Details for: HNRNPK

Gene ID: 3190

Symbol: HNRNPK

Ensembl ID: ENSG00000165119

Description: heterogeneous nuclear ribonucleoprotein K

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 842.0702
    Cell Significance Index: -130.9800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 525.0679
    Cell Significance Index: -133.1800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 407.0421
    Cell Significance Index: -167.6800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 353.2345
    Cell Significance Index: -166.7700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 350.4677
    Cell Significance Index: -142.3800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 311.8869
    Cell Significance Index: -160.4300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 249.2019
    Cell Significance Index: -167.2200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 149.6110
    Cell Significance Index: -142.8400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 124.7896
    Cell Significance Index: -153.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 42.5565
    Cell Significance Index: -167.9300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 42.2727
    Cell Significance Index: -113.2400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 36.6113
    Cell Significance Index: -112.4500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 20.5703
    Cell Significance Index: -45.0200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 5.5957
    Cell Significance Index: 194.4500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 5.4550
    Cell Significance Index: 143.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.3910
    Cell Significance Index: 91.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.0093
    Cell Significance Index: 492.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.0060
    Cell Significance Index: 109.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.4972
    Cell Significance Index: 480.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.4115
    Cell Significance Index: 615.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.3594
    Cell Significance Index: 157.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.2648
    Cell Significance Index: 243.3200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.2645
    Cell Significance Index: 35.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.2021
    Cell Significance Index: 168.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.1904
    Cell Significance Index: 376.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.9956
    Cell Significance Index: 193.2600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.9706
    Cell Significance Index: 1313.3800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.7820
    Cell Significance Index: 356.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.7122
    Cell Significance Index: 1481.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.5778
    Cell Significance Index: 333.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.4207
    Cell Significance Index: 171.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.3583
    Cell Significance Index: 62.9700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.8088
    Cell Significance Index: 51.8500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.8010
    Cell Significance Index: 14.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.5644
    Cell Significance Index: 72.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5449
    Cell Significance Index: 306.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.4504
    Cell Significance Index: 417.3400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.4379
    Cell Significance Index: 25.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0764
    Cell Significance Index: 215.9300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.0009
    Cell Significance Index: 18.5000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.9668
    Cell Significance Index: 28.4000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.9237
    Cell Significance Index: 11.8300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.7192
    Cell Significance Index: 8.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5875
    Cell Significance Index: 210.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4541
    Cell Significance Index: 23.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3729
    Cell Significance Index: 10.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2746
    Cell Significance Index: 5.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2069
    Cell Significance Index: 13.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1955
    Cell Significance Index: 37.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1693
    Cell Significance Index: 16.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0920
    Cell Significance Index: 69.6500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0866
    Cell Significance Index: 1.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0541
    Cell Significance Index: 37.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0489
    Cell Significance Index: 35.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0470
    Cell Significance Index: 88.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0165
    Cell Significance Index: 14.9300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0148
    Cell Significance Index: 0.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0303
    Cell Significance Index: -55.8800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0467
    Cell Significance Index: -71.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0658
    Cell Significance Index: -41.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0731
    Cell Significance Index: -99.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0929
    Cell Significance Index: -9.4900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0983
    Cell Significance Index: -2.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1859
    Cell Significance Index: -137.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2014
    Cell Significance Index: -91.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2409
    Cell Significance Index: -41.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2780
    Cell Significance Index: -156.7800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.3063
    Cell Significance Index: -191.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.3204
    Cell Significance Index: -52.1100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.3446
    Cell Significance Index: -37.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3570
    Cell Significance Index: -21.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4245
    Cell Significance Index: -14.9200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.5207
    Cell Significance Index: -23.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5243
    Cell Significance Index: -76.2200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5430
    Cell Significance Index: -5.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7984
    Cell Significance Index: -25.5700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8549
    Cell Significance Index: -21.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.8699
    Cell Significance Index: -183.2200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.9342
    Cell Significance Index: -108.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.0116
    Cell Significance Index: -115.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.0537
    Cell Significance Index: -30.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.2020
    Cell Significance Index: -16.4000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.2573
    Cell Significance Index: -18.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.2678
    Cell Significance Index: -97.2900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.3379
    Cell Significance Index: -105.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.3633
    Cell Significance Index: -91.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.3991
    Cell Significance Index: -72.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.5399
    Cell Significance Index: -160.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.6464
    Cell Significance Index: -113.8600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.9315
    Cell Significance Index: -11.6700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.9587
    Cell Significance Index: -52.4000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -2.0435
    Cell Significance Index: -35.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.6828
    Cell Significance Index: -164.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.8312
    Cell Significance Index: -72.7800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -2.8485
    Cell Significance Index: -17.5300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -2.8802
    Cell Significance Index: -40.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.9760
    Cell Significance Index: -131.6400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.0471
    Cell Significance Index: -89.7500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -3.2423
    Cell Significance Index: -38.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -3.3753
    Cell Significance Index: -84.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HNRNPK is a large protein (approximately 450 kDa) composed of three distinct domains: an RNA-binding domain, a protein-binding domain, and a nuclear localization signal. The protein is primarily localized to the nucleus, where it interacts with various RNA and protein partners to regulate different cellular processes. HNRNPK has been shown to bind to numerous RNAs, including pre-mRNAs, snRNAs, and small RNAs, and has been implicated in the regulation of RNA stability, localization, and translation. The protein's ability to interact with other proteins, including transcription factors and signaling molecules, has also been highlighted in various studies. **Pathways and Functions** HNRNPK is involved in several key cellular pathways, including: 1. **RNA processing**: HNRNPK plays a critical role in the assembly and disassembly of spliceosomes, which are essential for pre-mRNA splicing. The protein's ability to interact with various RNAs and protein partners allows it to regulate different aspects of RNA processing, including splicing, stability, and localization. 2. **Transcription regulation**: HNRNPK has been shown to regulate transcription by interacting with transcription factors and other RNA-binding proteins. The protein's ability to modulate transcriptional activity has been implicated in various cellular processes, including cell growth, differentiation, and stress responses. 3. **Stress granule formation**: HNRNPK has been implicated in the formation of stress granules, which are dynamic structures that form in response to stress or other cellular perturbations. The protein's ability to interact with other RNA-binding proteins and signaling molecules allows it to regulate stress granule formation and function. 4. **Apoptosis regulation**: HNRNPK has been shown to regulate apoptosis by interacting with pro-apoptotic proteins and signaling molecules. The protein's ability to modulate apoptosis has been implicated in various cellular processes, including cell growth, differentiation, and survival. **Clinical Significance** Dysregulation of HNRNPK has been implicated in various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. For example, studies have shown that HNRNPK is overexpressed in certain types of cancer, including breast and lung cancer, and that its expression is associated with poor prognosis. Additionally, HNRNPK has been implicated in the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS). The protein's ability to regulate RNA processing and transcription has also been highlighted in various studies, suggesting that dysregulation of HNRNPK may contribute to the development of certain diseases. In conclusion, HNRNPK is a multifunctional protein that plays a critical role in various cellular processes, including RNA processing, transcription regulation, and stress granule formation. Its dysregulation has been implicated in various diseases, highlighting the importance of this protein in maintaining cellular homeostasis. Further studies are needed to fully elucidate the role of HNRNPK in different cellular processes and its potential as a therapeutic target for various diseases.

Genular Protein ID: 1964909542

Symbol: HNRPK_HUMAN

Name: Heterogeneous nuclear ribonucleoprotein K

UniProtKB Accession Codes:

P61978 Q07244 Q15671 Q59F98 Q5T6W4 Q60577 Q6IBN1 Q922Y7 Q96J62

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CORUM 1 CPTAC 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 12 Ensembl 15 EvolutionaryTrace 1 ExpressionAtlas 1 GO 33 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 4 RefSeq 10 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 2 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1729596

Title: Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein.

PubMed ID: 1729596

DOI: 10.1128/mcb.12.1.164-171.1992

PubMed ID: 8107114

Title: Identification, molecular cloning, expression and chromosome mapping of a family of transformation upregulated hnRNP-K proteins derived by alternative splicing.

PubMed ID: 8107114

DOI: 10.1006/jmbi.1994.1116

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9651361

Title: Hepatitis C virus core protein interacts with heterogeneous nuclear ribonucleoprotein K.

PubMed ID: 9651361

DOI: 10.1074/jbc.273.28.17651

PubMed ID: 12183465

Title: An RNA helicase, DDX1, interacting with poly(A) RNA and heterogeneous nuclear ribonucleoprotein K.

PubMed ID: 12183465

DOI: 10.1074/jbc.m206981200

PubMed ID: 11840567

Title: Cluster analysis of an extensive human breast cancer cell line protein expression map database.

PubMed ID: 11840567

DOI: 10.1002/1615-9861(200202)2:2<212::aid-prot212>3.0.co;2-h

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 16360036

Title: hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage.

PubMed ID: 16360036

DOI: 10.1016/j.cell.2005.09.032

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16564677

Title: PITK, a PP1 targeting subunit that modulates the phosphorylation of the transcriptional regulator hnRNP K.

PubMed ID: 16564677

DOI: 10.1016/j.cellsig.2006.01.019

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18775702

Title: African swine fever virus protein p30 interaction with heterogeneous nuclear ribonucleoprotein K (hnRNP-K) during infection.

PubMed ID: 18775702

DOI: 10.1016/j.febslet.2008.08.031

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20673990

Title: A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response.

PubMed ID: 20673990

DOI: 10.1016/j.cell.2010.06.040

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22967762

Title: Characterization of O-GlcNAc cycling and proteomic identification of differentially O-GlcNAcylated proteins during G1/S transition.

PubMed ID: 22967762

DOI: 10.1016/j.bbagen.2012.08.024

PubMed ID: 22721921

Title: Proteomic analysis of podosome fractions from macrophages reveals similarities to spreading initiation centres.

PubMed ID: 22721921

DOI: 10.1016/j.ejcb.2012.05.005

PubMed ID: 22825850

Title: DNA damage-induced heterogeneous nuclear ribonucleoprotein K SUMOylation regulates p53 transcriptional activation.

PubMed ID: 22825850

DOI: 10.1074/jbc.m112.390120

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23825951

Title: Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing.

PubMed ID: 23825951

DOI: 10.1371/journal.ppat.1003460

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25678563

Title: Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes.

PubMed ID: 25678563

DOI: 10.1093/brain/awv005

PubMed ID: 26173930

Title: GeneMatcher aids in the identification of a new malformation syndrome with intellectual disability, unique facial dysmorphisms, and skeletal and connective tissue abnormalities caused by de novo variants in HNRNPK.

PubMed ID: 26173930

DOI: 10.1002/humu.22837

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 33174841

Title: circZNF827 nucleates a transcription inhibitory complex to balance neuronal differentiation.

PubMed ID: 33174841

DOI: 10.7554/elife.58478

PubMed ID: 10369774

Title: High precision solution structure of the C-terminal KH domain of heterogeneous nuclear ribonucleoprotein K, a c-myc transcription factor.

PubMed ID: 10369774

DOI: 10.1006/jmbi.1999.2818

PubMed ID: 12093748

Title: Molecular basis of sequence-specific single-stranded DNA recognition by KH domains: solution structure of a complex between hnRNP K KH3 and single-stranded DNA.

PubMed ID: 12093748

DOI: 10.1093/emboj/cdf352

PubMed ID: 30538201

Title: Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression.

PubMed ID: 30538201

DOI: 10.1073/pnas.1818012115

Sequence Information:

  • Length: 463
  • Mass: 50976
  • Checksum: 0F70EE169B2A064A
  • Sequence:
    • METEQPEETF PNTETNGEFG KRPAEDMEEE QAFKRSRNTD EMVELRILLQ SKNAGAVIGK 
GGKNIKALRT DYNASVSVPD SSGPERILSI SADIETIGEI LKKIIPTLEE GLQLPSPTAT 
SQLPLESDAV ECLNYQHYKG SDFDCELRLL IHQSLAGGII GVKGAKIKEL RENTQTTIKL 
FQECCPHSTD RVVLIGGKPD RVVECIKIIL DLISESPIKG RAQPYDPNFY DETYDYGGFT 
MMFDDRRGRP VGFPMRGRGG FDRMPPGRGG RPMPPSRRDY DDMSPRRGPP PPPPGRGGRG 
GSRARNLPLP PPPPPRGGDL MAYDRRGRPG DRYDGMVGFS ADETWDSAID TWSPSEWQMA 
YEPQGGSGYD YSYAGGRGSY GDLGGPIITT QVTIPKDLAG SIIGKGGQRI KQIRHESGAS 
IKIDEPLEGS EDRIITITGT QDQIQNAQYL LQNSVKQYSG KFF

Genular Protein ID: 3013953584

Symbol: B4DUQ1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DUQ1

Database IDs:

ARBA 16 BioGRID-ORCS 1 CDD 3 CTD 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 4 GO 7 Gene3D 1 GeneTree 1 HGNC 1 IntAct 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 3 SAM 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 439
  • Mass: 48510
  • Checksum: 7BCA66B4E39776DB
  • Sequence:
    • METEQPEETF PNTETNGEFG KRPAEDMEEE QAFKRSRNTD EMVELRILLQ SKNAGAVIGK 
GGKNIKALRT DYNASVSVPD SSGPERILSI SADIETIGEI LKKIIPTLEE YQHYKGSDFD 
CELRLLIHQS LAGGIIGVKG AKIKELRENT QTTIKLFQEC CPHSTDRVVL IGGKPDRVVE 
CIKIILDLIS ESPIKGRAQP YDPNFYDETY DYGGFTMMFD DRRGRPVGFP MRGRGGFDRM 
PPGRGGRPMP PSRRDYDDMS PRRGPPPPPP GRGGRGGSRA RNLPLPPPPP PRGGDLMAYD 
RRGRPGDRYD GMVGFSADET WDSAIDTWSP SEWQMAYEPQ GGSGYDYSYA GGRGSYGDLG 
GPIITTQVTI PKDLAGSIIG KGGQRIKQIR HESGASIKID EPLEGSEDRI ITITGTQDQI 
QNAQYLLQNS VKQYSGKFF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.