Details for: LDHB
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 637.1137
Cell Significance Index: -99.1000 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 286.0801
Cell Significance Index: -117.8500 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 245.2117
Cell Significance Index: -115.7700 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 244.1617
Cell Significance Index: -61.9300 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 232.9285
Cell Significance Index: -119.8200 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 173.2879
Cell Significance Index: -116.2800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 90.4453
Cell Significance Index: -111.5200 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 30.2645
Cell Significance Index: -119.4300 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 27.0974
Cell Significance Index: -72.5900 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 26.9286
Cell Significance Index: -82.7100 - Cell Name: kidney cell (CL1000497)
Fold Change: 14.8054
Cell Significance Index: 118.2100 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 8.9483
Cell Significance Index: 97.2800 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 7.8564
Cell Significance Index: 100.6200 - Cell Name: theca cell (CL0000503)
Fold Change: 7.2834
Cell Significance Index: 42.7900 - Cell Name: granulosa cell (CL0000501)
Fold Change: 6.8701
Cell Significance Index: 180.6500 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 6.8119
Cell Significance Index: 357.6500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 6.7422
Cell Significance Index: 234.2900 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 6.7212
Cell Significance Index: 140.6900 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 6.7085
Cell Significance Index: 197.0200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 4.9452
Cell Significance Index: 608.0600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 4.6655
Cell Significance Index: 640.7000 - Cell Name: cell in vitro (CL0001034)
Fold Change: 4.5858
Cell Significance Index: 2504.4000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 4.3720
Cell Significance Index: 788.1300 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 4.3481
Cell Significance Index: 40.0400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 3.8909
Cell Significance Index: 1119.5200 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 3.3408
Cell Significance Index: 89.2100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 3.2631
Cell Significance Index: 258.4400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 3.1742
Cell Significance Index: 374.3300 - Cell Name: lactocyte (CL0002325)
Fold Change: 3.0001
Cell Significance Index: 387.5900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.9968
Cell Significance Index: 223.3500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 2.9124
Cell Significance Index: 136.8800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.8976
Cell Significance Index: 186.9400 - Cell Name: odontoblast (CL0000060)
Fold Change: 1.9450
Cell Significance Index: 249.3400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.7867
Cell Significance Index: 92.8200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 1.7211
Cell Significance Index: 1261.8800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.4690
Cell Significance Index: 238.9300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.4475
Cell Significance Index: 247.1700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.3344
Cell Significance Index: 36.3200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.2121
Cell Significance Index: 535.8800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.9818
Cell Significance Index: 196.9500 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.9639
Cell Significance Index: 14.2300 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.8840
Cell Significance Index: 15.1500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.8535
Cell Significance Index: 65.5000 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.6806
Cell Significance Index: 129.5300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.5698
Cell Significance Index: 431.3200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5367
Cell Significance Index: 192.5000 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.4347
Cell Significance Index: 12.4600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.4076
Cell Significance Index: 28.8300 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3485
Cell Significance Index: 24.1000 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1763
Cell Significance Index: 3.8200 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1207
Cell Significance Index: 2.0200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0498
Cell Significance Index: -1.7500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0563
Cell Significance Index: -106.0000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0653
Cell Significance Index: -6.6700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0725
Cell Significance Index: -53.6900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0741
Cell Significance Index: -136.6400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0891
Cell Significance Index: -137.2200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.1022
Cell Significance Index: -138.9400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1429
Cell Significance Index: -89.2500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1575
Cell Significance Index: -88.8000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1719
Cell Significance Index: -109.1700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.1826
Cell Significance Index: -5.2600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.2569
Cell Significance Index: -116.6000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3350
Cell Significance Index: -18.8000 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3554
Cell Significance Index: -9.0800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.3648
Cell Significance Index: -36.0900 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.3679
Cell Significance Index: -4.1800 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.4594
Cell Significance Index: -12.3100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.5096
Cell Significance Index: -101.1400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.5172
Cell Significance Index: -108.9300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.5421
Cell Significance Index: -33.3200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.6031
Cell Significance Index: -38.0100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.6343
Cell Significance Index: -73.9200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.7704
Cell Significance Index: -111.9800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.8069
Cell Significance Index: -37.6200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.8249
Cell Significance Index: -94.5100 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.8824
Cell Significance Index: -100.7300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.8995
Cell Significance Index: -28.8100 - Cell Name: sensory neuron (CL0000101)
Fold Change: -0.9535
Cell Significance Index: -5.4200 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.9765
Cell Significance Index: -11.6400 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -1.0053
Cell Significance Index: -17.3300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -1.0493
Cell Significance Index: -47.5600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.1547
Cell Significance Index: -120.2300 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: -1.1649
Cell Significance Index: -6.1300 - Cell Name: peg cell (CL4033014)
Fold Change: -1.1890
Cell Significance Index: -27.4700 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -1.3298
Cell Significance Index: -23.5000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -1.4134
Cell Significance Index: -39.5000 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.4428
Cell Significance Index: -38.6000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.5662
Cell Significance Index: -96.0200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.7811
Cell Significance Index: -119.7600 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.7979
Cell Significance Index: -38.2900 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.8993
Cell Significance Index: -48.8200 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -1.9185
Cell Significance Index: -19.8600 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -2.0826
Cell Significance Index: -108.4800 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -2.0929
Cell Significance Index: -17.5800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -2.1259
Cell Significance Index: -94.0400 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -2.1515
Cell Significance Index: -63.3700 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -2.1714
Cell Significance Index: -54.2800 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -2.4249
Cell Significance Index: -13.2200 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -2.4839
Cell Significance Index: -33.8900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3442828945
Symbol: LDHB_HUMAN
Name: L-lactate dehydrogenase B chain
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2930497
Title: Structure of the human lactate dehydrogenase B gene.
PubMed ID: 2930497
DOI: 10.1042/bj2570921
PubMed ID: 3435492
Title: The cDNA and protein sequences of human lactate dehydrogenase B.
PubMed ID: 3435492
DOI: 10.1042/bj2480933
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10508479
Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.
PubMed ID: 10508479
DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5
PubMed ID: 15592455
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
PubMed ID: 15592455
DOI: 10.1038/nbt1046
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27618187
Title: Lactate metabolism is associated with mammalian mitochondria.
PubMed ID: 27618187
PubMed ID: 33406399
Title: An Upstream Open Reading Frame in Phosphatase and Tensin Homolog Encodes a Circuit Breaker of Lactate Metabolism.
PubMed ID: 33406399
PubMed ID: 33535099
PubMed ID: 11276087
Title: Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase.
PubMed ID: 11276087
DOI: 10.1002/1097-0134(20010501)43:2<175::aid-prot1029>3.0.co;2-#
PubMed ID: 8314553
Title: Analysis of a genetic mutation in an electrophoretic variant of the human lactate dehydrogenase-B(H) subunit.
PubMed ID: 8314553
DOI: 10.1007/bf00217765
PubMed ID: 8462975
Title: Detection and characterization of new genetic mutations in individuals heterozygous for lactate dehydrogenase-B(H) deficiency using DNA conformation polymorphism analysis and silver staining.
PubMed ID: 8462975
DOI: 10.1007/bf00222718
PubMed ID: 1587525
Title: Molecular characterization of genetic mutations in human lactate dehydrogenase (LDH) B (H) variant.
PubMed ID: 1587525
DOI: 10.1007/bf00217116
PubMed ID: 2334429
Title: A missense mutation found in human lactate dehydrogenase-B (H) variant gene.
PubMed ID: 2334429
PubMed ID: 8611651
Title: Arginine to tryptophan substitution in the active site of a human lactate dehydrogenase variant -- LDHB GUA1: postulated effects on subunit structure and catalysis.
PubMed ID: 8611651
PubMed ID: 10211631
Title: A novel in-frame deletion mutation in a case of lactate dehydrogenase (LD) H subunit deficiency showing an atypical LD isoenzyme pattern in serum and erythrocytes.
PubMed ID: 10211631
PubMed ID: 10509905
Title: Genetic analyses in homozygous and heterozygous variants of lactate dehydrogenase-B (H) subunit--LD-B Matsumoto I and II (LD-B W323R).
PubMed ID: 10509905
PubMed ID: 9929983
Title: First case of missense mutation (LDH-H:R171P) in exon 4 of the lactate dehydrogenase gene detected in a Japanese patient.
PubMed ID: 9929983
PubMed ID: 11509017
Title: A novel missense mutation in human lactate dehydrogenase b-subunit gene.
PubMed ID: 11509017
Sequence Information:
- Length: 334
- Mass: 36638
- Checksum: 3AD605DEED0D54A2
- Sequence:
MATLKEKLIA PVAEEEATVP NNKITVVGVG QVGMACAISI LGKSLADELA LVDVLEDKLK GEMMDLQHGS LFLQTPKIVA DKDYSVTANS KIVVVTAGVR QQEGESRLNL VQRNVNVFKF IIPQIVKYSP DCIIIVVSNP VDILTYVTWK LSGLPKHRVI GSGCNLDSAR FRYLMAEKLG IHPSSCHGWI LGEHGDSSVA VWSGVNVAGV SLQELNPEMG TDNDSENWKE VHKMVVESAY EVIKLKGYTN WAIGLSVADL IESMLKNLSR IHPVSTMVKG MYGIENEVFL SLPCILNARG LTSVINQKLK DDEVAQLKKS ADTLWDIQKD LKDL
Genular Protein ID: 4074315222
Symbol: A0A5F9ZHM4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
Sequence Information:
- Length: 341
- Mass: 37406
- Checksum: CD93C20D584617DA
- Sequence:
MATLKEKLIA PVAEEEATVP NNKITVVGVG QVGMACAISI LGKSLADELA LVDVLEDKLK GEMMDLQHGS LFLQTPKIVA DKDYSVTANS KIVVVTAGVR QQEGESRLNL VQRNVNVFKF IIPQIVKYSP DCIIIVVSNP VDILTYVTWK LSGLPKHRVI GSGCNLDSAR FRYLMAEKLG IHPSSCHGWI LGEHGDSSVA VWSGVNVAGV SLQELNPEMG TDNDSENWKE VHKMVVESAY EVIKLKGYTN WAIGLSVADL IESMLKNLSR IHPVSTMVKG MYGIENEVFL SLPCILNARG LTSVINQKLK DDEVAQLKKS ADTLWDIQKD LKDLXLVSSR L
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.