Details for: FAT2

Gene ID: 2196

Symbol: FAT2

Ensembl ID: ENSG00000086570

Description: FAT atypical cadherin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 56.2537
    Cell Significance Index: -8.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 4.8843
    Cell Significance Index: 66.6400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 3.8818
    Cell Significance Index: 66.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.6776
    Cell Significance Index: 74.8300
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 2.6614
    Cell Significance Index: 6.0000
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.5556
    Cell Significance Index: 29.1000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.5430
    Cell Significance Index: 155.9100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.2279
    Cell Significance Index: 71.3600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.4055
    Cell Significance Index: 9.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9387
    Cell Significance Index: 42.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9001
    Cell Significance Index: 46.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8168
    Cell Significance Index: 155.4500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7910
    Cell Significance Index: 19.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7164
    Cell Significance Index: 129.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7031
    Cell Significance Index: 86.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.6800
    Cell Significance Index: 17.4800
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.4817
    Cell Significance Index: 5.4700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4336
    Cell Significance Index: 42.9000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.3913
    Cell Significance Index: 5.5700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3817
    Cell Significance Index: 344.6100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3471
    Cell Significance Index: 24.5500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3158
    Cell Significance Index: 6.7300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.2840
    Cell Significance Index: 2.4400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2720
    Cell Significance Index: 29.5800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2487
    Cell Significance Index: 14.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2414
    Cell Significance Index: 106.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2347
    Cell Significance Index: 38.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1870
    Cell Significance Index: 7.0800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1847
    Cell Significance Index: 2.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1817
    Cell Significance Index: 36.4400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.1780
    Cell Significance Index: 5.6300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1302
    Cell Significance Index: 2.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1169
    Cell Significance Index: 8.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0860
    Cell Significance Index: 3.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0823
    Cell Significance Index: 111.9500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0810
    Cell Significance Index: 2.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0729
    Cell Significance Index: 39.8000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.0700
    Cell Significance Index: 0.4400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0570
    Cell Significance Index: 1.3900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0450
    Cell Significance Index: 31.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0264
    Cell Significance Index: 1.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0203
    Cell Significance Index: 31.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0179
    Cell Significance Index: 32.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0142
    Cell Significance Index: 0.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0071
    Cell Significance Index: 2.5400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0032
    Cell Significance Index: 0.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0019
    Cell Significance Index: 3.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0075
    Cell Significance Index: -1.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0090
    Cell Significance Index: -0.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0098
    Cell Significance Index: -0.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0102
    Cell Significance Index: -6.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0119
    Cell Significance Index: -8.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0122
    Cell Significance Index: -9.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0153
    Cell Significance Index: -9.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0156
    Cell Significance Index: -7.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0166
    Cell Significance Index: -9.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0195
    Cell Significance Index: -1.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0210
    Cell Significance Index: -6.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0351
    Cell Significance Index: -0.7600
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0414
    Cell Significance Index: -0.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0420
    Cell Significance Index: -7.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0443
    Cell Significance Index: -6.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0448
    Cell Significance Index: -9.4400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0458
    Cell Significance Index: -0.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0530
    Cell Significance Index: -6.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0600
    Cell Significance Index: -6.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0647
    Cell Significance Index: -8.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0713
    Cell Significance Index: -8.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0773
    Cell Significance Index: -9.0100
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -0.0779
    Cell Significance Index: -0.6700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0826
    Cell Significance Index: -4.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0836
    Cell Significance Index: -8.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0868
    Cell Significance Index: -4.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1035
    Cell Significance Index: -6.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1152
    Cell Significance Index: -8.8400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1162
    Cell Significance Index: -3.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1193
    Cell Significance Index: -8.8900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1255
    Cell Significance Index: -4.1100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1536
    Cell Significance Index: -3.2600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1544
    Cell Significance Index: -5.4100
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.1548
    Cell Significance Index: -1.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1554
    Cell Significance Index: -8.7200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1564
    Cell Significance Index: -3.7500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1628
    Cell Significance Index: -4.0600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1670
    Cell Significance Index: -4.1700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1961
    Cell Significance Index: -7.2000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2043
    Cell Significance Index: -4.0400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2063
    Cell Significance Index: -1.9000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2099
    Cell Significance Index: -4.8500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2165
    Cell Significance Index: -4.7400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2215
    Cell Significance Index: -2.1000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2277
    Cell Significance Index: -2.7100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2533
    Cell Significance Index: -10.3800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2578
    Cell Significance Index: -8.9600
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.2666
    Cell Significance Index: -5.5600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2673
    Cell Significance Index: -4.0600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2749
    Cell Significance Index: -7.8500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2754
    Cell Significance Index: -5.5300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2777
    Cell Significance Index: -5.4200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2850
    Cell Significance Index: -7.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell-cell adhesion:** FAT2 is involved in homophilic cell adhesion, where Fat 2 molecules on adjacent cells interact to maintain tissue integrity and prevent cell migration. 2. **Expression in epithelial cells:** FAT2 is highly expressed in epithelial cells, including those found in the trachea, colon, and kidney, suggesting its importance in epithelial function and development. 3. **Homology to other cadherins:** FAT2 shares sequence homology with other cadherins, such as N-cadherin and E-cadherin, highlighting its conserved role in cell-cell adhesion. 4. **Alternative splicing:** FAT2 undergoes alternative splicing, resulting in multiple isoforms with distinct functions, which may be tissue-specific. **Pathways and Functions:** 1. **Adherens junction formation:** FAT2 contributes to the formation of adherens junctions, which are essential for maintaining tissue structure and preventing cell migration. 2. **Epithelial cell migration:** FAT2 regulates epithelial cell migration, which is critical for development, tissue repair, and cancer metastasis. 3. **Cell-substrate adhesion:** FAT2 also mediates cell-substrate adhesion, which is important for cell attachment and signaling. 4. **Golgi apparatus and extracellular exosome:** FAT2 is localized to the Golgi apparatus and extracellular exosome, suggesting its involvement in protein sorting and secretion. **Clinical Significance:** 1. **Cancer:** Alterations in FAT2 expression have been linked to various cancers, including colon and breast cancer, suggesting its potential as a biomarker or therapeutic target. 2. **Neurological disorders:** FAT2 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where disruptions in cell-cell adhesion and tissue structure may contribute to disease progression. 3. **Inflammatory disorders:** FAT2 may play a role in inflammatory disorders, such as asthma and rheumatoid arthritis, where epithelial dysfunction and cell-cell adhesion defects contribute to disease pathogenesis. 4. **Developmental disorders:** FAT2 is essential for embryonic development, and alterations in FAT2 expression have been linked to developmental disorders, such as congenital heart defects and neural tube defects. In conclusion, the FAT2 gene is a critical component of cell-cell adhesion and epithelial function, with significant implications for various diseases and disorders. Further research is needed to fully elucidate the role of FAT2 in human disease and to explore its potential as a therapeutic target or biomarker.

Genular Protein ID: 2290323064

Symbol: FAT2_HUMAN

Name: Protocadherin Fat 2

UniProtKB Accession Codes:

Q9NYQ8 O75091 Q9NSR7

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 6 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10716726

Title: Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.

PubMed ID: 10716726

DOI: 10.1073/pnas.97.7.3124

PubMed ID: 9693030

Title: Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.

PubMed ID: 9693030

DOI: 10.1006/geno.1998.5341

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16865240

Title: Comparative integromics on FAT1, FAT2, FAT3 and FAT4.

PubMed ID: 16865240

PubMed ID: 17900869

Title: Human Fat2 is localized at immature adherens junctions in epidermal keratinocytes.

PubMed ID: 17900869

DOI: 10.1016/j.jdermsci.2007.07.010

PubMed ID: 18534823

Title: Knockdown of Fat2 by siRNA inhibits the migration of human squamous carcinoma cells.

PubMed ID: 18534823

DOI: 10.1016/j.jdermsci.2008.04.006

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 29053796

Title: Exome sequencing and network analysis identifies shared mechanisms underlying spinocerebellar ataxia.

PubMed ID: 29053796

DOI: 10.1093/brain/awx251

Sequence Information:

  • Length: 4349
  • Mass: 479317
  • Checksum: FCEDBB52E252A996
  • Sequence:
    • MTIALLGFAI FLLHCATCEK PLEGILSSSA WHFTHSHYNA TIYENSSPKT YVESFEKMGI 
YLAEPQWAVR YRIISGDVAN VFKTEEYVVG NFCFLRIRTK SSNTALLNRE VRDSYTLIIQ 
ATEKTLELEA LTRVVVHILD QNDLKPLFSP PSYRVTISED MPLKSPICKV TATDADLGQN 
AEFYYAFNTR SEMFAIHPTS GVVTVAGKLN VTWRGKHELQ VLAVDRMRKI SEGNGFGSLA 
ALVVHVEPAL RKPPAIASVV VTPPDSNDGT TYATVLVDAN SSGAEVESVE VVGGDPGKHF 
KAIKSYARSN EFSLVSVKDI NWMEYLHGFN LSLQARSGSG PYFYSQIRGF HLPPSKLSSL 
KFEKAVYRVQ LSEFSPPGSR VVMVRVTPAF PNLQYVLKPS SENVGFKLNA RTGLITTTKL 
MDFHDRAHYQ LHIRTSPGQA STVVVIDIVD CNNHAPLFNR SSYDGTLDEN IPPGTSVLAV 
TATDRDHGEN GYVTYSIAGP KALPFSIDPY LGIISTSKPM DYELMKRIYT FRVRASDWGS 
PFRREKEVSI FLQLRNLNDN QPMFEEVNCT GSIRQDWPVG KSIMTMSAID VDELQNLKYE 
IVSGNELEYF DLNHFSGVIS LKRPFINLTA GQPTSYSLKI TASDGKNYAS PTTLNITVVK 
DPHFEVPVTC DKTGVLTQFT KTILHFIGLQ NQESSDEEFT SLSTYQINHY TPQFEDHFPQ 
SIDVLESVPI NTPLARLAAT DPDAGFNGKL VYVIADGNEE GCFDIELETG LLTVAAPLDY 
EATNFYILNV TVYDLGTPQK SSWKLLTVNV KDWNDNAPRF PPGGYQLTIS EDTEVGTTIA 
ELTTKDADSE DNGRVRYTLL SPTEKFSLHP LTGELVVTGH LDRESEPRYI LKVEARDQPS 
KGHQLFSVTD LIITLEDVND NSPQCITEHN RLKVPEDLPP GTVLTFLDAS DPDLGPAGEV 
RYVLMDGAHG TFRVDLMTGA LILERELDFE RRAGYNLSLW ASDGGRPLAR RTLCHVEVIV 
LDVNENLHPP HFASFVHQGQ VQENSPSGTQ VIVVAAQDDD SGLDGELQYF LRAGTGLAAF 
SINQDTGMIQ TLAPLDREFA SYYWLTVLAV DRGSVPLSSV TEVYIEVTDA NDNPPQMSQA 
VFYPSIQEDA PVGTSVLQLD AWDPDSSSKG KLTFNITSGN YMGFFMIHPV TGLLSTAQQL 
DRENKDEHIL EVTVLDNGEP SLKSTSRVVV GILDVNDNPP IFSHKLFNVR LPERLSPVSP 
GPVYRLVASD LDEGLNGRVT YSIEDSDEEA FSIDLVTGVV SSSSTFTAGE YNILTIKATD 
SGQPPLSASV RLHIEWIPWP RPSSIPLAFD ETYYSFTVME TDPVNHMVGV ISVEGRPGLF 
WFNISGGDKD MDFDIEKTTG SIVIARPLDT RRRSNYNLTV EVTDGSRTIA TQVHIFMIAN 
INHHRPQFLE TRYEVRVPQD TVPGVELLRV QAIDQDKGKS LIYTIHGSQD PGSASLFQLD 
PSSGVLVTVG KLDLGSGPSQ HTLTVMVRDQ EIPIKRNFVW VTIHVEDGNL HPPRFTQLHY 
EASVPDTIAP GTELLQVRAM DADRGVNAEV HYSLLKGNSE GFFNINALLG IITLAQKLDQ 
ANHAPHTLTV KAEDQGSPQW HDLATVIIHV YPSDRSAPIF SKSEYFVEIP ESIPVGSPIL 
LVSAMSPSEV TYELREGNKD GVFSMNSYSG LISTQKKLDH EKISSYQLKI RGSNMAGAFT 
DVMVVVDIID ENDNAPMFLK STFVGQISEA APLYSMIMDK NNNPFVIHAS DSDKEANSLL 
VYKILEPEAL KFFKIDPSMG TLTIVSEMDY ESMPSFQFCV YVHDQGSPVL FAPRPAQVII 
HVRDVNDSPP RFSEQIYEVA IVGPIHPGME LLMVRASDED SEVNYSIKTG NADEAVTIHP 
VTGSISVLNP AFLGLSRKLT IRASDGLYQD TALVKISLTQ VLDKSLQFDQ DVYWAAVKEN 
LQDRKALVIL GAQGNHLNDT LSYFLLNGTD MFHMVQSAGV LQTRGVAFDR EQQDTHELAV 
EVRDNRTPQR VAQGLVRVSI EDVNDNPPKF KHLPYYTIIQ DGTEPGDVLF QVSATDEDLG 
TNGAVTYEFA EDYTYFRIDP YLGDISLKKP FDYQALNKYH LKVIARDGGT PSLQSEEEVL 
VTVRNKSNPL FQSPYYKVRV PENITLYTPI LHTQARSPEG LRLIYNIVEE EPLMLFTTDF 
KTGVLTVTGP LDYESKTKHV FTVRATDTAL GSFSEATVEV LVEDVNDNPP TFSQLVYTTS 
ISEGLPAQTP VIQLLASDQD SGRNRDVSYQ IVEDGSDVSK FFQINGSTGE MSTVQELDYE 
AQQHFHVKVR AMDKGDPPLT GETLVVVNVS DINDNPPEFR QPQYEANVSE LATCGHLVLK 
VQAIDPDSRD TSRLEYLILS GNQDRHFFIN SSSGIISMFN LCKKHLDSSY NLRVGASDGV 
FRATVPVYIN TTNANKYSPE FQQHLYEAEL AENAMVGTKV IDLLAIDKDS GPYGTIDYTI 
INKLASEKFS INPNGQIATL QKLDRENSTE RVIAIKVMAR DGGGRVAFCT VKIILTDEND 
NPPQFKASEY TVSIQSNVSK DSPVIQVLAY DADEGQNADV TYSVNPEDLV KDVIEINPVT 
GVVKVKDSLV GLENQTLDFF IKAQDGGPPH WNSLVPVRLQ VVPKKVSLPK FSEPLYTFSA 
PEDLPEGSEI GIVKAVAAQD PVIYSLVRGT TPESNKDGVF SLDPDTGVIK VRKPMDHEST 
KLYQIDVMAH CLQNTDVVSL VSVNIQVGDV NDNRPVFEAD PYKAVLTENM PVGTSVIQVT 
AIDKDTGRDG QVSYRLSADP GSNVHELFAI DSESGWITTL QELDCETCQT YHFHVVAYDH 
GQTIQLSSQA LVQVSITDEN DNAPRFASEE YRGSVVENSE PGELVATLKT LDADISEQNR 
QVTCYITEGD PLGQFGISQV GDEWRISSRK TLDREHTAKY LLRVTASDGK FQASVTVEIF 
VLDVNDNSPQ CSQLLYTGKV HEDVFPGHFI LKVSATDLDT DTNAQITYSL HGPGAHEFKL 
DPHTGELTTL TALDRERKDV FNLVAKATDG GGRSCQADIT LHVEDVNDNA PRFFPSHCAV 
AVFDNTTVKT PVAVVFARDP DQGANAQVVY SLPDSAEGHF SIDATTGVIR LEKPLQVRPQ 
APLELTVRAS DLGTPIPLST LGTVTVSVVG LEDYLPVFLN TEHSVQVPED APPGTEVLQL 
ATLTRPGAEK TGYRVVSGNE QGRFRLDART GILYVNASLD FETSPKYFLS IECSRKSSSS 
LSDVTTVMVN ITDVNEHRPQ FPQDPYSTRV LENALVGDVI LTVSATDEDG PLNSDITYSL 
IGGNQLGHFT IHPKKGELQV AKALDREQAS SYSLKLRATD SGQPPLHEDT DIAIQVADVN 
DNPPRFFQLN YSTTVQENSP IGSKVLQLIL SDPDSPENGP PYSFRITKGN NGSAFRVTPD 
GWLVTAEGLS RRAQEWYQLQ IQASDSGIPP LSSLTSVRVH VTEQSHYAPS ALPLEIFITV 
GEDEFQGGMV GKIHATDRDP QDTLTYSLAE EETLGRHFSV GAPDGKIIAA QGLPRGHYSF 
NVTVSDGTFT TTAGVHVYVW HVGQEALQQA MWMGFYQLTP EELVSDHWRN LQRFLSHKLD 
IKRANIHLAS LQPAEAVAGV DVLLVFEGHS GTFYEFQELA SIITHSAKEM EHSVGVQMRS 
AMPMVPCQGP TCQGQICHNT VHLDPKVGPT YSTARLSILT PRHHLQRSCS CNGTATRFSG 
QSYVRYRAPA ARNWHIHFYL KTLQPQAILL FTNETASVSL KLASGVPQLE YHCLGGFYGN 
LSSQRHVNDH EWHSILVEEM DASIRLMVDS MGNTSLVVPE NCRGLRPERH LLLGGLILLH 
SSSNVSQGFE GCLDAVVVNE EALDLLAPGK TVAGLLETQA LTQCCLHSDY CSQNTCLNGG 
KCSWTHGAGY VCKCPPQFSG KHCEQGRENC TFAPCLEGGT CILSPKGASC NCPHPYTGDR 
CEMEARGCSE GHCLVTPEIQ RGDWGQQELL IITVAVAFII ISTVGLLFYC RRCKSHKPVA 
MEDPDLLARS VGVDTQAMPA IELNPLSASS CNNLNQPEPS KASVPNELVT FGPNSKQRPV 
VCSVPPRLPP AAVPSHSDNE PVIKRTWSSE EMVYPGGAMV WPPTYSRNER WEYPHSEVTQ 
GPLPPSAHRH STPVVMPEPN GLYGGFPFPL EMENKRAPLP PRYSNQNLED LMPSRPPSPR 
ERLVAPCLNE YTAISYYHSQ FRQGGGGPCL ADGGYKGVGM RLSRAGPSYA VCEVEGAPLA 
GQGQPRVPPN YEGSDMVESD YGSCEEVMF

Genular Protein ID: 1175541984

Symbol: Q6PIA2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6PIA2

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 2 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 1 SMART 3 SMR 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 740
  • Mass: 81183
  • Checksum: CD65B60BEC40BBA4
  • Sequence:
    • TTTAGVHVYV WHVGQEALQQ AIWMGFYQLT PEELVSDHWR NLQRFLSHKL DIKRANIHLA 
SLQPAEAVAG VDVLLVFEGH SGTFYEFQEL ASIITHSAKE MEHSVGVQMR SAMPMVPCQG 
PTCQGQICHN TVHLDPKVGP TYSTARLSIL TPRHHLQRSC SCNGTATRFS GQSYVRYRAP 
AARNWHIHFY LKTLQPQAIL LFTNETASVS LKLASGVPQL EYHCLGGFYG NLSSQRHVND 
HEWHSILVEE MDASIRLMVD SMGNTSLVVP ENCRGLRPER HLLLGGLILL HSSSNVSQGF 
EGCLDAVVVN EEALDLLAPG KTVAGLLETQ ALTQCCLHSD YCSQNTCLNG GKCSWTHGAG 
YVCKCPPQFS GKHCEQGREN CTFAPCLEGG TCILSPKGAS CNCPHPYTGD RCEMEARGCS 
EGHCLVTPEI QRGDWGQQEL LIITVAVAFI IISTVGLLFY CRRCKSHKPV AMEDPDLLAR 
SVGVDTQAMP AIELNPLSAS SCNNLNQLEP SKASVPNELV TFGPNSKQRP VVCSVPPRLP 
PAAVPSHSDN EPVIKRTWSS EEMVYPGGAM VWPPTYSRNE RWEYPHSEVT QGPLPPSAHR 
HSTPVVMPEP NGLYGGFPFP LEMENKRAPL PPRYSNQNLE DLMPSRPPSP RERLVAPCLN 
EYTAISYYHS QFRQGGGGPC LADGGYKGVG MRLSRAGPSY AVCEVEGAPL AGQGQPRVPP 
NYEGSDMVES DYGSCEEVMF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.