Details for: UQCRH

Gene ID: 7388

Symbol: UQCRH

Ensembl ID: ENSG00000173660

Description: ubiquinol-cytochrome c reductase hinge protein

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 4.85
    Marker Score: 3658
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 4.03
    Marker Score: 54158
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 3.97
    Marker Score: 3891
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.93
    Marker Score: 6058
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.92
    Marker Score: 10512
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.77
    Marker Score: 49775
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.76
    Marker Score: 3920
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.71
    Marker Score: 9059.5
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.59
    Marker Score: 1181
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 3.48
    Marker Score: 1283
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.47
    Marker Score: 6343
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.45
    Marker Score: 34176
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.44
    Marker Score: 8678
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.44
    Marker Score: 192257
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 3.44
    Marker Score: 1547.5
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.43
    Marker Score: 4145
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.43
    Marker Score: 3661
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.41
    Marker Score: 9718
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.34
    Marker Score: 38802
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.32
    Marker Score: 1770
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.31
    Marker Score: 3124
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.31
    Marker Score: 112529.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.3
    Marker Score: 11730
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.29
    Marker Score: 21419.5
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 3.28
    Marker Score: 2197.5
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.28
    Marker Score: 24386
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.25
    Marker Score: 25347
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3.23
    Marker Score: 5771
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.2
    Marker Score: 2523
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.2
    Marker Score: 5303
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 3.13
    Marker Score: 1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.12
    Marker Score: 108234
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.12
    Marker Score: 7086.5
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3.12
    Marker Score: 2786
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.08
    Marker Score: 2898
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.08
    Marker Score: 1872
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.05
    Marker Score: 3000.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 3.03
    Marker Score: 3209
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.02
    Marker Score: 720.5
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.01
    Marker Score: 2362.5
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3
    Marker Score: 9406
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.99
    Marker Score: 2547
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.98
    Marker Score: 19017
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.97
    Marker Score: 2251
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.97
    Marker Score: 15621
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 2.96
    Marker Score: 1229
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.93
    Marker Score: 1466
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.93
    Marker Score: 19112
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.92
    Marker Score: 17330
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.92
    Marker Score: 5932
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.91
    Marker Score: 6631
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.89
    Marker Score: 13876
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.88
    Marker Score: 152457
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.88
    Marker Score: 1808
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.88
    Marker Score: 4071
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.87
    Marker Score: 2912
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.87
    Marker Score: 9058
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.86
    Marker Score: 5365
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.84
    Marker Score: 4665
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.84
    Marker Score: 2537
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.84
    Marker Score: 24492.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.83
    Marker Score: 5512.5
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.83
    Marker Score: 1704.5
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.83
    Marker Score: 8382
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.82
    Marker Score: 2700
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.81
    Marker Score: 2814.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.81
    Marker Score: 3627
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.81
    Marker Score: 1383.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.81
    Marker Score: 3972
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.81
    Marker Score: 3210
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.79
    Marker Score: 7713
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.78
    Marker Score: 4471
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.77
    Marker Score: 1258
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.76
    Marker Score: 951
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.76
    Marker Score: 1153
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.76
    Marker Score: 4385
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.75
    Marker Score: 30946.5
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.75
    Marker Score: 70364
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.74
    Marker Score: 1607
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.74
    Marker Score: 4781
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.74
    Marker Score: 17514
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.73
    Marker Score: 659
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.73
    Marker Score: 1222
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.73
    Marker Score: 11155
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.72
    Marker Score: 5683
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.71
    Marker Score: 1397
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.71
    Marker Score: 960
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.7
    Marker Score: 10413
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.69
    Marker Score: 713
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.69
    Marker Score: 1393
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.67
    Marker Score: 797
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.67
    Marker Score: 2251
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.66
    Marker Score: 1942
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.66
    Marker Score: 5321.5
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.65
    Marker Score: 1902
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.65
    Marker Score: 1885
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.65
    Marker Score: 1707
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.65
    Marker Score: 850
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.64
    Marker Score: 685.5
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.64
    Marker Score: 2868

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Other Information

**Key Characteristics:** 1. **Subunit of Complex III**: UQCRH is a subunit of the respiratory supercomplex III, which is a critical component of the mitochondrial electron transport chain. 2. **Electron Transfer**: UQCRH facilitates the transfer of electrons from ubiquinol to cytochrome c, a process essential for the generation of ATP. 3. **Hinge Function**: As a hinge protein, UQCRH bridges the interface between the mitochondrial inner membrane and the respiratory supercomplex III, ensuring efficient electron transfer and energy production. 4. **High Expression in Various Tissues**: UQCRH is significantly expressed in various tissues, including hematopoietic stem cells, pancreatic A cells, and mesenchymal stem cells. **Pathways and Functions:** 1. **Aerobic Respiration**: UQCRH is involved in the aerobic respiration pathway, which is the primary mechanism for generating ATP in cells. 2. **Mitochondrial Electron Transport**: UQCRH plays a critical role in the mitochondrial electron transport chain, facilitating the transfer of electrons from ubiquinol to cytochrome c. 3. **Oxidative Phosphorylation**: UQCRH is involved in the oxidative phosphorylation process, which generates ATP from the transfer of electrons. 4. **Heat Production**: UQCRH is also involved in the production of heat through the uncoupling of oxidative phosphorylation. **Clinical Significance:** Dysregulation of UQCRH has been implicated in various diseases, including: 1. **Mitochondrial Diseases**: Mutations in the UQCRH gene have been associated with mitochondrial diseases, such as Leber's hereditary optic neuropathy. 2. **Cancer**: Altered expression of UQCRH has been observed in various types of cancer, including leukemia and pancreatic cancer. 3. **Neurodegenerative Disorders**: UQCRH has been implicated in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Cardiovascular Disease**: Abnormal expression of UQCRH has been linked to cardiovascular disease, including hypertension and atherosclerosis. In conclusion, UQCRH is a critical component of the mitochondrial electron transport chain, playing a pivotal role in facilitating the transfer of electrons and energy production. Its dysregulation has been implicated in various diseases, highlighting its importance in maintaining cellular homeostasis. Further research is necessary to fully elucidate the functions and clinical significance of UQCRH.

Genular Protein ID: 2953718954

Symbol: QCR6_HUMAN

Name: Cytochrome b-c1 complex subunit 6, mitochondrial

UniProtKB Accession Codes:

P07919 B2R4V9 D3DQ18 Q5TDF6 Q6LDB8 Q9BQ91

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 EMBL 12 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2826252

Title: An extremely acidic amino-terminal presequence of the precursor for the human mitochondrial hinge protein.

PubMed ID: 2826252

DOI: 10.1016/0014-5793(87)80573-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7684318

Title: Elevated expression of the human mitochondrial hinge protein gene in cancer.

PubMed ID: 7684318

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 34750991

Title: Characterising a homozygous two-exon deletion in UQCRH: comparing human and mouse phenotypes.

PubMed ID: 34750991

DOI: 10.15252/emmm.202114397

PubMed ID: 28844695

Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.

PubMed ID: 28844695

DOI: 10.1016/j.cell.2017.07.050

Sequence Information:

  • Length: 91
  • Mass: 10739
  • Checksum: 499B5D069E738F4C
  • Sequence:
    • MGLEDEQKML TESGDPEEEE EEEEELVDPL TTVREQCEQL EKCVKARERL ELCDERVSSR 
SHTEEDCTEE LFDFLHARDH CVAHKLFNNL K

Genular Protein ID: 2420232068

Symbol: Q567R0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q567R0

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 3 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 85
  • Mass: 9953
  • Checksum: B1CD22D8F160CE0C
  • Sequence:
    • MGDRILPFLA AVWLCQLAFC TDPLTTVREQ CEQLEKCVKA RERLELCDER VSSRSHTEED 
CTEELFDFLH ARDHCVAHKL FNNLK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.