Details for: UQCRH

Gene ID: 7388

Symbol: UQCRH

Ensembl ID: ENSG00000173660

Description: ubiquinol-cytochrome c reductase hinge protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 729.8520
    Cell Significance Index: -113.5300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 406.0425
    Cell Significance Index: -102.9900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 372.5838
    Cell Significance Index: -153.4900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 318.5825
    Cell Significance Index: -150.4100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 295.4789
    Cell Significance Index: -151.9900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 224.4635
    Cell Significance Index: -150.6200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 114.3674
    Cell Significance Index: -141.0100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 39.9965
    Cell Significance Index: -107.1500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 38.3143
    Cell Significance Index: -151.1900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 34.0686
    Cell Significance Index: -104.6400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 21.6852
    Cell Significance Index: -47.4600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 7.4962
    Cell Significance Index: 200.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.3966
    Cell Significance Index: 146.8900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 5.2227
    Cell Significance Index: 109.3200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 4.8154
    Cell Significance Index: 52.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.6034
    Cell Significance Index: 566.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.5267
    Cell Significance Index: 621.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 4.4731
    Cell Significance Index: 806.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.3333
    Cell Significance Index: 203.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.2263
    Cell Significance Index: 2308.0900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 4.2018
    Cell Significance Index: 297.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.0083
    Cell Significance Index: 210.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.8432
    Cell Significance Index: 496.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.7252
    Cell Significance Index: 439.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.6965
    Cell Significance Index: 97.2000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.5131
    Cell Significance Index: 122.0800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.4941
    Cell Significance Index: 1544.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.4417
    Cell Significance Index: 160.4700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.2122
    Cell Significance Index: 94.3400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.1374
    Cell Significance Index: 25.0500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.6660
    Cell Significance Index: 31.7800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.4468
    Cell Significance Index: 157.8600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.1512
    Cell Significance Index: 19.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.0701
    Cell Significance Index: 154.2800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.0587
    Cell Significance Index: 26.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.9897
    Cell Significance Index: 572.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.9062
    Cell Significance Index: 99.0200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.8476
    Cell Significance Index: 20.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.5140
    Cell Significance Index: 194.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3141
    Cell Significance Index: 28.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2627
    Cell Significance Index: 253.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.2219
    Cell Significance Index: 77.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.2130
    Cell Significance Index: 32.3900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.1803
    Cell Significance Index: 27.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1787
    Cell Significance Index: 53.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.1593
    Cell Significance Index: 197.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1122
    Cell Significance Index: 32.0500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9758
    Cell Significance Index: 158.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9548
    Cell Significance Index: 862.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9146
    Cell Significance Index: 181.5000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.8949
    Cell Significance Index: 16.5400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8669
    Cell Significance Index: 24.8500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.7967
    Cell Significance Index: 584.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6864
    Cell Significance Index: 67.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6572
    Cell Significance Index: 125.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4710
    Cell Significance Index: 36.1400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.4381
    Cell Significance Index: 34.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3775
    Cell Significance Index: 135.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.3656
    Cell Significance Index: 276.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1117
    Cell Significance Index: 1.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0883
    Cell Significance Index: 166.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0482
    Cell Significance Index: -35.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0492
    Cell Significance Index: -90.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0753
    Cell Significance Index: -7.6900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0815
    Cell Significance Index: -125.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0998
    Cell Significance Index: -63.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1028
    Cell Significance Index: -64.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1183
    Cell Significance Index: -160.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1285
    Cell Significance Index: -3.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1303
    Cell Significance Index: -4.5800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1728
    Cell Significance Index: -97.4300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2007
    Cell Significance Index: -91.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3311
    Cell Significance Index: -69.7400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3667
    Cell Significance Index: -6.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.4668
    Cell Significance Index: -32.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5270
    Cell Significance Index: -16.8800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.5462
    Cell Significance Index: -32.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5935
    Cell Significance Index: -68.0000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6001
    Cell Significance Index: -15.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7022
    Cell Significance Index: -43.1600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.7145
    Cell Significance Index: -6.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.7742
    Cell Significance Index: -112.5400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.8230
    Cell Significance Index: -12.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.8364
    Cell Significance Index: -97.4700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.9156
    Cell Significance Index: -13.7200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.1691
    Cell Significance Index: -133.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.3663
    Cell Significance Index: -76.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.4091
    Cell Significance Index: -146.7200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.5322
    Cell Significance Index: -11.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.7452
    Cell Significance Index: -117.3500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.7547
    Cell Significance Index: -30.0700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.9674
    Cell Significance Index: -49.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.9971
    Cell Significance Index: -122.4400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -2.2802
    Cell Significance Index: -31.1100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.6326
    Cell Significance Index: -77.5400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.7599
    Cell Significance Index: -16.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.7912
    Cell Significance Index: -123.4600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -3.1049
    Cell Significance Index: -53.5300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -3.1905
    Cell Significance Index: -82.0100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -3.3372
    Cell Significance Index: -116.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit of Complex III**: UQCRH is a subunit of the respiratory supercomplex III, which is a critical component of the mitochondrial electron transport chain. 2. **Electron Transfer**: UQCRH facilitates the transfer of electrons from ubiquinol to cytochrome c, a process essential for the generation of ATP. 3. **Hinge Function**: As a hinge protein, UQCRH bridges the interface between the mitochondrial inner membrane and the respiratory supercomplex III, ensuring efficient electron transfer and energy production. 4. **High Expression in Various Tissues**: UQCRH is significantly expressed in various tissues, including hematopoietic stem cells, pancreatic A cells, and mesenchymal stem cells. **Pathways and Functions:** 1. **Aerobic Respiration**: UQCRH is involved in the aerobic respiration pathway, which is the primary mechanism for generating ATP in cells. 2. **Mitochondrial Electron Transport**: UQCRH plays a critical role in the mitochondrial electron transport chain, facilitating the transfer of electrons from ubiquinol to cytochrome c. 3. **Oxidative Phosphorylation**: UQCRH is involved in the oxidative phosphorylation process, which generates ATP from the transfer of electrons. 4. **Heat Production**: UQCRH is also involved in the production of heat through the uncoupling of oxidative phosphorylation. **Clinical Significance:** Dysregulation of UQCRH has been implicated in various diseases, including: 1. **Mitochondrial Diseases**: Mutations in the UQCRH gene have been associated with mitochondrial diseases, such as Leber's hereditary optic neuropathy. 2. **Cancer**: Altered expression of UQCRH has been observed in various types of cancer, including leukemia and pancreatic cancer. 3. **Neurodegenerative Disorders**: UQCRH has been implicated in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Cardiovascular Disease**: Abnormal expression of UQCRH has been linked to cardiovascular disease, including hypertension and atherosclerosis. In conclusion, UQCRH is a critical component of the mitochondrial electron transport chain, playing a pivotal role in facilitating the transfer of electrons and energy production. Its dysregulation has been implicated in various diseases, highlighting its importance in maintaining cellular homeostasis. Further research is necessary to fully elucidate the functions and clinical significance of UQCRH.

Genular Protein ID: 2953718954

Symbol: QCR6_HUMAN

Name: Cytochrome b-c1 complex subunit 6, mitochondrial

UniProtKB Accession Codes:

P07919 B2R4V9 D3DQ18 Q5TDF6 Q6LDB8 Q9BQ91

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 EMBL 12 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2826252

Title: An extremely acidic amino-terminal presequence of the precursor for the human mitochondrial hinge protein.

PubMed ID: 2826252

DOI: 10.1016/0014-5793(87)80573-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7684318

Title: Elevated expression of the human mitochondrial hinge protein gene in cancer.

PubMed ID: 7684318

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 34750991

Title: Characterising a homozygous two-exon deletion in UQCRH: comparing human and mouse phenotypes.

PubMed ID: 34750991

DOI: 10.15252/emmm.202114397

PubMed ID: 28844695

Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.

PubMed ID: 28844695

DOI: 10.1016/j.cell.2017.07.050

Sequence Information:

  • Length: 91
  • Mass: 10739
  • Checksum: 499B5D069E738F4C
  • Sequence:
    • MGLEDEQKML TESGDPEEEE EEEEELVDPL TTVREQCEQL EKCVKARERL ELCDERVSSR 
SHTEEDCTEE LFDFLHARDH CVAHKLFNNL K

Genular Protein ID: 2420232068

Symbol: Q567R0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q567R0

Database IDs:

ARBA 14 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 GO 2 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 85
  • Mass: 9953
  • Checksum: B1CD22D8F160CE0C
  • Sequence:
    • MGDRILPFLA AVWLCQLAFC TDPLTTVREQ CEQLEKCVKA RERLELCDER VSSRSHTEED 
CTEELFDFLH ARDHCVAHKL FNNLK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.