Details for: SPI1

Gene ID: 6688

Symbol: SPI1

Ensembl ID: ENSG00000066336

Description: Spi-1 proto-oncogene

Associated with

  • Developmental biology
    (R-HSA-1266738)
  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Runx1 regulates transcription of genes involved in differentiation of hscs
    (R-HSA-8939236)
  • Transcriptional regulation by runx1
    (R-HSA-8878171)
  • Transcriptional regulation of granulopoiesis
    (R-HSA-9616222)
  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Chromatin binding
    (GO:0003682)
  • Cis-regulatory region sequence-specific dna binding
    (GO:0000987)
  • Defense response to tumor cell
    (GO:0002357)
  • Dna-binding transcription activator activity
    (GO:0001216)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription factor binding
    (GO:0140297)
  • Dna-binding transcription repressor activity
    (GO:0001217)
  • Endothelial to hematopoietic transition
    (GO:0098508)
  • Histone deacetylase binding
    (GO:0042826)
  • Interleukin-6-mediated signaling pathway
    (GO:0070102)
  • Molecular adaptor activity
    (GO:0060090)
  • Myeloid leukocyte differentiation
    (GO:0002573)
  • Negative regulation of adipose tissue development
    (GO:1904178)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of neutrophil degranulation
    (GO:0043314)
  • Negative regulation of nf-kappab transcription factor activity
    (GO:0032088)
  • Negative regulation of non-canonical nf-kappab signal transduction
    (GO:1901223)
  • Negative regulation of protein localization to chromatin
    (GO:0120186)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nfat protein binding
    (GO:0051525)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Oncogene-induced cell senescence
    (GO:0090402)
  • Pericyte cell differentiation
    (GO:1904238)
  • Positive regulation of antifungal innate immune response
    (GO:1905036)
  • Positive regulation of b cell differentiation
    (GO:0045579)
  • Positive regulation of microglial cell mediated cytotoxicity
    (GO:1904151)
  • Positive regulation of mirna transcription
    (GO:1902895)
  • Positive regulation of p38mapk cascade
    (GO:1900745)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Pro-t cell differentiation
    (GO:0002572)
  • Protein binding
    (GO:0005515)
  • Protein sequestering activity
    (GO:0140311)
  • Regulation of dna-binding transcription factor activity
    (GO:0051090)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of erythrocyte differentiation
    (GO:0045646)
  • Regulation of myeloid progenitor cell differentiation
    (GO:1905453)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna binding
    (GO:0003723)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Stat family protein binding
    (GO:0097677)
  • Trail-activated apoptotic signaling pathway
    (GO:0036462)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription initiation-coupled chromatin remodeling
    (GO:0045815)
  • Transcription regulator complex
    (GO:0005667)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 102.4782
    Cell Significance Index: -15.9400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 54.9652
    Cell Significance Index: -22.3300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 46.1911
    Cell Significance Index: -23.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 40.1745
    Cell Significance Index: -10.1900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.7446
    Cell Significance Index: -22.6700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.9121
    Cell Significance Index: -15.9200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 9.4013
    Cell Significance Index: 173.7600
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 5.8199
    Cell Significance Index: 38.6100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.6094
    Cell Significance Index: 71.3200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.1725
    Cell Significance Index: -16.4700
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 3.1788
    Cell Significance Index: 13.2300
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 3.0641
    Cell Significance Index: 19.5600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.8877
    Cell Significance Index: -6.3200
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.5674
    Cell Significance Index: 5.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.6087
    Cell Significance Index: 103.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4687
    Cell Significance Index: 173.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2627
    Cell Significance Index: 27.3600
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 1.1476
    Cell Significance Index: 19.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6733
    Cell Significance Index: 66.6100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5888
    Cell Significance Index: 15.7500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5845
    Cell Significance Index: 527.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3232
    Cell Significance Index: 52.5600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.3199
    Cell Significance Index: 4.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2362
    Cell Significance Index: 44.9500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2339
    Cell Significance Index: 161.7900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1760
    Cell Significance Index: 19.1400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0978
    Cell Significance Index: 1.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0742
    Cell Significance Index: 14.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0651
    Cell Significance Index: 6.6500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0395
    Cell Significance Index: 2.7300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0208
    Cell Significance Index: 39.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0128
    Cell Significance Index: 0.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0047
    Cell Significance Index: -8.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0086
    Cell Significance Index: -13.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0115
    Cell Significance Index: -0.3300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0149
    Cell Significance Index: -0.3800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0152
    Cell Significance Index: -0.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0158
    Cell Significance Index: -21.4300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0177
    Cell Significance Index: -7.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0181
    Cell Significance Index: -13.6700
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0235
    Cell Significance Index: -0.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0275
    Cell Significance Index: -20.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0282
    Cell Significance Index: -15.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0283
    Cell Significance Index: -20.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0322
    Cell Significance Index: -20.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0341
    Cell Significance Index: -21.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0373
    Cell Significance Index: -21.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0378
    Cell Significance Index: -1.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0399
    Cell Significance Index: -14.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0412
    Cell Significance Index: -18.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0427
    Cell Significance Index: -2.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0429
    Cell Significance Index: -8.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0457
    Cell Significance Index: -2.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0486
    Cell Significance Index: -13.9900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0666
    Cell Significance Index: -0.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0687
    Cell Significance Index: -5.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0807
    Cell Significance Index: -9.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0891
    Cell Significance Index: -16.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0913
    Cell Significance Index: -11.7100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0932
    Cell Significance Index: -3.5300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0950
    Cell Significance Index: -1.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0955
    Cell Significance Index: -13.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1006
    Cell Significance Index: -13.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1021
    Cell Significance Index: -21.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1177
    Cell Significance Index: -20.0900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1321
    Cell Significance Index: -7.9300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1486
    Cell Significance Index: -7.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1488
    Cell Significance Index: -15.4900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1514
    Cell Significance Index: -3.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1540
    Cell Significance Index: -18.9300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1653
    Cell Significance Index: -21.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1823
    Cell Significance Index: -5.8400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1847
    Cell Significance Index: -13.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1899
    Cell Significance Index: -21.7600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1995
    Cell Significance Index: -3.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2133
    Cell Significance Index: -10.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2327
    Cell Significance Index: -12.2200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2362
    Cell Significance Index: -10.2700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2440
    Cell Significance Index: -2.1500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2502
    Cell Significance Index: -2.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2556
    Cell Significance Index: -13.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2561
    Cell Significance Index: -5.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2582
    Cell Significance Index: -17.3600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2716
    Cell Significance Index: -3.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2725
    Cell Significance Index: -20.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2852
    Cell Significance Index: -22.5900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2858
    Cell Significance Index: -18.0100
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.2917
    Cell Significance Index: -2.5500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3117
    Cell Significance Index: -7.5500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3141
    Cell Significance Index: -16.3600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3146
    Cell Significance Index: -11.0200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.3174
    Cell Significance Index: -3.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3224
    Cell Significance Index: -18.0900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3268
    Cell Significance Index: -13.3900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3322
    Cell Significance Index: -10.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3335
    Cell Significance Index: -20.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3406
    Cell Significance Index: -9.5200
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.3641
    Cell Significance Index: -3.3900
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.3976
    Cell Significance Index: -3.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4067
    Cell Significance Index: -18.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Spi-1 is a transcription factor that belongs to the IRF family of proteins. It is characterized by its ability to bind to specific DNA sequences, known as IRF-1 binding sites, which are located in the promoter regions of target genes. Spi-1 regulates the expression of genes involved in immune responses, cell differentiation, and development by interacting with other transcription factors and co-regulators. The protein is highly conserved across species, suggesting its importance in evolution. **Pathways and Functions:** Spi-1 is involved in various signaling pathways, including: 1. **Interferon Signaling Pathway:** Spi-1 regulates the expression of interferon-stimulated genes (ISGs), which are critical for the defense against viral infections. 2. **Immune Response:** Spi-1 regulates the expression of cytokines and chemokines, which are essential for the activation and differentiation of immune cells. 3. **Cell Differentiation:** Spi-1 regulates the expression of genes involved in the differentiation of myeloid cells, including monocytes, macrophages, and dendritic cells. 4. **Developmental Biology:** Spi-1 regulates the expression of genes involved in embryonic development, including the development of the immune system. **Clinical Significance:** Abnormal expression of Spi-1 has been implicated in various diseases, including: 1. **Cancer:** Spi-1 is overexpressed in certain types of cancer, including leukemia and lymphoma, where it promotes tumor growth and survival. 2. **Autoimmune Disorders:** Spi-1 is involved in the regulation of autoimmune responses, and its dysregulation has been implicated in diseases such as multiple sclerosis and rheumatoid arthritis. 3. **Inflammatory Conditions:** Spi-1 regulates the expression of pro-inflammatory cytokines, and its dysregulation has been implicated in diseases such as asthma and chronic obstructive pulmonary disease (COPD). In conclusion, Spi-1 is a critical regulator of immune responses, cell differentiation, and development. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in human health and disease. Further research is needed to fully understand the mechanisms by which Spi-1 regulates immune responses and to explore its potential as a therapeutic target for diseases involving immune dysregulation.

Genular Protein ID: 2655367886

Symbol: SPI1_HUMAN

Name: 31 kDa-transforming protein

UniProtKB Accession Codes:

P17947

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEBI 4 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 49 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NIAGADS 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 23 PDBsum 23 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1693183

Title: The human homologue of the putative proto-oncogene Spi-1: characterization and expression in tumors.

PubMed ID: 1693183

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 10196196

Title: SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1.

PubMed ID: 10196196

DOI: 10.1074/jbc.274.16.11115

PubMed ID: 10207087

Title: Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias.

PubMed ID: 10207087

DOI: 10.1128/mcb.19.5.3635

PubMed ID: 17197705

Title: The transcriptional repressor GFI-1 antagonizes PU.1 activity through protein-protein interaction.

PubMed ID: 17197705

DOI: 10.1074/jbc.m607613200

PubMed ID: 23166356

Title: BCL6 positively regulates AID and germinal center gene expression via repression of miR-155.

PubMed ID: 23166356

DOI: 10.1084/jem.20121387

PubMed ID: 23658224

Title: Mechanisms of in vivo binding site selection of the hematopoietic master transcription factor PU.1.

PubMed ID: 23658224

DOI: 10.1093/nar/gkt355

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26019275

Title: A novel in-frame deletion in the leucine zipper domain of C/EBPepsilon leads to neutrophil-specific granule deficiency.

PubMed ID: 26019275

DOI: 10.4049/jimmunol.1402222

PubMed ID: 33951726

Title: Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients.

PubMed ID: 33951726

DOI: 10.1084/jem.20201750

Sequence Information:

  • Length: 270
  • Mass: 31083
  • Checksum: 9592DAA1D85053ED
  • Sequence:
    • MLQACKMEGF PLVPPPSEDL VPYDTDLYQR QTHEYYPYLS SDGESHSDHY WDFHPHHVHS 
EFESFAENNF TELQSVQPPQ LQQLYRHMEL EQMHVLDTPM VPPHPSLGHQ VSYLPRMCLQ 
YPSLSPAQPS SDEEEGERQS PPLEVSDGEA DGLEPGPGLL PGETGSKKKI RLYQFLLDLL 
RSGDMKDSIW WVDKDKGTFQ FSSKHKEALA HRWGIQKGNR KKMTYQKMAR ALRNYGKTGE 
VKKVKKKLTY QFSGEVLGRG GLAERRHPPH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.