Details for: PEBP1

Gene ID: 5037

Symbol: PEBP1

Ensembl ID: ENSG00000089220

Description: phosphatidylethanolamine binding protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 910.1533
    Cell Significance Index: -141.5700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 463.0517
    Cell Significance Index: -117.4500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 359.6088
    Cell Significance Index: -148.1400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 308.3521
    Cell Significance Index: -145.5800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 276.6409
    Cell Significance Index: -142.3000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 217.5040
    Cell Significance Index: -145.9500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 122.0238
    Cell Significance Index: -150.4500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 39.0847
    Cell Significance Index: -154.2300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 38.6676
    Cell Significance Index: -103.5900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 37.2071
    Cell Significance Index: -114.2800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 24.8356
    Cell Significance Index: -54.3600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 12.8591
    Cell Significance Index: 675.1500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 7.3604
    Cell Significance Index: 67.7800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 6.0619
    Cell Significance Index: 480.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.4907
    Cell Significance Index: 256.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.7840
    Cell Significance Index: 356.5500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 4.6340
    Cell Significance Index: 161.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.5479
    Cell Significance Index: 624.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 4.5022
    Cell Significance Index: 811.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 4.4293
    Cell Significance Index: 1274.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.3178
    Cell Significance Index: 530.9200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 4.1172
    Cell Significance Index: 31.7400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.7104
    Cell Significance Index: 97.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.6085
    Cell Significance Index: 98.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.4664
    Cell Significance Index: 447.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.4467
    Cell Significance Index: 684.0000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.3228
    Cell Significance Index: 235.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.2447
    Cell Significance Index: 152.5000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.1215
    Cell Significance Index: 1380.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.1028
    Cell Significance Index: 1694.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.0405
    Cell Significance Index: 196.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 2.9040
    Cell Significance Index: 2129.1800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.7186
    Cell Significance Index: 62.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.4578
    Cell Significance Index: 315.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1680
    Cell Significance Index: 434.9000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.9690
    Cell Significance Index: 41.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.8133
    Cell Significance Index: 309.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.7134
    Cell Significance Index: 45.9100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6962
    Cell Significance Index: 101.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4608
    Cell Significance Index: 523.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.2300
    Cell Significance Index: 145.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0786
    Cell Significance Index: 28.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.0515
    Cell Significance Index: 64.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9082
    Cell Significance Index: 47.1800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.8078
    Cell Significance Index: 6.4500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6924
    Cell Significance Index: 112.6200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.3118
    Cell Significance Index: 235.9700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2782
    Cell Significance Index: 52.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1987
    Cell Significance Index: 12.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1588
    Cell Significance Index: 298.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1511
    Cell Significance Index: 205.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1385
    Cell Significance Index: 9.3100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1212
    Cell Significance Index: 3.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0700
    Cell Significance Index: 2.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0425
    Cell Significance Index: 65.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0288
    Cell Significance Index: 53.1700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0134
    Cell Significance Index: 0.2300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0129
    Cell Significance Index: 0.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0030
    Cell Significance Index: 1.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0162
    Cell Significance Index: -14.5900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0350
    Cell Significance Index: -0.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0473
    Cell Significance Index: -35.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0702
    Cell Significance Index: -7.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0800
    Cell Significance Index: -7.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1188
    Cell Significance Index: -74.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1737
    Cell Significance Index: -97.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2331
    Cell Significance Index: -105.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2631
    Cell Significance Index: -55.4100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4556
    Cell Significance Index: -5.8300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5501
    Cell Significance Index: -63.0200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5698
    Cell Significance Index: -16.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.6075
    Cell Significance Index: -88.3100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6500
    Cell Significance Index: -74.2000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.6646
    Cell Significance Index: -4.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6663
    Cell Significance Index: -77.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.8647
    Cell Significance Index: -48.5300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8943
    Cell Significance Index: -25.5200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.9113
    Cell Significance Index: -23.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.0124
    Cell Significance Index: -45.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.0860
    Cell Significance Index: -30.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.1050
    Cell Significance Index: -23.9400
  • Cell Name: theca cell (CL0000503)
    Fold Change: -1.2102
    Cell Significance Index: -7.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.2474
    Cell Significance Index: -86.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.2697
    Cell Significance Index: -97.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.3624
    Cell Significance Index: -141.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.3894
    Cell Significance Index: -44.5000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.3953
    Cell Significance Index: -24.6600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.6311
    Cell Significance Index: -27.4800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.7969
    Cell Significance Index: -21.4200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.8243
    Cell Significance Index: -24.8900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -1.9022
    Cell Significance Index: -21.6100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.0440
    Cell Significance Index: -54.6800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -2.0461
    Cell Significance Index: -49.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.0691
    Cell Significance Index: -91.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.1139
    Cell Significance Index: -129.6000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -2.2837
    Cell Significance Index: -33.7100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.4921
    Cell Significance Index: -62.3000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.5918
    Cell Significance Index: -76.3400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.6910
    Cell Significance Index: -101.9000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -2.9227
    Cell Significance Index: -24.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Phosphatidylethanolamine binding:** PEBP1 exhibits a high affinity for phosphatidylethanolamine (PE), a phospholipid component of cellular membranes. This binding property is crucial for regulating PEBP1's interactions with other proteins and lipids. 2. **Multifunctional protein:** PEBP1 has been shown to interact with various proteins, including kinases, phosphatases, and transcription factors, thereby modulating multiple signaling pathways. 3. **Cell type-specific expression:** PEBP1 is significantly expressed in specific cell types, such as thyroid follicular cells, hepatoblasts, and glycinergic neurons, suggesting its involvement in tissue-specific functions. **Pathways and Functions:** 1. **MAPK signaling cascades:** PEBP1 has been implicated in the regulation of MAPK signaling pathways, including the Raf/MAPK/ERK pathway, which is involved in cell growth, differentiation, and survival. 2. **Negative regulation of MAPK pathways:** PEBP1 acts as a negative regulator of MAPK signaling, which can modulate the response to growth factors and cytokines. 3. **Serine-type endopeptidase inhibitor activity:** PEBP1 possesses serine-type endopeptidase inhibitor activity, which can regulate the activity of enzymes involved in protein degradation and signaling. 4. **RNA binding:** PEBP1 has been shown to interact with RNA, which can regulate gene expression and translation. 5. **Oncogenic signaling:** PEBP1 has been implicated in the regulation of oncogenic signaling pathways, including the Ras/MAPK pathway, which is involved in cancer development. **Clinical Significance:** 1. **Cancer:** PEBP1 has been implicated in various cancers, including thyroid cancer, where it is overexpressed and associated with poor prognosis. 2. **Neurological disorders:** PEBP1 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it is involved in the regulation of signaling pathways and protein aggregation. 3. **Inflammatory diseases:** PEBP1 has been implicated in inflammatory diseases, such as atherosclerosis and rheumatoid arthritis, where it regulates the activity of inflammatory cells and cytokines. 4. **Immunological disorders:** PEBP1 has been implicated in immunological disorders, such as autoimmune diseases and immunodeficiency disorders, where it regulates the activity of immune cells and cytokines. In conclusion, PEBP1 is a multifunctional protein that plays a critical role in regulating cellular signaling and disease pathways. Further research is necessary to fully understand its mechanisms of action and its implications in human disease.

Genular Protein ID: 3878413457

Symbol: PEBP1_HUMAN

Name: Phosphatidylethanolamine-binding protein 1

UniProtKB Accession Codes:

P30086 B2R4S1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 3 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 9 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 7 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8144042

Title: A human cDNA sequence homologue of bovine phosphatidylethanolamine-binding protein.

PubMed ID: 8144042

DOI: 10.1016/0378-1119(94)90562-2

PubMed ID: 7637590

Title: Sequence homology of rat and human HCNP precursor proteins, bovine phosphatidylethanolamine-binding protein and rat 23-kDa protein associated with the opioid-binding protein.

PubMed ID: 7637590

DOI: 10.1016/0169-328x(95)00029-r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286669

Title: Human liver protein map: a reference database established by microsequencing and gel comparison.

PubMed ID: 1286669

DOI: 10.1002/elps.11501301201

PubMed ID: 7807553

Title: Amino acid sequence of the Homo sapiens brain 21-23-kDa protein (neuropolypeptide h3), comparison with its counterparts from Rattus norvegicus and Bos taurus species, and expression of its mRNA in different tissues.

PubMed ID: 7807553

DOI: 10.1007/bf00160411

PubMed ID: 10622376

Title: Hippocampal cholinergic neurostimulating peptides (HCNP).

PubMed ID: 10622376

DOI: 10.1016/s0301-0082(99)00021-0

PubMed ID: 10490027

Title: Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP.

PubMed ID: 10490027

DOI: 10.1038/43686

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18294816

Title: The RKIP (Raf-1 Kinase Inhibitor Protein) conserved pocket binds to the phosphorylated N-region of Raf-1 and inhibits the Raf-1-mediated activated phosphorylation of MEK.

PubMed ID: 18294816

DOI: 10.1016/j.cellsig.2008.01.012

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21831839

Title: 15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells.

PubMed ID: 21831839

DOI: 10.1073/pnas.1018075108

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9782050

Title: Function from structure? The crystal structure of human phosphatidylethanolamine-binding protein suggests a role in membrane signal transduction.

PubMed ID: 9782050

DOI: 10.1016/s0969-2126(98)00125-7

Sequence Information:

  • Length: 187
  • Mass: 21057
  • Checksum: F1E9F17E2CD11C36
  • Sequence:
    • MPVDLSKWSG PLSLQEVDEQ PQHPLHVTYA GAAVDELGKV LTPTQVKNRP TSISWDGLDS 
GKLYTLVLTD PDAPSRKDPK YREWHHFLVV NMKGNDISSG TVLSDYVGSG PPKGTGLHRY 
VWLVYEQDRP LKCDEPILSN RSGDHRGKFK VASFRKKYEL RAPVAGTCYQ AEWDDYVPKL 
YEQLSGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.