Details for: HSPA5

Gene ID: 3309

Symbol: HSPA5

Ensembl ID: ENSG00000044574

Description: heat shock protein family A (Hsp70) member 5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 5.47
    Marker Score: 4,281
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 3.58
    Marker Score: 987
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.55
    Marker Score: 120,921
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.55
    Marker Score: 3,025
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.51
    Marker Score: 1,873
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.4
    Marker Score: 4,108
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.4
    Marker Score: 8,298
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 3.33
    Marker Score: 2,351
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.28
    Marker Score: 9,199
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 3.24
    Marker Score: 2,760
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 3.21
    Marker Score: 844
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.09
    Marker Score: 40,808
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.98
    Marker Score: 1,871
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.98
    Marker Score: 7,975
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.96
    Marker Score: 19,255
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.96
    Marker Score: 102,380
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.94
    Marker Score: 1,226
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.94
    Marker Score: 6,702
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.92
    Marker Score: 1,311
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.92
    Marker Score: 9,224
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.92
    Marker Score: 11,243
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.91
    Marker Score: 4,017
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.9
    Marker Score: 8,014
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.89
    Marker Score: 8,443
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.87
    Marker Score: 12,317
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.85
    Marker Score: 3,048
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.83
    Marker Score: 4,363
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.83
    Marker Score: 2,380
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 2.83
    Marker Score: 2,141
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.82
    Marker Score: 32,814
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.82
    Marker Score: 3,304
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.79
    Marker Score: 2,485
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.79
    Marker Score: 895
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.79
    Marker Score: 20,742
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.79
    Marker Score: 24,456
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.71
    Marker Score: 2,221
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.7
    Marker Score: 644
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.69
    Marker Score: 4,407
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.69
    Marker Score: 2,358
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.65
    Marker Score: 3,902
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.65
    Marker Score: 1,191
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.65
    Marker Score: 1,509
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.63
    Marker Score: 11,345
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.63
    Marker Score: 1,617
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.62
    Marker Score: 12,890
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.62
    Marker Score: 2,531
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.61
    Marker Score: 1,748
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.59
    Marker Score: 6,309
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.56
    Marker Score: 2,012
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.56
    Marker Score: 3,521
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.56
    Marker Score: 2,415
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.55
    Marker Score: 25,207
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.53
    Marker Score: 3,058
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.52
    Marker Score: 2,558
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.51
    Marker Score: 951
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.51
    Marker Score: 1,826
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 2.5
    Marker Score: 1,743
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.5
    Marker Score: 4,024
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.49
    Marker Score: 13,108
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.49
    Marker Score: 3,964
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.49
    Marker Score: 5,204
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.48
    Marker Score: 14,702
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.48
    Marker Score: 1,687
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.47
    Marker Score: 1,948
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.46
    Marker Score: 27,734
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.46
    Marker Score: 1,763
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.46
    Marker Score: 3,170
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.45
    Marker Score: 1,427
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.44
    Marker Score: 1,158
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.44
    Marker Score: 1,786
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.43
    Marker Score: 6,135
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.42
    Marker Score: 2,982
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.41
    Marker Score: 832
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.41
    Marker Score: 7,564
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.4
    Marker Score: 126,901
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.4
    Marker Score: 2,001
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.39
    Marker Score: 2,132
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.39
    Marker Score: 24,047
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.39
    Marker Score: 2,141
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.38
    Marker Score: 6,231
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.38
    Marker Score: 6,476
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.37
    Marker Score: 2,221
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.37
    Marker Score: 2,577
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 2.37
    Marker Score: 647
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.36
    Marker Score: 4,006
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.36
    Marker Score: 1,220
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.35
    Marker Score: 4,167
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.35
    Marker Score: 1,069
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.35
    Marker Score: 4,289
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.35
    Marker Score: 15,302
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.34
    Marker Score: 1,093
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 2.34
    Marker Score: 1,604
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.34
    Marker Score: 20,316
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.34
    Marker Score: 619
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.33
    Marker Score: 1,007
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.33
    Marker Score: 2,723
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.32
    Marker Score: 574
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.32
    Marker Score: 1,466
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.32
    Marker Score: 2,654
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.31
    Marker Score: 1,545

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HSPA5 shares several key characteristics with other HSP70 family members, including: 1. **Molecular structure**: HSPA5 consists of four structural domains: the N-terminal domain, the DNA-binding domain, the substrate-binding domain, and the C-terminal domain. 2. **Chaperone function**: HSPA5 assists in the proper folding and assembly of proteins, preventing protein misfolding and aggregation. 3. **ER localization**: HSPA5 is primarily localized to the endoplasmic reticulum (ER), where it plays a crucial role in ER stress response. 4. **Induction of unfolded protein response (UPR)**: HSPA5 is involved in the regulation of the UPR, a cellular response to ER stress that aims to restore ER homeostasis. **Pathways and Functions** HSPA5 is involved in several cellular pathways and functions, including: 1. **Adaptive immune system**: HSPA5 is expressed in immune cells, such as T cells and B cells, and plays a role in antigen presentation and immune response. 2. **Antigen presentation**: HSPA5 assists in the proper folding and assembly of class I MHC molecules, which are essential for antigen presentation to CD8+ T cells. 3. **ER stress response**: HSPA5 is involved in the regulation of the UPR, which aims to restore ER homeostasis and prevent cell death. 4. **Protein folding and refolding**: HSPA5 assists in the proper folding and refolding of proteins, preventing protein misfolding and aggregation. 5. **Cellular responses to stimuli**: HSPA5 is involved in various cellular responses to stimuli, including heat shock, glucose starvation, and ER stress. **Clinical Significance** HSPA5 has been implicated in several diseases and disorders, including: 1. **Cancer**: HSPA5 is overexpressed in several types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative diseases**: HSPA5 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Infectious diseases**: HSPA5 plays a role in the immune response to infections, such as HIV and tuberculosis. 4. **Autoimmune diseases**: HSPA5 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. In conclusion, HSPA5 is a multifunctional protein that plays a crucial role in maintaining protein homeostasis and responding to various forms of cellular stress. Its expression and function have been implicated in several diseases and disorders, making it a potential target for therapeutic intervention.

Genular Protein ID: 972276839

Symbol: BIP_HUMAN

Name: N/A

UniProtKB Accession Codes:

P11021 B0QZ61 Q2EF78 Q9NPF1 Q9UK02

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 3 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DisProt 1 DrugBank 5 EC 1 ELM 1 EMBL 10 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 56 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 30 PDBsum 23 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 8 RefSeq 1 Rhea 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

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PubMed ID: 2840249

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PubMed ID: 15164053

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PubMed ID: 1480470

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PubMed ID: 1480470

DOI: 10.1093/nar/20.24.6481

PubMed ID: 11160188

Title: The human endoplasmic reticulum molecular chaperone BiP is an autoantigen for rheumatoid arthritis and prevents the induction of experimental arthritis.

PubMed ID: 11160188

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PubMed ID: 9150946

Title: Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.

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PubMed ID: 2294010

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PubMed ID: 1550958

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PubMed ID: 12643545

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PubMed ID: 18502753

Title: Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP.

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PubMed ID: 18264092

Title: OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD.

PubMed ID: 18264092

DOI: 10.1038/ncb1689

PubMed ID: 19538957

Title: Activation of mammalian IRE1alpha upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins.

PubMed ID: 19538957

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PubMed ID: 20484814

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PubMed ID: 21080038

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PubMed ID: 25601083

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PubMed ID: 25944712

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PubMed ID: 26657846

DOI: 10.1016/j.bbrc.2015.11.117

PubMed ID: 26940976

Title: Glucose-regulated protein 78 (GRP78) binds directly to PIP3 phosphatase SKIP and determines its localization.

PubMed ID: 26940976

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PubMed ID: 27159390

Title: Bicarbonate correction of ketoacidosis alters host-pathogen interactions and alleviates mucormycosis.

PubMed ID: 27159390

DOI: 10.1172/jci82744

PubMed ID: 28286085

Title: HSPA5 Gene encoding Hsp70 chaperone BiP in the endoplasmic reticulum.

PubMed ID: 28286085

DOI: 10.1016/j.gene.2017.03.005

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

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Title: LOXL2 drives epithelial-mesenchymal transition via activation of IRE1-XBP1 signalling pathway.

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PubMed ID: 28053106

Title: GRP78 Is an Important Host Factor for Japanese Encephalitis Virus Entry and Replication in Mammalian Cells.

PubMed ID: 28053106

DOI: 10.1128/jvi.02274-16

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Title: Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier.

PubMed ID: 29719251

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Title: Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection.

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Title: GRP78 and Integrins Play Different Roles in Host Cell Invasion during Mucormycosis.

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Title: A functional interaction between GRP78 and Zika virus E protein.

PubMed ID: 33432092

DOI: 10.1038/s41598-020-79803-z

PubMed ID: 20072699

Title: Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78.

PubMed ID: 20072699

DOI: 10.1371/journal.pone.0008625

PubMed ID: 21526763

Title: Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.

PubMed ID: 21526763

DOI: 10.1021/jm101625x

PubMed ID: 26655470

Title: Close and allosteric opening of the polypeptide-binding site in a human Hsp70 chaperone BiP.

PubMed ID: 26655470

DOI: 10.1016/j.str.2015.10.012

Sequence Information:

  • Length: 654
  • Mass: 72333
  • Checksum: 59B7D8D85BC32A00
  • Sequence:
    • MKLSLVAAML LLLSAARAEE EDKKEDVGTV VGIDLGTTYS CVGVFKNGRV EIIANDQGNR 
ITPSYVAFTP EGERLIGDAA KNQLTSNPEN TVFDAKRLIG RTWNDPSVQQ DIKFLPFKVV 
EKKTKPYIQV DIGGGQTKTF APEEISAMVL TKMKETAEAY LGKKVTHAVV TVPAYFNDAQ 
RQATKDAGTI AGLNVMRIIN EPTAAAIAYG LDKREGEKNI LVFDLGGGTF DVSLLTIDNG 
VFEVVATNGD THLGGEDFDQ RVMEHFIKLY KKKTGKDVRK DNRAVQKLRR EVEKAKRALS 
SQHQARIEIE SFYEGEDFSE TLTRAKFEEL NMDLFRSTMK PVQKVLEDSD LKKSDIDEIV 
LVGGSTRIPK IQQLVKEFFN GKEPSRGINP DEAVAYGAAV QAGVLSGDQD TGDLVLLDVC 
PLTLGIETVG GVMTKLIPRN TVVPTKKSQI FSTASDNQPT VTIKVYEGER PLTKDNHLLG 
TFDLTGIPPA PRGVPQIEVT FEIDVNGILR VTAEDKGTGN KNKITITNDQ NRLTPEEIER 
MVNDAEKFAE EDKKLKERID TRNELESYAY SLKNQIGDKE KLGGKLSSED KETMEKAVEE 
KIEWLESHQD ADIEDFKAKK KELEEIVQPI ISKLYGSAGP PPTGEEDTAE KDEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.