Details for: MIR193BHG

Gene ID: 100129781

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: MIR193BHG

Ensembl ID: ENSG00000262454

Description: MIR193b-365a host gene

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • epicardial adipocyte CL1000309
    CSI 4.18
    rCSI 13.59%
    PRS 97.78
  • extravillous trophoblast CL0008036
    CSI 4.11
    rCSI 5.09%
    PRS 98.16
  • adipocyte CL0000136
    CSI 4.01
    rCSI 5.15%
    PRS 96.69
  • cardiac muscle cell CL0000746
    CSI 3.28
    rCSI 4.7%
    PRS 96.17
  • placental villous trophoblast CL2000060
    CSI 2.8
    rCSI 4.33%
    PRS 98.17
  • chondrocyte CL0000138
    CSI 2.76
    rCSI 4.39%
    PRS 97.38
  • corneal epithelial cell CL0000575
    CSI 2.04
    rCSI 5.85%
    PRS 98.63
  • basal cell CL0000646
    CSI 1.96
    rCSI 2.62%
    PRS 98.11
  • syncytiotrophoblast cell CL0000525
    CSI 1.66
    rCSI 4.77%
    PRS 97.56
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 1.43
    rCSI 1.74%
    PRS 89.3
  • regular ventricular cardiac myocyte CL0002131
    CSI 0.87
    rCSI 5.42%
    PRS 96.6
  • indirect pathway medium spiny neuron CL4023029
    CSI 0.5
    rCSI 12.17%
    PRS 93.9
  • direct pathway medium spiny neuron CL4023026
    CSI 0.37
    rCSI 8.77%
    PRS 94.21

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [MIR193BHG](/details-gene/100129781) is a non-coding RNA (ncRNA) host gene located on chromosome 16p13.12 in humans. The gene product itself does not code for a protein but serves as the precursor for microRNAs, including miR-193b and miR-365a. Expression data indicates that [MIR193BHG](/details-gene/100129781) shows high significance in specific cell types associated with metabolic function, placental development, and muscle tissue. Notably, its strong expression in [adipocytes](/details-cell/CL0000136), various [trophoblast](/details-cell/CL0008036) subtypes, and [cardiac muscle cells](/details-cell/CL0000746) suggests its involvement in processes such as lipid metabolism, embryonic development, and cardiac homeostasis. ## Cellular Roles and Expression Landscape **Overall**, the expression profile of [MIR193BHG](/details-gene/100129781) points to a specialized role in several distinct biological systems. The gene's highest significance is observed in cells related to energy storage and metabolism, including [epicardial adipocyte](/details-cell/CL1000309) (CSI: 4.18) and [adipocyte](/details-cell/CL0000136) (CSI: 4.01), suggesting a key function in adipose tissue biology. A second major functional niche for [MIR193BHG](/details-gene/100129781) is the placenta. It is highly significant in [extravillous trophoblast](/details-cell/CL0008036) (CSI: 4.11), [placental villous trophoblast](/details-cell/CL2000060) (CSI: 2.80), and [syncytiotrophoblast cell](/details-cell/CL0000525) (CSI: 1.66), which are all critical for implantation, nutrient exchange, and maternal-fetal interface maintenance. Furthermore, [MIR193BHG](/details-gene/100129781) demonstrates notable significance in muscle and structural cells, including [cardiac muscle cell](/details-cell/CL0000746) (CSI: 3.28) and [chondrocyte](/details-cell/CL0000138) (CSI: 2.76). Its expression in [regular ventricular cardiac myocyte](/details-cell/CL0002131) further solidifies its potential relevance in cardiac function. The gene also shows moderate significance in certain epithelial lineages like [corneal epithelial cell](/details-cell/CL0000575) and a minor signal in immune cells such as [CD8-positive, alpha-beta memory T cell, CD45RO-positive](/details-cell/CL0001203). Conversely, the very low significance of [MIR193BHG](/details-gene/100129781) in neuronal cell types, such as [indirect pathway medium spiny neuron](/details-cell/CL4023029) and [direct pathway medium spiny neuron](/details-cell/CL4023026), suggests its functions are largely constrained to non-neuronal tissues. ## Pathways and Molecular Function The functional annotations for [MIR193BHG](/details-gene/100129781) were not provided in the dataset. However, as a host gene for miR-193b and miR-365a, its primary molecular function is to serve as the precursor transcript from which these mature microRNAs are processed. These microRNAs, in turn, regulate the expression of target messenger RNAs post-transcriptionally. Based on the cell types where it is highly expressed, the pathways regulated by the microRNAs derived from [MIR193BHG](/details-gene/100129781) are likely involved in adipogenesis, lipid metabolism, placental development, and the regulation of cardiac muscle cell physiology. ## Research Directions The specific and high-level expression of [MIR193BHG](/details-gene/100129781) in adipocytes, trophoblasts, and cardiac muscle cells provides a foundation for several testable hypotheses. 1. **Hypothesis 1 (Metabolism):** Given its high significance in adipocytes, [MIR193BHG](/details-gene/100129781) and its derived microRNAs likely function as key regulators of adipocyte differentiation and lipid storage. Dysregulation of this lncRNA could therefore contribute to the pathophysiology of metabolic disorders such as obesity and type 2 diabetes. 2. **Hypothesis 2 (Placental Biology):** The prominent expression of [MIR193BHG](/details-gene/100129781) across multiple trophoblast subtypes suggests it plays a critical role in placental function. It is plausible that aberrant expression of this gene could impair trophoblast invasion or differentiation, potentially leading to pregnancy complications like pre-eclampsia or intrauterine growth restriction. 3. **Hypothesis 3 (Cardiac Function):** The notable expression in [cardiac muscle cells](/details-cell/CL0000746) indicates a potential role in maintaining cardiac homeostasis. Altered levels of [MIR193BHG](/details-gene/100129781) might be implicated in the cellular response to cardiac stress or in the development of cardiomyopathies. **Experimental Approach to Test Hypothesis 1:** To investigate the role of [MIR193BHG](/details-gene/100129781) in adipogenesis, a loss-of-function study could be performed. Human pre-adipocyte cells (e.g., SGBS cells) could be transfected with antisense oligonucleotides (ASOs) or a CRISPRi system targeting the [MIR193BHG](/details-gene/100129781) transcript. Following knockdown, adipocyte differentiation would be induced. The impact on adipogenesis could be quantified by measuring lipid droplet accumulation using Oil Red O staining and by assessing the expression of key adipogenic marker genes (e.g., *PPARG*, *CEBPA*, *FABP4*) via RT-qPCR and Western blot. **Therapeutic Potential:** As a long non-coding RNA, [MIR193BHG](/details-gene/100129781) is a tractable target for RNA-based therapeutics, such as ASOs or siRNAs. If its overexpression is linked to metabolic disease, therapeutic inhibition in adipose tissue could be a viable strategy to modulate lipid metabolism. However, its significant expression in cardiac muscle presents a potential safety concern, as off-target effects in the heart could lead to cardiotoxicity. Therefore, any therapeutic strategy would require a highly targeted delivery system to specifically reach adipose tissue while sparing the heart and other vital organs.