Details for: HSPA5
Gene ID: 3309
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: HSPA5
Ensembl ID: ENSG00000044574
Description: heat shock protein family A (Hsp70) member 5
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 119.44rCSI 93.96%PRS 4.88
-
CSI 90.03rCSI 77.95%PRS 4.55
-
CSI 79.05rCSI 97.79%PRS 3.59
-
CSI 78.36rCSI 63.36%PRS 4.02
-
CSI 73.78rCSI 71.02%PRS 4.23
-
CSI 70.7rCSI 62.17%PRS 2.95
-
CSI 68.6rCSI 61.95%PRS 3.61
-
CSI 67.58rCSI 70.79%PRS 3.82
-
CSI 64.96rCSI 67.9%PRS 4.35
-
CSI 64.19rCSI 63.14%PRS 4.49
-
CSI 62.66rCSI 41.65%PRS 4.89
-
CSI 60.78rCSI 40.51%PRS 11.57
-
CSI 60.7rCSI 63.59%PRS 4.38
-
CSI 55.02rCSI 56.32%PRS 7.77
-
CSI 54.89rCSI 84.81%PRS 3.84
-
CSI 54.7rCSI 36.85%PRS 4.98
-
CSI 53.92rCSI 41.8%PRS 3.9
-
CSI 53.35rCSI 51.44%PRS 2.06
-
CSI 51.81rCSI 67.91%PRS 22.12
-
CSI 49.24rCSI 52.32%PRS 7.32
-
CSI 47.47rCSI 42.14%PRS 4.1
-
CSI 46.69rCSI 67.34%PRS 5.7
-
CSI 45.4rCSI 31.7%PRS 4.32
-
CSI 45.02rCSI 37.32%PRS 3.83
-
CSI 43.83rCSI 33.16%PRS 5.76
-
CSI 43.29rCSI 32.53%PRS 4.22
-
CSI 42.13rCSI 43.96%PRS 4.19
-
CSI 42.09rCSI 52.82%PRS 5.2
-
CSI 41.97rCSI 55.78%PRS 4.47
-
CSI 40rCSI 57.66%PRS 6.64
-
CSI 38.41rCSI 36.29%PRS 4.27
-
CSI 38.09rCSI 45.63%PRS 7.13
-
CSI 37.84rCSI 29.91%PRS 2.83
-
CSI 37.42rCSI 31.37%PRS 4.92
-
CSI 37.32rCSI 57.08%PRS 6.7
-
CSI 37.31rCSI 29.62%PRS 7.31
-
CSI 36.97rCSI 30.04%PRS 4.3
-
CSI 35.23rCSI 68.51%PRS 4.18
-
CSI 34.65rCSI 25.98%PRS 12.45
-
CSI 34.2rCSI 64.56%PRS 5.12
-
CSI 33.53rCSI 51.52%PRS 5.91
-
CSI 33.12rCSI 38.41%PRS 6.15
-
CSI 32.36rCSI 52.19%PRS 6.66
-
CSI 31.75rCSI 38.11%PRS 4.09
-
CSI 31.39rCSI 53.78%PRS 5.48
-
CSI 29.72rCSI 25.62%PRS 6.79
-
CSI 29.57rCSI 53.73%PRS 6.27
-
CSI 28.98rCSI 49.58%PRS 8.96
-
CSI 28.61rCSI 42.24%PRS 6.48
-
CSI 28.06rCSI 67.32%PRS 7.79
-
CSI 27.91rCSI 37.3%PRS 7.86
-
CSI 27.02rCSI 48.77%PRS 12.51
-
CSI 26.5rCSI 32.96%PRS 4.37
-
CSI 26.1rCSI 24.08%PRS 4.14
-
CSI 25.12rCSI 34.79%PRS 5.9
-
CSI 24.94rCSI 31.99%PRS 4.73
-
CSI 24.3rCSI 53.06%PRS 8.4
-
CSI 23.61rCSI 32.27%PRS 4.53
-
CSI 23.46rCSI 24.5%PRS 13.27
-
CSI 23.19rCSI 33.98%PRS 4.86
-
CSI 23.06rCSI 51.05%PRS 3.85
-
CSI 22.59rCSI 80.18%PRS 6.75
-
CSI 22.37rCSI 64.44%PRS 8.35
-
CSI 22.03rCSI 21.99%PRS 3.46
-
CSI 21.89rCSI 23.46%PRS 3.78
-
CSI 21.22rCSI 24.92%PRS 39.12
-
CSI 21.09rCSI 50.38%PRS 6.64
-
CSI 20.83rCSI 66.84%PRS 6.15
-
CSI 20.82rCSI 28.46%PRS 4.64
-
CSI 20.71rCSI 59.96%PRS 4.64
-
CSI 20.58rCSI 18.08%PRS 4.59
-
CSI 20.13rCSI 20.85%PRS 4.81
-
CSI 20.01rCSI 37.55%PRS 8.17
-
CSI 19.81rCSI 42.17%PRS 6.65
-
CSI 19.03rCSI 49.46%PRS 12.7
-
CSI 18.87rCSI 75.13%PRS 7.33
-
CSI 18.41rCSI 20.73%PRS 6.86
-
CSI 18.13rCSI 14.65%PRS 10
-
CSI 17.81rCSI 16.58%PRS 4.08
-
CSI 17.79rCSI 62.42%PRS 7.44
-
CSI 17.72rCSI 20.5%PRS 2.97
-
CSI 17.54rCSI 25.04%PRS 4.66
-
CSI 17.44rCSI 48.88%PRS 6.44
-
CSI 17.19rCSI 17.41%PRS 26.78
-
CSI 17.01rCSI 26.38%PRS 6.5
-
CSI 17rCSI 26.85%PRS 4.11
-
CSI 16.73rCSI 15.36%PRS 4.69
-
CSI 16.72rCSI 44.03%PRS 8
-
CSI 16.7rCSI 38.94%PRS 10.9
-
CSI 16.61rCSI 73.86%PRS 19.01
-
CSI 16.43rCSI 39.05%PRS 6.24
-
CSI 16.39rCSI 89.23%PRS 10.59
-
CSI 16.33rCSI 20.79%PRS 4.78
-
CSI 16.26rCSI 17.81%PRS 4.76
-
CSI 16.26rCSI 94.6%PRS 6.15
-
CSI 15.16rCSI 34.67%PRS 3.98
-
CSI 15.01rCSI 40.47%PRS 5.33
-
CSI 15.01rCSI 73.98%PRS 5.54
-
CSI 15rCSI 67.47%PRS 22.23
-
CSI 14.68rCSI 21.72%PRS 4.71
-
CSI -11.5rCSI -25.8%PRS 2.7%
-
CSI -9.9rCSI -43.5%PRS 4.2%
-
CSI -9.6rCSI -30.2%PRS 2.9%
-
CSI -9.4rCSI -31.6%PRS 3.8%
-
CSI -8.7rCSI -17.5%PRS 3.1%
-
CSI -7.9rCSI -29.7%PRS 8.7%
-
CSI -7.6rCSI -17.6%PRS 3.7%
-
CSI -7.2rCSI -5.8%PRS 7.6%
-
CSI -6.9rCSI -8.3%PRS 2.5%
-
CSI -6.8rCSI -42.7%PRS 3.4%
-
CSI -6.6rCSI -18.3%PRS 4.8%
-
CSI -6.5rCSI -8.1%PRS 2.3%
-
CSI -5.6rCSI -27.0%PRS 2.3%
-
CSI -5.2rCSI -12.5%PRS 2.5%
-
CSI -4.6rCSI -18.9%PRS 12.4%
-
CSI -4.5rCSI -21.6%PRS 7.0%
-
CSI -4.5rCSI -76.1%PRS 21.3%
-
CSI -3.8rCSI -5.6%PRS 4.2%
-
CSI -3.3rCSI -12.4%PRS 2.7%
-
CSI -3.0rCSI -5.4%PRS 5.5%
-
CSI -2.8rCSI -27.3%PRS 44.6%
-
CSI -2.2rCSI -1.5%PRS 4.8%
-
CSI -1.9rCSI -5.7%PRS 7.0%
-
CSI -1.8rCSI -3.7%PRS 4.7%
-
CSI -1.7rCSI -6.2%PRS 2.2%
-
CSI -1.5rCSI -4.7%PRS 2.7%
-
CSI -1.5rCSI -3.0%PRS 1.4%
-
CSI -1.4rCSI -3.7%PRS 4.9%
-
CSI -1.3rCSI -24.4%PRS 34.1%
-
CSI -1.2rCSI -2.7%PRS 10.5%
-
CSI -1.2rCSI -13.1%PRS 51.9%
-
CSI -0.8rCSI -1.8%PRS 4.5%
-
CSI -0.8rCSI -3.9%PRS 21.1%
-
CSI -0.7rCSI -3.6%PRS 29.9%
-
CSI -0.7rCSI -22.4%PRS 60.7%
-
CSI -0.7rCSI -9.7%PRS 42.7%
-
CSI -0.6rCSI -2.4%PRS 5.1%
-
CSI -0.5rCSI -1.2%PRS 4.9%
-
CSI -0.4rCSI -0.7%PRS 2.5%
-
CSI -0.3rCSI -1.9%PRS 20.0%
-
CSI -0.3rCSI -1.9%PRS 2.8%
-
CSI -0.3rCSI -0.5%PRS 13.4%
-
CSI -0.2rCSI -0.6%PRS 6.0%
-
CSI -0.1rCSI -0.2%PRS 2.6%
-
CSI -0.1rCSI -0.1%PRS 7.2%
-
CSI 0.0rCSI -0.5%PRS 39.3%
-
CSI 0.0rCSI 0.3%PRS 64.6%
-
CSI 0.1rCSI 0.1%PRS 4.2%
-
CSI 0.1rCSI 0.2%PRS 2.7%
-
CSI 0.2rCSI 0.2%PRS 3.9%
-
CSI 0.2rCSI 0.4%PRS 3.0%
-
CSI 0.2rCSI 3.9%PRS 35.5%
-
CSI 0.2rCSI 0.5%PRS 9.1%
-
CSI 0.3rCSI 2.4%PRS 28.1%
-
CSI 0.3rCSI 1.6%PRS 15.6%
-
CSI 0.3rCSI 1.8%PRS 6.4%
-
CSI 0.3rCSI 4.6%PRS 44.9%
-
CSI 0.4rCSI 0.8%PRS 3.2%
-
CSI 0.5rCSI 2.1%PRS 11.5%
-
CSI 0.5rCSI 10.5%PRS 26.5%
-
CSI 0.6rCSI 1.7%PRS 3.6%
-
CSI 0.6rCSI 4.6%PRS 23.5%
-
CSI 0.6rCSI 0.9%PRS 3.5%
-
CSI 0.6rCSI 1.5%PRS 7.3%
-
CSI 0.6rCSI 11.0%PRS 17.4%
-
CSI 0.7rCSI 1.2%PRS 8.5%
-
CSI 0.7rCSI 1.2%PRS 2.5%
-
CSI 0.7rCSI 1.4%PRS 4.5%
-
CSI 0.7rCSI 1.4%PRS 10.1%
-
CSI 0.7rCSI 22.9%PRS 50.3%
-
CSI 0.8rCSI 10.7%PRS 25.3%
-
CSI 0.8rCSI 19.3%PRS 30.3%
-
CSI 0.9rCSI 18.3%PRS 35.2%
-
CSI 0.9rCSI 1.4%PRS 2.9%
-
CSI 0.9rCSI 1.7%PRS 6.6%
-
CSI 0.9rCSI 5.5%PRS 23.1%
-
CSI 1.0rCSI 9.9%PRS 12.6%
-
CSI 1.0rCSI 3.7%PRS 20.9%
-
CSI 1.0rCSI 1.4%PRS 4.5%
-
CSI 1.0rCSI 2.5%PRS 29.3%
-
CSI 1.1rCSI 4.5%PRS 18.2%
-
CSI 1.2rCSI 3.8%PRS 4.9%
-
CSI 1.2rCSI 3.0%PRS 3.3%
-
CSI 1.2rCSI 0.9%PRS 6.0%
-
CSI 1.3rCSI 20.5%PRS 27.3%
-
CSI 1.3rCSI 29.6%PRS 23.6%
-
CSI 1.4rCSI 3.6%PRS 7.0%
-
CSI 1.4rCSI 7.5%PRS 10.5%
-
CSI 1.4rCSI 13.0%PRS 15.9%
-
CSI 1.5rCSI 11.9%PRS 4.4%
-
CSI 1.5rCSI 6.7%PRS 16.6%
-
CSI 1.5rCSI 9.7%PRS 7.3%
-
CSI 1.6rCSI 14.7%PRS 18.5%
-
CSI 1.6rCSI 12.6%PRS 18.7%
-
CSI 1.6rCSI 16.6%PRS 37.4%
-
CSI 1.6rCSI 2.9%PRS 4.0%
-
CSI 1.7rCSI 2.7%PRS 10.5%
-
CSI 1.7rCSI 6.6%PRS 4.5%
-
CSI 1.8rCSI 4.0%PRS 5.9%
-
CSI 1.8rCSI 3.5%PRS 12.0%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 972276839
Symbol: BIP_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2840249
Title: Human gene encoding the 78,000-dalton glucose-regulated protein and its pseudogene: structure, conservation, and regulation.
PubMed ID: 2840249
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1480470
Title: A direct-repeat sequence of the human BiP gene is required for A23187-mediated inducibility and an inducible nuclear factor binding.
PubMed ID: 1480470
PubMed ID: 11160188
Title: The human endoplasmic reticulum molecular chaperone BiP is an autoantigen for rheumatoid arthritis and prevents the induction of experimental arthritis.
PubMed ID: 11160188
PubMed ID: 9150946
Title: Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.
PubMed ID: 9150946
PubMed ID: 2294010
PubMed ID: 9150948
Title: A two-dimensional gel database of human colon carcinoma proteins.
PubMed ID: 9150948
PubMed ID: 1550958
Title: Analysis in vivo of GRP78-BiP/substrate interactions and their role in induction of the GRP78-BiP gene.
PubMed ID: 1550958
DOI: 10.1091/mbc.3.2.143
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21289099
Title: Protective role of Gipie, a Girdin family protein, in endoplasmic reticulum stress responses in endothelial cells.
PubMed ID: 21289099
PubMed ID: 23349634
Title: A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.
PubMed ID: 23349634
PubMed ID: 12475965
Title: A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins.
PubMed ID: 12475965
PubMed ID: 12699405
Title: Association of stress proteins with autoantigens: a possible mechanism for triggering autoimmunity?
PubMed ID: 12699405
PubMed ID: 12411443
Title: ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress.
PubMed ID: 12411443
PubMed ID: 12643545
Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.
PubMed ID: 12643545
DOI: 10.1021/pr025562r
PubMed ID: 15098107
Title: Identification of GRP 78 (BiP) as a liver cell expressed receptor element for dengue virus serotype 2.
PubMed ID: 15098107
PubMed ID: 18621045
Title: Novel interactions of CLN3 protein link Batten disease to dysregulation of fodrin-Na+, K+ ATPase complex.
PubMed ID: 18621045
PubMed ID: 17081065
Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
PubMed ID: 17081065
DOI: 10.1021/pr060363j
PubMed ID: 18502753
Title: Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP.
PubMed ID: 18502753
PubMed ID: 18264092
Title: OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD.
PubMed ID: 18264092
DOI: 10.1038/ncb1689
PubMed ID: 19538957
Title: Activation of mammalian IRE1alpha upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins.
PubMed ID: 19538957
PubMed ID: 20484814
Title: The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic mice.
PubMed ID: 20484814
DOI: 10.1172/jci42164
PubMed ID: 21080038
Title: The precursor to the germ cell-specific PCSK4 proteinase is inefficiently activated in transfected somatic cells: evidence of interaction with the BiP chaperone.
PubMed ID: 21080038
PubMed ID: 22637475
Title: Mesencephalic astrocyte-derived neurotrophic factor protects the heart from ischemic damage and is selectively secreted upon sarco/endoplasmic reticulum calcium depletion.
PubMed ID: 22637475
PubMed ID: 22905912
Title: Resveratrol-induced changes of the human adipocyte secretion profile.
PubMed ID: 22905912
DOI: 10.1021/pr300539b
PubMed ID: 23921388
Title: Identification and characterization of a novel human methyltransferase modulating Hsp70 function through lysine methylation.
PubMed ID: 23921388
PubMed ID: 23990668
Title: Unraveling the role of KIAA1199, a novel endoplasmic reticulum protein, in cancer cell migration.
PubMed ID: 23990668
DOI: 10.1093/jnci/djt224
PubMed ID: 23769672
Title: ERdj5 is the ER reductase that catalyzes the removal of non-native disulfides and correct folding of the LDL receptor.
PubMed ID: 23769672
PubMed ID: 22689054
Title: GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer.
PubMed ID: 22689054
DOI: 10.1038/onc.2012.212
PubMed ID: 24355926
Title: CotH3 mediates fungal invasion of host cells during mucormycosis.
PubMed ID: 24355926
DOI: 10.1172/jci71349
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 25114211
Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
PubMed ID: 25114211
PubMed ID: 26045166
Title: KIAA1324 Suppresses Gastric Cancer Progression by Inhibiting the Oncoprotein GRP78.
PubMed ID: 26045166
PubMed ID: 25601083
Title: A novel link between Fic (filamentation induced by cAMP)-mediated adenylylation/AMPylation and the unfolded protein response.
PubMed ID: 25601083
PubMed ID: 25755297
Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
PubMed ID: 25755297
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 26657846
Title: Versatile function of the circadian protein CIPC as a regulator of Erk activation.
PubMed ID: 26657846
PubMed ID: 26940976
Title: Glucose-regulated protein 78 (GRP78) binds directly to PIP3 phosphatase SKIP and determines its localization.
PubMed ID: 26940976
DOI: 10.1111/gtc.12353
PubMed ID: 27159390
Title: Bicarbonate correction of ketoacidosis alters host-pathogen interactions and alleviates mucormycosis.
PubMed ID: 27159390
DOI: 10.1172/jci82744
PubMed ID: 28286085
Title: HSPA5 Gene encoding Hsp70 chaperone BiP in the endoplasmic reticulum.
PubMed ID: 28286085
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 28332555
Title: LOXL2 drives epithelial-mesenchymal transition via activation of IRE1-XBP1 signalling pathway.
PubMed ID: 28332555
DOI: 10.1038/srep44988
PubMed ID: 28053106
Title: GRP78 Is an Important Host Factor for Japanese Encephalitis Virus Entry and Replication in Mammalian Cells.
PubMed ID: 28053106
DOI: 10.1128/jvi.02274-16
PubMed ID: 29719251
Title: Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier.
PubMed ID: 29719251
PubMed ID: 29497057
Title: Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection.
PubMed ID: 29497057
PubMed ID: 32487760
Title: GRP78 and Integrins Play Different Roles in Host Cell Invasion during Mucormycosis.
PubMed ID: 32487760
PubMed ID: 33432092
Title: A functional interaction between GRP78 and Zika virus E protein.
PubMed ID: 33432092
PubMed ID: 20072699
Title: Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78.
PubMed ID: 20072699
PubMed ID: 21526763
Title: Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.
PubMed ID: 21526763
DOI: 10.1021/jm101625x
PubMed ID: 26655470
Title: Close and allosteric opening of the polypeptide-binding site in a human Hsp70 chaperone BiP.
PubMed ID: 26655470
Sequence Information:
- Length: 654
- Mass: 72333
- Checksum: 59B7D8D85BC32A00
- Sequence:
MKLSLVAAML LLLSAARAEE EDKKEDVGTV VGIDLGTTYS CVGVFKNGRV EIIANDQGNR ITPSYVAFTP EGERLIGDAA KNQLTSNPEN TVFDAKRLIG RTWNDPSVQQ DIKFLPFKVV EKKTKPYIQV DIGGGQTKTF APEEISAMVL TKMKETAEAY LGKKVTHAVV TVPAYFNDAQ RQATKDAGTI AGLNVMRIIN EPTAAAIAYG LDKREGEKNI LVFDLGGGTF DVSLLTIDNG VFEVVATNGD THLGGEDFDQ RVMEHFIKLY KKKTGKDVRK DNRAVQKLRR EVEKAKRALS SQHQARIEIE SFYEGEDFSE TLTRAKFEEL NMDLFRSTMK PVQKVLEDSD LKKSDIDEIV LVGGSTRIPK IQQLVKEFFN GKEPSRGINP DEAVAYGAAV QAGVLSGDQD TGDLVLLDVC PLTLGIETVG GVMTKLIPRN TVVPTKKSQI FSTASDNQPT VTIKVYEGER PLTKDNHLLG TFDLTGIPPA PRGVPQIEVT FEIDVNGILR VTAEDKGTGN KNKITITNDQ NRLTPEEIER MVNDAEKFAE EDKKLKERID TRNELESYAY SLKNQIGDKE KLGGKLSSED KETMEKAVEE KIEWLESHQD ADIEDFKAKK KELEEIVQPI ISKLYGSAGP PPTGEEDTAE KDEL