TLR9 | ENSG00000239732 | NCBI 54106

Details for: TLR9

Gene ID: 54106

Symbol: TLR9

Ensembl ID: ENSG00000239732

Description: toll like receptor 9

Associated with

Disease
(R-HSA-1643685)
Igf1r signaling cascade
(R-HSA-2428924)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Insulin receptor signalling cascade
(R-HSA-74751)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Pi3k cascade
(R-HSA-109704)
Potential therapeutics for sars
(R-HSA-9679191)
Sars-cov infections
(R-HSA-9679506)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Signal transduction
(R-HSA-162582)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Traf6 mediated irf7 activation in tlr7/8 or 9 signaling
(R-HSA-975110)
Trafficking and processing of endosomal tlr
(R-HSA-1679131)
Viral infection pathways
(R-HSA-9824446)
Apical plasma membrane
(GO:0016324)
Basolateral plasma membrane
(GO:0016323)
Canonical nf-kappab signal transduction
(GO:0007249)
Cellular response to chloroquine
(GO:1902350)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to metal ion
(GO:0071248)
Cytoplasm
(GO:0005737)
Defense response to bacterium
(GO:0042742)
Defense response to gram-negative bacterium
(GO:0050829)
Defense response to virus
(GO:0051607)
Detection of molecule of bacterial origin
(GO:0032490)
Early phagosome
(GO:0032009)
Endolysosome
(GO:0036019)
Endolysosome membrane
(GO:0036020)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Endosome
(GO:0005768)
Endosome membrane
(GO:0010008)
Extracellular region
(GO:0005576)
Golgi membrane
(GO:0000139)
Innate immune response
(GO:0045087)
Interleukin-1 receptor binding
(GO:0005149)
Lysosome
(GO:0005764)
Maintenance of gastrointestinal epithelium
(GO:0030277)
Male gonad development
(GO:0008584)
Microglial cell activation
(GO:0001774)
Myd88-dependent toll-like receptor signaling pathway
(GO:0002755)
Negative regulation of atpase-coupled calcium transmembrane transporter activity
(GO:1901895)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Pattern recognition receptor activity
(GO:0038187)
Plasma membrane
(GO:0005886)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of b cell activation
(GO:0050871)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of granulocyte macrophage colony-stimulating factor production
(GO:0032725)
Positive regulation of immunoglobulin production
(GO:0002639)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of interferon-alpha production
(GO:0032727)
Positive regulation of interferon-beta production
(GO:0032728)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of interleukin-10 production
(GO:0032733)
Positive regulation of interleukin-12 production
(GO:0032735)
Positive regulation of interleukin-18 production
(GO:0032741)
Positive regulation of intestinal epithelial cell development
(GO:1905300)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of non-canonical nf-kappab signal transduction
(GO:1901224)
Positive regulation of toll-like receptor 9 signaling pathway
(GO:0034165)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of type ii interferon production
(GO:0032729)
Protein homodimerization activity
(GO:0042803)
Regulation of b cell differentiation
(GO:0045577)
Regulation of dendritic cell cytokine production
(GO:0002730)
Regulation of protein phosphorylation
(GO:0001932)
Regulation of toll-like receptor 9 signaling pathway
(GO:0034163)
Sirna binding
(GO:0035197)
Toll-like receptor 9 signaling pathway
(GO:0034162)
Toll-like receptor signaling pathway
(GO:0002224)
Unmethylated cpg binding
(GO:0045322)

Other Information

Proteins

Toll-like receptor 9

Genular Protein ID: 1665298148

Symbol: TLR9_HUMAN

Name: Toll-like receptor 9

UniProtKB Accession Codes:

Q9NR96 B3Y661 D1CS56 Q6UVZ2 Q9HD68 Q9HD69 Q9HD70 Q9NYC2 Q9NYC3

Database IDs:

Citations:

PubMed ID: 11022119

Title: Three novel mammalian Toll-like receptors: gene structure, expression, and evolution.

PubMed ID: 11022119

PubMed ID: 11022120

Title: Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9.

PubMed ID: 11022120

PubMed ID: 11130078

Title: A Toll-like receptor recognizes bacterial DNA.

PubMed ID: 11130078

DOI: 10.1038/35047123

PubMed ID: 18810425

Title: Natural selection in the TLR-related genes in the course of primate evolution.

PubMed ID: 18810425

DOI: 10.1007/s00251-008-0332-0

PubMed ID: 19924287

Title: The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes.

PubMed ID: 19924287

DOI: 10.1371/journal.pone.0007803

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11564765

Title: Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells.

PubMed ID: 11564765

DOI: 10.4049/jimmunol.167.7.3555

PubMed ID: 17932028

Title: Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase.

PubMed ID: 17932028

DOI: 10.1074/jbc.m707682200

PubMed ID: 20865800

Title: Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone.

PubMed ID: 20865800

DOI: 10.1038/ncomms1070

PubMed ID: 23857366

Title: FCRL3 promotes TLR9-induced B-cell activation and suppresses plasma cell differentiation.

PubMed ID: 23857366

DOI: 10.1002/eji.201243068

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 1032
Mass: 115860
Checksum: 71280AA9680EDCE2
Sequence:

MGFCRSALHP LSLLVQAIML AMTLALGTLP AFLPCELQPH GLVNCNWLFL KSVPHFSMAA 
PRGNVTSLSL SSNRIHHLHD SDFAHLPSLR HLNLKWNCPP VGLSPMHFPC HMTIEPSTFL 
AVPTLEELNL SYNNIMTVPA LPKSLISLSL SHTNILMLDS ASLAGLHALR FLFMDGNCYY 
KNPCRQALEV APGALLGLGN LTHLSLKYNN LTVVPRNLPS SLEYLLLSYN RIVKLAPEDL 
ANLTALRVLD VGGNCRRCDH APNPCMECPR HFPQLHPDTF SHLSRLEGLV LKDSSLSWLN 
ASWFRGLGNL RVLDLSENFL YKCITKTKAF QGLTQLRKLN LSFNYQKRVS FAHLSLAPSF 
GSLVALKELD MHGIFFRSLD ETTLRPLARL PMLQTLRLQM NFINQAQLGI FRAFPGLRYV 
DLSDNRISGA SELTATMGEA DGGEKVWLQP GDLAPAPVDT PSSEDFRPNC STLNFTLDLS 
RNNLVTVQPE MFAQLSHLQC LRLSHNCISQ AVNGSQFLPL TGLQVLDLSH NKLDLYHEHS 
FTELPRLEAL DLSYNSQPFG MQGVGHNFSF VAHLRTLRHL SLAHNNIHSQ VSQQLCSTSL 
RALDFSGNAL GHMWAEGDLY LHFFQGLSGL IWLDLSQNRL HTLLPQTLRN LPKSLQVLRL 
RDNYLAFFKW WSLHFLPKLE VLDLAGNQLK ALTNGSLPAG TRLRRLDVSC NSISFVAPGF 
FSKAKELREL NLSANALKTV DHSWFGPLAS ALQILDVSAN PLHCACGAAF MDFLLEVQAA 
VPGLPSRVKC GSPGQLQGLS IFAQDLRLCL DEALSWDCFA LSLLAVALGL GVPMLHHLCG 
WDLWYCFHLC LAWLPWRGRQ SGRDEDALPY DAFVVFDKTQ SAVADWVYNE LRGQLEECRG 
RWALRLCLEE RDWLPGKTLF ENLWASVYGS RKTLFVLAHT DRVSGLLRAS FLLAQQRLLE 
DRKDVVVLVI LSPDGRRSRY VRLRQRLCRQ SVLLWPHQPS GQRSFWAQLG MALTRDNHHF 
YNRNFCQGPT AE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TLR9

Associated with

Other Information

Three novel mammalian Toll-like receptors: gene structure, expression, and evolution. PubMed ID: 11022119

Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9. PubMed ID: 11022120

A Toll-like receptor recognizes bacterial DNA. PubMed ID: 11130078

Natural selection in the TLR-related genes in the course of primate evolution. PubMed ID: 18810425

The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes. PubMed ID: 19924287

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells. PubMed ID: 11564765

Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase. PubMed ID: 17932028

Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone. PubMed ID: 20865800

FCRL3 promotes TLR9-induced B-cell activation and suppresses plasma cell differentiation. PubMed ID: 23857366

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974