Details for: KLK10

Gene ID: 5655

Symbol: KLK10

Ensembl ID: ENSG00000129451

Description: kallikrein related peptidase 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.5965
    Cell Significance Index: 114.9000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 2.1023
    Cell Significance Index: 18.0700
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.7285
    Cell Significance Index: 17.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.6995
    Cell Significance Index: 928.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6042
    Cell Significance Index: 72.7200
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.3529
    Cell Significance Index: 6.5800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.2427
    Cell Significance Index: 28.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1097
    Cell Significance Index: 211.1900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9807
    Cell Significance Index: 13.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8285
    Cell Significance Index: 23.1600
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.8013
    Cell Significance Index: 9.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7962
    Cell Significance Index: 78.7700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.7866
    Cell Significance Index: 12.1700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7240
    Cell Significance Index: 653.7400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.5571
    Cell Significance Index: 8.4000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4985
    Cell Significance Index: 15.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4944
    Cell Significance Index: 57.6200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.4746
    Cell Significance Index: 1.0700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.4727
    Cell Significance Index: 11.4500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3599
    Cell Significance Index: 58.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3578
    Cell Significance Index: 46.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3417
    Cell Significance Index: 9.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3221
    Cell Significance Index: 6.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3184
    Cell Significance Index: 34.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2993
    Cell Significance Index: 132.3300
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.2104
    Cell Significance Index: 1.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1978
    Cell Significance Index: 13.6800
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.1500
    Cell Significance Index: 1.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1427
    Cell Significance Index: 6.7100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0957
    Cell Significance Index: 2.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0523
    Cell Significance Index: 3.1400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0418
    Cell Significance Index: 0.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0247
    Cell Significance Index: 1.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0213
    Cell Significance Index: 7.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0206
    Cell Significance Index: 3.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0050
    Cell Significance Index: 0.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0002
    Cell Significance Index: -0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0029
    Cell Significance Index: -5.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0034
    Cell Significance Index: -0.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0040
    Cell Significance Index: -7.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0050
    Cell Significance Index: -7.6900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0052
    Cell Significance Index: -0.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0059
    Cell Significance Index: -7.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0069
    Cell Significance Index: -0.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0072
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0089
    Cell Significance Index: -6.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0108
    Cell Significance Index: -6.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0116
    Cell Significance Index: -7.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0129
    Cell Significance Index: -3.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0133
    Cell Significance Index: -0.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0167
    Cell Significance Index: -2.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0175
    Cell Significance Index: -7.9500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0182
    Cell Significance Index: -0.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0188
    Cell Significance Index: -3.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0240
    Cell Significance Index: -1.4700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0250
    Cell Significance Index: -1.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0312
    Cell Significance Index: -6.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0313
    Cell Significance Index: -6.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0326
    Cell Significance Index: -4.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0390
    Cell Significance Index: -6.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0497
    Cell Significance Index: -7.2200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0507
    Cell Significance Index: -1.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0559
    Cell Significance Index: -6.4000
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0640
    Cell Significance Index: -0.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0776
    Cell Significance Index: -7.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0800
    Cell Significance Index: -5.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0863
    Cell Significance Index: -5.8100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0921
    Cell Significance Index: -1.0100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0964
    Cell Significance Index: -3.5400
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.1067
    Cell Significance Index: -0.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1135
    Cell Significance Index: -8.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1138
    Cell Significance Index: -8.0500
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1188
    Cell Significance Index: -1.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1192
    Cell Significance Index: -6.1900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1237
    Cell Significance Index: -3.0900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1272
    Cell Significance Index: -1.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1320
    Cell Significance Index: -3.4700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1331
    Cell Significance Index: -8.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1368
    Cell Significance Index: -7.6800
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.1709
    Cell Significance Index: -1.3400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1750
    Cell Significance Index: -5.7300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1752
    Cell Significance Index: -1.9900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1801
    Cell Significance Index: -3.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1875
    Cell Significance Index: -6.5700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1921
    Cell Significance Index: -1.2800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2072
    Cell Significance Index: -6.6000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2133
    Cell Significance Index: -5.3200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2143
    Cell Significance Index: -2.7600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2180
    Cell Significance Index: -2.3000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2189
    Cell Significance Index: -1.4800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2236
    Cell Significance Index: -6.3800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2250
    Cell Significance Index: -7.8200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2254
    Cell Significance Index: -6.0400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2306
    Cell Significance Index: -2.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2337
    Cell Significance Index: -6.2500
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.2353
    Cell Significance Index: -2.5000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2358
    Cell Significance Index: -2.9400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2367
    Cell Significance Index: -10.4700
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.2377
    Cell Significance Index: -2.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2442
    Cell Significance Index: -6.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KLK10 is a small, secreted protein that belongs to the kallikrein-related peptidase family. It is characterized by its ability to cleave specific peptide substrates, including growth factors, cytokines, and other proteins. KLK10 is highly expressed in various cell types, including progenitor cells, enterocytes, epithelial cells, and immune cells. Its expression is also observed in different tissues, such as the esophagus, large intestine, and colon. **Pathways and Functions:** KLK10 has been shown to participate in several key pathways, including: 1. **Cell cycle regulation:** KLK10 has been implicated in the regulation of cell proliferation and differentiation, particularly in the context of cancer. 2. **Proteolysis:** KLK10's serine-type peptidase activity enables it to cleave specific peptide substrates, leading to the activation of various signaling pathways. 3. **Immune response:** KLK10 has been shown to play a role in the regulation of immune responses, including the activation of immune cells and the modulation of cytokine production. 4. **Tissue remodeling:** KLK10 has been implicated in the regulation of tissue remodeling, particularly in the context of wound healing and fibrosis. **Clinical Significance:** KLK10 has been implicated in various diseases, including: 1. **Cancer:** Elevated levels of KLK10 have been observed in several types of cancer, including breast, lung, and colon cancer. 2. **Inflammatory bowel disease:** KLK10 has been shown to play a role in the regulation of immune responses in inflammatory bowel disease. 3. **Wound healing:** KLK10 has been implicated in the regulation of wound healing, particularly in the context of diabetic foot ulcers. 4. **Cardiovascular disease:** KLK10 has been shown to play a role in the regulation of cardiovascular disease, particularly in the context of atherosclerosis. In conclusion, KLK10 is a multifunctional protein that plays a significant role in various physiological and pathological processes. Its involvement in cell cycle regulation, proteolysis, immune response, and tissue remodeling makes it an attractive target for therapeutic interventions. Further research is needed to fully elucidate the mechanisms of KLK10 and its clinical significance in different diseases.

Genular Protein ID: 2787601440

Symbol: KLK10_HUMAN

Name: Kallikrein-10

UniProtKB Accession Codes:

O43240 A6NC12 Q53YL3 Q99920 Q9GZW9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 Ensembl 3 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 2 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 8 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8764136

Title: Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression.

PubMed ID: 8764136

PubMed ID: 9647736

Title: Structural characterization and mapping of the normal epithelial cell-specific 1 gene.

PubMed ID: 9647736

DOI: 10.1006/bbrc.1998.8793

PubMed ID: 11054574

Title: Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.

PubMed ID: 11054574

DOI: 10.1016/s0378-1119(00)00382-6

PubMed ID: 16103744

Title: Identification of new splice variants and differential expression of the human kallikrein 10 gene, a candidate cancer biomarker.

PubMed ID: 16103744

DOI: 10.1159/000087377

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9809976

Title: The role for NES1 serine protease as a novel tumor suppressor.

PubMed ID: 9809976

Sequence Information:

  • Length: 276
  • Mass: 30170
  • Checksum: 4CFB32E0AF686E96
  • Sequence:
    • MRAPHLHLSA ASGARALAKL LPLLMAQLWA AEAALLPQND TRLDPEAYGS PCARGSQPWQ 
VSLFNGLSFH CAGVLVDQSW VLTAAHCGNK PLWARVGDDH LLLLQGEQLR RTTRSVVHPK 
YHQGSGPILP RRTDEHDLML LKLARPVVLG PRVRALQLPY RCAQPGDQCQ VAGWGTTAAR 
RVKYNKGLTC SSITILSPKE CEVFYPGVVT NNMICAGLDR GQDPCQSDSG GPLVCDETLQ 
GILSWGVYPC GSAQHPAVYT QICKYMSWIN KVIRSN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.