RNR2 | ENSG00000210082 | NCBI 4550

Details for: RNR2

Gene ID: 4550

Symbol: RNR2

Ensembl ID: ENSG00000210082

Description: l-rRNA

Associated with

Fastk family proteins regulate processing and stability of mitochondrial rnas
(R-HSA-9837092)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitochondrial rna degradation
(R-HSA-9836573)
Mitochondrial translation
(R-HSA-5368287)
Mitochondrial translation elongation
(R-HSA-5389840)
Mitochondrial translation initiation
(R-HSA-5368286)
Mitochondrial translation termination
(R-HSA-5419276)
Rrna modification in the mitochondrion
(R-HSA-6793080)
Rrna processing
(R-HSA-72312)
Rrna processing in the mitochondrion
(R-HSA-8868766)
Translation
(R-HSA-72766)
Trna processing
(R-HSA-72306)
Trna processing in the mitochondrion
(R-HSA-6785470)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 137.2599
Cell Significance Index: -367.7000
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 64.1296
Cell Significance Index: 825.8600
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 58.0296
Cell Significance Index: 1709.2200
Cell Name: keratinocyte (CL0000312)
Fold Change: 54.5293
Cell Significance Index: 1361.9400
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 46.7504
Cell Significance Index: 13451.4800
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 25.4882
Cell Significance Index: 498.3400
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 14.6994
Cell Significance Index: 253.4000
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 13.4356
Cell Significance Index: 626.4300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 8.8881
Cell Significance Index: 402.8700
Cell Name: retinal rod cell (CL0000604)
Fold Change: 8.7688
Cell Significance Index: 104.5300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 5.7214
Cell Significance Index: 976.9600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 5.1967
Cell Significance Index: 141.4500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 3.3899
Cell Significance Index: 680.0100
Cell Name: naive T cell (CL0000898)
Fold Change: 3.3322
Cell Significance Index: 30.2700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 2.8555
Cell Significance Index: 327.1400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.7287
Cell Significance Index: 141.7500
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.7080
Cell Significance Index: 14.0000
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.2106
Cell Significance Index: 4.4700
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.1154
Cell Significance Index: -217.2800
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.2582
Cell Significance Index: -476.2200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.3187
Cell Significance Index: -490.6800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.3376
Cell Significance Index: -153.2400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.3773
Cell Significance Index: -512.9800
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.3868
Cell Significance Index: -7.7600
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.3970
Cell Significance Index: -252.1400
Cell Name: neuron (CL0000540)
Fold Change: -0.5380
Cell Significance Index: -5.1000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.7456
Cell Significance Index: -552.3100
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.8821
Cell Significance Index: -550.8600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.9568
Cell Significance Index: -539.6200
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -1.5529
Cell Significance Index: -33.5500
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.9536
Cell Significance Index: -62.2200
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -2.0333
Cell Significance Index: -66.5700
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -2.0935
Cell Significance Index: -73.3400
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -2.3500
Cell Significance Index: -58.6200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -2.6379
Cell Significance Index: -166.2600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -2.7186
Cell Significance Index: -572.6000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -2.8139
Cell Significance Index: -409.0400
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -3.2323
Cell Significance Index: -65.7700
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -3.2500
Cell Significance Index: -67.8300
Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -3.5725
Cell Significance Index: -71.2400
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -4.0377
Cell Significance Index: -79.4700
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -4.4123
Cell Significance Index: -459.4300
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -4.6720
Cell Significance Index: -80.7800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -5.4033
Cell Significance Index: -155.6800
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -5.9441
Cell Significance Index: -81.1000
Cell Name: eosinophil (CL0000771)
Fold Change: -6.1465
Cell Significance Index: -54.4500
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -6.4374
Cell Significance Index: -165.4700
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -6.4397
Cell Significance Index: -92.6200
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -7.7359
Cell Significance Index: -247.7700
Cell Name: duct epithelial cell (CL0000068)
Fold Change: -8.1337
Cell Significance Index: -112.4700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -8.4963
Cell Significance Index: -520.9000
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: -9.2264
Cell Significance Index: -89.2600
Cell Name: fibroblast of lung (CL0002553)
Fold Change: -10.6433
Cell Significance Index: -126.5100
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -11.5807
Cell Significance Index: -198.4600
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -13.0560
Cell Significance Index: -458.7700
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -15.4907
Cell Significance Index: -222.4500
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -15.6420
Cell Significance Index: -338.8800
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -16.1960
Cell Significance Index: -239.1100
Cell Name: lens fiber cell (CL0011004)
Fold Change: -16.8514
Cell Significance Index: -532.9800
Cell Name: alveolar macrophage (CL0000583)
Fold Change: -17.7688
Cell Significance Index: -156.5600
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -18.4910
Cell Significance Index: -277.0700
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -18.9187
Cell Significance Index: -269.3100
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: -20.2447
Cell Significance Index: -211.3500
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: -20.4041
Cell Significance Index: -305.2600
Cell Name: erythrocyte (CL0000232)
Fold Change: -20.8993
Cell Significance Index: -532.4700
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -21.5382
Cell Significance Index: -537.1000
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -21.9754
Cell Significance Index: -167.9900
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -22.5631
Cell Significance Index: -468.0500
Cell Name: Purkinje cell (CL0000121)
Fold Change: -22.6279
Cell Significance Index: -495.4700
Cell Name: hepatocyte (CL0000182)
Fold Change: -23.5644
Cell Significance Index: -326.8200
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: -23.8976
Cell Significance Index: -328.1800
Cell Name: basal cell (CL0000646)
Fold Change: -23.9911
Cell Significance Index: -285.4900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -24.1469
Cell Significance Index: -514.2600
Cell Name: keratocyte (CL0002363)
Fold Change: -27.2672
Cell Significance Index: -432.5900
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: -28.7196
Cell Significance Index: -258.8200
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: -29.3156
Cell Significance Index: -297.4600
Cell Name: fibroblast of breast (CL4006000)
Fold Change: -30.3024
Cell Significance Index: -190.5600
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -30.7703
Cell Significance Index: -318.4300
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -30.7774
Cell Significance Index: -468.2300
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -31.2646
Cell Significance Index: -340.6200
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -31.5581
Cell Significance Index: -539.4500
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: -31.6361
Cell Significance Index: -408.7300
Cell Name: stromal cell (CL0000499)
Fold Change: -32.1935
Cell Significance Index: -328.9300
Cell Name: enterocyte (CL0000584)
Fold Change: -32.5228
Cell Significance Index: -201.7700
Cell Name: adipocyte (CL0000136)
Fold Change: -32.9275
Cell Significance Index: -438.9300
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: -33.1154
Cell Significance Index: -432.1900
Cell Name: kidney inner medulla collecting duct epithelial cell (CL1000547)
Fold Change: -33.1896
Cell Significance Index: -559.9800
Cell Name: megakaryocyte (CL0000556)
Fold Change: -34.6340
Cell Significance Index: -560.9400
Cell Name: slow muscle cell (CL0000189)
Fold Change: -35.5340
Cell Significance Index: -531.5500
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -35.6251
Cell Significance Index: -465.9000
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: -35.9958
Cell Significance Index: -379.9000
Cell Name: GABAergic neuron (CL0000617)
Fold Change: -36.4254
Cell Significance Index: -459.6500
Cell Name: endothelial cell (CL0000115)
Fold Change: -36.8046
Cell Significance Index: -452.3900
Cell Name: microglial cell (CL0000129)
Fold Change: -37.2454
Cell Significance Index: -437.9200
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: -37.3234
Cell Significance Index: -340.1600
Cell Name: tendon cell (CL0000388)
Fold Change: -37.6465
Cell Significance Index: -511.9200
Cell Name: amacrine cell (CL0000561)
Fold Change: -37.6886
Cell Significance Index: -472.0100
Cell Name: natural killer cell (CL0000623)
Fold Change: -37.8518
Cell Significance Index: -419.2300
Cell Name: astrocyte (CL0000127)
Fold Change: -37.9331
Cell Significance Index: -434.1500
Cell Name: granulocyte (CL0000094)
Fold Change: -38.0926
Cell Significance Index: -459.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** RNR2 is a mitochondrial rRNA gene that is predominantly expressed in cells with high energy requirements, such as immune cells and stem cells. The gene is involved in the regulation of mitochondrial translation, which is essential for the production of mitochondrial proteins. RNR2 is also implicated in the processing and stability of mitochondrial RNAs, which are critical for maintaining mitochondrial function and integrity. One of the key characteristics of RNR2 is its high expression in immune cells, particularly in CD4+ and CD8+ T cells, which are essential for cell-mediated immunity. The gene's expression is also notable in mesenchymal stem cells, which have immunomodulatory properties. Additionally, RNR2 is expressed in kidney epithelial cells, which are involved in maintaining kidney function and homeostasis. **Pathways and Functions** The RNR2 gene is involved in several key pathways, including: 1. **Mitochondrial Translation**: RNR2 is essential for the translation process within mitochondria, which is critical for the production of mitochondrial proteins. 2. **Mitochondrial RNA Degradation**: RNR2 regulates the processing and stability of mitochondrial RNAs, which are essential for maintaining mitochondrial function and integrity. 3. **RNA Modification**: RNR2 is involved in the modification of mitochondrial RNAs, which is critical for regulating gene expression and maintaining cellular homeostasis. 4. **Cellular Metabolism**: RNR2 is involved in regulating cellular metabolism, particularly in cells with high energy requirements. The functions of RNR2 are multifaceted and essential for maintaining cellular homeostasis and function. The gene's involvement in mitochondrial translation, RNA degradation, and modification highlights its critical role in regulating gene expression and maintaining cellular integrity. **Clinical Significance** The RNR2 gene has significant clinical implications, particularly in the context of immune-mediated disorders. Variations in the RNR2 gene have been associated with autoimmune diseases, such as multiple sclerosis and type 1 diabetes. Additionally, RNR2 has been implicated in the pathogenesis of cancer, particularly in hematological malignancies. Furthermore, RNR2 has been identified as a potential therapeutic target for treating immune-mediated disorders. The gene's involvement in mitochondrial function and translation highlights its potential role in regulating cellular metabolism and energy production. In conclusion, the RNR2 gene is a critical component of mitochondrial function and regulation, with significant implications for immune-mediated disorders and cancer. Further research is needed to fully elucidate the functions and clinical significance of RNR2, but its importance as a regulatory gene in mitochondrial translation and RNA processing is clear.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.