Details for: PEX11A

Gene ID: 8800

Symbol: PEX11A

Ensembl ID: ENSG00000166821

Description: peroxisomal biogenesis factor 11 alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 73.7406
    Cell Significance Index: -11.4700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 42.7865
    Cell Significance Index: -10.8500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 24.6334
    Cell Significance Index: -11.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.3713
    Cell Significance Index: -11.7100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.9523
    Cell Significance Index: -11.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.6796
    Cell Significance Index: 265.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6307
    Cell Significance Index: 84.7100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.2291
    Cell Significance Index: -2.6900
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 1.0859
    Cell Significance Index: 1.4100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0337
    Cell Significance Index: 112.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8368
    Cell Significance Index: 755.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7607
    Cell Significance Index: 16.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7239
    Cell Significance Index: 117.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7062
    Cell Significance Index: 32.0100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6027
    Cell Significance Index: 5.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5692
    Cell Significance Index: 39.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5565
    Cell Significance Index: 39.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5123
    Cell Significance Index: 14.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5072
    Cell Significance Index: 91.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4385
    Cell Significance Index: 87.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4276
    Cell Significance Index: 26.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4198
    Cell Significance Index: 48.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3362
    Cell Significance Index: 41.3400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2529
    Cell Significance Index: 4.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1822
    Cell Significance Index: 3.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1818
    Cell Significance Index: 36.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1817
    Cell Significance Index: 8.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1525
    Cell Significance Index: 83.3100
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.1470
    Cell Significance Index: 0.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1389
    Cell Significance Index: 19.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1321
    Cell Significance Index: 3.6000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1315
    Cell Significance Index: 1.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1239
    Cell Significance Index: 9.5100
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.0937
    Cell Significance Index: 1.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0890
    Cell Significance Index: 2.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0847
    Cell Significance Index: 6.3100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0812
    Cell Significance Index: 1.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0772
    Cell Significance Index: 27.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0699
    Cell Significance Index: 13.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0695
    Cell Significance Index: 8.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0646
    Cell Significance Index: 28.5800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0456
    Cell Significance Index: 1.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0447
    Cell Significance Index: 1.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0313
    Cell Significance Index: 58.9000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0271
    Cell Significance Index: 18.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0253
    Cell Significance Index: 4.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0228
    Cell Significance Index: 14.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0215
    Cell Significance Index: 0.6000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0185
    Cell Significance Index: 0.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0118
    Cell Significance Index: 1.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0025
    Cell Significance Index: 4.6900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0012
    Cell Significance Index: 0.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0012
    Cell Significance Index: 1.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0016
    Cell Significance Index: -1.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0053
    Cell Significance Index: -7.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0075
    Cell Significance Index: -0.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0080
    Cell Significance Index: -6.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0153
    Cell Significance Index: -11.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0164
    Cell Significance Index: -7.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0167
    Cell Significance Index: -1.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0197
    Cell Significance Index: -11.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0202
    Cell Significance Index: -1.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0212
    Cell Significance Index: -13.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0245
    Cell Significance Index: -7.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0281
    Cell Significance Index: -2.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0381
    Cell Significance Index: -0.5200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0459
    Cell Significance Index: -1.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0512
    Cell Significance Index: -6.6200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0551
    Cell Significance Index: -0.7100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0559
    Cell Significance Index: -0.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0566
    Cell Significance Index: -6.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0581
    Cell Significance Index: -2.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0608
    Cell Significance Index: -3.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0632
    Cell Significance Index: -13.3100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0730
    Cell Significance Index: -0.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0732
    Cell Significance Index: -4.1100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0742
    Cell Significance Index: -1.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0744
    Cell Significance Index: -5.0000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0768
    Cell Significance Index: -2.6700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0932
    Cell Significance Index: -0.9700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0937
    Cell Significance Index: -0.9700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0958
    Cell Significance Index: -1.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1058
    Cell Significance Index: -11.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1075
    Cell Significance Index: -8.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1155
    Cell Significance Index: -7.0800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1361
    Cell Significance Index: -2.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1510
    Cell Significance Index: -3.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1570
    Cell Significance Index: -6.9500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1633
    Cell Significance Index: -4.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1707
    Cell Significance Index: -11.0200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1772
    Cell Significance Index: -3.7100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1926
    Cell Significance Index: -7.3000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2004
    Cell Significance Index: -3.3700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2100
    Cell Significance Index: -2.9900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2192
    Cell Significance Index: -3.7900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2194
    Cell Significance Index: -5.6400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2268
    Cell Significance Index: -5.2400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2357
    Cell Significance Index: -3.7400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2484
    Cell Significance Index: -3.5600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2509
    Cell Significance Index: -2.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Peroxisomal biogenesis factor:** PEX11A is a protein that plays a central role in the biogenesis of peroxisomes, which are organelles responsible for the breakdown of fatty acids and amino acids. 2. **Membrane biogenesis:** PEX11A is involved in the formation and maintenance of peroxisomal membranes, which are essential for the proper functioning of peroxisomes. 3. **Regulation of lipid metabolism:** PEX11A influences lipid metabolism by regulating the expression of genes involved in fatty acid breakdown and synthesis. 4. **Cellular localization:** PEX11A is primarily localized to the peroxisome, where it interacts with other proteins to regulate peroxisome biogenesis and function. **Pathways and Functions:** 1. **Peroxisome biogenesis pathway:** PEX11A interacts with other proteins to regulate peroxisome biogenesis, including the assembly of peroxisomal membranes and the import of peroxisomal proteins. 2. **Lipid metabolism pathway:** PEX11A influences lipid metabolism by regulating the expression of genes involved in fatty acid breakdown and synthesis. 3. **Signaling pathways:** PEX11A interacts with other proteins to regulate signaling pathways involved in cell differentiation, growth, and survival. 4. **Protein complex formation:** PEX11A forms protein complexes with other proteins to regulate peroxisome biogenesis and function. **Clinical Significance:** Dysregulation of PEX11A has been implicated in several diseases, including: 1. **Peroxisomal disorders:** Mutations in PEX11A have been associated with peroxisomal disorders, such as X-linked adrenoleukodystrophy (ALD) and Zellweger syndrome. 2. **Metabolic disorders:** Aberrations in PEX11A have been linked to metabolic disorders, including obesity, diabetes, and dyslipidemia. 3. **Neurological disorders:** PEX11A has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 4. **Cancer:** Aberrations in PEX11A have been detected in various types of cancer, including breast, lung, and colon cancer. In conclusion, PEX11A is a critical gene involved in peroxisomal biogenesis and lipid metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis. Further research is necessary to fully elucidate the role of PEX11A in human disease and to develop therapeutic strategies to target this gene in disease prevention and treatment.

Genular Protein ID: 2188212214

Symbol: PX11A_HUMAN

Name: Peroxisomal membrane protein 11A

UniProtKB Accession Codes:

O75192 B4DV88

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9714566

Title: Clofibrate-inducible, 28-kDa peroxisomal integral membrane protein is encoded by PEX11.

PubMed ID: 9714566

DOI: 10.1016/s0014-5793(98)00815-1

PubMed ID: 9792670

Title: Expression of PEX11beta mediates peroxisome proliferation in the absence of extracellular stimuli.

PubMed ID: 9792670

DOI: 10.1074/jbc.273.45.29607

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10704444

Title: PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.

PubMed ID: 10704444

DOI: 10.1083/jcb.148.5.931

PubMed ID: 20826455

Title: PEX11 family members are membrane elongation factors that coordinate peroxisome proliferation and maintenance.

PubMed ID: 20826455

DOI: 10.1242/jcs.064907

Sequence Information:

  • Length: 247
  • Mass: 28353
  • Checksum: D904EC715271FF87
  • Sequence:
    • MDAFTRFTNQ TQGRDRLFRA TQYTCMLLRY LLEPKAGKEK VVMKLKKLES SVSTGRKWFR 
LGNVVHAIQA TEQSIHATDL VPRLCLTLAN LNRVIYFICD TILWVRSVGL TSGINKEKWR 
TRAAHHYYYS LLLSLVRDLY EISLQMKRVT CDRAKKEKSA SQDPLWFSVA EEETEWLQSF 
LLLLFRSLKQ HPPLLLDTVK NLCDILNPLD QLGIYKSNPG IIGLGGLVSS IAGMITVAYP 
QMKLKTR

Genular Protein ID: 724693854

Symbol: B4DMF6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DMF6

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 102
  • Mass: 11459
  • Checksum: 76F881944233F357
  • Sequence:
    • MKRVTCDRAK KEKSASQDPL WFSVAEEETE WLQSFLLLLF RSLKQHPPLL LDTVKNLCDI 
LNPLDQLGIY KSNPGIIGLG GLVSSIAGMI TVAYPQMKLK TR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.