Details for: LDHB

Gene ID: 3945

Symbol: LDHB

Ensembl ID: ENSG00000111716

Description: lactate dehydrogenase B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 8.6
    Marker Score: 6492.5
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 4.49
    Marker Score: 2393
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 4.37
    Marker Score: 11724.5
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 4.32
    Marker Score: 4506
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.26
    Marker Score: 225244
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 4.01
    Marker Score: 14222
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4
    Marker Score: 39632
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.97
    Marker Score: 52382
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 3.87
    Marker Score: 2496
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.87
    Marker Score: 16592
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 3.84
    Marker Score: 6586
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 3.82
    Marker Score: 1408
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.71
    Marker Score: 5708
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.59
    Marker Score: 9060
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3.55
    Marker Score: 6339
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.55
    Marker Score: 4285
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.48
    Marker Score: 22668
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.48
    Marker Score: 2724
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 3.43
    Marker Score: 1097
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.39
    Marker Score: 25232
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.36
    Marker Score: 1107
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.33
    Marker Score: 8142
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.32
    Marker Score: 3131
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.31
    Marker Score: 2374
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.26
    Marker Score: 5400
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 3.24
    Marker Score: 1346
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 3.23
    Marker Score: 4575
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.18
    Marker Score: 1589
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.18
    Marker Score: 7758
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.15
    Marker Score: 20533
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 3.15
    Marker Score: 1977
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.14
    Marker Score: 108846
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 3.12
    Marker Score: 2255
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 3.04
    Marker Score: 2848
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 3.03
    Marker Score: 3210
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 3
    Marker Score: 3046
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3
    Marker Score: 2554
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 3
    Marker Score: 1045
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.99
    Marker Score: 4235
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.96
    Marker Score: 3562
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.96
    Marker Score: 5559
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.92
    Marker Score: 9227
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.89
    Marker Score: 1301
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.89
    Marker Score: 3081.5
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.88
    Marker Score: 18397
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.87
    Marker Score: 1684
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.86
    Marker Score: 5821
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.85
    Marker Score: 5958
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.84
    Marker Score: 1685
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.83
    Marker Score: 3344
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.83
    Marker Score: 11591
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.8
    Marker Score: 24331
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.8
    Marker Score: 2048
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.78
    Marker Score: 4560
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.78
    Marker Score: 16490
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.78
    Marker Score: 2613
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.77
    Marker Score: 4447
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.77
    Marker Score: 3602
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.76
    Marker Score: 7744.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.73
    Marker Score: 7434
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.72
    Marker Score: 1969
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.71
    Marker Score: 1025.5
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.7
    Marker Score: 2887
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 2.7
    Marker Score: 820
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.7
    Marker Score: 2115
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.69
    Marker Score: 3025
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.69
    Marker Score: 27083
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.68
    Marker Score: 1267
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.68
    Marker Score: 11562.5
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.68
    Marker Score: 10330
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.67
    Marker Score: 30102
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.67
    Marker Score: 4542.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.64
    Marker Score: 6218
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.64
    Marker Score: 2847
  • Cell Name: basophil (CL0000767)
    Fold Change: 2.64
    Marker Score: 1253
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.63
    Marker Score: 7274
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.63
    Marker Score: 2211
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.62
    Marker Score: 35254
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.62
    Marker Score: 89210
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.62
    Marker Score: 4559
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.6
    Marker Score: 1892
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.59
    Marker Score: 7683
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.58
    Marker Score: 4711
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.55
    Marker Score: 1702
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.55
    Marker Score: 2568
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.55
    Marker Score: 1550
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.54
    Marker Score: 1056
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.53
    Marker Score: 1200.5
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 2.52
    Marker Score: 669.5
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 2.52
    Marker Score: 2787
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.51
    Marker Score: 805
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 2.5
    Marker Score: 2696
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.49
    Marker Score: 596
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.49
    Marker Score: 1773
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.49
    Marker Score: 25223
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.49
    Marker Score: 1036
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.47
    Marker Score: 2887
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.47
    Marker Score: 830
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.46
    Marker Score: 1864
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.44
    Marker Score: 1094

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Other Information

## Summary Lactate dehydrogenase B (LDHB) is a multi-functional enzyme found in various tissues and cell types. It plays a crucial role in the citric acid (TCA) cycle, a central metabolic pathway involved in energy production and detoxification. LDHB is also involved in the cytoplasm, cytosol, and mitochondria of eukaryotic cells. ## Key characteristics - LDHB is a glycoprotein with a molecular weight of approximately 120 kDa. - It is expressed in high levels in skeletal muscle, heart, liver, and kidney. - LDHB is a key enzyme in the TCA cycle, catalyzing the transfer of a hydrogen atom from L-lactate to pyruvate, resulting in the formation of acetyl-CoA. - It is also involved in the pyruvate metabolic process and the production of ATP through oxidative phosphorylation. - LDHB is a highly regulated protein, with its expression being influenced by factors such as nutrient availability, hormones, and metabolic conditions. ## Pathways and functions **1. Citric Acid (TCA) Cycle:** - LDHB is central to the TCA cycle, a central metabolic pathway involved in energy production and detoxification. - It catalyzes the transfer of a hydrogen atom from L-lactate to pyruvate, resulting in the formation of acetyl-CoA. - Acetyl-CoA can then enter the citric acid cycle and participate in the subsequent reactions. **2. Cytoplasm and Cytosol:** - LDHB is also found in the cytoplasm and cytosol of eukaryotic cells. - It is involved in the metabolism of nutrients, waste products, and signaling molecules. **3. Mitochondrial Inner Membrane:** - LDHB is present in the mitochondrial inner membrane, where it is involved in the citric acid cycle and other mitochondrial metabolic pathways. **4. Protein Binding:** - LDHB can bind to various proteins, including pyruvate kinase, lactate dehydrogenase A, and NAD. - These interactions regulate the activity of LDHB and can influence the flux of metabolites through the TCA cycle. **5. Pyruvate Metabolic Process:** - In addition to its role in the TCA cycle, LDHB is also involved in the pyruvate metabolic process, where pyruvate is broken down to generate energy. **6. Clinical Significance:** - LDHB is a clinically relevant protein, especially in conditions characterized by metabolic imbalances, such as lactic acidosis, where there is a buildup of lactic acid due to impaired glucose metabolism. - It is often used as a marker for diseases involving the liver, kidney, and cardiovascular system. - LDHB levels can be elevated in conditions such as diabetic ketoacidosis, sepsis, and liver failure. ## Conclusion LDHB is a versatile enzyme with critical roles in energy production, detoxification, and metabolism in various tissues and cell types. Its clinical significance lies in its involvement in conditions associated with metabolic imbalances, making it a valuable biomarker for disease diagnosis and monitoring.

Genular Protein ID: 3442828945

Symbol: LDHB_HUMAN

Name: L-lactate dehydrogenase B chain

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2930497

Title: Structure of the human lactate dehydrogenase B gene.

PubMed ID: 2930497

DOI: 10.1042/bj2570921

PubMed ID: 3435492

Title: The cDNA and protein sequences of human lactate dehydrogenase B.

PubMed ID: 3435492

DOI: 10.1042/bj2480933

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27618187

Title: Lactate metabolism is associated with mammalian mitochondria.

PubMed ID: 27618187

DOI: 10.1038/nchembio.2172

PubMed ID: 33406399

Title: An Upstream Open Reading Frame in Phosphatase and Tensin Homolog Encodes a Circuit Breaker of Lactate Metabolism.

PubMed ID: 33406399

DOI: 10.1016/j.cmet.2020.12.008

PubMed ID: 33535099

Title:

PubMed ID: 33535099

DOI: 10.1016/j.cmet.2021.01.008

PubMed ID: 11276087

Title: Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase.

PubMed ID: 11276087

DOI: 10.1002/1097-0134(20010501)43:2<175::aid-prot1029>3.0.co;2-#

PubMed ID: 8314553

Title: Analysis of a genetic mutation in an electrophoretic variant of the human lactate dehydrogenase-B(H) subunit.

PubMed ID: 8314553

DOI: 10.1007/bf00217765

PubMed ID: 8462975

Title: Detection and characterization of new genetic mutations in individuals heterozygous for lactate dehydrogenase-B(H) deficiency using DNA conformation polymorphism analysis and silver staining.

PubMed ID: 8462975

DOI: 10.1007/bf00222718

PubMed ID: 1587525

Title: Molecular characterization of genetic mutations in human lactate dehydrogenase (LDH) B (H) variant.

PubMed ID: 1587525

DOI: 10.1007/bf00217116

PubMed ID: 2334429

Title: A missense mutation found in human lactate dehydrogenase-B (H) variant gene.

PubMed ID: 2334429

DOI: 10.1016/0006-291x(90)92373-8

PubMed ID: 8611651

Title: Arginine to tryptophan substitution in the active site of a human lactate dehydrogenase variant -- LDHB GUA1: postulated effects on subunit structure and catalysis.

PubMed ID: 8611651

DOI: 10.1016/0925-4439(95)00089-5

PubMed ID: 10211631

Title: A novel in-frame deletion mutation in a case of lactate dehydrogenase (LD) H subunit deficiency showing an atypical LD isoenzyme pattern in serum and erythrocytes.

PubMed ID: 10211631

DOI: 10.1016/s0009-9120(98)00097-6

PubMed ID: 9929983

Title: First case of missense mutation (LDH-H:R171P) in exon 4 of the lactate dehydrogenase gene detected in a Japanese patient.

PubMed ID: 9929983

DOI: 10.1007/s100380050111

PubMed ID: 11509017

Title: A novel missense mutation in human lactate dehydrogenase b-subunit gene.

PubMed ID: 11509017

DOI: 10.1006/mgme.2001.3203

Sequence Information:

  • Length: 334
  • Mass: 36638
  • Checksum: 3AD605DEED0D54A2
  • Sequence:
  • MATLKEKLIA PVAEEEATVP NNKITVVGVG QVGMACAISI LGKSLADELA LVDVLEDKLK 
    GEMMDLQHGS LFLQTPKIVA DKDYSVTANS KIVVVTAGVR QQEGESRLNL VQRNVNVFKF 
    IIPQIVKYSP DCIIIVVSNP VDILTYVTWK LSGLPKHRVI GSGCNLDSAR FRYLMAEKLG 
    IHPSSCHGWI LGEHGDSSVA VWSGVNVAGV SLQELNPEMG TDNDSENWKE VHKMVVESAY 
    EVIKLKGYTN WAIGLSVADL IESMLKNLSR IHPVSTMVKG MYGIENEVFL SLPCILNARG 
    LTSVINQKLK DDEVAQLKKS ADTLWDIQKD LKDL

Genular Protein ID: 4074315222

Symbol: A0A5F9ZHM4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 341
  • Mass: 37406
  • Checksum: CD93C20D584617DA
  • Sequence:
  • MATLKEKLIA PVAEEEATVP NNKITVVGVG QVGMACAISI LGKSLADELA LVDVLEDKLK 
    GEMMDLQHGS LFLQTPKIVA DKDYSVTANS KIVVVTAGVR QQEGESRLNL VQRNVNVFKF 
    IIPQIVKYSP DCIIIVVSNP VDILTYVTWK LSGLPKHRVI GSGCNLDSAR FRYLMAEKLG 
    IHPSSCHGWI LGEHGDSSVA VWSGVNVAGV SLQELNPEMG TDNDSENWKE VHKMVVESAY 
    EVIKLKGYTN WAIGLSVADL IESMLKNLSR IHPVSTMVKG MYGIENEVFL SLPCILNARG 
    LTSVINQKLK DDEVAQLKKS ADTLWDIQKD LKDLXLVSSR L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.