Details for: XBP1

Gene ID: 7494

Symbol: XBP1

Ensembl ID: ENSG00000100219

Description: X-box binding protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4.92
    Marker Score: 3940.5
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 4.17
    Marker Score: 7608
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 4.15
    Marker Score: 3537
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.83
    Marker Score: 130206.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.46
    Marker Score: 7882.5
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.39
    Marker Score: 2891
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.35
    Marker Score: 12912.5
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 3.34
    Marker Score: 922
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 3.29
    Marker Score: 1312
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 3.2
    Marker Score: 1806
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 3.09
    Marker Score: 848
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3
    Marker Score: 1249
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.98
    Marker Score: 7280
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.94
    Marker Score: 1453
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.88
    Marker Score: 8402
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 2.85
    Marker Score: 750
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.83
    Marker Score: 1890
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.8
    Marker Score: 2684
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.79
    Marker Score: 2975.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.77
    Marker Score: 18070
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 2.74
    Marker Score: 1001
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.74
    Marker Score: 1595
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.68
    Marker Score: 1123
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.68
    Marker Score: 2392.5
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.68
    Marker Score: 13161
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.62
    Marker Score: 1225
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.61
    Marker Score: 5932
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.61
    Marker Score: 654
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.6
    Marker Score: 4141
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.58
    Marker Score: 4143.5
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.55
    Marker Score: 808
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.54
    Marker Score: 7018.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.54
    Marker Score: 87917
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.51
    Marker Score: 10826
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 2.5
    Marker Score: 1763
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.48
    Marker Score: 13035.5
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 2.46
    Marker Score: 1074
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.4
    Marker Score: 5059
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.39
    Marker Score: 24170
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.38
    Marker Score: 686
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.37
    Marker Score: 591
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.36
    Marker Score: 17559
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.35
    Marker Score: 591
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.35
    Marker Score: 4168
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.35
    Marker Score: 834.5
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.32
    Marker Score: 1814.5
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 2.3
    Marker Score: 1125
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.3
    Marker Score: 1810
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.27
    Marker Score: 1294
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.27
    Marker Score: 2647
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.23
    Marker Score: 1548
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.22
    Marker Score: 828
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.22
    Marker Score: 2540
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.22
    Marker Score: 14145
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.21
    Marker Score: 2611
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 2.21
    Marker Score: 1536
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.18
    Marker Score: 751
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.12
    Marker Score: 3129
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.06
    Marker Score: 1492.5
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 2.05
    Marker Score: 941
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.05
    Marker Score: 6464
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.05
    Marker Score: 23042
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.04
    Marker Score: 1059
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.03
    Marker Score: 8302
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.02
    Marker Score: 1114
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.99
    Marker Score: 5025
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.97
    Marker Score: 470.5
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.97
    Marker Score: 1656
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.96
    Marker Score: 5125
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.95
    Marker Score: 49895
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.94
    Marker Score: 708
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.94
    Marker Score: 7177.5
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.93
    Marker Score: 435
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.93
    Marker Score: 1931
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.93
    Marker Score: 750
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.93
    Marker Score: 1218
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.93
    Marker Score: 4579
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 1.93
    Marker Score: 538
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.92
    Marker Score: 830
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.92
    Marker Score: 668
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.92
    Marker Score: 1794
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.92
    Marker Score: 473
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.89
    Marker Score: 9078
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.89
    Marker Score: 771
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.89
    Marker Score: 971
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.88
    Marker Score: 3088
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.88
    Marker Score: 2203
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.88
    Marker Score: 8041
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.87
    Marker Score: 808
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.87
    Marker Score: 838
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.86
    Marker Score: 883
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.85
    Marker Score: 1085
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.83
    Marker Score: 3041
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.83
    Marker Score: 1220
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.83
    Marker Score: 465
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.83
    Marker Score: 1246
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.82
    Marker Score: 1982
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.82
    Marker Score: 684
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.81
    Marker Score: 29091
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.8
    Marker Score: 910

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Other Information

**Key Characteristics:** 1. **Transcriptional regulation:** XBP1 acts as a transcription factor that binds to specific DNA sequences, regulating the expression of genes involved in protein folding, degradation, and transport. 2. **ER stress response:** XBP1 is activated in response to ER stress, triggering the transcription of chaperone genes and other UPR-related genes. 3. **Multifaceted expression:** XBP1 is expressed in various cell types, including early promyelocytes, secretory cells, and progenitor cells of mammary luminal epithelium. 4. **Diverse cellular responses:** XBP1 regulates cellular responses to stimuli, including amino acid, glucose, and insulin stimuli, as well as responses to stress, inflammation, and nutrient deprivation. **Pathways and Functions:** 1. **Unfolded protein response (UPR):** XBP1 mediates the transcription of genes involved in protein folding, degradation, and transport, promoting cellular homeostasis in response to ER stress. 2. **Chaperone gene regulation:** XBP1 activates the transcription of chaperone genes, which are essential for protein folding and degradation. 3. **Autophagy:** XBP1 regulates autophagy, a cellular process that degrades and recycles damaged or dysfunctional proteins. 4. **Adipose tissue development:** XBP1 plays a critical role in adipose tissue development, regulating the expression of genes involved in lipid metabolism and storage. 5. **Angiogenesis:** XBP1 promotes angiogenesis, the formation of new blood vessels, by regulating the expression of genes involved in vascular development. **Clinical Significance:** 1. **Cancer:** XBP1 has been implicated in cancer development and progression, particularly in types such as pancreatic cancer, where it promotes tumor growth and metastasis. 2. **Neurodegenerative diseases:** XBP1 has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's, where it may contribute to protein misfolding and aggregation. 3. **Metabolic disorders:** XBP1 has been associated with metabolic disorders, such as obesity and insulin resistance, where it may regulate lipid metabolism and glucose homeostasis. 4. **Infectious diseases:** XBP1 has been implicated in the regulation of immune responses to infectious diseases, such as influenza and tuberculosis. In conclusion, XBP1 is a multifaceted transcription factor that plays a critical role in various cellular processes, including stress response, development, and homeostasis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its mechanisms and clinical significance.

Genular Protein ID: 925945303

Symbol: XBP1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P17861 Q8WYK6 Q969P1 Q96BD7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 4 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 100 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2321018

Title: A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter.

PubMed ID: 2321018

DOI: 10.1126/science.2321018

PubMed ID: 2196176

Title: Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain.

PubMed ID: 2196176

DOI: 10.1002/j.1460-2075.1990.tb07434.x

PubMed ID: 8349596

Title: The regulatory gene, hXBP-1, and its target, HLA-DRA, utilize both common and distinct regulatory elements and protein complexes.

PubMed ID: 8349596

DOI: 10.1016/s0021-9258(19)85304-8

PubMed ID: 11779464

Title: XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor.

PubMed ID: 11779464

DOI: 10.1016/s0092-8674(01)00611-0

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1903538

Title: Human X-box-binding protein 1 is required for the transcription of a subset of human class II major histocompatibility genes and forms a heterodimer with c-fos.

PubMed ID: 1903538

DOI: 10.1073/pnas.88.10.4309

PubMed ID: 8627152

Title: Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1.

PubMed ID: 8627152

DOI: 10.1084/jem.183.2.393

PubMed ID: 8657566

Title: The basic domain/leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE-like sequences containing an ACGT core.

PubMed ID: 8657566

DOI: 10.1093/nar/24.10.1855

PubMed ID: 10375612

Title: Identification of c-myc promoter-binding protein and X-box binding protein 1 as interleukin-6 target genes in human multiple myeloma cells.

PubMed ID: 10375612

DOI: 10.3892/ijo.15.1.173

PubMed ID: 11460154

Title: Plasma cell differentiation requires the transcription factor XBP-1.

PubMed ID: 11460154

DOI: 10.1038/35085509

PubMed ID: 12949534

Title: Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder.

PubMed ID: 12949534

DOI: 10.1038/ng1235

PubMed ID: 15466483

Title: XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.

PubMed ID: 15466483

DOI: 10.1083/jcb.200406136

PubMed ID: 17110785

Title: XBP1 is critical to protect cells from endoplasmic reticulum stress: evidence from Site-2 protease-deficient Chinese hamster ovary cells.

PubMed ID: 17110785

DOI: 10.1247/csf.06016

PubMed ID: 16461360

Title: pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response.

PubMed ID: 16461360

DOI: 10.1083/jcb.200508145

PubMed ID: 17765680

Title: Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1.

PubMed ID: 17765680

DOI: 10.1016/j.devcel.2007.07.018

PubMed ID: 19622636

Title: Unconventional splicing of XBP1 mRNA occurs in the cytoplasm during the mammalian unfolded protein response.

PubMed ID: 19622636

DOI: 10.1242/jcs.040584

PubMed ID: 19394296

Title: Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA.

PubMed ID: 19394296

DOI: 10.1016/j.molcel.2009.02.033

PubMed ID: 19416856

Title: Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow.

PubMed ID: 19416856

DOI: 10.1073/pnas.0903197106

PubMed ID: 20348923

Title: A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response.

PubMed ID: 20348923

DOI: 10.1038/nm.2121

PubMed ID: 20955178

Title: Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation.

PubMed ID: 20955178

DOI: 10.1042/bj20101293

PubMed ID: 21233347

Title: Translational pausing ensures membrane targeting and cytoplasmic splicing of XBP1u mRNA.

PubMed ID: 21233347

DOI: 10.1126/science.1197142

PubMed ID: 23529610

Title: Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis.

PubMed ID: 23529610

DOI: 10.1161/circulationaha.112.001337

PubMed ID: 23184933

Title: XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation.

PubMed ID: 23184933

DOI: 10.1074/jbc.m112.412783

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25280941

Title: XBP1 induces snail expression to promote epithelial-to-mesenchymal transition and invasion of breast cancer cells.

PubMed ID: 25280941

DOI: 10.1016/j.cellsig.2014.09.018

PubMed ID: 25239945

Title: Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u.

PubMed ID: 25239945

DOI: 10.15252/embj.201488208

PubMed ID: 25190803

Title: Unspliced X-box-binding protein 1 (XBP1) protects endothelial cells from oxidative stress through interaction with histone deacetylase 3.

PubMed ID: 25190803

DOI: 10.1074/jbc.m114.571984

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17224074

Title: Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas.

PubMed ID: 17224074

DOI: 10.1186/bcr1637

Sequence Information:

  • Length: 261
  • Mass: 28695
  • Checksum: A4EF69EEE0D344A6
  • Sequence:
    • MVVVAAAPNP ADGTPKVLLL SGQPASAAGA PAGQALPLMV PAQRGASPEA ASGGLPQARK 
RQRLTHLSPE EKALRRKLKN RVAAQTARDR KKARMSELEQ QVVDLEEENQ KLLLENQLLR 
EKTHGLVVEN QELRQRLGMD ALVAEEEAEA KGNEVRPVAG SAESAALRLR APLQQVQAQL 
SPLQNISPWI LAVLTLQIQS LISCWAFWTT WTQSCSSNAL PQSLPAWRSS QRSTQKDPVP 
YQPPFLCQWG RHQPSWKPLM N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.