Details for: NDUFB4

Gene ID: 4710

Symbol: NDUFB4

Ensembl ID: ENSG00000065518

Description: NADH:ubiquinone oxidoreductase subunit B4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 467.8382
    Cell Significance Index: -72.7700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 289.9543
    Cell Significance Index: -73.5500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 245.4196
    Cell Significance Index: -101.1000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 210.6548
    Cell Significance Index: -85.5800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 204.5655
    Cell Significance Index: -96.5800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 186.4945
    Cell Significance Index: -95.9300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 144.7195
    Cell Significance Index: -97.1100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 91.0193
    Cell Significance Index: -86.9000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 74.0659
    Cell Significance Index: -91.3200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 27.6200
    Cell Significance Index: -73.9900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 24.6626
    Cell Significance Index: -97.3200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 22.6114
    Cell Significance Index: -69.4500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.0652
    Cell Significance Index: -35.1600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 8.5813
    Cell Significance Index: 91.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.6825
    Cell Significance Index: 171.7000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.4831
    Cell Significance Index: 27.8100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.0597
    Cell Significance Index: 70.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.9597
    Cell Significance Index: 1616.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.9347
    Cell Significance Index: 403.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.9341
    Cell Significance Index: 137.9000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.9161
    Cell Significance Index: 79.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.7843
    Cell Significance Index: 207.5100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.6786
    Cell Significance Index: 30.4300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.5254
    Cell Significance Index: 1116.5300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.4437
    Cell Significance Index: 127.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.3471
    Cell Significance Index: 166.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.2243
    Cell Significance Index: 400.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.1266
    Cell Significance Index: 55.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.0727
    Cell Significance Index: 267.7700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.0638
    Cell Significance Index: 60.6100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.0589
    Cell Significance Index: 18.9600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.0471
    Cell Significance Index: 241.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.9860
    Cell Significance Index: 41.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.9731
    Cell Significance Index: 242.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.9666
    Cell Significance Index: 252.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.9594
    Cell Significance Index: 88.8200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.9377
    Cell Significance Index: 11.9300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.8791
    Cell Significance Index: 98.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.6401
    Cell Significance Index: 105.8100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.3293
    Cell Significance Index: 35.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2798
    Cell Significance Index: 66.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.0690
    Cell Significance Index: 182.5300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.0204
    Cell Significance Index: 29.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.0095
    Cell Significance Index: 63.6200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.9539
    Cell Significance Index: 10.3700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.8702
    Cell Significance Index: 11.1500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7421
    Cell Significance Index: 11.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7252
    Cell Significance Index: 71.7400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.6253
    Cell Significance Index: 11.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5986
    Cell Significance Index: 120.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4960
    Cell Significance Index: 94.3900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4000
    Cell Significance Index: 10.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3796
    Cell Significance Index: 26.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.3236
    Cell Significance Index: 237.2400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2316
    Cell Significance Index: 4.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2136
    Cell Significance Index: 161.7100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1891
    Cell Significance Index: 6.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1430
    Cell Significance Index: 28.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0922
    Cell Significance Index: 33.0800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0663
    Cell Significance Index: 1.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0089
    Cell Significance Index: 16.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0050
    Cell Significance Index: -3.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0388
    Cell Significance Index: -71.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0392
    Cell Significance Index: -4.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0454
    Cell Significance Index: -28.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0494
    Cell Significance Index: -76.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0787
    Cell Significance Index: -107.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0796
    Cell Significance Index: -2.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0826
    Cell Significance Index: -6.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0831
    Cell Significance Index: -52.7800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1030
    Cell Significance Index: -2.7500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1151
    Cell Significance Index: -64.8900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1354
    Cell Significance Index: -61.4500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1542
    Cell Significance Index: -9.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1547
    Cell Significance Index: -32.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1988
    Cell Significance Index: -22.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.2396
    Cell Significance Index: -38.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2442
    Cell Significance Index: -7.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2520
    Cell Significance Index: -72.5100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4247
    Cell Significance Index: -10.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4391
    Cell Significance Index: -26.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4476
    Cell Significance Index: -52.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4620
    Cell Significance Index: -67.1500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6375
    Cell Significance Index: -72.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7535
    Cell Significance Index: -10.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7619
    Cell Significance Index: -58.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.8041
    Cell Significance Index: -17.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.8087
    Cell Significance Index: -22.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8988
    Cell Significance Index: -93.5900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.9591
    Cell Significance Index: -5.8000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.0369
    Cell Significance Index: -17.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.0699
    Cell Significance Index: -60.0400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.1222
    Cell Significance Index: -8.6500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.1518
    Cell Significance Index: -13.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.1541
    Cell Significance Index: -77.6000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.3738
    Cell Significance Index: -11.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.5789
    Cell Significance Index: -96.8000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.6616
    Cell Significance Index: -48.9400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.0135
    Cell Significance Index: -34.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.0159
    Cell Significance Index: -89.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NDUFB4 is a mitochondrial gene, specifically encoding a subunit of the NADH:ubiquinone oxidoreductase complex I. This complex is a transmembrane enzyme that spans the inner mitochondrial membrane, where it plays a central role in the electron transport chain. The gene's product, NDUB4, is a beta subunit of the complex, which interacts with other subunits to form the functional enzyme. NDUFB4 is highly conserved across species, suggesting its essential role in energy metabolism. **Pathways and Functions** The NDUFB4 gene is involved in several key pathways, including: 1. **Aerobic Respiration**: NDUFB4 plays a critical role in the electron transport chain, where it facilitates the transfer of electrons from NADH to ubiquinone, generating a proton gradient that drives ATP synthesis. 2. **Mitochondrial Electron Transport**: The NDUFB4 subunit is integral to the mitochondrial inner membrane, where it participates in the electron transport chain, contributing to the production of ATP. 3. **Metabolism**: NDUFB4 is required for the efficient metabolism of NADH, a key energy source for many cellular processes. 4. **Response to Oxidative Stress**: The NDUFB4 subunit is involved in the regulation of mitochondrial function in response to oxidative stress, where it helps maintain mitochondrial homeostasis. **Clinical Significance** Dysregulation of NDUFB4 has been implicated in various diseases, including: 1. **Mitochondrial Myopathies**: Mutations in the NDUFB4 gene have been associated with mitochondrial myopathies, a group of disorders characterized by muscle weakness and fatigue. 2. **Neurodegenerative Diseases**: Altered expression of NDUFB4 has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's, where mitochondrial dysfunction plays a key role. 3. **Cancer**: NDUFB4 has been identified as a potential target for cancer therapy, as its dysregulation is associated with tumor progression and metastasis. In conclusion, NDUFB4 is a critical gene involved in energy metabolism, mitochondrial function, and response to oxidative stress. Its dysregulation has been implicated in various diseases, highlighting the importance of maintaining proper NDUFB4 expression and function in maintaining cellular homeostasis.

Genular Protein ID: 195860356

Symbol: NDUB4_HUMAN

Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4

UniProtKB Accession Codes:

O95168 B2RUY3 B9EJC7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9878551

Title: cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed.

PubMed ID: 9878551

DOI: 10.1006/bbrc.1998.9786

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12611891

Title: The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.

PubMed ID: 12611891

DOI: 10.1074/jbc.c300064200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27626371

Title: Accessory subunits are integral for assembly and function of human mitochondrial complex I.

PubMed ID: 27626371

DOI: 10.1038/nature19754

Sequence Information:

  • Length: 129
  • Mass: 15209
  • Checksum: E5060D0BF46FFF28
  • Sequence:
    • MSFPKYKPSS LRTLPETLDP AEYNISPETR RAQAERLAIR AQLKREYLLQ YNDPNRRGLI 
ENPALLRWAY ARTINVYPNF RPTPKNSLMG ALCGFGPLIF IYYIIKTERD RKEKLIQEGK 
LDRTFHLSY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.