Details for: PEBP1
Gene ID: 5037
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PEBP1
Ensembl ID: ENSG00000089220
Description: phosphatidylethanolamine binding protein 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 107.89rCSI 71.71%PRS 4.53
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CSI 98.37rCSI 94.69%PRS 3.94
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CSI 97.28rCSI 76.53%PRS 4.52
-
CSI 95.76rCSI 84.21%PRS 2.75
-
CSI 91.72rCSI 82.83%PRS 3.35
-
CSI 88.87rCSI 71.86%PRS 3.73
-
CSI 87.94rCSI 73.72%PRS 4.58
-
CSI 87.46rCSI 91.62%PRS 4.08
-
CSI 87.05rCSI 83.93%PRS 1.83
-
CSI 86.6rCSI 90.51%PRS 4.05
-
CSI 74.3rCSI 58.73%PRS 2.63
-
CSI 73.39rCSI 86.19%PRS 4.62
-
CSI 73.14rCSI 100%PRS 6.7
-
CSI 70.43rCSI 60.98%PRS 4.22
-
CSI 70.41rCSI 69.25%PRS 4.18
-
CSI 70.27rCSI 70.13%PRS 3.23
-
CSI 69.17rCSI 94.25%PRS 3.44
-
CSI 68.81rCSI 72.08%PRS 3.56
-
CSI 67.28rCSI 100%PRS 4.88
-
CSI 65.84rCSI 48.77%PRS 3.56
-
CSI 65.12rCSI 52.91%PRS 4.01
-
CSI 63.25rCSI 79.38%PRS 4.83
-
CSI 62.34rCSI 51.68%PRS 3.56
-
CSI 57.98rCSI 93.49%PRS 6.2
-
CSI 57.77rCSI 50.73%PRS 4.25
-
CSI 57.06rCSI 44.23%PRS 3.64
-
CSI 55.83rCSI 76.29%PRS 4.22
-
CSI 53.42rCSI 100%PRS 3.89
-
CSI 52.38rCSI 75.49%PRS 6.18
-
CSI 51.41rCSI 45.64%PRS 3.82
-
CSI 50.3rCSI 58.17%PRS 2.76
-
CSI 50.18rCSI 77.54%PRS 3.57
-
CSI 50.18rCSI 57.44%PRS 7.94
-
CSI 49.4rCSI 51.55%PRS 3.9
-
CSI 48.6rCSI 60.12%PRS 3.34
-
CSI 47.73rCSI 61.25%PRS 3.79
-
CSI 45.13rCSI 47.95%PRS 6.8
-
CSI 44.03rCSI 52.85%PRS 3.81
-
CSI 43.9rCSI 83.8%PRS 9.36
-
CSI 43.51rCSI 66.45%PRS 3.79
-
CSI 43.27rCSI 57.51%PRS 4.16
-
CSI 43.27rCSI 57.82%PRS 7.29
-
CSI 42.65rCSI 65.23%PRS 6.24
-
CSI 42.56rCSI 94.23%PRS 3.59
-
CSI 42.51rCSI 76.08%PRS 3.69
-
CSI 41.83rCSI 34.64%PRS 3.81
-
CSI 41.77rCSI 58.04%PRS 4.02
-
CSI 40.95rCSI 60.05%PRS 5.01
-
CSI 40.95rCSI 100%PRS 3.95
-
CSI 40.71rCSI 62.05%PRS 3.59
-
CSI 40.18rCSI 46.4%PRS 3.48
-
CSI 38.54rCSI 70.02%PRS 5.84
-
CSI 38.42rCSI 54.83%PRS 4.34
-
CSI 37.35rCSI 89.61%PRS 7.25
-
CSI 36.99rCSI 27.79%PRS 3.92
-
CSI 36.42rCSI 56.48%PRS 6.05
-
CSI 35.53rCSI 56.68%PRS 3.33
-
CSI 34.53rCSI 94.88%PRS 6.37
-
CSI 33.33rCSI 23.27%PRS 4.01
-
CSI 33.2rCSI 87.42%PRS 7.44
-
CSI 32.82rCSI 33.45%PRS 5.51
-
CSI 31.71rCSI 46.91%PRS 4.38
-
CSI 31.56rCSI 29.12%PRS 3.84
-
CSI 31.53rCSI 85.01%PRS 4.96
-
CSI 31.04rCSI 44.76%PRS 5.29
-
CSI 30.75rCSI 31.85%PRS 4.48
-
CSI 29.33rCSI 31.43%PRS 3.52
-
CSI 29.22rCSI 69.47%PRS 5.81
-
CSI 29.21rCSI 62.17%PRS 6.19
-
CSI 29.15rCSI 44.8%PRS 5.5
-
CSI 28.94rCSI 61.54%PRS 7.38
-
CSI 28.67rCSI 27.09%PRS 3.98
-
CSI 28.39rCSI 36.4%PRS 4.4
-
CSI 28.25rCSI 81.79%PRS 4.32
-
CSI 27.84rCSI 24%PRS 6.35
-
CSI 27.05rCSI 55.54%PRS 9.26
-
CSI 26.89rCSI 86.27%PRS 5.75
-
CSI 26.29rCSI 42.6%PRS 3.87
-
CSI 25.67rCSI 66.36%PRS 3.6
-
CSI 24.65rCSI 49.5%PRS 2.85
-
CSI 24.27rCSI 22.28%PRS 4.36
-
CSI 24.02rCSI 39.57%PRS 4.42
-
CSI 23.97rCSI 32.77%PRS 4.31
-
CSI 23.85rCSI 68.09%PRS 6.77
-
CSI 23.73rCSI 32.86%PRS 5.49
-
CSI 23.45rCSI 53.51%PRS 3.56
-
CSI 23.32rCSI 49.34%PRS 8.47
-
CSI 23.12rCSI 64.79%PRS 6
-
CSI 23.06rCSI 66.7%PRS 8.49
-
CSI 22.98rCSI 25.17%PRS 4.44
-
CSI 22.96rCSI 55.19%PRS 5.93
-
CSI 22.61rCSI 35.7%PRS 3.84
-
CSI 22.5rCSI 78.93%PRS 6.93
-
CSI 21.65rCSI 30.68%PRS 3.66
-
CSI 21.39rCSI 61.6%PRS 7.77
-
CSI 21.37rCSI 63.08%PRS 4.88
-
CSI 21.36rCSI 48.69%PRS 4.01
-
CSI 21.26rCSI 33.76%PRS 4.99
-
CSI 21.06rCSI 30.19%PRS 5.33
-
CSI 20.56rCSI 38.87%PRS 8.6
-
CSI -16.8rCSI -32.1%PRS 6.1%
-
CSI -14.5rCSI -32.7%PRS 9.7%
-
CSI -14.0rCSI -11.2%PRS 7.1%
-
CSI -13.7rCSI -18.0%PRS 5.3%
-
CSI -12.7rCSI -11.6%PRS 6.0%
-
CSI -10.2rCSI -7.9%PRS 3.4%
-
CSI -9.6rCSI -30.7%PRS 2.9%
-
CSI -9.3rCSI -12.6%PRS 5.9%
-
CSI -9.2rCSI -18.2%PRS 11.1%
-
CSI -9.2rCSI -21.3%PRS 10.2%
-
CSI -8.6rCSI -19.6%PRS 3.7%
-
CSI -8.0rCSI -6.5%PRS 9.3%
-
CSI -7.7rCSI -13.9%PRS 10.9%
-
CSI -7.7rCSI -19.8%PRS 13.8%
-
CSI -7.4rCSI -7.3%PRS 6.1%
-
CSI -7.3rCSI -5.5%PRS 5.1%
-
CSI -7.1rCSI -8.5%PRS 6.7%
-
CSI -6.4rCSI -8.6%PRS 22.6%
-
CSI -5.9rCSI -5.4%PRS 7.0%
-
CSI -5.6rCSI -9.8%PRS 3.0%
-
CSI -5.2rCSI -20.9%PRS 4.3%
-
CSI -4.8rCSI -13.9%PRS 5.5%
-
CSI -4.7rCSI -79.4%PRS 20.1%
-
CSI -4.6rCSI -14.9%PRS 6.3%
-
CSI -3.5rCSI -2.5%PRS 5.2%
-
CSI -3.5rCSI -2.6%PRS 11.6%
-
CSI -3.2rCSI -7.2%PRS 2.5%
-
CSI -3.2rCSI -2.5%PRS 5.5%
-
CSI -3.0rCSI -5.9%PRS 12.1%
-
CSI -2.9rCSI -6.0%PRS 3.8%
-
CSI -2.9rCSI -54.9%PRS 31.3%
-
CSI -2.7rCSI -17.1%PRS 10.4%
-
CSI -2.4rCSI -1.4%PRS 5.3%
-
CSI -2.4rCSI -4.7%PRS 8.8%
-
CSI -2.4rCSI -1.7%PRS 5.5%
-
CSI -2.3rCSI -2.7%PRS 5.8%
-
CSI -2.3rCSI -11.2%PRS 28.2%
-
CSI -2.2rCSI -67.9%PRS 57.1%
-
CSI -1.9rCSI -8.4%PRS 3.6%
-
CSI -1.8rCSI -1.7%PRS 11.5%
-
CSI -1.7rCSI -6.2%PRS 19.6%
-
CSI -1.5rCSI -6.2%PRS 8.9%
-
CSI -1.4rCSI -7.9%PRS 6.0%
-
CSI -1.3rCSI -7.9%PRS 3.2%
-
CSI -1.1rCSI -3.0%PRS 18.7%
-
CSI -1.1rCSI -2.8%PRS 4.6%
-
CSI -1.0rCSI -1.6%PRS 9.7%
-
CSI -1.0rCSI -10.3%PRS 26.5%
-
CSI -0.5rCSI -3.1%PRS 13.2%
-
CSI -0.4rCSI -1.9%PRS 6.5%
-
CSI -0.3rCSI -0.5%PRS 23.1%
-
CSI -0.3rCSI -1.5%PRS 9.8%
-
CSI -0.2rCSI -0.2%PRS 17.7%
-
CSI -0.2rCSI -0.7%PRS 7.1%
-
CSI -0.2rCSI -0.1%PRS 6.3%
-
CSI 0.2rCSI 3.4%PRS 24.5%
-
CSI 0.2rCSI 3.1%PRS 37.2%
-
CSI 0.3rCSI 0.4%PRS 3.7%
-
CSI 0.3rCSI 0.2%PRS 8.3%
-
CSI 0.3rCSI 0.4%PRS 3.2%
-
CSI 0.3rCSI 0.9%PRS 5.3%
-
CSI 0.4rCSI 1.3%PRS 8.2%
-
CSI 0.4rCSI 2.1%PRS 5.2%
-
CSI 0.5rCSI 3.0%PRS 7.0%
-
CSI 0.5rCSI 15.1%PRS 47.5%
-
CSI 0.5rCSI 12.6%PRS 14.6%
-
CSI 0.6rCSI 7.9%PRS 37.4%
-
CSI 0.6rCSI 1.8%PRS 7.7%
-
CSI 0.6rCSI 3.7%PRS 6.9%
-
CSI 0.6rCSI 1.5%PRS 5.1%
-
CSI 0.7rCSI 0.7%PRS 16.8%
-
CSI 0.7rCSI 4.4%PRS 19.5%
-
CSI 0.7rCSI 1.5%PRS 6.3%
-
CSI 0.8rCSI 2.0%PRS 27.0%
-
CSI 0.8rCSI 16.3%PRS 14.1%
-
CSI 0.9rCSI 4.6%PRS 8.4%
-
CSI 0.9rCSI 7.6%PRS 6.8%
-
CSI 0.9rCSI 2.1%PRS 5.3%
-
CSI 1.0rCSI 6.3%PRS 7.1%
-
CSI 1.0rCSI 4.5%PRS 18.4%
-
CSI 1.0rCSI 1.4%PRS 5.7%
-
CSI 1.0rCSI 8.9%PRS 24.3%
-
CSI 1.0rCSI 4.5%PRS 20.6%
-
CSI 1.0rCSI 1.7%PRS 8.3%
-
CSI 1.0rCSI 7.9%PRS 7.0%
-
CSI 1.3rCSI 4.8%PRS 6.6%
-
CSI 1.3rCSI 34.4%PRS 22.8%
-
CSI 1.3rCSI 3.1%PRS 3.5%
-
CSI 1.4rCSI 9.9%PRS 1.8%
-
CSI 1.4rCSI 1.6%PRS 13.3%
-
CSI 1.4rCSI 6.1%PRS 8.3%
-
CSI 1.5rCSI 12.1%PRS 39.1%
-
CSI 1.6rCSI 6.1%PRS 17.0%
-
CSI 1.6rCSI 5.1%PRS 2.0%
-
CSI 1.6rCSI 4.7%PRS 2.6%
-
CSI 1.7rCSI 9.7%PRS 21.6%
-
CSI 1.8rCSI 12.8%PRS 43.1%
-
CSI 1.8rCSI 4.7%PRS 4.6%
-
CSI 1.8rCSI 1.6%PRS 6.4%
-
CSI 1.8rCSI 26.1%PRS 3.1%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3878413457
Symbol: PEBP1_HUMAN
Name: Phosphatidylethanolamine-binding protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8144042
Title: A human cDNA sequence homologue of bovine phosphatidylethanolamine-binding protein.
PubMed ID: 8144042
PubMed ID: 7637590
Title: Sequence homology of rat and human HCNP precursor proteins, bovine phosphatidylethanolamine-binding protein and rat 23-kDa protein associated with the opioid-binding protein.
PubMed ID: 7637590
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1286669
Title: Human liver protein map: a reference database established by microsequencing and gel comparison.
PubMed ID: 1286669
PubMed ID: 7807553
Title: Amino acid sequence of the Homo sapiens brain 21-23-kDa protein (neuropolypeptide h3), comparison with its counterparts from Rattus norvegicus and Bos taurus species, and expression of its mRNA in different tissues.
PubMed ID: 7807553
DOI: 10.1007/bf00160411
PubMed ID: 10622376
Title: Hippocampal cholinergic neurostimulating peptides (HCNP).
PubMed ID: 10622376
PubMed ID: 10490027
Title: Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP.
PubMed ID: 10490027
DOI: 10.1038/43686
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18294816
Title: The RKIP (Raf-1 Kinase Inhibitor Protein) conserved pocket binds to the phosphorylated N-region of Raf-1 and inhibits the Raf-1-mediated activated phosphorylation of MEK.
PubMed ID: 18294816
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21831839
Title: 15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells.
PubMed ID: 21831839
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22905912
Title: Resveratrol-induced changes of the human adipocyte secretion profile.
PubMed ID: 22905912
DOI: 10.1021/pr300539b
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 9782050
Title: Function from structure? The crystal structure of human phosphatidylethanolamine-binding protein suggests a role in membrane signal transduction.
PubMed ID: 9782050
Sequence Information:
- Length: 187
- Mass: 21057
- Checksum: F1E9F17E2CD11C36
- Sequence:
MPVDLSKWSG PLSLQEVDEQ PQHPLHVTYA GAAVDELGKV LTPTQVKNRP TSISWDGLDS GKLYTLVLTD PDAPSRKDPK YREWHHFLVV NMKGNDISSG TVLSDYVGSG PPKGTGLHRY VWLVYEQDRP LKCDEPILSN RSGDHRGKFK VASFRKKYEL RAPVAGTCYQ AEWDDYVPKL YEQLSGK