Details for: HSPA5

Gene ID: 3309

Symbol: HSPA5

Ensembl ID: ENSG00000044574

Description: heat shock protein family A (Hsp70) member 5

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 5.47
    Marker Score: 4281
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 3.58
    Marker Score: 987
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.55
    Marker Score: 120921
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.55
    Marker Score: 3025
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.51
    Marker Score: 1873
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.4
    Marker Score: 4107.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.4
    Marker Score: 8298
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 3.33
    Marker Score: 2351
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.28
    Marker Score: 9198.5
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 3.24
    Marker Score: 2760
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 3.21
    Marker Score: 844
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.09
    Marker Score: 40808
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.98
    Marker Score: 1870.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.98
    Marker Score: 7975
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.96
    Marker Score: 19254.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.96
    Marker Score: 102380
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.94
    Marker Score: 1226
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.94
    Marker Score: 6702
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.92
    Marker Score: 1311
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.92
    Marker Score: 9224
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.92
    Marker Score: 11243
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.91
    Marker Score: 4017
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.9
    Marker Score: 8014
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.89
    Marker Score: 8443
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.87
    Marker Score: 12317
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.85
    Marker Score: 3048
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.83
    Marker Score: 4362.5
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.83
    Marker Score: 2380
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 2.83
    Marker Score: 2141
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.82
    Marker Score: 32813.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.82
    Marker Score: 3304
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.79
    Marker Score: 2485
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.79
    Marker Score: 895
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.79
    Marker Score: 20742
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.79
    Marker Score: 24456
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.71
    Marker Score: 2221
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.7
    Marker Score: 644
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.69
    Marker Score: 4407
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.69
    Marker Score: 2358
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.65
    Marker Score: 3902
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.65
    Marker Score: 1191
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.65
    Marker Score: 1509
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.63
    Marker Score: 11345
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.63
    Marker Score: 1617
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.62
    Marker Score: 12890
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.62
    Marker Score: 2531
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.61
    Marker Score: 1748
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.59
    Marker Score: 6309
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.56
    Marker Score: 2011.5
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.56
    Marker Score: 3521
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.56
    Marker Score: 2414.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.55
    Marker Score: 25207
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.53
    Marker Score: 3058
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.52
    Marker Score: 2558
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.51
    Marker Score: 951
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.51
    Marker Score: 1826
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 2.5
    Marker Score: 1743
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.5
    Marker Score: 4024
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.49
    Marker Score: 13108
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.49
    Marker Score: 3964
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.49
    Marker Score: 5204
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.48
    Marker Score: 14701.5
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.48
    Marker Score: 1687
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.47
    Marker Score: 1947.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.46
    Marker Score: 27734
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.46
    Marker Score: 1763
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.46
    Marker Score: 3170
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.45
    Marker Score: 1427
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.44
    Marker Score: 1158
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.44
    Marker Score: 1786
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.43
    Marker Score: 6135
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.42
    Marker Score: 2982
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.41
    Marker Score: 832
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.41
    Marker Score: 7564
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.4
    Marker Score: 126901
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.4
    Marker Score: 2001
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.39
    Marker Score: 2132
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.39
    Marker Score: 24047
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.39
    Marker Score: 2141
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.38
    Marker Score: 6231
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.38
    Marker Score: 6476
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.37
    Marker Score: 2221
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.37
    Marker Score: 2576.5
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 2.37
    Marker Score: 647
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.36
    Marker Score: 4006
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.36
    Marker Score: 1220
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.35
    Marker Score: 4167
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.35
    Marker Score: 1069
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.35
    Marker Score: 4289
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.35
    Marker Score: 15302
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.34
    Marker Score: 1093
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 2.34
    Marker Score: 1604
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.34
    Marker Score: 20316
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.34
    Marker Score: 619
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.33
    Marker Score: 1007
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.33
    Marker Score: 2723
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.32
    Marker Score: 574
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.32
    Marker Score: 1465.5
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.32
    Marker Score: 2654
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.31
    Marker Score: 1545

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Other Information

**Key characteristics:** * HSPA5 is a chaperone protein that is induced in response to heat stress and other forms of stress. * It is a key regulator of the unfolded protein response (uPR). * It is involved in the folding, assembly, and peptide loading of class i major histocompatibility complex (MHC) molecules. * It is also involved in the regulation of platelet activation and aggregation. **Pathways and functions:** * HSPA5 is involved in the adaptive immune system through the regulation of class i MHC-mediated antigen processing and presentation. * It is also involved in the regulation of platelet activation and aggregation. * It is involved in the stress responses by helping to protect cells from damage caused by heat stress. * It is also involved in the regulation of inflammation. **Clinical significance:** HSPA5 is a promising target for the treatment of a variety of diseases, including cancer, autoimmune disorders, and neurodegenerative diseases.

Genular Protein ID: 972276839

Symbol: BIP_HUMAN

Name: N/A

UniProtKB Accession Codes:

P11021 B0QZ61 Q2EF78 Q9NPF1 Q9UK02

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 3 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DisProt 1 DrugBank 5 EC 1 ELM 1 EMBL 10 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 56 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 30 PDBsum 23 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 8 RefSeq 1 Rhea 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2840249

Title: Human gene encoding the 78,000-dalton glucose-regulated protein and its pseudogene: structure, conservation, and regulation.

PubMed ID: 2840249

DOI: 10.1089/dna.1988.7.275

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1480470

Title: A direct-repeat sequence of the human BiP gene is required for A23187-mediated inducibility and an inducible nuclear factor binding.

PubMed ID: 1480470

DOI: 10.1093/nar/20.24.6481

PubMed ID: 11160188

Title: The human endoplasmic reticulum molecular chaperone BiP is an autoantigen for rheumatoid arthritis and prevents the induction of experimental arthritis.

PubMed ID: 11160188

DOI: 10.4049/jimmunol.166.3.1492

PubMed ID: 9150946

Title: Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.

PubMed ID: 9150946

DOI: 10.1002/elps.1150180342

PubMed ID: 2294010

Title: Heat shock proteins bind calcitonin.

PubMed ID: 2294010

DOI: 10.1210/endo-126-1-672

PubMed ID: 9150948

Title: A two-dimensional gel database of human colon carcinoma proteins.

PubMed ID: 9150948

DOI: 10.1002/elps.1150180344

PubMed ID: 1550958

Title: Analysis in vivo of GRP78-BiP/substrate interactions and their role in induction of the GRP78-BiP gene.

PubMed ID: 1550958

DOI: 10.1091/mbc.3.2.143

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21289099

Title: Protective role of Gipie, a Girdin family protein, in endoplasmic reticulum stress responses in endothelial cells.

PubMed ID: 21289099

DOI: 10.1091/mbc.e10-08-0724

PubMed ID: 23349634

Title: A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.

PubMed ID: 23349634

DOI: 10.1371/journal.pgen.1003210

PubMed ID: 12475965

Title: A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins.

PubMed ID: 12475965

DOI: 10.1091/mbc.e02-05-0311

PubMed ID: 12699405

Title: Association of stress proteins with autoantigens: a possible mechanism for triggering autoimmunity?

PubMed ID: 12699405

DOI: 10.1046/j.1365-2249.2003.02153.x

PubMed ID: 12411443

Title: ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress.

PubMed ID: 12411443

DOI: 10.1074/jbc.m206995200

PubMed ID: 12643545

Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.

PubMed ID: 12643545

DOI: 10.1021/pr025562r

PubMed ID: 15098107

Title: Identification of GRP 78 (BiP) as a liver cell expressed receptor element for dengue virus serotype 2.

PubMed ID: 15098107

DOI: 10.1007/s00705-003-0263-x

PubMed ID: 18621045

Title: Novel interactions of CLN3 protein link Batten disease to dysregulation of fodrin-Na+, K+ ATPase complex.

PubMed ID: 18621045

DOI: 10.1016/j.yexcr.2008.06.016

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 18502753

Title: Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP.

PubMed ID: 18502753

DOI: 10.1074/jbc.m709336200

PubMed ID: 18264092

Title: OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD.

PubMed ID: 18264092

DOI: 10.1038/ncb1689

PubMed ID: 19538957

Title: Activation of mammalian IRE1alpha upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins.

PubMed ID: 19538957

DOI: 10.1016/j.yexcr.2009.06.009

PubMed ID: 20484814

Title: The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic mice.

PubMed ID: 20484814

DOI: 10.1172/jci42164

PubMed ID: 21080038

Title: The precursor to the germ cell-specific PCSK4 proteinase is inefficiently activated in transfected somatic cells: evidence of interaction with the BiP chaperone.

PubMed ID: 21080038

DOI: 10.1007/s11010-010-0635-y

PubMed ID: 22637475

Title: Mesencephalic astrocyte-derived neurotrophic factor protects the heart from ischemic damage and is selectively secreted upon sarco/endoplasmic reticulum calcium depletion.

PubMed ID: 22637475

DOI: 10.1074/jbc.m112.356345

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 23921388

Title: Identification and characterization of a novel human methyltransferase modulating Hsp70 function through lysine methylation.

PubMed ID: 23921388

DOI: 10.1074/jbc.m113.483248

PubMed ID: 23990668

Title: Unraveling the role of KIAA1199, a novel endoplasmic reticulum protein, in cancer cell migration.

PubMed ID: 23990668

DOI: 10.1093/jnci/djt224

PubMed ID: 23769672

Title: ERdj5 is the ER reductase that catalyzes the removal of non-native disulfides and correct folding of the LDL receptor.

PubMed ID: 23769672

DOI: 10.1016/j.molcel.2013.05.014

PubMed ID: 22689054

Title: GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer.

PubMed ID: 22689054

DOI: 10.1038/onc.2012.212

PubMed ID: 24355926

Title: CotH3 mediates fungal invasion of host cells during mucormycosis.

PubMed ID: 24355926

DOI: 10.1172/jci71349

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 26045166

Title: KIAA1324 Suppresses Gastric Cancer Progression by Inhibiting the Oncoprotein GRP78.

PubMed ID: 26045166

DOI: 10.1158/0008-5472.can-14-3751

PubMed ID: 25601083

Title: A novel link between Fic (filamentation induced by cAMP)-mediated adenylylation/AMPylation and the unfolded protein response.

PubMed ID: 25601083

DOI: 10.1074/jbc.m114.618348

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26657846

Title: Versatile function of the circadian protein CIPC as a regulator of Erk activation.

PubMed ID: 26657846

DOI: 10.1016/j.bbrc.2015.11.117

PubMed ID: 26940976

Title: Glucose-regulated protein 78 (GRP78) binds directly to PIP3 phosphatase SKIP and determines its localization.

PubMed ID: 26940976

DOI: 10.1111/gtc.12353

PubMed ID: 27159390

Title: Bicarbonate correction of ketoacidosis alters host-pathogen interactions and alleviates mucormycosis.

PubMed ID: 27159390

DOI: 10.1172/jci82744

PubMed ID: 28286085

Title: HSPA5 Gene encoding Hsp70 chaperone BiP in the endoplasmic reticulum.

PubMed ID: 28286085

DOI: 10.1016/j.gene.2017.03.005

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28332555

Title: LOXL2 drives epithelial-mesenchymal transition via activation of IRE1-XBP1 signalling pathway.

PubMed ID: 28332555

DOI: 10.1038/srep44988

PubMed ID: 28053106

Title: GRP78 Is an Important Host Factor for Japanese Encephalitis Virus Entry and Replication in Mammalian Cells.

PubMed ID: 28053106

DOI: 10.1128/jvi.02274-16

PubMed ID: 29719251

Title: Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier.

PubMed ID: 29719251

DOI: 10.1016/j.celrep.2018.03.122

PubMed ID: 29497057

Title: Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection.

PubMed ID: 29497057

DOI: 10.1038/s41467-018-03355-0

PubMed ID: 32487760

Title: GRP78 and Integrins Play Different Roles in Host Cell Invasion during Mucormycosis.

PubMed ID: 32487760

DOI: 10.1128/mbio.01087-20

PubMed ID: 33432092

Title: A functional interaction between GRP78 and Zika virus E protein.

PubMed ID: 33432092

DOI: 10.1038/s41598-020-79803-z

PubMed ID: 20072699

Title: Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78.

PubMed ID: 20072699

DOI: 10.1371/journal.pone.0008625

PubMed ID: 21526763

Title: Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.

PubMed ID: 21526763

DOI: 10.1021/jm101625x

PubMed ID: 26655470

Title: Close and allosteric opening of the polypeptide-binding site in a human Hsp70 chaperone BiP.

PubMed ID: 26655470

DOI: 10.1016/j.str.2015.10.012

Sequence Information:

  • Length: 654
  • Mass: 72333
  • Checksum: 59B7D8D85BC32A00
  • Sequence:
    • MKLSLVAAML LLLSAARAEE EDKKEDVGTV VGIDLGTTYS CVGVFKNGRV EIIANDQGNR 
ITPSYVAFTP EGERLIGDAA KNQLTSNPEN TVFDAKRLIG RTWNDPSVQQ DIKFLPFKVV 
EKKTKPYIQV DIGGGQTKTF APEEISAMVL TKMKETAEAY LGKKVTHAVV TVPAYFNDAQ 
RQATKDAGTI AGLNVMRIIN EPTAAAIAYG LDKREGEKNI LVFDLGGGTF DVSLLTIDNG 
VFEVVATNGD THLGGEDFDQ RVMEHFIKLY KKKTGKDVRK DNRAVQKLRR EVEKAKRALS 
SQHQARIEIE SFYEGEDFSE TLTRAKFEEL NMDLFRSTMK PVQKVLEDSD LKKSDIDEIV 
LVGGSTRIPK IQQLVKEFFN GKEPSRGINP DEAVAYGAAV QAGVLSGDQD TGDLVLLDVC 
PLTLGIETVG GVMTKLIPRN TVVPTKKSQI FSTASDNQPT VTIKVYEGER PLTKDNHLLG 
TFDLTGIPPA PRGVPQIEVT FEIDVNGILR VTAEDKGTGN KNKITITNDQ NRLTPEEIER 
MVNDAEKFAE EDKKLKERID TRNELESYAY SLKNQIGDKE KLGGKLSSED KETMEKAVEE 
KIEWLESHQD ADIEDFKAKK KELEEIVQPI ISKLYGSAGP PPTGEEDTAE KDEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.