Details for: PFKFB1

Gene ID: 5207

Symbol: PFKFB1

Ensembl ID: ENSG00000158571

Description: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 5.08
    Marker Score: 14827.5
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 4.24
    Marker Score: 4062
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.5
    Marker Score: 29640
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.43
    Marker Score: 9846
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 3.28
    Marker Score: 9725
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.95
    Marker Score: 1432
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.32
    Marker Score: 6615
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.74
    Marker Score: 975
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1172
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.52
    Marker Score: 9773
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.44
    Marker Score: 7739
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.35
    Marker Score: 5847
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 856
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4817
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 503
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71829
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48053
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.99
    Marker Score: 361
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.98
    Marker Score: 407
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5338
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.89
    Marker Score: 521
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.88
    Marker Score: 1659
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.85
    Marker Score: 578
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.82
    Marker Score: 477
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 628
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.76
    Marker Score: 200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.74
    Marker Score: 492
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 462
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.66
    Marker Score: 2164
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 387
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.63
    Marker Score: 1491
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.6
    Marker Score: 647
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.58
    Marker Score: 1177
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 459
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 239
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.55
    Marker Score: 178
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.55
    Marker Score: 171
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.54
    Marker Score: 8383
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.5
    Marker Score: 109
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 475
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.48
    Marker Score: 3188
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.39
    Marker Score: 242
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.37
    Marker Score: 520
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.37
    Marker Score: 915
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.33
    Marker Score: 123
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.32
    Marker Score: 327
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.31
    Marker Score: 189
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.31
    Marker Score: 109
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.31
    Marker Score: 116
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.28
    Marker Score: 301
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.27
    Marker Score: 238
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.27
    Marker Score: 71
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.26
    Marker Score: 1021
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.25
    Marker Score: 121
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.24
    Marker Score: 77
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.24
    Marker Score: 71
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.24
    Marker Score: 185
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.23
    Marker Score: 230
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.23
    Marker Score: 93
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.22
    Marker Score: 798
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.22
    Marker Score: 219
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.22
    Marker Score: 129
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.21
    Marker Score: 64
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.19
    Marker Score: 60
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.19
    Marker Score: 106
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.19
    Marker Score: 82
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.18
    Marker Score: 88
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.18
    Marker Score: 733
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.17
    Marker Score: 92
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.17
    Marker Score: 697
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.16
    Marker Score: 73
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.15
    Marker Score: 3286
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.15
    Marker Score: 84
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.15
    Marker Score: 167
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.15
    Marker Score: 186
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.15
    Marker Score: 232
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.15
    Marker Score: 233
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.14
    Marker Score: 131
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.14
    Marker Score: 127
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.14
    Marker Score: 55
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.14
    Marker Score: 1797
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.13
    Marker Score: 1140
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.13
    Marker Score: 4461

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Other Information

**Key characteristics:** - PFKFB1 is a protein of the phosphatase family. - It is involved in the regulation of glucose metabolism, especially in the liver. - PFKFB1 is highly expressed in cells of the central nervous system, including retinal cells and hepatocytes. **Pathways and functions:** - PFKFB1 activity is regulated by a variety of factors, including the hormones glucagon and epinephrine. - It is also regulated by changes in blood glucose levels. - PFKFB1 activity is essential for the regulation of hepatic glucose production, the production of glucose from non-carbohydrate sources, and the regulation of lipid metabolism. - PFKFB1 is a key regulator of the metabolic processes that occur in the liver, including glycolysis, gluconeogenesis, and lipid synthesis. **Clinical significance:** - Mutations in the PFKFB1 gene have been linked to a number of human diseases, including diabetes, obesity, and fatty liver disease. - PFKFB1 inhibitors are being investigated as potential treatments for these diseases.

Genular Protein ID: 4178592275

Symbol: F261_HUMAN

Name: 6PF-2-K/Fru-2,6-P2ase liver isozyme

UniProtKB Accession Codes:

P16118 B2RA88 B4DUN5 Q5JXS5 Q99951

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 31 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 EC 2 EMBL 7 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 3 Rhea 4 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2163524

Title: Sequence of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

PubMed ID: 2163524

DOI: 10.1093/nar/18.12.3652

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2837207

Title: Molecular cloning, sequence analysis, and expression of a human liver cDNA coding for fructose-6-P,2-kinase:fructose-2,6-bisphosphatase.

PubMed ID: 2837207

DOI: 10.1016/s0006-291x(88)81226-9

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12379646

Title: Tissue-specific structure/function differentiation of the liver isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

PubMed ID: 12379646

DOI: 10.1074/jbc.m209105200

Sequence Information:

  • Length: 471
  • Mass: 54681
  • Checksum: C4FF081A295FB7D3
  • Sequence:
    • MSPEMGELTQ TRLQKIWIPH SSGSSRLQRR RGSSIPQFTN SPTMVIMVGL PARGKTYIST 
KLTRYLNWIG TPTKVFNLGQ YRREAVSYKN YEFFLPDNME ALQIRKQCAL AALKDVHNYL 
SHEEGHVAVF DATNTTRERR SLILQFAKEH GYKVFFIESI CNDPGIIAEN IRQVKLGSPD 
YIDCDREKVL EDFLKRIECY EVNYQPLDEE LDSHLSYIKI FDVGTRYMVN RVQDHIQSRT 
VYYLMNIHVT PRSIYLCRHG ESELNIRGRI GGDSGLSVRG KQYAYALANF IQSQGISSLK 
VWTSHMKRTI QTAEALGVPY EQWKALNEID AGVCEEMTYE EIQEHYPEEF ALRDQDKYRY 
RYPKGESYED LVQRLEPVIM ELERQENVLV ICHQAVMRCL LAYFLDKSSD ELPYLKCPLH 
TVLKLTPVAY GCKVESIYLN VEAVNTHREK PENVDITREP EEALDTVPAH Y

Genular Protein ID: 2309598238

Symbol: I1Z9G4_HUMAN

Name: N/A

UniProtKB Accession Codes:

I1Z9G4

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 5 Gene3D 2 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 3 RefSeq 1 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 449
  • Mass: 51958
  • Checksum: 4187ABB37C782804
  • Sequence:
    • MSPEMGELTQ TRLQKIWIPH SSGSSRLQRR RGSSIPQFTN SPTMVIMVGL PARGKTYIST 
KLTRYLNWIG TPTKDNMEAL QIRKQCALAA LKDVHNYLSH EEGHVAVFDA TNTTRERRSL 
ILQFAKEHGY KVFFIESICN DPGIIAENIR QVKLGSPDYI DCDREKVLED FLKRIECYEV 
NYQPLDEELD SHLSYIKIFD VGTRYMVNRV QDHIQSRTVY YLMNIHVTPR SIYLCRHGES 
ELNIRGRIGG DSGLSVRGKQ YAYALANFIQ SQGISSLKVW TSHMKRTIQT AEALGVPYEQ 
WKALNEIDAG VCEEMTYEEI QEHYPEEFAL RDQDKYRYRY PKGESYEDLV QRLEPVIMEL 
ERQENVLVIC HQAVMRCLLA YFLDKSSDEL PYLKCPLHTV LKLTPVAYGC KVESIYLNVE 
AVNTHREKPE NVDITREPEE ALDTVPAHY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.