LEP | ENSG00000174697 | NCBI 3952

Details for: LEP

Gene ID: 3952

Symbol: LEP

Ensembl ID: ENSG00000174697

Description: leptin

Associated with

Adipogenesis
(R-HSA-9843745)
Developmental biology
(R-HSA-1266738)
Incretin synthesis, secretion, and inactivation
(R-HSA-400508)
Metabolism of proteins
(R-HSA-392499)
Peptide hormone metabolism
(R-HSA-2980736)
Signaling by leptin
(R-HSA-2586552)
Signal transduction
(R-HSA-162582)
Synthesis, secretion, and deacylation of ghrelin
(R-HSA-422085)
Synthesis, secretion, and inactivation of glucagon-like peptide-1 (glp-1)
(R-HSA-381771)
Transcriptional regulation of white adipocyte differentiation
(R-HSA-381340)
Adipose tissue development
(GO:0060612)
Adult feeding behavior
(GO:0008343)
Angiogenesis
(GO:0001525)
Aorta development
(GO:0035904)
Bile acid metabolic process
(GO:0008206)
Bone mineralization involved in bone maturation
(GO:0035630)
Cardiac muscle hypertrophy
(GO:0003300)
Cell surface receptor signaling pathway via jak-stat
(GO:0007259)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to leptin stimulus
(GO:0044320)
Central nervous system neuron development
(GO:0021954)
Cholesterol metabolic process
(GO:0008203)
Circadian rhythm
(GO:0007623)
Determination of adult lifespan
(GO:0008340)
Dna binding
(GO:0003677)
Eating behavior
(GO:0042755)
Elastin metabolic process
(GO:0051541)
Energy reserve metabolic process
(GO:0006112)
Fatty acid beta-oxidation
(GO:0006635)
Female pregnancy
(GO:0007565)
Glucose homeostasis
(GO:0042593)
Glucose metabolic process
(GO:0006006)
Glycerol biosynthetic process
(GO:0006114)
Hormone activity
(GO:0005179)
Hormone metabolic process
(GO:0042445)
Insulin secretion
(GO:0030073)
Intestinal absorption
(GO:0050892)
Intracellular signal transduction
(GO:0035556)
Leptin-mediated signaling pathway
(GO:0033210)
Leptin receptor binding
(GO:1990460)
Leukocyte tethering or rolling
(GO:0050901)
Lipid metabolic process
(GO:0006629)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of appetite
(GO:0032099)
Negative regulation of appetite by leptin-mediated signaling pathway
(GO:0038108)
Negative regulation of autophagy
(GO:0010507)
Negative regulation of cartilage development
(GO:0061037)
Negative regulation of d-glucose import
(GO:0046325)
Negative regulation of lipid storage
(GO:0010888)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of vasoconstriction
(GO:0045906)
Ovulation from ovarian follicle
(GO:0001542)
Peptide hormone receptor binding
(GO:0051428)
Phagocytosis
(GO:0006909)
Placenta development
(GO:0001890)
Positive regulation of developmental growth
(GO:0048639)
Positive regulation of follicle-stimulating hormone secretion
(GO:0046881)
Positive regulation of insulin receptor signaling pathway
(GO:0046628)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of interleukin-12 production
(GO:0032735)
Positive regulation of luteinizing hormone secretion
(GO:0033686)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of monoatomic ion transport
(GO:0043270)
Positive regulation of peroxisome proliferator activated receptor signaling pathway
(GO:0035360)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of protein import into nucleus
(GO:0042307)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of receptor signaling pathway via jak-stat
(GO:0046427)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of tor signaling
(GO:0032008)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Prostaglandin secretion
(GO:0032310)
Protein binding
(GO:0005515)
Regulation of angiogenesis
(GO:0045765)
Regulation of blood pressure
(GO:0008217)
Regulation of bone remodeling
(GO:0046850)
Regulation of cell cycle
(GO:0051726)
Regulation of endothelial cell proliferation
(GO:0001936)
Regulation of gluconeogenesis
(GO:0006111)
Regulation of insulin secretion
(GO:0050796)
Regulation of intestinal cholesterol absorption
(GO:0030300)
Regulation of lipoprotein lipid oxidation
(GO:0060587)
Regulation of natural killer cell activation
(GO:0032814)
Regulation of natural killer cell mediated cytotoxicity
(GO:0042269)
Regulation of natural killer cell proliferation
(GO:0032817)
Regulation of nitric-oxide synthase activity
(GO:0050999)
Regulation of steroid biosynthetic process
(GO:0050810)
Response to activity
(GO:0014823)
Response to dietary excess
(GO:0002021)
Response to estradiol
(GO:0032355)
Response to ethanol
(GO:0045471)
Response to hypoxia
(GO:0001666)
Response to insulin
(GO:0032868)
Response to vitamin e
(GO:0033197)
Sexual reproduction
(GO:0019953)
T cell differentiation
(GO:0030217)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 14.9028
Cell Significance Index: -3.7800
Cell Name: adipocyte of breast (CL0002617)
Fold Change: 2.7136
Cell Significance Index: 34.1700
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 1.0278
Cell Significance Index: 24.9000
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.6043
Cell Significance Index: 9.3500
Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 0.4962
Cell Significance Index: 2.1600
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.0853
Cell Significance Index: 0.5300
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.0676
Cell Significance Index: 1.3200
Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.0551
Cell Significance Index: 0.6400
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.0172
Cell Significance Index: 0.1400
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0144
Cell Significance Index: 9.9700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0110
Cell Significance Index: 2.2100
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.0110
Cell Significance Index: 0.1500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0019
Cell Significance Index: 0.0500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.0010
Cell Significance Index: 0.3000
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0008
Cell Significance Index: -0.2900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0013
Cell Significance Index: -2.4300
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0029
Cell Significance Index: -5.2800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0036
Cell Significance Index: -5.4900
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0038
Cell Significance Index: -5.1600
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0057
Cell Significance Index: -3.6200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0057
Cell Significance Index: -4.3400
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0061
Cell Significance Index: -3.3500
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0068
Cell Significance Index: -5.0700
Cell Name: trophoblast giant cell (CL0002488)
Fold Change: -0.0083
Cell Significance Index: -0.0600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0084
Cell Significance Index: -4.7100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0098
Cell Significance Index: -4.4300
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0137
Cell Significance Index: -2.7100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0171
Cell Significance Index: -3.0900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0234
Cell Significance Index: -3.2100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0235
Cell Significance Index: -4.0200
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0237
Cell Significance Index: -3.4500
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0279
Cell Significance Index: -0.7600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0300
Cell Significance Index: -6.3200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0305
Cell Significance Index: -3.7500
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0333
Cell Significance Index: -1.4500
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0342
Cell Significance Index: -3.9900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0373
Cell Significance Index: -3.8800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0382
Cell Significance Index: -3.9000
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0394
Cell Significance Index: -1.8400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0421
Cell Significance Index: -4.8300
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -0.0463
Cell Significance Index: -0.4400
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0506
Cell Significance Index: -1.0600
Cell Name: medium spiny neuron (CL1001474)
Fold Change: -0.0519
Cell Significance Index: -0.7000
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0550
Cell Significance Index: -3.7000
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0590
Cell Significance Index: -4.5300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0596
Cell Significance Index: -2.7000
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0680
Cell Significance Index: -4.1800
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0723
Cell Significance Index: -3.2000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0745
Cell Significance Index: -3.5000
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0754
Cell Significance Index: -3.9300
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0779
Cell Significance Index: -2.7300
Cell Name: pulmonary capillary endothelial cell (CL4028001)
Fold Change: -0.0789
Cell Significance Index: -1.0800
Cell Name: microglial cell (CL0000129)
Fold Change: -0.0791
Cell Significance Index: -0.9300
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0838
Cell Significance Index: -1.2000
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0856
Cell Significance Index: -3.2400
Cell Name: stromal cell of endometrium (CL0002255)
Fold Change: -0.0872
Cell Significance Index: -1.2400
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0892
Cell Significance Index: -2.9200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0893
Cell Significance Index: -5.0100
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0899
Cell Significance Index: -1.5400
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0899
Cell Significance Index: -4.7200
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0911
Cell Significance Index: -2.9000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0922
Cell Significance Index: -4.7900
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: -0.0942
Cell Significance Index: -1.0400
Cell Name: slow muscle cell (CL0000189)
Fold Change: -0.0943
Cell Significance Index: -1.4100
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: -0.0953
Cell Significance Index: -1.0400
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.1012
Cell Significance Index: -1.1000
Cell Name: retinal astrocyte (CL4033015)
Fold Change: -0.1042
Cell Significance Index: -1.0200
Cell Name: connective tissue cell (CL0002320)
Fold Change: -0.1058
Cell Significance Index: -1.0200
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: -0.1072
Cell Significance Index: -1.0800
Cell Name: osteoblast (CL0000062)
Fold Change: -0.1093
Cell Significance Index: -1.0600
Cell Name: keratocyte (CL0002363)
Fold Change: -0.1141
Cell Significance Index: -1.8100
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1158
Cell Significance Index: -2.9500
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1176
Cell Significance Index: -3.1500
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.1191
Cell Significance Index: -2.9700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1202
Cell Significance Index: -3.2200
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1277
Cell Significance Index: -3.7600
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.1329
Cell Significance Index: -1.9300
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.1350
Cell Significance Index: -2.8700
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: -0.1365
Cell Significance Index: -0.9800
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.1366
Cell Significance Index: -2.9900
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.1402
Cell Significance Index: -4.0000
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.1430
Cell Significance Index: -3.0900
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1451
Cell Significance Index: -3.7300
Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.1486
Cell Significance Index: -1.8800
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.1490
Cell Significance Index: -2.5100
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.1492
Cell Significance Index: -1.9300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1497
Cell Significance Index: -4.2900
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.1502
Cell Significance Index: -2.5900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1511
Cell Significance Index: -5.3100
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.1560
Cell Significance Index: -3.3400
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.1562
Cell Significance Index: -3.2600
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: -0.1584
Cell Significance Index: -0.9800
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.1586
Cell Significance Index: -2.2000
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.1624
Cell Significance Index: -3.2600
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.1644
Cell Significance Index: -3.2500
Cell Name: ependymal cell (CL0000065)
Fold Change: -0.1655
Cell Significance Index: -1.9500
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1689
Cell Significance Index: -6.2000
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1704
Cell Significance Index: -4.7600
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.1717
Cell Significance Index: -3.3800
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.1720
Cell Significance Index: -2.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Production and Regulation:** Leptin is produced by adipose tissue and is regulated by various factors, including energy balance, nutrient availability, and hormonal signals. 2. **Structure and Function:** Leptin is a 167-amino acid protein that functions as a hormone, signaling through the leptin receptor to regulate downstream pathways. 3. **Expression and Signaling:** Leptin is expressed in various tissues, including adipose tissue, hypothalamus, and pancreas, and its signaling pathways involve multiple proteins, including JAK/STAT, MAPK, and PI3K/AKT. 4. **Cellular and Tissue-Specific Expression:** Leptin is expressed in various cell types, including endothelial cells, immune cells, and epithelial cells, and its expression is regulated by different transcription factors. **Pathways and Functions:** 1. **Energy Balance and Metabolism:** Leptin regulates energy balance by influencing appetite, glucose and lipid metabolism, and energy expenditure. 2. **Growth and Development:** Leptin plays a crucial role in fetal development, including embryonic growth, and influences postnatal growth and development. 3. **Hypothalamic-Pituitary-Adrenal Axis:** Leptin signals to the hypothalamus and pituitary gland to regulate stress response, appetite, and energy homeostasis. 4. **Inflammation and Immune Response:** Leptin modulates immune responses, including inflammation and cytokine production, and influences the development and function of immune cells. 5. **Cardiovascular and Renal Functions:** Leptin regulates blood pressure, cardiovascular function, and renal function, and influences the development of cardiovascular and renal diseases. **Clinical Significance:** 1. **Obesity and Metabolic Disorders:** Leptin dysregulation is a hallmark of obesity and metabolic disorders, such as diabetes, cardiovascular disease, and metabolic syndrome. 2. **Cancer and Tumor Development:** Leptin has been implicated in cancer development and progression, particularly in breast, prostate, and colon cancers. 3. **Neurological and Psychiatric Disorders:** Leptin dysregulation has been linked to neurological and psychiatric disorders, including depression, anxiety, and autism spectrum disorder. 4. **Reproductive and Fertility Issues:** Leptin plays a crucial role in reproductive functions, including ovulation, menstruation, and fertility, and its dysregulation can lead to reproductive disorders. In conclusion, leptin is a multifaceted hormone that plays a critical role in regulating metabolism, growth, and development. Its dysregulation has significant clinical implications, including obesity, metabolic disorders, and various cancers. Further research is needed to fully understand the mechanisms of leptin signaling and its clinical applications.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Obese protein

Genular Protein ID: 1881838937

Symbol: LEP_HUMAN

Name: Obese protein

UniProtKB Accession Codes:

P41159 O15158 Q56A88

Database IDs:

Citations:

PubMed ID: 7984236

Title: Positional cloning of the mouse obese gene and its human homologue.

PubMed ID: 7984236

DOI: 10.1038/372425a0

PubMed ID: 7789654

Title: Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue.

PubMed ID: 7789654

DOI: 10.2337/diab.44.7.855

PubMed ID: 8626726

Title: Genomic structure and promoter analysis of the human obese gene.

PubMed ID: 8626726

DOI: 10.1074/jbc.271.8.3971

PubMed ID: 7499240

Title: Structural organization and chromosomal assignment of the human obese gene.

PubMed ID: 7499240

DOI: 10.1074/jbc.270.46.27728

PubMed ID: 8621021

Title: Human obese gene: molecular screening in Japanese and Asian Indian NIDDM patients associated with obesity.

PubMed ID: 8621021

DOI: 10.2337/diab.45.5.675

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8589726

Title: Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin.

PubMed ID: 8589726

DOI: 10.1038/ng0396-318

PubMed ID: 10428856

Title: OB-BP1/Siglec-6. A leptin- and sialic acid-binding protein of the immunoglobulin superfamily.

PubMed ID: 10428856

DOI: 10.1074/jbc.274.32.22729

PubMed ID: 10896907

Title: Leptin secretion and leptin receptor in the human stomach.

PubMed ID: 10896907

DOI: 10.1136/gut.47.2.178

PubMed ID: 11460888

Title: Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro.

PubMed ID: 11460888

DOI: 10.1038/emm.2001.17

PubMed ID: 12448771

Title: Intralobular ducts of human major salivary glands contain leptin and its receptor.

PubMed ID: 12448771

DOI: 10.1046/j.0021-8782.2002.00106.x

PubMed ID: 12504075

Title: Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines.

PubMed ID: 12504075

DOI: 10.1016/s0006-291x(02)02838-3

PubMed ID: 15122202

Title: The weight of leptin in immunity.

PubMed ID: 15122202

DOI: 10.1038/nri1350

PubMed ID: 15899045

Title: signaling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1.

PubMed ID: 15899045

DOI: 10.1186/ar1708

PubMed ID: 16052473

Title: Leptin expression in human primary skeletal muscle cells is reduced during differentiation.

PubMed ID: 16052473

DOI: 10.1002/jcb.20521

PubMed ID: 17344214

Title: leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3.

PubMed ID: 17344214

DOI: 10.1074/jbc.m609798200

PubMed ID: 18242580

Title: up-regulation of survivin by leptin/STAT3 signaling in MCF-7 cells.

PubMed ID: 18242580

DOI: 10.1016/j.bbrc.2007.04.004

PubMed ID: 19688109

Title: Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage--mediator role of NO in leptin-induced PGE2, IL-6, and IL-8 production.

PubMed ID: 19688109

DOI: 10.1155/2009/345838

PubMed ID: 24340098

Title: Leptin inhibits glucose intestinal absorption via PKC, p38MAPK, PI3K and MEK/ERK.

PubMed ID: 24340098

DOI: 10.1371/journal.pone.0083360

PubMed ID: 25232147

Title: 20 years of leptin: connecting leptin signaling to biological function.

PubMed ID: 25232147

DOI: 10.1530/joe-14-0404

PubMed ID: 25060689

Title: Leptin modulates autophagy in human CD4+CD25- conventional T cells.

PubMed ID: 25060689

DOI: 10.1016/j.metabol.2014.06.010

PubMed ID: 9166907

Title: Leptin is a four-helix bundle: secondary structure by NMR.

PubMed ID: 9166907

DOI: 10.1016/s0014-5793(97)00353-0

PubMed ID: 9144295

Title: Crystal structure of the obese protein leptin-E100.

PubMed ID: 9144295

DOI: 10.1038/387206a0

PubMed ID: 9500540

Title: A leptin missense mutation associated with hypogonadism and morbid obesity.

PubMed ID: 9500540

DOI: 10.1038/ng0398-213

PubMed ID: 25551525

Title: Biologically inactive leptin and early-onset extreme obesity.

PubMed ID: 25551525

DOI: 10.1056/nejmoa1406653

Sequence Information:

Length: 167
Mass: 18641
Checksum: C91A121E92D37B69
Sequence:

MHWGTLCGFL WLWPYLFYVQ AVPIQKVQDD TKTLIKTIVT RINDISHTQS VSSKQKVTGL 
DFIPGLHPIL TLSKMDQTLA VYQQILTSMP SRNVIQISND LENLRDLLHV LAFSKSCHLP 
WASGLETLDS LGGVLEASGY STEVVALSRL QGSLQDMLWQ LDLSPGC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: LEP

Associated with

Cells (max top 100)

Other Information

Positional cloning of the mouse obese gene and its human homologue. PubMed ID: 7984236

Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue. PubMed ID: 7789654

Genomic structure and promoter analysis of the human obese gene. PubMed ID: 8626726

Structural organization and chromosomal assignment of the human obese gene. PubMed ID: 7499240

Human obese gene: molecular screening in Japanese and Asian Indian NIDDM patients associated with obesity. PubMed ID: 8621021

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. PubMed ID: 8589726

OB-BP1/Siglec-6. A leptin- and sialic acid-binding protein of the immunoglobulin superfamily. PubMed ID: 10428856

Leptin secretion and leptin receptor in the human stomach. PubMed ID: 10896907

Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro. PubMed ID: 11460888

Intralobular ducts of human major salivary glands contain leptin and its receptor. PubMed ID: 12448771

Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines. PubMed ID: 12504075

The weight of leptin in immunity. PubMed ID: 15122202

signaling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1. PubMed ID: 15899045

Leptin expression in human primary skeletal muscle cells is reduced during differentiation. PubMed ID: 16052473

leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. PubMed ID: 17344214

up-regulation of survivin by leptin/STAT3 signaling in MCF-7 cells. PubMed ID: 18242580

Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage--mediator role of NO in leptin-induced PGE2, IL-6, and IL-8 production. PubMed ID: 19688109

Leptin inhibits glucose intestinal absorption via PKC, p38MAPK, PI3K and MEK/ERK. PubMed ID: 24340098

20 years of leptin: connecting leptin signaling to biological function. PubMed ID: 25232147

Leptin modulates autophagy in human CD4+CD25- conventional T cells. PubMed ID: 25060689

Leptin is a four-helix bundle: secondary structure by NMR. PubMed ID: 9166907

Crystal structure of the obese protein leptin-E100. PubMed ID: 9144295

A leptin missense mutation associated with hypogonadism and morbid obesity. PubMed ID: 9500540

Biologically inactive leptin and early-onset extreme obesity. PubMed ID: 25551525