Gene LEP - ENSG00000174697 | NCBI Gene ID: 3952

Details for: LEP

Gene ID: 3952

Symbol: LEP

Ensembl ID: ENSG00000174697

Description: leptin

Associated with

Developmental biology
(R-HSA-1266738)
Incretin synthesis, secretion, and inactivation
(R-HSA-400508)
Metabolism of proteins
(R-HSA-392499)
Peptide hormone metabolism
(R-HSA-2980736)
Signaling by leptin
(R-HSA-2586552)
Signal transduction
(R-HSA-162582)
Synthesis, secretion, and deacylation of ghrelin
(R-HSA-422085)
Synthesis, secretion, and inactivation of glucagon-like peptide-1 (glp-1)
(R-HSA-381771)
Transcriptional regulation of white adipocyte differentiation
(R-HSA-381340)
Adipose tissue development
(GO:0060612)
Adult feeding behavior
(GO:0008343)
Angiogenesis
(GO:0001525)
Aorta development
(GO:0035904)
Bile acid metabolic process
(GO:0008206)
Bone mineralization involved in bone maturation
(GO:0035630)
Cardiac muscle hypertrophy
(GO:0003300)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to leptin stimulus
(GO:0044320)
Central nervous system neuron development
(GO:0021954)
Cholesterol metabolic process
(GO:0008203)
Circadian rhythm
(GO:0007623)
Determination of adult lifespan
(GO:0008340)
Dna binding
(GO:0003677)
Eating behavior
(GO:0042755)
Elastin metabolic process
(GO:0051541)
Energy reserve metabolic process
(GO:0006112)
Fatty acid beta-oxidation
(GO:0006635)
Female pregnancy
(GO:0007565)
Glucose homeostasis
(GO:0042593)
Glucose metabolic process
(GO:0006006)
Glycerol biosynthetic process
(GO:0006114)
Hormone activity
(GO:0005179)
Hormone metabolic process
(GO:0042445)
Insulin secretion
(GO:0030073)
Intestinal absorption
(GO:0050892)
Intracellular signal transduction
(GO:0035556)
Leptin-mediated signaling pathway
(GO:0033210)
Leptin receptor binding
(GO:1990460)
Leukocyte tethering or rolling
(GO:0050901)
Lipid metabolic process
(GO:0006629)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of appetite
(GO:0032099)
Negative regulation of appetite by leptin-mediated signaling pathway
(GO:0038108)
Negative regulation of autophagy
(GO:0010507)
Negative regulation of cartilage development
(GO:0061037)
Negative regulation of glucose import
(GO:0046325)
Negative regulation of lipid storage
(GO:0010888)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of vasoconstriction
(GO:0045906)
Ovulation from ovarian follicle
(GO:0001542)
Peptide hormone receptor binding
(GO:0051428)
Phagocytosis
(GO:0006909)
Placenta development
(GO:0001890)
Positive regulation of developmental growth
(GO:0048639)
Positive regulation of follicle-stimulating hormone secretion
(GO:0046881)
Positive regulation of insulin receptor signaling pathway
(GO:0046628)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of interleukin-12 production
(GO:0032735)
Positive regulation of luteinizing hormone secretion
(GO:0033686)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of monoatomic ion transport
(GO:0043270)
Positive regulation of peroxisome proliferator activated receptor signaling pathway
(GO:0035360)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of protein import into nucleus
(GO:0042307)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of receptor signaling pathway via jak-stat
(GO:0046427)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of tor signaling
(GO:0032008)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of tyrosine phosphorylation of stat protein
(GO:0042531)
Prostaglandin secretion
(GO:0032310)
Protein binding
(GO:0005515)
Regulation of angiogenesis
(GO:0045765)
Regulation of blood pressure
(GO:0008217)
Regulation of bone remodeling
(GO:0046850)
Regulation of cell cycle
(GO:0051726)
Regulation of endothelial cell proliferation
(GO:0001936)
Regulation of gluconeogenesis
(GO:0006111)
Regulation of insulin secretion
(GO:0050796)
Regulation of intestinal cholesterol absorption
(GO:0030300)
Regulation of lipoprotein lipid oxidation
(GO:0060587)
Regulation of natural killer cell activation
(GO:0032814)
Regulation of natural killer cell mediated cytotoxicity
(GO:0042269)
Regulation of natural killer cell proliferation
(GO:0032817)
Regulation of nitric-oxide synthase activity
(GO:0050999)
Regulation of steroid biosynthetic process
(GO:0050810)
Response to activity
(GO:0014823)
Response to dietary excess
(GO:0002021)
Response to estradiol
(GO:0032355)
Response to ethanol
(GO:0045471)
Response to hypoxia
(GO:0001666)
Response to insulin
(GO:0032868)
Response to vitamin e
(GO:0033197)
Sexual reproduction
(GO:0019953)
T cell differentiation
(GO:0030217)
Tyrosine phosphorylation of stat protein
(GO:0007260)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 2.27
Marker Score: 2284
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 1.63
Marker Score: 1122
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.62
Marker Score: 1175
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.6
Marker Score: 778
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 1.36
Marker Score: 498
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.27
Marker Score: 860
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.18
Marker Score: 490
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4822
Cell Name: goblet cell (CL0000160)
Fold Change: 1.14
Marker Score: 7591
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.12
Marker Score: 708
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.1
Marker Score: 506
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251815.5
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71833.5
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48058
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 512
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 465
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30409
Cell Name: fat cell (CL0000136)
Fold Change: 0.96
Marker Score: 539
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.94
Marker Score: 376
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5353
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2743
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 328
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5290
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.86
Marker Score: 654
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.82
Marker Score: 1668
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.78
Marker Score: 1484
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1269
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 711
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 399
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 464
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 180
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.69
Marker Score: 10872
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.59
Marker Score: 470
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.55
Marker Score: 292
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 175
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.47
Marker Score: 279
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.46
Marker Score: 275
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 0.45
Marker Score: 118
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.42
Marker Score: 408.5
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.4
Marker Score: 192
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.39
Marker Score: 163
Cell Name: mast cell (CL0000097)
Fold Change: 0.38
Marker Score: 219
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 374
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.32
Marker Score: 180.5
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.32
Marker Score: 84
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.3
Marker Score: 199
Cell Name: B cell (CL0000236)
Fold Change: 0.29
Marker Score: 278
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.27
Marker Score: 170
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.25
Marker Score: 192
Cell Name: macrophage (CL0000235)
Fold Change: 0.24
Marker Score: 272
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.24
Marker Score: 498
Cell Name: neutrophil (CL0000775)
Fold Change: 0.24
Marker Score: 145
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 65
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.22
Marker Score: 99
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 75
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.19
Marker Score: 102
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.17
Marker Score: 77
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 42
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.16
Marker Score: 203
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.15
Marker Score: 154
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.15
Marker Score: 80
Cell Name: retina horizontal cell (CL0000745)
Fold Change: 0.15
Marker Score: 144.5
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.13
Marker Score: 74
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.13
Marker Score: 115
Cell Name: trophoblast giant cell (CL0002488)
Fold Change: 0.13
Marker Score: 41.5
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.11
Marker Score: 35
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.11
Marker Score: 35
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.09
Marker Score: 18
Cell Name: glial cell (CL0000125)
Fold Change: 0.09
Marker Score: 98
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.08
Marker Score: 28
Cell Name: pericyte (CL0000669)
Fold Change: 0.08
Marker Score: 44
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.07
Marker Score: 18
Cell Name: granulocyte (CL0000094)
Fold Change: 0.07
Marker Score: 30
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.07
Marker Score: 37
Cell Name: fibroblast (CL0000057)
Fold Change: 0.06
Marker Score: 61
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.06
Marker Score: 15
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.06
Marker Score: 56
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.06
Marker Score: 41
Cell Name: plasma cell (CL0000786)
Fold Change: 0.06
Marker Score: 66
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.06
Marker Score: 15
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.06
Marker Score: 86
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.06
Marker Score: 20
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.05
Marker Score: 15
Cell Name: melanocyte (CL0000148)
Fold Change: 0.05
Marker Score: 22
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.05
Marker Score: 66.5
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.05
Marker Score: 44
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.05
Marker Score: 55
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.05
Marker Score: 18
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.05
Marker Score: 121
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.05
Marker Score: 18
Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.05
Marker Score: 16
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.05
Marker Score: 33
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.05
Marker Score: 18
Cell Name: eosinophil (CL0000771)
Fold Change: 0.05
Marker Score: 16
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.05
Marker Score: 18
Cell Name: astrocyte (CL0000127)
Fold Change: 0.05
Marker Score: 42
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.05
Marker Score: 14
Cell Name: amacrine cell (CL0000561)
Fold Change: 0.05
Marker Score: 147
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.05
Marker Score: 21

Hover over a box to see details here...

**Key characteristics:** - Leptin is a glycoprotein with a molecular weight of approximately 120 kDa. - It is a key factor in regulating food intake and body weight. - It is produced in response to fasting or starvation and acts on the leptin receptor to stimulate food intake and reduce metabolism. - It also plays a role in regulating the growth and development of white adipose tissue. - It is involved in the regulation of fertility and may play a role in pregnancy. **Pathways and functions:** - Leptin binds to the leptin receptor on the surface of target cells, which are typically cells of the central nervous system. - This binding triggers a cascade of intracellular events that lead to the activation of downstream signaling pathways. - These pathways include the activation of the PI3K/Akt pathway, which is involved in cell growth, metabolism, and survival. - Leptin also plays a role in the regulation of hunger and thirst. - It inhibits the expression of genes involved in appetite, such as those encoding for ghrelin and leptin receptors. - It also promotes the expression of genes involved in energy metabolism, such as those encoding for lipase and acetyl-CoA carboxylase. **Clinical significance:** - Mutations in the LEP gene have been linked to obesity, type 2 diabetes, and other metabolic disorders. - In humans, a single copy of the LEP gene is sufficient to maintain normal body weight. - However, people with two copies of the gene are more likely to be obese and have a higher risk of developing type 2 diabetes. - Leptin is a potential therapeutic target for the treatment of obesity and related metabolic disorders. **Conclusion:** Leptin is a key regulator of energy balance and metabolism. It plays a critical role in maintaining body weight, regulating food intake, and promoting fertility. Mutations in the LEP gene have been linked to a number of metabolic disorders, highlighting its importance in human health.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Obese protein

Genular Protein ID: 1881838937

Symbol: LEP_HUMAN

Name: Obese protein

UniProtKB Accession Codes:

P41159 O15158 Q56A88

Database IDs:

Citations:

PubMed ID: 7984236

Title: Positional cloning of the mouse obese gene and its human homologue.

PubMed ID: 7984236

DOI: 10.1038/372425a0

PubMed ID: 7789654

Title: Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue.

PubMed ID: 7789654

DOI: 10.2337/diab.44.7.855

PubMed ID: 8626726

Title: Genomic structure and promoter analysis of the human obese gene.

PubMed ID: 8626726

DOI: 10.1074/jbc.271.8.3971

PubMed ID: 7499240

Title: Structural organization and chromosomal assignment of the human obese gene.

PubMed ID: 7499240

DOI: 10.1074/jbc.270.46.27728

PubMed ID: 8621021

Title: Human obese gene: molecular screening in Japanese and Asian Indian NIDDM patients associated with obesity.

PubMed ID: 8621021

DOI: 10.2337/diab.45.5.675

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8589726

Title: Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin.

PubMed ID: 8589726

DOI: 10.1038/ng0396-318

PubMed ID: 10428856

Title: OB-BP1/Siglec-6. A leptin- and sialic acid-binding protein of the immunoglobulin superfamily.

PubMed ID: 10428856

DOI: 10.1074/jbc.274.32.22729

PubMed ID: 10896907

Title: Leptin secretion and leptin receptor in the human stomach.

PubMed ID: 10896907

DOI: 10.1136/gut.47.2.178

PubMed ID: 11460888

Title: Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro.

PubMed ID: 11460888

DOI: 10.1038/emm.2001.17

PubMed ID: 12448771

Title: Intralobular ducts of human major salivary glands contain leptin and its receptor.

PubMed ID: 12448771

DOI: 10.1046/j.0021-8782.2002.00106.x

PubMed ID: 12504075

Title: Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines.

PubMed ID: 12504075

DOI: 10.1016/s0006-291x(02)02838-3

PubMed ID: 15122202

Title: The weight of leptin in immunity.

PubMed ID: 15122202

DOI: 10.1038/nri1350

PubMed ID: 15899045

Title: signaling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1.

PubMed ID: 15899045

DOI: 10.1186/ar1708

PubMed ID: 16052473

Title: Leptin expression in human primary skeletal muscle cells is reduced during differentiation.

PubMed ID: 16052473

DOI: 10.1002/jcb.20521

PubMed ID: 17344214

Title: leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3.

PubMed ID: 17344214

DOI: 10.1074/jbc.m609798200

PubMed ID: 18242580

Title: up-regulation of survivin by leptin/STAT3 signaling in MCF-7 cells.

PubMed ID: 18242580

DOI: 10.1016/j.bbrc.2007.04.004

PubMed ID: 19688109

Title: Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage--mediator role of NO in leptin-induced PGE2, IL-6, and IL-8 production.

PubMed ID: 19688109

DOI: 10.1155/2009/345838

PubMed ID: 24340098

Title: Leptin inhibits glucose intestinal absorption via PKC, p38MAPK, PI3K and MEK/ERK.

PubMed ID: 24340098

DOI: 10.1371/journal.pone.0083360

PubMed ID: 25232147

Title: 20 years of leptin: connecting leptin signaling to biological function.

PubMed ID: 25232147

DOI: 10.1530/joe-14-0404

PubMed ID: 25060689

Title: Leptin modulates autophagy in human CD4+CD25- conventional T cells.

PubMed ID: 25060689

DOI: 10.1016/j.metabol.2014.06.010

PubMed ID: 9166907

Title: Leptin is a four-helix bundle: secondary structure by NMR.

PubMed ID: 9166907

DOI: 10.1016/s0014-5793(97)00353-0

PubMed ID: 9144295

Title: Crystal structure of the obese protein leptin-E100.

PubMed ID: 9144295

DOI: 10.1038/387206a0

PubMed ID: 9500540

Title: A leptin missense mutation associated with hypogonadism and morbid obesity.

PubMed ID: 9500540

DOI: 10.1038/ng0398-213

PubMed ID: 25551525

Title: Biologically inactive leptin and early-onset extreme obesity.

PubMed ID: 25551525

DOI: 10.1056/nejmoa1406653

Sequence Information:

Length: 167
Mass: 18641
Checksum: C91A121E92D37B69
Sequence:

MHWGTLCGFL WLWPYLFYVQ AVPIQKVQDD TKTLIKTIVT RINDISHTQS VSSKQKVTGL 
DFIPGLHPIL TLSKMDQTLA VYQQILTSMP SRNVIQISND LENLRDLLHV LAFSKSCHLP 
WASGLETLDS LGGVLEASGY STEVVALSRL QGSLQDMLWQ LDLSPGC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: LEP

Associated with

Cells (max top 100)

Other Information

Positional cloning of the mouse obese gene and its human homologue. PubMed ID: 7984236

Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue. PubMed ID: 7789654

Genomic structure and promoter analysis of the human obese gene. PubMed ID: 8626726

Structural organization and chromosomal assignment of the human obese gene. PubMed ID: 7499240

Human obese gene: molecular screening in Japanese and Asian Indian NIDDM patients associated with obesity. PubMed ID: 8621021

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. PubMed ID: 8589726

OB-BP1/Siglec-6. A leptin- and sialic acid-binding protein of the immunoglobulin superfamily. PubMed ID: 10428856

Leptin secretion and leptin receptor in the human stomach. PubMed ID: 10896907

Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro. PubMed ID: 11460888

Intralobular ducts of human major salivary glands contain leptin and its receptor. PubMed ID: 12448771

Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines. PubMed ID: 12504075

The weight of leptin in immunity. PubMed ID: 15122202

signaling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1. PubMed ID: 15899045

Leptin expression in human primary skeletal muscle cells is reduced during differentiation. PubMed ID: 16052473

leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. PubMed ID: 17344214

up-regulation of survivin by leptin/STAT3 signaling in MCF-7 cells. PubMed ID: 18242580

Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage--mediator role of NO in leptin-induced PGE2, IL-6, and IL-8 production. PubMed ID: 19688109

Leptin inhibits glucose intestinal absorption via PKC, p38MAPK, PI3K and MEK/ERK. PubMed ID: 24340098

20 years of leptin: connecting leptin signaling to biological function. PubMed ID: 25232147

Leptin modulates autophagy in human CD4+CD25- conventional T cells. PubMed ID: 25060689

Leptin is a four-helix bundle: secondary structure by NMR. PubMed ID: 9166907

Crystal structure of the obese protein leptin-E100. PubMed ID: 9144295

A leptin missense mutation associated with hypogonadism and morbid obesity. PubMed ID: 9500540

Biologically inactive leptin and early-onset extreme obesity. PubMed ID: 25551525