Details for: XBP1

Gene ID: 7494

Symbol: XBP1

Ensembl ID: ENSG00000100219

Description: X-box binding protein 1

Associated with

  • Atf6 (atf6-alpha) activates chaperone genes
    (R-HSA-381183)
  • Atf6 (atf6-alpha) activates chaperones
    (R-HSA-381033)
  • Cellular responses to stimuli
    (R-HSA-8953897)
  • Cellular responses to stress
    (R-HSA-2262752)
  • Ire1alpha activates chaperones
    (R-HSA-381070)
  • Unfolded protein response (upr)
    (R-HSA-381119)
  • Xbp1(s) activates chaperone genes
    (R-HSA-381038)
  • Adipose tissue development
    (GO:0060612)
  • Angiogenesis
    (GO:0001525)
  • Apoptotic process
    (GO:0006915)
  • Atf6-mediated unfolded protein response
    (GO:0036500)
  • Autophagy
    (GO:0006914)
  • Cellular response to amino acid stimulus
    (GO:0071230)
  • Cellular response to fluid shear stress
    (GO:0071498)
  • Cellular response to fructose stimulus
    (GO:0071332)
  • Cellular response to glucose starvation
    (GO:0042149)
  • Cellular response to glucose stimulus
    (GO:0071333)
  • Cellular response to insulin stimulus
    (GO:0032869)
  • Cellular response to interleukin-4
    (GO:0071353)
  • Cellular response to laminar fluid shear stress
    (GO:0071499)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Cellular response to nutrient
    (GO:0031670)
  • Cellular response to oxidative stress
    (GO:0034599)
  • Cellular response to peptide hormone stimulus
    (GO:0071375)
  • Cellular response to vascular endothelial growth factor stimulus
    (GO:0035924)
  • Cholesterol homeostasis
    (GO:0042632)
  • Chromatin dna binding
    (GO:0031490)
  • Cis-regulatory region sequence-specific dna binding
    (GO:0000987)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Endoplasmic reticulum unfolded protein response
    (GO:0030968)
  • Endothelial cell proliferation
    (GO:0001935)
  • Erad pathway
    (GO:0036503)
  • Fatty acid biosynthetic process
    (GO:0006633)
  • Fatty acid homeostasis
    (GO:0055089)
  • Identical protein binding
    (GO:0042802)
  • Immune response
    (GO:0006955)
  • Intracellular triglyceride homeostasis
    (GO:0035356)
  • Ire1-mediated unfolded protein response
    (GO:0036498)
  • Liver development
    (GO:0001889)
  • Muscle organ development
    (GO:0007517)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
    (GO:1902236)
  • Negative regulation of endoplasmic reticulum unfolded protein response
    (GO:1900102)
  • Negative regulation of erk1 and erk2 cascade
    (GO:0070373)
  • Negative regulation of myotube differentiation
    (GO:0010832)
  • Negative regulation of smad protein signal transduction
    (GO:0060392)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of transforming growth factor beta receptor signaling pathway
    (GO:0030512)
  • Neuron development
    (GO:0048666)
  • Nuclear estrogen receptor binding
    (GO:0030331)
  • Phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0043491)
  • Positive regulation of angiogenesis
    (GO:0045766)
  • Positive regulation of autophagy
    (GO:0010508)
  • Positive regulation of b cell differentiation
    (GO:0045579)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of fat cell differentiation
    (GO:0045600)
  • Positive regulation of immunoglobulin production
    (GO:0002639)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of lactation
    (GO:1903489)
  • Positive regulation of mhc class ii biosynthetic process
    (GO:0045348)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of phospholipid biosynthetic process
    (GO:0071073)
  • Positive regulation of plasma cell differentiation
    (GO:1900100)
  • Positive regulation of protein acetylation
    (GO:1901985)
  • Positive regulation of protein import into nucleus
    (GO:0042307)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Positive regulation of t cell differentiation
    (GO:0045582)
  • Positive regulation of tor signaling
    (GO:0032008)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of vascular wound healing
    (GO:0035470)
  • Protease binding
    (GO:0002020)
  • Protein binding
    (GO:0005515)
  • Protein destabilization
    (GO:0031648)
  • Protein heterodimerization activity
    (GO:0046982)
  • Protein kinase binding
    (GO:0019901)
  • Protein transport
    (GO:0015031)
  • Regulation of cell growth
    (GO:0001558)
  • Regulation of protein stability
    (GO:0031647)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to endoplasmic reticulum stress
    (GO:0034976)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Sterol homeostasis
    (GO:0055092)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Ubiquitin-dependent protein catabolic process
    (GO:0006511)
  • Ubiquitin protein ligase binding
    (GO:0031625)
  • Vascular endothelial growth factor receptor signaling pathway
    (GO:0048010)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 412.7417
    Cell Significance Index: -64.2000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 186.5771
    Cell Significance Index: -76.8600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 182.0272
    Cell Significance Index: -46.1700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 161.1295
    Cell Significance Index: -65.4600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 148.3936
    Cell Significance Index: -70.0600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 140.0312
    Cell Significance Index: -72.0300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 104.2290
    Cell Significance Index: -69.9400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 68.5944
    Cell Significance Index: -65.4900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 54.0246
    Cell Significance Index: -66.6100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 28.7138
    Cell Significance Index: 176.7100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 21.7313
    Cell Significance Index: -58.2200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.5129
    Cell Significance Index: -53.7900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.1463
    Cell Significance Index: -67.6600
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 9.6573
    Cell Significance Index: 4.8500
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 9.5710
    Cell Significance Index: 6.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 8.7672
    Cell Significance Index: 653.4100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 8.4826
    Cell Significance Index: 176.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 7.7399
    Cell Significance Index: 360.8700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.4980
    Cell Significance Index: -16.4100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 7.2547
    Cell Significance Index: 77.0800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 6.6341
    Cell Significance Index: 190.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.9290
    Cell Significance Index: 184.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.8978
    Cell Significance Index: 106.1000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.8559
    Cell Significance Index: 89.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.1095
    Cell Significance Index: 530.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.9086
    Cell Significance Index: 375.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.8467
    Cell Significance Index: 183.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.6612
    Cell Significance Index: 2402.8300
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 2.6608
    Cell Significance Index: 14.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.4454
    Cell Significance Index: 1335.4700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.9176
    Cell Significance Index: 189.6900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.8298
    Cell Significance Index: 16.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7425
    Cell Significance Index: 345.8000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.7401
    Cell Significance Index: 30.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.7090
    Cell Significance Index: 49.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.6122
    Cell Significance Index: 221.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5484
    Cell Significance Index: 279.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5021
    Cell Significance Index: 68.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3091
    Cell Significance Index: 160.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2920
    Cell Significance Index: 210.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.0393
    Cell Significance Index: 25.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0001
    Cell Significance Index: 51.9500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9774
    Cell Significance Index: 125.3000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.9412
    Cell Significance Index: 9.7400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9108
    Cell Significance Index: 31.6500
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.8564
    Cell Significance Index: 8.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7448
    Cell Significance Index: 51.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6625
    Cell Significance Index: 17.6900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5636
    Cell Significance Index: 4.5000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5303
    Cell Significance Index: 11.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4962
    Cell Significance Index: 219.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4744
    Cell Significance Index: 90.2900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2993
    Cell Significance Index: 3.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2919
    Cell Significance Index: 220.9200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2689
    Cell Significance Index: 7.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1302
    Cell Significance Index: 3.8300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0928
    Cell Significance Index: 6.5600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.0306
    Cell Significance Index: 0.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0240
    Cell Significance Index: 0.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0236
    Cell Significance Index: 8.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0203
    Cell Significance Index: 4.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0035
    Cell Significance Index: -6.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0070
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0193
    Cell Significance Index: -14.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0202
    Cell Significance Index: -1.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0210
    Cell Significance Index: -15.3900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0215
    Cell Significance Index: -0.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0246
    Cell Significance Index: -45.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0279
    Cell Significance Index: -42.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0337
    Cell Significance Index: -3.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0378
    Cell Significance Index: -4.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0435
    Cell Significance Index: -59.1500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0587
    Cell Significance Index: -36.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0601
    Cell Significance Index: -38.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0627
    Cell Significance Index: -1.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0820
    Cell Significance Index: -46.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1025
    Cell Significance Index: -21.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1082
    Cell Significance Index: -49.1000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1661
    Cell Significance Index: -18.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1824
    Cell Significance Index: -20.9000
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1866
    Cell Significance Index: -1.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1965
    Cell Significance Index: -56.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2404
    Cell Significance Index: -34.9500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2560
    Cell Significance Index: -15.3700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2889
    Cell Significance Index: -7.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3105
    Cell Significance Index: -8.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3185
    Cell Significance Index: -8.9000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3188
    Cell Significance Index: -16.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3268
    Cell Significance Index: -38.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3923
    Cell Significance Index: -30.1100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.4048
    Cell Significance Index: -44.0300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.4465
    Cell Significance Index: -5.7500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4912
    Cell Significance Index: -7.2500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5599
    Cell Significance Index: -8.3900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5772
    Cell Significance Index: -23.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6301
    Cell Significance Index: -65.6100
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.6516
    Cell Significance Index: -4.0200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7523
    Cell Significance Index: -4.5500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.7822
    Cell Significance Index: -5.3000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8001
    Cell Significance Index: -63.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional regulation:** XBP1 acts as a transcription factor that binds to specific DNA sequences, regulating the expression of genes involved in protein folding, degradation, and transport. 2. **ER stress response:** XBP1 is activated in response to ER stress, triggering the transcription of chaperone genes and other UPR-related genes. 3. **Multifaceted expression:** XBP1 is expressed in various cell types, including early promyelocytes, secretory cells, and progenitor cells of mammary luminal epithelium. 4. **Diverse cellular responses:** XBP1 regulates cellular responses to stimuli, including amino acid, glucose, and insulin stimuli, as well as responses to stress, inflammation, and nutrient deprivation. **Pathways and Functions:** 1. **Unfolded protein response (UPR):** XBP1 mediates the transcription of genes involved in protein folding, degradation, and transport, promoting cellular homeostasis in response to ER stress. 2. **Chaperone gene regulation:** XBP1 activates the transcription of chaperone genes, which are essential for protein folding and degradation. 3. **Autophagy:** XBP1 regulates autophagy, a cellular process that degrades and recycles damaged or dysfunctional proteins. 4. **Adipose tissue development:** XBP1 plays a critical role in adipose tissue development, regulating the expression of genes involved in lipid metabolism and storage. 5. **Angiogenesis:** XBP1 promotes angiogenesis, the formation of new blood vessels, by regulating the expression of genes involved in vascular development. **Clinical Significance:** 1. **Cancer:** XBP1 has been implicated in cancer development and progression, particularly in types such as pancreatic cancer, where it promotes tumor growth and metastasis. 2. **Neurodegenerative diseases:** XBP1 has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's, where it may contribute to protein misfolding and aggregation. 3. **Metabolic disorders:** XBP1 has been associated with metabolic disorders, such as obesity and insulin resistance, where it may regulate lipid metabolism and glucose homeostasis. 4. **Infectious diseases:** XBP1 has been implicated in the regulation of immune responses to infectious diseases, such as influenza and tuberculosis. In conclusion, XBP1 is a multifaceted transcription factor that plays a critical role in various cellular processes, including stress response, development, and homeostasis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its mechanisms and clinical significance.

Genular Protein ID: 925945303

Symbol: XBP1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P17861 Q8WYK6 Q969P1 Q96BD7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 4 Ensembl 2 ExpressionAtlas 1 GO 99 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2321018

Title: A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter.

PubMed ID: 2321018

DOI: 10.1126/science.2321018

PubMed ID: 2196176

Title: Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain.

PubMed ID: 2196176

DOI: 10.1002/j.1460-2075.1990.tb07434.x

PubMed ID: 8349596

Title: The regulatory gene, hXBP-1, and its target, HLA-DRA, utilize both common and distinct regulatory elements and protein complexes.

PubMed ID: 8349596

DOI: 10.1016/s0021-9258(19)85304-8

PubMed ID: 11779464

Title: XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor.

PubMed ID: 11779464

DOI: 10.1016/s0092-8674(01)00611-0

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1903538

Title: Human X-box-binding protein 1 is required for the transcription of a subset of human class II major histocompatibility genes and forms a heterodimer with c-fos.

PubMed ID: 1903538

DOI: 10.1073/pnas.88.10.4309

PubMed ID: 8627152

Title: Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1.

PubMed ID: 8627152

DOI: 10.1084/jem.183.2.393

PubMed ID: 8657566

Title: The basic domain/leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE-like sequences containing an ACGT core.

PubMed ID: 8657566

DOI: 10.1093/nar/24.10.1855

PubMed ID: 10375612

Title: Identification of c-myc promoter-binding protein and X-box binding protein 1 as interleukin-6 target genes in human multiple myeloma cells.

PubMed ID: 10375612

DOI: 10.3892/ijo.15.1.173

PubMed ID: 11460154

Title: Plasma cell differentiation requires the transcription factor XBP-1.

PubMed ID: 11460154

DOI: 10.1038/35085509

PubMed ID: 12949534

Title: Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder.

PubMed ID: 12949534

DOI: 10.1038/ng1235

PubMed ID: 15466483

Title: XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.

PubMed ID: 15466483

DOI: 10.1083/jcb.200406136

PubMed ID: 17110785

Title: XBP1 is critical to protect cells from endoplasmic reticulum stress: evidence from Site-2 protease-deficient Chinese hamster ovary cells.

PubMed ID: 17110785

DOI: 10.1247/csf.06016

PubMed ID: 16461360

Title: pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response.

PubMed ID: 16461360

DOI: 10.1083/jcb.200508145

PubMed ID: 17765680

Title: Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1.

PubMed ID: 17765680

DOI: 10.1016/j.devcel.2007.07.018

PubMed ID: 19622636

Title: Unconventional splicing of XBP1 mRNA occurs in the cytoplasm during the mammalian unfolded protein response.

PubMed ID: 19622636

DOI: 10.1242/jcs.040584

PubMed ID: 19394296

Title: Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA.

PubMed ID: 19394296

DOI: 10.1016/j.molcel.2009.02.033

PubMed ID: 19416856

Title: Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow.

PubMed ID: 19416856

DOI: 10.1073/pnas.0903197106

PubMed ID: 20348923

Title: A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response.

PubMed ID: 20348923

DOI: 10.1038/nm.2121

PubMed ID: 20955178

Title: Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation.

PubMed ID: 20955178

DOI: 10.1042/bj20101293

PubMed ID: 21233347

Title: Translational pausing ensures membrane targeting and cytoplasmic splicing of XBP1u mRNA.

PubMed ID: 21233347

DOI: 10.1126/science.1197142

PubMed ID: 23529610

Title: Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis.

PubMed ID: 23529610

DOI: 10.1161/circulationaha.112.001337

PubMed ID: 23184933

Title: XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation.

PubMed ID: 23184933

DOI: 10.1074/jbc.m112.412783

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25280941

Title: XBP1 induces snail expression to promote epithelial-to-mesenchymal transition and invasion of breast cancer cells.

PubMed ID: 25280941

DOI: 10.1016/j.cellsig.2014.09.018

PubMed ID: 25239945

Title: Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u.

PubMed ID: 25239945

DOI: 10.15252/embj.201488208

PubMed ID: 25190803

Title: Unspliced X-box-binding protein 1 (XBP1) protects endothelial cells from oxidative stress through interaction with histone deacetylase 3.

PubMed ID: 25190803

DOI: 10.1074/jbc.m114.571984

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17224074

Title: Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas.

PubMed ID: 17224074

DOI: 10.1186/bcr1637

Sequence Information:

  • Length: 261
  • Mass: 28695
  • Checksum: A4EF69EEE0D344A6
  • Sequence:
    • MVVVAAAPNP ADGTPKVLLL SGQPASAAGA PAGQALPLMV PAQRGASPEA ASGGLPQARK 
RQRLTHLSPE EKALRRKLKN RVAAQTARDR KKARMSELEQ QVVDLEEENQ KLLLENQLLR 
EKTHGLVVEN QELRQRLGMD ALVAEEEAEA KGNEVRPVAG SAESAALRLR APLQQVQAQL 
SPLQNISPWI LAVLTLQIQS LISCWAFWTT WTQSCSSNAL PQSLPAWRSS QRSTQKDPVP 
YQPPFLCQWG RHQPSWKPLM N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.