Details for: LINC01348

Gene ID: 731656

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: LINC01348

Ensembl ID: ENSG00000280587

Description: long intergenic non-protein coding RNA 1348

Cell Significance Landscape

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • midzonal region hepatocyte CL0019028
    CSI 5.84
    rCSI 13.7%
    PRS 98.7
  • vascular associated smooth muscle cell CL0000359
    CSI 5.2
    rCSI 16.88%
    PRS 99.53
  • periportal region hepatocyte CL0019026
    CSI 3.53
    rCSI 13.72%
    PRS 98.66
  • centrilobular region hepatocyte CL0019029
    CSI 2.5
    rCSI 6.53%
    PRS 98.4
  • epicardial adipocyte CL1000309
    CSI 2.3
    rCSI 7.5%
    PRS 98.98

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [LINC01348](/details-gene/731656) is a long non-coding RNA (lncRNA) located on chromosome 1q42.3. Expression analysis indicates that it is a highly significant marker for several distinct cell types, most notably [hepatocytes](/details-cell/CL0000182) within the liver, [vascular associated smooth muscle cells](/details-cell/CL0000359), and [epicardial adipocytes](/details-cell/CL1000309). This specific expression pattern suggests a potential regulatory role in metabolic processes, liver homeostasis, and cardiovascular function. As a non-coding gene, its function is likely mediated through the regulation of target gene expression at the transcriptional or post-transcriptional level. ## Cellular Roles and Expression Landscape **Overall**, the expression profile of [LINC01348](/details-gene/731656) highlights its significance in a select group of metabolically active and structural cell types. Its most prominent expression is observed in the liver, where it shows a high Cell Significance Index (CSI) across different functional zones, including [midzonal region hepatocytes](/details-cell/CL0019028) (CSI: 5.84), [periportal region hepatocytes](/details-cell/CL0019026) (CSI: 3.53), and [centrilobular region hepatocytes](/details-cell/CL0019029) (CSI: 2.50). This broad and strong expression throughout the liver parenchyma suggests a fundamental role in maintaining core hepatic functions. Beyond the liver, [LINC01348](/details-gene/731656) is a defining marker for [vascular associated smooth muscle cells](/details-cell/CL0000359) (CSI: 5.20), indicating potential involvement in regulating vascular tone, proliferation, or response to injury. Furthermore, its notable expression in [epicardial adipocytes](/details-cell/CL1000309) (CSI: 2.30) points towards a specialized function within the unique fat depot surrounding the heart, possibly related to local energy metabolism or paracrine signaling that influences cardiac and coronary artery health. The colocalization in these specific cell types suggests [LINC01348](/details-gene/731656) may participate in integrated physiological networks governing metabolism and cardiovascular homeostasis. ## Pathways and Molecular Function The precise molecular functions and biological pathways involving [LINC01348](/details-gene/731656) remain to be fully elucidated. As a long non-coding RNA, it is hypothesized to act as a regulatory molecule, potentially by serving as a scaffold for protein complexes, acting as a decoy for microRNAs, or guiding chromatin-modifying enzymes to specific genomic loci to control gene expression. Given its prominent expression in [hepatocytes](/details-cell/CL0000182), [vascular smooth muscle cells](/details-cell/CL0000359), and [adipocytes](/details-cell/CL1000309), its regulatory targets are likely involved in key pathways such as lipid metabolism, glucose homeostasis, cellular contractility, and intercellular signaling. ## Research Directions The specific and robust expression pattern of [LINC01348](/details-gene/731656) gives rise to several testable hypotheses regarding its function in health and disease. **Proposed Hypotheses:** 1. [LINC01348](/details-gene/731656) functions as a master regulator of metabolic homeostasis in the liver. Its downregulation may compromise the liver's ability to manage lipid and glucose levels, thereby contributing to the pathogenesis of metabolic-associated steatotic liver disease (MASLD). 2. In the cardiovascular system, [LINC01348](/details-gene/731656) may coordinate the function of [vascular smooth muscle cells](/details-cell/CL0000359) and [epicardial adipocytes](/details-cell/CL1000309). Its dysregulation could disrupt the paracrine signaling axis between epicardial fat and coronary arteries, potentially contributing to the development of atherosclerosis or other vascular pathologies. **Experimental Approach:** To test the hypothesis of its role in liver metabolism, a targeted knockdown of [LINC01348](/details-gene/731656) could be performed in vitro using primary human [hepatocytes](/details-cell/CL0000182) and in vivo in a mouse model, utilizing antisense oligonucleotides (ASOs). The effects of its depletion would be assessed through a combination of transcriptomic profiling (RNA-seq) to identify downstream targets and functional assays to measure key metabolic outputs, such as lipid droplet formation, de novo lipogenesis, and glucose production. **Therapeutic Potential:** As a lncRNA with a highly cell-type-specific expression profile, [LINC01348](/details-gene/731656) represents an attractive therapeutic target. Its specificity for liver, vascular, and cardiac-associated cells may allow for the development of targeted therapies with a reduced risk of off-target effects. If its overexpression is causally linked to a disease state, ASO-mediated **inhibition** could be a viable strategy. Conversely, if its loss of function is pathogenic, developing methods to restore or enhance its expression could offer a novel therapeutic avenue for metabolic or cardiovascular diseases.