Details for: PFKFB1

Gene ID: 5207

Symbol: PFKFB1

Ensembl ID: ENSG00000158571

Description: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 3.9640
    Cell Significance Index: 49.9200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.1089
    Cell Significance Index: 52.2900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.8103
    Cell Significance Index: 47.3400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.1220
    Cell Significance Index: 28.8400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.0482
    Cell Significance Index: 25.5800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.0053
    Cell Significance Index: 16.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7893
    Cell Significance Index: 156.6300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6298
    Cell Significance Index: 13.7900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2575
    Cell Significance Index: 49.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2270
    Cell Significance Index: 22.4600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1935
    Cell Significance Index: 174.7600
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.1930
    Cell Significance Index: 0.8400
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.1858
    Cell Significance Index: 1.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1413
    Cell Significance Index: 4.0700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0996
    Cell Significance Index: 1.4700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0935
    Cell Significance Index: 1.9400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0795
    Cell Significance Index: 2.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0561
    Cell Significance Index: 9.1200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0548
    Cell Significance Index: 1.0700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0547
    Cell Significance Index: 5.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0507
    Cell Significance Index: 1.7800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0492
    Cell Significance Index: 0.7000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0417
    Cell Significance Index: 8.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0340
    Cell Significance Index: 2.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0286
    Cell Significance Index: 5.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0279
    Cell Significance Index: 8.0200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.0268
    Cell Significance Index: 0.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0227
    Cell Significance Index: 1.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0220
    Cell Significance Index: 0.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0192
    Cell Significance Index: 6.9000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0174
    Cell Significance Index: 1.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0143
    Cell Significance Index: 0.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0044
    Cell Significance Index: 0.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0026
    Cell Significance Index: 0.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0021
    Cell Significance Index: 3.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0019
    Cell Significance Index: 3.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0017
    Cell Significance Index: 2.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0014
    Cell Significance Index: 2.5800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0033
    Cell Significance Index: -0.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0036
    Cell Significance Index: -2.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0039
    Cell Significance Index: -2.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0051
    Cell Significance Index: -3.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0051
    Cell Significance Index: -2.8100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0053
    Cell Significance Index: -3.8700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0054
    Cell Significance Index: -3.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0060
    Cell Significance Index: -2.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0080
    Cell Significance Index: -1.1700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0103
    Cell Significance Index: -0.1400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0108
    Cell Significance Index: -0.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0113
    Cell Significance Index: -0.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0115
    Cell Significance Index: -1.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0159
    Cell Significance Index: -1.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0159
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0168
    Cell Significance Index: -3.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0180
    Cell Significance Index: -2.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0214
    Cell Significance Index: -1.2000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0230
    Cell Significance Index: -0.3300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0233
    Cell Significance Index: -3.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0233
    Cell Significance Index: -2.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0257
    Cell Significance Index: -2.9900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0258
    Cell Significance Index: -0.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0283
    Cell Significance Index: -0.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0296
    Cell Significance Index: -2.2700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0330
    Cell Significance Index: -3.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0347
    Cell Significance Index: -1.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0353
    Cell Significance Index: -0.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0374
    Cell Significance Index: -3.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0439
    Cell Significance Index: -2.2800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0473
    Cell Significance Index: -0.8100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0505
    Cell Significance Index: -0.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0553
    Cell Significance Index: -2.6000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0571
    Cell Significance Index: -1.8700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0650
    Cell Significance Index: -2.0700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0659
    Cell Significance Index: -2.3100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0676
    Cell Significance Index: -3.5200
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0698
    Cell Significance Index: -0.9300
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.0728
    Cell Significance Index: -0.7700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0764
    Cell Significance Index: -2.0800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0765
    Cell Significance Index: -2.8100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0774
    Cell Significance Index: -1.6200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0796
    Cell Significance Index: -1.2000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0804
    Cell Significance Index: -2.3000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0826
    Cell Significance Index: -1.9800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0857
    Cell Significance Index: -1.0000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0890
    Cell Significance Index: -2.2200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0896
    Cell Significance Index: -1.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0896
    Cell Significance Index: -2.8700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0938
    Cell Significance Index: -1.3200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0939
    Cell Significance Index: -2.9700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0951
    Cell Significance Index: -1.2300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0967
    Cell Significance Index: -2.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0992
    Cell Significance Index: -2.6500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1001
    Cell Significance Index: -2.0100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1004
    Cell Significance Index: -2.3200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1046
    Cell Significance Index: -2.2200
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: -0.1053
    Cell Significance Index: -1.2300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1065
    Cell Significance Index: -1.0100
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.1102
    Cell Significance Index: -0.4200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1108
    Cell Significance Index: -2.1900
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1110
    Cell Significance Index: -0.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Dual Enzyme Function:** PFKFB1 exhibits dual kinase and phosphatase activities, allowing it to regulate glycolysis and gluconeogenesis through the modulation of fructose-2,6-bisphosphate levels. 2. **Regulation by Hormones and Signaling Pathways:** PFKFB1 is responsive to various hormones, including insulin, glucagon, glucocorticoids, and cyclic AMP, which modulate its activity to fine-tune energy metabolism. 3. **Cell-Specific Expression:** The PFKFB1 gene is expressed in distinct cell types, including retinal bipolar cells, adipocytes, and colon goblet cells, highlighting its role in specific tissue functions. 4. **Metabolic Pathways:** PFKFB1 is involved in multiple metabolic pathways, including glycolysis, gluconeogenesis, and carbohydrate phosphorylation, emphasizing its central role in energy metabolism. **Pathways and Functions:** 1. **Glycolysis:** PFKFB1 regulates glycolysis by phosphorylating fructose-2,6-bisphosphate, a potent activator of the enzyme phosphofructokinase-1 (PFK-1), thereby promoting glucose uptake and metabolism. 2. **Gluconeogenesis:** PFKFB1 inhibits gluconeogenesis by dephosphorylating fructose-2,6-bisphosphate, reducing the activity of PFK-1 and impairing glucose production. 3. **Carbohydrate Phosphorylation:** PFKFB1 is involved in the phosphorylation of fructose-6-phosphate, a key intermediate in glycolysis, further highlighting its role in regulating carbohydrate metabolism. 4. **Energy Metabolism:** PFKFB1 integrates energy metabolism by responding to hormonal signals and modulating the activity of key enzymes involved in glycolysis and gluconeogenesis. **Clinical Significance:** 1. **Diabetes and Metabolic Disorders:** Alterations in PFKFB1 expression or activity have been linked to various metabolic disorders, including type 2 diabetes, obesity, and insulin resistance. 2. **Cancer:** PFKFB1 has been implicated in cancer progression, as its overexpression can promote glycolysis and tumor growth. 3. **Neurological Disorders:** PFKFB1 has been associated with neurological disorders, such as Alzheimer's disease, where its dysregulation can contribute to energy metabolism abnormalities. 4. **Therapeutic Applications:** Targeting PFKFB1 or its regulatory pathways may offer novel therapeutic strategies for the treatment of metabolic disorders, cancer, and neurological diseases. In conclusion, PFKFB1 is a multifaceted gene that plays a crucial role in regulating energy metabolism, glycolysis, and gluconeogenesis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying PFKFB1 function and its potential therapeutic applications.

Genular Protein ID: 4178592275

Symbol: F261_HUMAN

Name: 6PF-2-K/Fru-2,6-P2ase liver isozyme

UniProtKB Accession Codes:

P16118 B2RA88 B4DUN5 Q5JXS5 Q99951

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 31 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 EC 2 EMBL 7 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 3 Rhea 4 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2163524

Title: Sequence of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

PubMed ID: 2163524

DOI: 10.1093/nar/18.12.3652

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2837207

Title: Molecular cloning, sequence analysis, and expression of a human liver cDNA coding for fructose-6-P,2-kinase:fructose-2,6-bisphosphatase.

PubMed ID: 2837207

DOI: 10.1016/s0006-291x(88)81226-9

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12379646

Title: Tissue-specific structure/function differentiation of the liver isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

PubMed ID: 12379646

DOI: 10.1074/jbc.m209105200

Sequence Information:

  • Length: 471
  • Mass: 54681
  • Checksum: C4FF081A295FB7D3
  • Sequence:
    • MSPEMGELTQ TRLQKIWIPH SSGSSRLQRR RGSSIPQFTN SPTMVIMVGL PARGKTYIST 
KLTRYLNWIG TPTKVFNLGQ YRREAVSYKN YEFFLPDNME ALQIRKQCAL AALKDVHNYL 
SHEEGHVAVF DATNTTRERR SLILQFAKEH GYKVFFIESI CNDPGIIAEN IRQVKLGSPD 
YIDCDREKVL EDFLKRIECY EVNYQPLDEE LDSHLSYIKI FDVGTRYMVN RVQDHIQSRT 
VYYLMNIHVT PRSIYLCRHG ESELNIRGRI GGDSGLSVRG KQYAYALANF IQSQGISSLK 
VWTSHMKRTI QTAEALGVPY EQWKALNEID AGVCEEMTYE EIQEHYPEEF ALRDQDKYRY 
RYPKGESYED LVQRLEPVIM ELERQENVLV ICHQAVMRCL LAYFLDKSSD ELPYLKCPLH 
TVLKLTPVAY GCKVESIYLN VEAVNTHREK PENVDITREP EEALDTVPAH Y

Genular Protein ID: 2309598238

Symbol: I1Z9G4_HUMAN

Name: N/A

UniProtKB Accession Codes:

I1Z9G4

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 2 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 3 RefSeq 1 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 449
  • Mass: 51958
  • Checksum: 4187ABB37C782804
  • Sequence:
    • MSPEMGELTQ TRLQKIWIPH SSGSSRLQRR RGSSIPQFTN SPTMVIMVGL PARGKTYIST 
KLTRYLNWIG TPTKDNMEAL QIRKQCALAA LKDVHNYLSH EEGHVAVFDA TNTTRERRSL 
ILQFAKEHGY KVFFIESICN DPGIIAENIR QVKLGSPDYI DCDREKVLED FLKRIECYEV 
NYQPLDEELD SHLSYIKIFD VGTRYMVNRV QDHIQSRTVY YLMNIHVTPR SIYLCRHGES 
ELNIRGRIGG DSGLSVRGKQ YAYALANFIQ SQGISSLKVW TSHMKRTIQT AEALGVPYEQ 
WKALNEIDAG VCEEMTYEEI QEHYPEEFAL RDQDKYRYRY PKGESYEDLV QRLEPVIMEL 
ERQENVLVIC HQAVMRCLLA YFLDKSSDEL PYLKCPLHTV LKLTPVAYGC KVESIYLNVE 
AVNTHREKPE NVDITREPEE ALDTVPAHY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.