S100A11 | ENSG00000163191 | NCBI 6282

Details for: S100A11

Gene ID: 6282

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: S100A11

Ensembl ID: ENSG00000163191

Description: S100 calcium binding protein A11

Cell Significance Landscape

Display Count:

Associated with

Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Neutrophil degranulation
(R-HSA-6798695)
Adherens junction
(GO:0005912)
Cadherin binding involved in cell-cell adhesion
(GO:0098641)
Calcium-dependent protein binding
(GO:0048306)
Calcium ion binding
(GO:0005509)
Cell-cell adhesion
(GO:0098609)
Cytoplasm
(GO:0005737)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna replication
(GO:0008156)
Nucleus
(GO:0005634)
Positive regulation of smooth muscle cell migration
(GO:0014911)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Ruffle
(GO:0001726)
S100 protein binding
(GO:0044548)
Secretory granule lumen
(GO:0034774)
Signal transduction
(GO:0007165)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

CD14-low, CD16-positive monocyte CL0002396

CSI 122.47

rCSI 94.36%

PRS 3.68
ciliated epithelial cell CL0000067

CSI 112.24

rCSI 98.7%

PRS 2.94
elicited macrophage CL0000861

CSI 111.91

rCSI 100%

PRS 4.67
epithelial cell of lower respiratory tract CL0002632

CSI 110.41

rCSI 85.6%

PRS 3.88
keratinocyte CL0000312

CSI 100.58

rCSI 84.31%

PRS 4.9
myeloid leukocyte CL0000766

CSI 93.01

rCSI 85.81%

PRS 4.12
fallopian tube secretory epithelial cell CL4030006

CSI 91.54

rCSI 88.12%

PRS 4.21
multi-ciliated epithelial cell CL0005012

CSI 90.49

rCSI 90.31%

PRS 3.45
secretory cell CL0000151

CSI 83.54

rCSI 87.16%

PRS 4.17
lung ciliated cell CL1000271

CSI 81.82

rCSI 94.61%

PRS 2.95
extravillous trophoblast CL0008036

CSI 81.77

rCSI 100%

PRS 3.57
epithelial cell of lung CL0000082

CSI 81.44

rCSI 67.51%

PRS 3.81
skin fibroblast CL0002620

CSI 79.74

rCSI 68.74%

PRS 6.76
duct epithelial cell CL0000068

CSI 77.77

rCSI 100%

PRS 4.31
respiratory basal cell CL0002633

CSI 77.62

rCSI 80.4%

PRS 4.79
bronchus fibroblast of lung CL2000093

CSI 77.1

rCSI 62.64%

PRS 4.28
respiratory suprabasal cell CL4033048

CSI 76.36

rCSI 97.93%

PRS 4.71
CD14-positive monocyte CL0001054

CSI 74.44

rCSI 92.71%

PRS 5.98
CD14-positive, CD16-positive monocyte CL0002397

CSI 72.97

rCSI 95.62%

PRS 5.72
CD1c-positive myeloid dendritic cell CL0002399

CSI 72.37

rCSI 87.41%

PRS 4.73
alternatively activated macrophage CL0000890

CSI 69.94

rCSI 87.92%

PRS 6.28
conjunctival epithelial cell CL1000432

CSI 67.16

rCSI 100%

PRS 4.06
nasal mucosa goblet cell CL0002480

CSI 66.46

rCSI 77.08%

PRS 6.12
placental villous trophoblast CL2000060

CSI 64.31

rCSI 99.38%

PRS 3.82
intestinal epithelial cell CL0002563

CSI 62.4

rCSI 65.22%

PRS 4.33
intermediate monocyte CL0002393

CSI 59.71

rCSI 90.09%

PRS 4.01
colon epithelial cell CL0011108

CSI 59.3

rCSI 62.11%

PRS 3.8
Langerhans cell CL0000453

CSI 58.88

rCSI 89.93%

PRS 7.17
M cell of gut CL0000682

CSI 58.25

rCSI 61.89%

PRS 7.29
intestine goblet cell CL0019031

CSI 57.93

rCSI 51.42%

PRS 4.08
mucous neck cell CL0000651

CSI 56.79

rCSI 81.84%

PRS 6.61
club cell CL0000158

CSI 56.63

rCSI 82.94%

PRS 4.85
classical monocyte CL0000860

CSI 56.26

rCSI 83.41%

PRS 42.33
non-classical monocyte CL0000875

CSI 56.26

rCSI 90.18%

PRS 13.37
respiratory hillock cell CL4030023

CSI 56.09

rCSI 100%

PRS 7.09
acinar cell CL0000622

CSI 55.53

rCSI 81.43%

PRS 5.36
promonocyte CL0000559

CSI 54.81

rCSI 93.9%

PRS 5.46
stem cell CL0000034

CSI 54.8

rCSI 52.83%

PRS 2.04
fibroblast of lung CL0002553

CSI 54.51

rCSI 50.73%

PRS 4.06
conventional dendritic cell CL0000990

CSI 54.28

rCSI 45.31%

PRS 13.25
alveolar macrophage CL0000583

CSI 52.11

rCSI 85.82%

PRS 4.72
Hofbauer cell CL3000001

CSI 51.41

rCSI 97.06%

PRS 5.1
tracheal goblet cell CL1000329

CSI 48.93

rCSI 100%

PRS 8.37
goblet cell CL0000160

CSI 48.23

rCSI 45.57%

PRS 4.26
pancreatic ductal cell CL0002079

CSI 48.09

rCSI 93.53%

PRS 4.16
melanocyte CL0000148

CSI 47.46

rCSI 35.15%

PRS 3.83
pulmonary alveolar type 2 cell CL0002063

CSI 47.29

rCSI 73.35%

PRS 6.47
foveolar cell of stomach CL0002179

CSI 44.72

rCSI 95.19%

PRS 6.63
epithelial cell CL0000066

CSI 44.45

rCSI 68.3%

PRS 5.89
dendritic cell CL0000451

CSI 43.89

rCSI 54.08%

PRS 13.64
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 43.64

rCSI 99.47%

PRS 4.29
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 43.05

rCSI 29%

PRS 4.96
transit amplifying cell of colon CL0009011

CSI 42.73

rCSI 50.19%

PRS 4.94
endothelial cell of artery CL1000413

CSI 42.1

rCSI 61.68%

PRS 24.67
alveolar adventitial fibroblast CL4028006

CSI 41.84

rCSI 66.08%

PRS 4.09
perivascular cell CL4033054

CSI 41.25

rCSI 56.39%

PRS 4.62
monocyte CL0000576

CSI 41.19

rCSI 74.45%

PRS 11.7
mucus secreting cell CL0000319

CSI 41

rCSI 65.12%

PRS 5.34
basal-myoepithelial cell of mammary gland CL0002324

CSI 39.27

rCSI 74.24%

PRS 9.2
ciliated cell CL0000064

CSI 38.56

rCSI 62.48%

PRS 4.14
basal cell CL0000646

CSI 38.5

rCSI 51.48%

PRS 4.46
luminal epithelial cell of mammary gland CL0002326

CSI 37.7

rCSI 68.49%

PRS 6.24
enterocyte CL0000584

CSI 36.98

rCSI 59.64%

PRS 6.63
lung macrophage CL1001603

CSI 36.84

rCSI 82.29%

PRS 4.61
syncytiotrophoblast cell CL0000525

CSI 36.68

rCSI 100%

PRS 8.32
granulocyte monocyte progenitor cell CL0000557

CSI 34.8

rCSI 30.13%

PRS 4.53
squamous epithelial cell CL0000076

CSI 34.45

rCSI 81.76%

PRS 5.49
macrophage CL0000235

CSI 34.39

rCSI 62.56%

PRS 19.6
myeloid dendritic cell CL0000782

CSI 33.81

rCSI 48.98%

PRS 6.01
mature T cell CL0002419

CSI 33.79

rCSI 26.28%

PRS 5.88
basal cell of prostate epithelium CL0002341

CSI 33.43

rCSI 96.71%

PRS 9.15
myofibroblast cell CL0000186

CSI 32.65

rCSI 45.22%

PRS 5.88
plasmacytoid dendritic cell, human CL0001058

CSI 30.71

rCSI 21.44%

PRS 4.31
pulmonary artery endothelial cell CL1001568

CSI 30.58

rCSI 41.61%

PRS 6.27
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 30.29

rCSI 17.89%

PRS 5.71
mononuclear phagocyte CL0000113

CSI 30.05

rCSI 66.14%

PRS 4.47
kidney epithelial cell CL0002518

CSI 28.52

rCSI 54.44%

PRS 10.02
transit amplifying cell CL0009010

CSI 28.09

rCSI 42.96%

PRS 6.68
adventitial cell CL0002503

CSI 27.89

rCSI 66.62%

PRS 6.61
renal alpha-intercalated cell CL0005011

CSI 27.73

rCSI 37.07%

PRS 5.56
microcirculation associated smooth muscle cell CL0008035

CSI 27.63

rCSI 80%

PRS 4.62
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 27.44

rCSI 46.95%

PRS 8.92
T-helper 17 cell CL0000899

CSI 27.42

rCSI 21.77%

PRS 7.28
dendritic cell, human CL0001056

CSI 27.22

rCSI 41.81%

PRS 4.74
keratocyte CL0002363

CSI 26.99

rCSI 64.89%

PRS 6.35
deuterosomal cell CL4033044

CSI 25.69

rCSI 86.87%

PRS 7.03
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 25.36

rCSI 50.56%

PRS 7
bronchial goblet cell CL1000312

CSI 25.01

rCSI 99.96%

PRS 9.1
pulmonary ionocyte CL0017000

CSI 24.99

rCSI 30.42%

PRS 5.16
glandular epithelial cell CL0000150

CSI 24.15

rCSI 63.59%

PRS 7.97
Kupffer cell CL0000091

CSI 23.82

rCSI 54.47%

PRS 3.96
stromal cell CL0000499

CSI 23.74

rCSI 66.78%

PRS 6.01
enteroendocrine cell CL0000164

CSI 23.72

rCSI 32.42%

PRS 4.51
intrahepatic cholangiocyte CL0002538

CSI 23.38

rCSI 56.1%

PRS 7.76
lung endothelial cell CL1001567

CSI 23.36

rCSI 54.46%

PRS 10.85
mammary gland epithelial cell CL0002327

CSI 23.32

rCSI 81.83%

PRS 7.41
ionocyte CL0005006

CSI 22.69

rCSI 24.31%

PRS 3.76
CD4-positive helper T cell CL0000492

CSI 22.02

rCSI 16.65%

PRS 5.73
T-helper 1 cell CL0000545

CSI 21.49

rCSI 38.79%

PRS 12.46
alveolar type 1 fibroblast cell CL4028004

CSI 21.2

rCSI 23.22%

PRS 4.74

immature B cell CL0000816

CSI -46.9

rCSI -34.8%

PRS 6.1%
vascular leptomeningeal cell CL4023051

CSI -29.9

rCSI -52.4%

PRS 3.2%
precursor B cell CL0000817

CSI -19.5

rCSI -17.1%

PRS 5.5%
peripheral nervous system neuron CL2000032

CSI -16.5

rCSI -22.5%

PRS 3.7%
unswitched memory B cell CL0000970

CSI -14.3

rCSI -12.0%

PRS 6.9%
IgM plasma cell CL0000986

CSI -10.5

rCSI -47.3%

PRS 22.1%
early lymphoid progenitor CL0000936

CSI -6.8

rCSI -5.9%

PRS 4.6%
kidney collecting duct principal cell CL1001431

CSI -6.4

rCSI -32.0%

PRS 23.2%
memory B cell CL0000787

CSI -6.1

rCSI -6.0%

PRS 18.0%
IgA plasma cell CL0000987

CSI -5.5

rCSI -5.6%

PRS 7.7%
brush cell CL0002204

CSI -4.8

rCSI -9.5%

PRS 11.9%
adipocyte CL0000136

CSI -3.8

rCSI -4.9%

PRS 5.1%
cerebral cortex endothelial cell CL1001602

CSI -3.1

rCSI -5.3%

PRS 3.1%
IgG plasma cell CL0000985

CSI -3.0

rCSI -3.6%

PRS 7.1%
megakaryocyte-erythroid progenitor cell CL0000050

CSI -2.9

rCSI -2.6%

PRS 3.6%
antibody secreting cell CL0000946

CSI -2.0

rCSI -9.1%

PRS 18.9%
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI -1.5

rCSI -1.4%

PRS 6.4%
choroid plexus epithelial cell CL0000706

CSI -1.5

rCSI -2.4%

PRS 3.2%
cord blood hematopoietic stem cell CL2000095

CSI -1.3

rCSI -25.0%

PRS 33.9%
ventricular cardiac muscle cell CL2000046

CSI -1.2

rCSI -4.2%

PRS 18.8%
endocrine cell CL0000163

CSI -0.8

rCSI -4.2%

PRS 19.3%
platelet CL0000233

CSI -0.6

rCSI -2.6%

PRS 12.3%
brush cell of tracheobronchial tree CL0002075

CSI -0.6

rCSI -1.8%

PRS 7.0%
hematopoietic multipotent progenitor cell CL0000837

CSI 0.0

rCSI 0.1%

PRS 6.4%
immature alpha-beta T cell CL0000790

CSI 0.3

rCSI 4.3%

PRS 57.9%
lung resident memory CD8-positive, alpha-beta T cell CL4033039

CSI 0.4

rCSI 1.1%

PRS 14.7%
double negative T regulatory cell CL0011024

CSI 0.4

rCSI 8.3%

PRS 35.4%
lymphoid lineage restricted progenitor cell CL0000838

CSI 0.5

rCSI 1.9%

PRS 6.8%
cytotoxic T cell CL0000910

CSI 0.5

rCSI 3.0%

PRS 6.4%
effector CD4-positive, alpha-beta T cell CL0001044

CSI 0.5

rCSI 1.5%

PRS 5.9%
pro-T cell CL0000827

CSI 0.6

rCSI 13.4%

PRS 26.3%
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI 0.6

rCSI 5.1%

PRS 10.6%
enterocyte of epithelium of large intestine CL0002071

CSI 0.6

rCSI 3.2%

PRS 8.3%
lung resident memory CD4-positive, alpha-beta T cell CL4033038

CSI 0.7

rCSI 6.5%

PRS 44.4%
germinal center B cell CL0000844

CSI 0.7

rCSI 2.1%

PRS 11.1%
renal interstitial pericyte CL1001318

CSI 0.8

rCSI 2.2%

PRS 4.7%
alpha-beta T cell CL0000789

CSI 0.8

rCSI 1.0%

PRS 6.6%
mesenchymal lymphangioblast CL0005021

CSI 0.9

rCSI 23.9%

PRS 22.8%
kidney connecting tubule principal cell CL4030018

CSI 1.0

rCSI 7.3%

PRS 44.3%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 1.1

rCSI 11.6%

PRS 6.9%
kidney collecting duct intercalated cell CL1001432

CSI 1.2

rCSI 8.7%

PRS 15.5%
endothelial cell of venule CL1000414

CSI 1.3

rCSI 11.2%

PRS 25.6%
kidney resident macrophage CL1000698

CSI 1.4

rCSI 27.6%

PRS 69.9%
thymocyte CL0000893

CSI 1.4

rCSI 5.0%

PRS 13.3%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 1.5

rCSI 1.9%

PRS 6.2%
cell of skeletal muscle CL0000188

CSI 1.6

rCSI 17.0%

PRS 28.3%
osteoblast CL0000062

CSI 1.6

rCSI 39.2%

PRS 36.3%
pluripotent stem cell CL0002248

CSI 1.7

rCSI 50.0%

PRS 10.0%
odontoblast CL0000060

CSI 1.7

rCSI 37.8%

PRS 23.5%
endocardial cell CL0002350

CSI 1.8

rCSI 8.4%

PRS 7.0%
erythroid lineage cell CL0000764

CSI 1.8

rCSI 11.5%

PRS 11.1%
class switched memory B cell CL0000972

CSI 2.0

rCSI 1.5%

PRS 6.9%
common lymphoid progenitor CL0000051

CSI 2.0

rCSI 2.7%

PRS 7.8%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 2.1

rCSI 10.3%

PRS 5.4%
tracheobronchial goblet cell CL0019003

CSI 2.1

rCSI 33.6%

PRS 63.1%
kidney interstitial cell CL1000500

CSI 2.4

rCSI 38.5%

PRS 41.5%
activated CD4-positive, alpha-beta T cell, human CL0001043

CSI 2.4

rCSI 5.9%

PRS 29.2%
tuft cell of colon CL0009041

CSI 2.5

rCSI 5.9%

PRS 10.0%
transitional stage B cell CL0000818

CSI 2.6

rCSI 8.4%

PRS 12.8%
enterocyte of epithelium of small intestine CL1000334

CSI 2.6

rCSI 40.4%

PRS 10.8%
erythroid progenitor cell CL0000038

CSI 2.7

rCSI 15.3%

PRS 6.4%
Merkel cell CL0000242

CSI 2.7

rCSI 62.8%

PRS 30.2%
CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074

CSI 2.8

rCSI 32.2%

PRS 18.1%
plasmablast CL0000980

CSI 2.8

rCSI 2.2%

PRS 4.9%
lung microvascular endothelial cell CL2000016

CSI 2.9

rCSI 56.8%

PRS 15.0%
epicardial adipocyte CL1000309

CSI 3.0

rCSI 9.7%

PRS 6.6%
epithelial cell of nephron CL1000449

CSI 3.0

rCSI 28.7%

PRS 18.4%
activated CD8-positive, alpha-beta T cell CL0000906

CSI 3.1

rCSI 3.0%

PRS 12.3%
cholangiocyte CL1000488

CSI 3.1

rCSI 18.5%

PRS 8.5%
myeloid lineage restricted progenitor cell CL0000839

CSI 3.2

rCSI 16.4%

PRS 8.2%
follicular dendritic cell CL0000442

CSI 3.2

rCSI 51.0%

PRS 27.2%
kidney interstitial alternatively activated macrophage CL1000695

CSI 3.3

rCSI 8.5%

PRS 4.9%
Schwann cell CL0002573

CSI 3.3

rCSI 9.4%

PRS 5.6%
glial cell CL0000125

CSI 3.4

rCSI 13.1%

PRS 4.5%
erythroblast CL0000765

CSI 3.6

rCSI 9.5%

PRS 7.0%
epithelial cell of urethra CL1000296

CSI 3.6

rCSI 91.5%

PRS 14.6%
P/D1 enteroendocrine cell CL0002268

CSI 3.7

rCSI 19.9%

PRS 10.6%
endothelial cell of arteriole CL1000412

CSI 3.7

rCSI 20.3%

PRS 19.9%
renal intercalated cell CL0005010

CSI 3.7

rCSI 33.0%

PRS 36.5%
acinar cell of salivary gland CL0002623

CSI 3.7

rCSI 86.5%

PRS 5.5%
bronchiolar smooth muscle cell CL4033017

CSI 3.7

rCSI 55.7%

PRS 13.8%
prostate gland microvascular endothelial cell CL2000059

CSI 3.8

rCSI 89.7%

PRS 15.6%
transit amplifying cell of small intestine CL0009012

CSI 3.8

rCSI 16.6%

PRS 8.0%
effector CD8-positive, alpha-beta T cell CL0001050

CSI 4.0

rCSI 3.0%

PRS 5.4%
endothelial cell of vascular tree CL0002139

CSI 4.0

rCSI 21.6%

PRS 10.4%
blood vessel smooth muscle cell CL0019018

CSI 4.0

rCSI 32.4%

PRS 4.3%
CD4-positive, alpha-beta memory T cell CL0000897

CSI 4.0

rCSI 2.9%

PRS 5.6%
enteric smooth muscle cell CL0002504

CSI 4.1

rCSI 5.8%

PRS 4.6%
activated type II NK T cell CL0000931

CSI 4.1

rCSI 4.6%

PRS 6.8%
pre-conventional dendritic cell CL0002010

CSI 4.1

rCSI 54.8%

PRS 14.4%
CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915

CSI 4.2

rCSI 19.2%

PRS 15.5%
decidual natural killer cell, human CL0002343

CSI 4.2

rCSI 42.9%

PRS 37.2%
uterine smooth muscle cell CL0002601

CSI 4.2

rCSI 27.9%

PRS 31.4%
corneal epithelial cell CL0000575

CSI 4.3

rCSI 12.2%

PRS 7.9%
megakaryocyte CL0000556

CSI 4.3

rCSI 18.5%

PRS 7.7%
memory T cell CL0000813

CSI 4.4

rCSI 8.4%

PRS 9.4%
paneth cell CL0000510

CSI 4.4

rCSI 6.5%

PRS 6.5%
hair follicular keratinocyte CL2000092

CSI 4.4

rCSI 76.9%

PRS 17.3%
renal beta-intercalated cell CL0002201

CSI 4.6

rCSI 11.0%

PRS 5.3%
parietal epithelial cell CL1000452

CSI 4.7

rCSI 12.5%

PRS 4.2%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Node Color (Target Cell CSI, relative to current network):
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- High
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- Low
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Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [S100A11](/details-gene/6282), or S100 calcium binding protein A11, is a protein-coding gene located on chromosome 1q21.3. As a member of the S100 family of calcium-binding proteins, [S100A11](/details-gene/6282) functions as a calcium sensor and is involved in a variety of cellular processes, including [cell-cell adhesion](/details-go/GO:0098609), regulation of cell proliferation, and signal transduction. **Overall**, expression data indicates that [S100A11](/details-gene/6282) is a significant marker for specific myeloid lineage cells, notably [CD14-low, CD16-positive monocyte](/details-cell/CL0002396)s, and a wide range of epithelial cell types, such as [ciliated epithelial cell](/details-cell/CL0000067)s and [keratinocyte](/details-cell/CL0000312)s. Its functional annotations in pathways like the [Innate immune system](/details-reactome/R-HSA-168249) and its role in [cadherin binding involved in cell-cell adhesion](/details-go/GO:0098641) are consistent with its prominent expression in these cellular contexts. ## Cellular Roles and Expression Landscape The expression profile of [S100A11](/details-gene/6282) highlights its dual importance in the innate immune system and in maintaining epithelial structures. **Overall**, the gene shows its highest significance in myeloid cells, including [CD14-low, CD16-positive monocyte](/details-cell/CL0002396) (CSI: 122.47) and [elicited macrophage](/details-cell/CL0000861) (CSI: 111.91), suggesting a key role in the function of these professional phagocytes. Concurrently, [S100A11](/details-gene/6282) is a prominent marker across diverse epithelial tissues. It is highly significant in [ciliated epithelial cell](/details-cell/CL0000067) (CSI: 112.24), [epithelial cell of lower respiratory tract](/details-cell/CL0002632) (CSI: 110.41), and [keratinocyte](/details-cell/CL0000312) (CSI: 100.58). This pattern suggests its involvement in barrier function, cell adhesion, and secretory processes within these lineages. Conversely, [S100A11](/details-gene/6282) shows significantly low expression in the B cell lineage, including [immature B cell](/details-cell/CL0000816) (CSI: -46.90) and [precursor B cell](/details-cell/CL0000817) (CSI: -19.48), as well as in various plasma cells. Its low significance in [peripheral nervous system neuron](/details-cell/CL2000032)s and [adipocyte](/details-cell/CL0000136)s further refines its role, indicating a specialized function largely restricted to myeloid and epithelial contexts, and outside of lymphoid, neural, or adipose tissues. ## Pathways and Molecular Function The molecular functions of [S100A11](/details-gene/6282) are intrinsically linked to its ability to bind calcium and other proteins. As a calcium sensor ([calcium ion binding](/details-go/GO:0005509)), it transduces calcium signals by interacting with various target proteins ([calcium-dependent protein binding](/details-go/GO:0048306)). Its involvement in biological processes is multifaceted. The gene's role in [cell-cell adhesion](/details-go/GO:0098609) and specifically [cadherin binding involved in cell-cell adhesion](/details-go/GO:0098641) is consistent with its high expression in epithelial cells and its localization to the [adherens junction](/details-go/GO:0005912). This points to a structural role in maintaining tissue integrity. Furthermore, its participation in the [Innate immune system](/details-reactome/R-HSA-168249) and [Neutrophil degranulation](/details-reactome/R-HSA-6798695) pathways aligns with its high CSI scores in monocytes and macrophages, suggesting it modulates key immune responses. The gene is also annotated to the [extracellular exosome](/details-go/GO:0070062), indicating it may also function in intercellular communication. ## Research Directions The specific expression pattern of [S100A11](/details-gene/6282) in myeloid and epithelial cells, coupled with literature suggesting its dysregulation in cancer ([Link](https://doi.org/10.1016/0304-3835(94)03687-e), [Link](https://doi.org/10.1006/geno.1995.1163)), opens several avenues for future research. **Proposed Hypotheses:** 1. Given its high significance in [CD14-low, CD16-positive monocyte](/details-cell/CL0002396)s and its link to the innate immune system, [S100A11](/details-gene/6282) may act as a critical regulator of inflammatory responses in these cells. Its depletion could alter cytokine production, migration, or differentiation in response to pathogenic stimuli. 2. The high expression of [S100A11](/details-gene/6282) in [keratinocyte](/details-cell/CL0000312)s and its role in [cadherin binding](/details-go/GO:0098641) suggest that it is essential for maintaining epidermal barrier function. Dysregulation of [S100A11](/details-gene/6282) could contribute to the pathogenesis of inflammatory skin disorders characterized by impaired barrier integrity, such as atopic dermatitis or psoriasis. 3. Based on reports of its overexpression in carcinomas, [S100A11](/details-gene/6282) may promote tumor progression by modulating cell adhesion dynamics. Its upregulation in epithelial cancers could disrupt normal adherens junctions, thereby facilitating epithelial-mesenchymal transition (EMT) and metastasis. **Experimental Approach:** To test the hypothesis that [S100A11](/details-gene/6282) regulates monocyte inflammatory function, one could use CRISPR-Cas9 to knock out the gene in a human monocytic cell line (e.g., THP-1) or in primary human CD14+ monocytes. Following differentiation into macrophages, these knockout and control cells could be stimulated with lipopolysaccharide (LPS). The impact of [S100A11](/details-gene/6282) loss could be assessed by measuring the secretion of key inflammatory cytokines (e.g., TNF-alpha, IL-6) via ELISA and by analyzing global transcriptomic changes using RNA-sequencing. **Therapeutic Potential:** The potential of [S100A11](/details-gene/6282) as a therapeutic target is context-dependent. Its reported overexpression in certain cancers suggests it could be a target for **inhibition**. Given that it is found in [extracellular exosome](/details-go/GO:0070062)s, targeting a secreted form of S100A11 with monoclonal antibodies could be a viable strategy to neutralize its pro-tumorigenic effects in the tumor microenvironment. However, its widespread expression in healthy epithelial and myeloid cells would necessitate highly targeted delivery systems to minimize off-target effects of any systemic inhibitor.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Protein S100-A11

Genular Protein ID: 1873279844

Symbol: S10AB_HUMAN

Name: Protein S100-A11

UniProtKB Accession Codes:

P31949 Q5VTK0

Database IDs:

Citations:

PubMed ID: 7889529

Title: Human calgizzarin; one colorectal cancer-related gene selected by a large scale random cDNA sequencing and northern blot analysis.

PubMed ID: 7889529

DOI: 10.1016/0304-3835(94)03687-e

PubMed ID: 7490069

Title: Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17.

PubMed ID: 7490069

DOI: 10.1006/geno.1995.1163

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 18618420

Title: The structure of S100A11 fragment explains a local structural change induced by phosphorylation.

PubMed ID: 18618420

DOI: 10.1002/psc.1050

Sequence Information:

Length: 105
Mass: 11740
Checksum: 1729ED680290CFE4
Sequence:

MAKISSPTET ERCIESLIAV FQKYAGKDGY NYTLSKTEFL SFMNTELAAF TKNQKDPGVL 
DRMMKKLDTN SDGQLDFSEF LNLIGGLAMA CHDSFLKAVP SQKRT

Details for: S100A11

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Human calgizzarin; one colorectal cancer-related gene selected by a large scale random cDNA sequencing and northern blot analysis. PubMed ID: 7889529

Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. PubMed ID: 7490069

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. PubMed ID: 1286667

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

The structure of S100A11 fragment explains a local structural change induced by phosphorylation. PubMed ID: 18618420