbiosis of NMR and crystallography.

PubMed ID: 1988949

DOI: 10.1073/pnas.88.2.502

PubMed ID: 10707023

Title: Receptor-binding conformation of the 'ELR' motif of IL-8: X-ray structure of the L5C/H33C variant at 2.35 A resolution.

PubMed ID: 10707023

DOI: 10.1002/(sici)1097-0134(20000301)38:4<361::aid-prot2>3.3.co;2-s

Sequence Information:

Length: 99
Mass: 11098
Checksum: 15C649996E89319F
Sequence:

MTSKLAVALL AAFLISAALC EGAVLPRSAK ELRCQCIKTY SKPFHPKFIK ELRVIESGPH 
CANTEIIVKL SDGRELCLDP KENWVQRVVE KFLKRAENS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CXCL8

Associated with

Cells (max top 100)

Other Information

Induction of mRNA for a serine protease and a beta-thromboglobulin-like protein in mitogen-stimulated human leukocytes. PubMed ID: 2953813

Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor. PubMed ID: 3260265

Genomic structure of the human monocyte-derived neutrophil chemotactic factor IL-8. PubMed ID: 2663993

Regulation of the mRNA for monocyte-derived neutrophil-activating peptide in differentiating HL60 promyelocytes. PubMed ID: 2664463

Coding region structure of interleukin-8 gene of human lung giant cell carcinoma LU65C cells that produce LUCT/interleukin-8: homogeneity in interleukin-8 genes. PubMed ID: 2200751

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Purification of granulocyte chemotactic peptide/interleukin-8 reveals N-terminal sequence heterogeneity similar to that of beta-thromboglobulin. PubMed ID: 2523801

The neutrophil-activating proteins interleukin 8 and beta-thromboglobulin: in vitro and in vivo comparison of NH2-terminally processed forms. PubMed ID: 2145175

Three forms of monocyte-derived neutrophil chemotactic factor (MDNCF) distinguished by different lengths of the amino-terminal sequence. PubMed ID: 2648135

Purification and partial primary sequence of a chemotactic protein for polymorphonuclear leukocytes derived from human lung giant cell carcinoma LU65C cells. PubMed ID: 2659722

Biochemical and biological characterization of NAP-1/IL-8-related cytokines in lesional psoriatic scale. PubMed ID: 1755384

Inflammatory cytokines induce synthesis and secretion of gro protein and a neutrophil chemotactic factor but not beta 2-microglobulin in human synovial cells and fibroblasts. PubMed ID: 2655583

Isolation and amino acid sequence of a chemotactic protein, LECT/interleukin 8, from a human myeloid leukemia cell line, ML-1. PubMed ID: 8344717

Structure determination of a human lymphocyte derived neutrophil activating peptide (LYNAP). PubMed ID: 3279957

Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines. PubMed ID: 3480540

Purification and amino acid sequencing of NAF, a novel neutrophil-activating factor produced by monocytes. PubMed ID: 3322281

Endothelial and leukocyte forms of IL-8. Conversion by thrombin and interactions with neutrophils. PubMed ID: 2212672

Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide. PubMed ID: 2007144

Structure and functional expression of a human interleukin-8 receptor. PubMed ID: 1840701

Cloning of complementary DNA encoding a functional human interleukin-8 receptor. PubMed ID: 1891716

IL-8 induces neutrophil chemotaxis predominantly via type I IL-8 receptors. PubMed ID: 7636208

Physical association of Gi2alpha with interleukin-8 receptors. PubMed ID: 8662698

IL-8 and the activation of eosinophils and neutrophils following nasal allergen challenge. PubMed ID: 9623510

Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-alpha and leaves RANTES and MCP-2 intact. PubMed ID: 11023497

Identification of biologically active chemokine isoforms from ascitic fluid and elevated levels of CCL18/pulmonary and activation-regulated chemokine in ovarian carcinoma. PubMed ID: 11978786

Signaling pathways involved in IL-8-dependent activation of adhesion through Mac-1. PubMed ID: 11971003

Interleukin-8, a chemotactic and inflammatory cytokine. PubMed ID: 1639201

Regulation of the immune response by the interaction of chemokines and proteases. PubMed ID: 14711052

Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation. PubMed ID: 18710930

The IL-8 protease SpyCEP/ScpC of group A Streptococcus promotes resistance to neutrophil killing. PubMed ID: 18692776

Citrullination of CXCL8 increases this chemokine's ability to mobilize neutrophils into the blood circulation. PubMed ID: 19608678

Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma. PubMed ID: 20829347

TSG-6 inhibits neutrophil migration via direct interaction with the chemokine CXCL8. PubMed ID: 24501198

Tick saliva protein Evasin-3 modulates chemotaxis by disrupting CXCL8 interactions with glycosaminoglycans and CXCR2. PubMed ID: 31235521

Determination of the secondary structure of interleukin-8 by nuclear magnetic resonance spectroscopy. PubMed ID: 2681204

Three-dimensional structure of interleukin 8 in solution. PubMed ID: 2184886

Structure and activity of a chimeric interleukin-8-melanoma-growth-stimulatory-activity protein. PubMed ID: 8631339

Structure of a CXC chemokine-receptor fragment in complex with interleukin-8. PubMed ID: 10368283

Crystallization of human interleukin-8. A protein chemotactic for neutrophils and T-lymphocytes. PubMed ID: 2182630

Comparison of the solution nuclear magnetic resonance and crystal structures of interleukin-8. Possible implications for the mechanism of receptor binding. PubMed ID: 2005614

Crystal structure of interleukin 8: symbiosis of NMR and crystallography. PubMed ID: 1988949

Receptor-binding conformation of the 'ELR' motif of IL-8: X-ray structure of the L5C/H33C variant at 2.35 A resolution. PubMed ID: 10707023