Details for: GPT

Gene ID: 2875

Symbol: GPT

Ensembl ID: ENSG00000167701

Description: glutamic--pyruvic transaminase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 4.47
    Marker Score: 4437
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.78
    Marker Score: 865
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.75
    Marker Score: 8383
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.52
    Marker Score: 4769
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169383
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.42
    Marker Score: 3341
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.31
    Marker Score: 985
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.27
    Marker Score: 6803
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.16
    Marker Score: 18218
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.08
    Marker Score: 6958
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.07
    Marker Score: 1643
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.06
    Marker Score: 4578
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48053
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.98
    Marker Score: 975
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.87
    Marker Score: 800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.86
    Marker Score: 5480
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 617
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 317
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.76
    Marker Score: 427
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 680
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.73
    Marker Score: 317
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3043
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.72
    Marker Score: 264
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.71
    Marker Score: 1686
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.68
    Marker Score: 15169
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.62
    Marker Score: 1415
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.62
    Marker Score: 420
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.6
    Marker Score: 642
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.59
    Marker Score: 387
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.58
    Marker Score: 553
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.56
    Marker Score: 162
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.55
    Marker Score: 1125
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.55
    Marker Score: 1961
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.55
    Marker Score: 1036
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.54
    Marker Score: 356
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.51
    Marker Score: 1801
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.48
    Marker Score: 200
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.46
    Marker Score: 143
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.44
    Marker Score: 433.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.42
    Marker Score: 241
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.4
    Marker Score: 169
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.4
    Marker Score: 8620
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4
    Marker Score: 99
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.4
    Marker Score: 96
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.39
    Marker Score: 112
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.38
    Marker Score: 337
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.36
    Marker Score: 174
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.35
    Marker Score: 91
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.34
    Marker Score: 129
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.34
    Marker Score: 168
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.33
    Marker Score: 120
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.33
    Marker Score: 87
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.33
    Marker Score: 145
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.33
    Marker Score: 222
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.33
    Marker Score: 122
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.31
    Marker Score: 92
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.31
    Marker Score: 315.5
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.3
    Marker Score: 78
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.3
    Marker Score: 179
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.29
    Marker Score: 249
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.28
    Marker Score: 90
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.27
    Marker Score: 101
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.26
    Marker Score: 558
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.26
    Marker Score: 480
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.26
    Marker Score: 69
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.26
    Marker Score: 71
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.25
    Marker Score: 160
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.24
    Marker Score: 178
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.24
    Marker Score: 100
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.24
    Marker Score: 542
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.24
    Marker Score: 1568
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.23
    Marker Score: 602
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.23
    Marker Score: 157
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.23
    Marker Score: 72
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.23
    Marker Score: 106
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.23
    Marker Score: 608
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.23
    Marker Score: 73
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.21
    Marker Score: 55
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.2
    Marker Score: 57
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.2
    Marker Score: 318
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.2
    Marker Score: 61
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2
    Marker Score: 67
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.2
    Marker Score: 273
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.19
    Marker Score: 87
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.19
    Marker Score: 112
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.18
    Marker Score: 68

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Other Information

**Key characteristics:** - The GPT gene is located on chromosome 15q21.1. - It is a single-exon gene with a size of approximately 1.6 kb. - It encodes a protein of 541 amino acids. - The protein is expressed as a transmembrane protein, with two extracellular domains and one intracellular domain. - The extracellular domains are involved in binding to substrates and regulatory proteins, while the intracellular domain is involved in the transfer of an aspartate group from L-alanine to pyruvate. **Pathways and functions:** - The GPT gene is involved in the metabolism of L-alanine, an amino acid that is produced by the deamination of glutamine and serine. - The enzyme encoded by the GPT gene catalyzes the transfer of an aspartate group from L-alanine to pyruvate, which is a key intermediate in the citric acid cycle. - This reaction is part of the biosynthesis of carnitine, which is an important metabolite involved in energy metabolism. - The GPT gene is also involved in the regulation of gluconeogenesis, the process by which the body converts non-protein nitrogen sources into glucose. - It is also involved in the response to starvation, as it is expressed in cells that are particularly sensitive to amino acid deprivation. **Clinical significance:** - Mutations in the GPT gene have been linked to several human diseases, including hepatic encephalopathy, lactic acidosis, and diabetic ketoacidosis. - These disorders are characterized by abnormal amino acid metabolism, which can be caused by defects in the GPT enzyme or by mutations in other genes that are involved in the metabolism of amino acids. - Genetic testing for GPT mutations is used to diagnose these disorders and to monitor the course of treatment.

Genular Protein ID: 332362941

Symbol: ALAT1_HUMAN

Name: Alanine aminotransferase 1

UniProtKB Accession Codes:

P24298 B0YJ18 D3DWM7 P78398 Q93076

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 5 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EC 2 EMBL 7 EPD 1 Ensembl 2 GO 9 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9119391

Title: Human glutamate pyruvate transaminase (GPT): localization to 8q24.3, cDNA and genomic sequences, and polymorphic sites.

PubMed ID: 9119391

DOI: 10.1006/geno.1996.4604

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1931970

Title: Complete amino acid sequence of human liver cytosolic alanine aminotransferase (GPT) determined by a combination of conventional and mass spectral methods.

PubMed ID: 1931970

DOI: 10.1021/bi00107a013

PubMed ID: 11863375

Title: cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase.

PubMed ID: 11863375

DOI: 10.1006/geno.2002.6722

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26477546

Title: Joubert Syndrome in French Canadians and Identification of Mutations in CEP104.

PubMed ID: 26477546

DOI: 10.1016/j.ajhg.2015.09.009

Sequence Information:

  • Length: 496
  • Mass: 54637
  • Checksum: 23705E7A3A4283B6
  • Sequence:
    • MASSTGDRSQ AVRHGLRAKV LTLDGMNPRV RRVEYAVRGP IVQRALELEQ ELRQGVKKPF 
TEVIRANIGD AQAMGQRPIT FLRQVLALCV NPDLLSSPNF PDDAKKRAER ILQACGGHSL 
GAYSVSSGIQ LIREDVARYI ERRDGGIPAD PNNVFLSTGA SDAIVTVLKL LVAGEGHTRT 
GVLIPIPQYP LYSATLAELG AVQVDYYLDE ERAWALDVAE LHRALGQARD HCRPRALCVI 
NPGNPTGQVQ TRECIEAVIR FAFEERLFLL ADEVYQDNVY AAGSQFHSFK KVLMEMGPPY 
AGQQELASFH STSKGYMGEC GFRGGYVEVV NMDAAVQQQM LKLMSVRLCP PVPGQALLDL 
VVSPPAPTDP SFAQFQAEKQ AVLAELAAKA KLTEQVFNEA PGISCNPVQG AMYSFPRVQL 
PPRAVERAQE LGLAPDMFFC LRLLEETGIC VVPGSGFGQR EGTYHFRMTI LPPLEKLRLL 
LEKLSRFHAK FTLEYS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.