Details for: S100A11

Gene ID: 6282

Symbol: S100A11

Ensembl ID: ENSG00000163191

Description: S100 calcium binding protein A11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 993.2802
    Cell Significance Index: -154.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 594.1413
    Cell Significance Index: -150.7000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 374.4408
    Cell Significance Index: -154.2500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 325.0215
    Cell Significance Index: -153.4500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 314.2099
    Cell Significance Index: -127.6500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 273.2679
    Cell Significance Index: -140.5700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 229.2771
    Cell Significance Index: -153.8500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 137.2097
    Cell Significance Index: -131.0000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 125.0653
    Cell Significance Index: -154.2000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 45.9587
    Cell Significance Index: -141.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 39.6827
    Cell Significance Index: -156.5900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 29.8243
    Cell Significance Index: 256.2800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 28.3889
    Cell Significance Index: -76.0500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 24.6757
    Cell Significance Index: -54.0100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 18.2155
    Cell Significance Index: 336.6700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 11.8198
    Cell Significance Index: 108.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 9.4598
    Cell Significance Index: 444.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 9.0194
    Cell Significance Index: 1625.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 8.2885
    Cell Significance Index: 1019.1500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 8.0660
    Cell Significance Index: 236.8900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 7.8664
    Cell Significance Index: 181.7400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 7.8638
    Cell Significance Index: 225.4200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 7.5249
    Cell Significance Index: 46.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 7.1843
    Cell Significance Index: 195.5500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 6.0253
    Cell Significance Index: 68.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 5.9190
    Cell Significance Index: 3232.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 5.8043
    Cell Significance Index: 432.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.1604
    Cell Significance Index: 240.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 4.9697
    Cell Significance Index: 642.0500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 4.9473
    Cell Significance Index: 30.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.9601
    Cell Significance Index: 1750.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.9395
    Cell Significance Index: 105.1900
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.4150
    Cell Significance Index: 21.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.9770
    Cell Significance Index: 155.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.9707
    Cell Significance Index: 154.3200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.9045
    Cell Significance Index: 20.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.8473
    Cell Significance Index: 201.3700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.7522
    Cell Significance Index: 48.6400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.9608
    Cell Significance Index: 251.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.8676
    Cell Significance Index: 256.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 1.3646
    Cell Significance Index: 1032.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3283
    Cell Significance Index: 131.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2945
    Cell Significance Index: 8.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2742
    Cell Significance Index: 52.1900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1382
    Cell Significance Index: 124.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0960
    Cell Significance Index: 70.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0864
    Cell Significance Index: 8.8300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0663
    Cell Significance Index: 1.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0607
    Cell Significance Index: 10.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0771
    Cell Significance Index: -57.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0777
    Cell Significance Index: -146.2300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0914
    Cell Significance Index: -4.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1016
    Cell Significance Index: -63.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1037
    Cell Significance Index: -191.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1255
    Cell Significance Index: -193.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1372
    Cell Significance Index: -27.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1443
    Cell Significance Index: -196.2100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1500
    Cell Significance Index: -3.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1652
    Cell Significance Index: -93.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2040
    Cell Significance Index: -129.5900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2163
    Cell Significance Index: -8.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2508
    Cell Significance Index: -72.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.3360
    Cell Significance Index: -152.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3956
    Cell Significance Index: -83.3300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4354
    Cell Significance Index: -5.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.4474
    Cell Significance Index: -160.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5548
    Cell Significance Index: -63.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.5638
    Cell Significance Index: -66.4900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5694
    Cell Significance Index: -3.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6689
    Cell Significance Index: -77.9500
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.6757
    Cell Significance Index: -3.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.8025
    Cell Significance Index: -160.9900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.8030
    Cell Significance Index: -91.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8908
    Cell Significance Index: -30.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.9488
    Cell Significance Index: -61.2100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.9843
    Cell Significance Index: -14.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.0166
    Cell Significance Index: -147.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.1653
    Cell Significance Index: -92.2900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.1779
    Cell Significance Index: -17.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.4490
    Cell Significance Index: -46.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.4837
    Cell Significance Index: -32.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.5246
    Cell Significance Index: -158.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.8425
    Cell Significance Index: -83.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.9101
    Cell Significance Index: -146.5800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.9462
    Cell Significance Index: -33.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.1600
    Cell Significance Index: -136.1400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -2.4351
    Cell Significance Index: -163.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.4386
    Cell Significance Index: -149.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -2.4573
    Cell Significance Index: -151.0400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.4679
    Cell Significance Index: -72.6900
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -2.6938
    Cell Significance Index: -56.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -2.7548
    Cell Significance Index: -58.6700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -2.9593
    Cell Significance Index: -75.6000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -2.9849
    Cell Significance Index: -24.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -3.0913
    Cell Significance Index: -173.4700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -3.3059
    Cell Significance Index: -173.5700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -3.3937
    Cell Significance Index: -124.5800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -3.5046
    Cell Significance Index: -68.4000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -3.5643
    Cell Significance Index: -24.1500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -3.6483
    Cell Significance Index: -30.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** S100A11 exhibits the following key characteristics: 1. **Calcium-binding protein**: S100A11 is a calcium-binding protein, which allows it to interact with other proteins and regulate various cellular processes. 2. **Cell-cell adhesion**: S100A11 is involved in cell-cell adhesion, particularly in adherens junctions, which are crucial for maintaining tissue structure and function. 3. **Immune system regulation**: S100A11 plays a role in regulating immune responses, including negative regulation of cell population proliferation, neutrophil degranulation, and positive regulation of smooth muscle cell migration. 4. **Protein binding and homodimerization**: S100A11 exhibits protein binding and homodimerization activities, which enable it to interact with other proteins and regulate cellular processes. **Pathways and Functions** S100A11 is involved in various signaling pathways and cellular processes, including: 1. **Adherens junction**: S100A11 regulates cell-cell adhesion through adherens junctions, which are critical for maintaining tissue structure and function. 2. **Immune system**: S100A11 plays a role in regulating immune responses, including negative regulation of cell population proliferation, neutrophil degranulation, and positive regulation of smooth muscle cell migration. 3. **Calcium-dependent protein binding**: S100A11 interacts with other proteins through calcium-dependent binding, which regulates various cellular processes. 4. **Protein binding and homodimerization**: S100A11 exhibits protein binding and homodimerization activities, which enable it to interact with other proteins and regulate cellular processes. **Clinical Significance** S100A11 has been implicated in various diseases and disorders, including: 1. **Inflammatory diseases**: S100A11 is upregulated in inflammatory diseases, such as atherosclerosis and rheumatoid arthritis, suggesting its involvement in inflammatory processes. 2. **Cancer**: S100A11 has been shown to be overexpressed in certain types of cancer, including breast cancer and prostate cancer, suggesting its potential role in tumorigenesis. 3. **Neurological disorders**: S100A11 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, suggesting its potential role in neurodegeneration. In conclusion, S100A11 is a multifunctional protein that plays a critical role in various cellular processes, including cell-cell adhesion, immune system regulation, and protein binding. Its dysregulation has been implicated in various diseases and disorders, highlighting the potential of S100A11 as a therapeutic target for the treatment of inflammatory and cancerous diseases.

Genular Protein ID: 1873279844

Symbol: S10AB_HUMAN

Name: Protein S100-A11

UniProtKB Accession Codes:

P31949 Q5VTK0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 7 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRIDE 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7889529

Title: Human calgizzarin; one colorectal cancer-related gene selected by a large scale random cDNA sequencing and northern blot analysis.

PubMed ID: 7889529

DOI: 10.1016/0304-3835(94)03687-e

PubMed ID: 7490069

Title: Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17.

PubMed ID: 7490069

DOI: 10.1006/geno.1995.1163

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 18618420

Title: The structure of S100A11 fragment explains a local structural change induced by phosphorylation.

PubMed ID: 18618420

DOI: 10.1002/psc.1050

Sequence Information:

  • Length: 105
  • Mass: 11740
  • Checksum: 1729ED680290CFE4
  • Sequence:
    • MAKISSPTET ERCIESLIAV FQKYAGKDGY NYTLSKTEFL SFMNTELAAF TKNQKDPGVL 
DRMMKKLDTN SDGQLDFSEF LNLIGGLAMA CHDSFLKAVP SQKRT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.