Details for: LBP

Gene ID: 3929

Symbol: LBP

Ensembl ID: ENSG00000129988

Description: lipopolysaccharide binding protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.5625
    Cell Significance Index: 60.0100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.7885
    Cell Significance Index: 46.9000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.3683
    Cell Significance Index: -2.9200
  • Cell Name: chorionic trophoblast cell (CL0011101)
    Fold Change: 2.2486
    Cell Significance Index: 6.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4291
    Cell Significance Index: 283.6000
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.3779
    Cell Significance Index: 7.9400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.9239
    Cell Significance Index: 23.0400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.8963
    Cell Significance Index: 21.8700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 0.6766
    Cell Significance Index: -2.6700
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.3080
    Cell Significance Index: 1.1600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.2898
    Cell Significance Index: 3.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.2861
    Cell Significance Index: 29.2300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1809
    Cell Significance Index: 2.6700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1676
    Cell Significance Index: 2.4000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1351
    Cell Significance Index: 2.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1319
    Cell Significance Index: 2.2600
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.1008
    Cell Significance Index: 0.2700
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.0531
    Cell Significance Index: 0.1400
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0168
    Cell Significance Index: 0.1600
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.0162
    Cell Significance Index: 0.1600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0139
    Cell Significance Index: 9.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0073
    Cell Significance Index: 1.4700
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.0069
    Cell Significance Index: 0.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0052
    Cell Significance Index: 0.8900
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.0040
    Cell Significance Index: 0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0003
    Cell Significance Index: 0.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0005
    Cell Significance Index: -0.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0012
    Cell Significance Index: -1.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0013
    Cell Significance Index: -0.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0020
    Cell Significance Index: -2.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0022
    Cell Significance Index: -0.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0029
    Cell Significance Index: -0.8400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0035
    Cell Significance Index: -2.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0037
    Cell Significance Index: -2.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0038
    Cell Significance Index: -2.9100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0049
    Cell Significance Index: -2.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0050
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0050
    Cell Significance Index: -3.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0065
    Cell Significance Index: -2.9600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0079
    Cell Significance Index: -0.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0142
    Cell Significance Index: -1.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0149
    Cell Significance Index: -2.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0151
    Cell Significance Index: -3.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0173
    Cell Significance Index: -2.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0181
    Cell Significance Index: -2.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0184
    Cell Significance Index: -2.5300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0189
    Cell Significance Index: -0.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0193
    Cell Significance Index: -0.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0219
    Cell Significance Index: -2.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0220
    Cell Significance Index: -2.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0271
    Cell Significance Index: -2.8200
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.0287
    Cell Significance Index: -0.1000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0321
    Cell Significance Index: -0.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0340
    Cell Significance Index: -0.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0376
    Cell Significance Index: -2.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0394
    Cell Significance Index: -3.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0409
    Cell Significance Index: -3.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0437
    Cell Significance Index: -1.1700
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0450
    Cell Significance Index: -0.3600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0485
    Cell Significance Index: -1.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0524
    Cell Significance Index: -3.2200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0535
    Cell Significance Index: -1.1200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0564
    Cell Significance Index: -1.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0567
    Cell Significance Index: -2.5100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0580
    Cell Significance Index: -1.0000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0597
    Cell Significance Index: -1.4900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0598
    Cell Significance Index: -1.3100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0602
    Cell Significance Index: -0.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0605
    Cell Significance Index: -2.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0660
    Cell Significance Index: -3.4400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0666
    Cell Significance Index: -1.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0674
    Cell Significance Index: -3.7800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0681
    Cell Significance Index: -1.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0691
    Cell Significance Index: -3.1300
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0698
    Cell Significance Index: -0.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0737
    Cell Significance Index: -3.8300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0759
    Cell Significance Index: -2.6600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0791
    Cell Significance Index: -2.5900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0794
    Cell Significance Index: -2.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0920
    Cell Significance Index: -4.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0954
    Cell Significance Index: -3.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0965
    Cell Significance Index: -3.3900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0985
    Cell Significance Index: -4.2800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0992
    Cell Significance Index: -1.3900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0997
    Cell Significance Index: -2.6600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0999
    Cell Significance Index: -2.8500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1021
    Cell Significance Index: -1.1100
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1027
    Cell Significance Index: -0.9400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1042
    Cell Significance Index: -2.1200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1050
    Cell Significance Index: -1.5300
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1057
    Cell Significance Index: -1.2500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1061
    Cell Significance Index: -3.0400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1064
    Cell Significance Index: -1.2100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1079
    Cell Significance Index: -5.4500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1086
    Cell Significance Index: -2.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1121
    Cell Significance Index: -3.2300
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1124
    Cell Significance Index: -1.0400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1131
    Cell Significance Index: -2.8900
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.1136
    Cell Significance Index: -1.1300
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: -0.1138
    Cell Significance Index: -1.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** LBP is a 18-kDa protein composed of four β-sheets and two α-helices. Its structure allows it to bind to LPS and LTA, facilitating their recognition by PRRs. 2. **Function:** LBP plays a central role in the recognition and response to bacterial components, including LPS and LTA. It binds to these components, which are then recognized by TLR4 and other PRRs, triggering a signaling cascade that activates immune cells. 3. **Cellular Expression:** LBP is expressed in various tissues, including the liver, lungs, kidneys, and endothelial cells. It is also found in epithelial cells and macrophages, where it plays a role in the recognition and response to bacterial components. 4. **Signaling Pathways:** LBP triggers a variety of signaling pathways, including the TLR4 cascade, which activates immune cells and leads to the production of pro-inflammatory cytokines and chemokines. **Pathways and Functions:** 1. **TLR4 Cascade:** LBP binds to LPS and LTA, which are then recognized by TLR4. This recognition triggers a signaling cascade that activates immune cells, including macrophages and neutrophils. 2. **Innate Immunity:** LBP plays a critical role in the innate immune response, which provides the first line of defense against pathogens. It helps to recognize and respond to bacterial components, including LPS and LTA. 3. **Pro-inflammatory Cytokines and Chemokines:** LBP triggers the production of pro-inflammatory cytokines and chemokines, which are essential for the elimination of pathogens. 4. **Macrophage Activation:** LBP activates macrophages, which are key immune cells involved in the phagocytosis and killing of pathogens. 5. **Neutrophil Chemotaxis:** LBP also triggers the production of chemokines that recruit neutrophils, which are essential for the elimination of pathogens. **Clinical Significance:** 1. **Infections:** LBP plays a critical role in the recognition and response to bacterial components, including LPS and LTA. Dysregulation of LBP has been implicated in various infections, including sepsis and pneumonia. 2. **Inflammatory Disorders:** LBP has been implicated in various inflammatory disorders, including rheumatoid arthritis and atherosclerosis. 3. **Cancer:** LBP has been shown to promote cancer progression by suppressing the immune response. 4. **Immunotherapy:** LBP has been identified as a potential target for immunotherapy, as it plays a critical role in the recognition and response to bacterial components. In conclusion, LBP is a critical component of the innate immune system that plays a pivotal role in the recognition and response to bacterial components. Its dysregulation has been implicated in various infections, inflammatory disorders, and cancer. Further research is needed to fully understand the role of LBP in the regulation of innate immunity and its potential as a therapeutic target.

Genular Protein ID: 3623877261

Symbol: LBP_HUMAN

Name: Lipopolysaccharide-binding protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2402637

Title: Structure and function of lipopolysaccharide binding protein.

PubMed ID: 2402637

DOI: 10.1126/science.2402637

PubMed ID: 7517398

Title: Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS-mediated cell activation.

PubMed ID: 7517398

DOI: 10.1016/s0021-9258(17)32454-7

PubMed ID: 9240454

Title: The genomic organization of the genes for human lipopolysaccharide binding protein (LBP) and bactericidal permeability increasing protein (BPI) is highly conserved.

PubMed ID: 9240454

DOI: 10.1006/bbrc.1997.6970

PubMed ID: 9441745

Title: Similar organization of the lipopolysaccharide-binding protein (LBP) and phospholipid transfer protein (PLTP) genes suggests a common gene family of lipid-binding proteins.

PubMed ID: 9441745

DOI: 10.1006/geno.1997.5030

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 1698311

Title: CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein.

PubMed ID: 1698311

DOI: 10.1126/science.1698311

PubMed ID: 17481951

Title: Structural biology of the LPS recognition.

PubMed ID: 17481951

DOI: 10.1016/j.ijmm.2007.04.001

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 20133493

Title: Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells.

PubMed ID: 20133493

DOI: 10.1093/intimm/dxq005

PubMed ID: 24120359

Title: The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity.

PubMed ID: 24120359

DOI: 10.1016/j.immuni.2013.09.005

Sequence Information:

  • Length: 481
  • Mass: 53384
  • Checksum: 5A0E4B9E5E604C72
  • Sequence:
  • MGALARALPS ILLALLLTST PEALGANPGL VARITDKGLQ YAAQEGLLAL QSELLRITLP 
    DFTGDLRIPH VGRGRYEFHS LNIHSCELLH SALRPVPGQG LSLSISDSSI RVQGRWKVRK 
    SFFKLQGSFD VSVKGISISV NLLLGSESSG RPTVTASSCS SDIADVEVDM SGDLGWLLNL 
    FHNQIESKFQ KVLESRICEM IQKSVSSDLQ PYLQTLPVTT EIDSFADIDY SLVEAPRATA 
    QMLEVMFKGE IFHRNHRSPV TLLAAVMSLP EEHNKMVYFA ISDYVFNTAS LVYHEEGYLN 
    FSITDDMIPP DSNIRLTTKS FRPFVPRLAR LYPNMNLELQ GSVPSAPLLN FSPGNLSVDP 
    YMEIDAFVLL PSSSKEPVFR LSVATNVSAT LTFNTSKITG FLKPGKVKVE LKESKVGLFN 
    AELLEALLNY YILNTFYPKF NDKLAEGFPL PLLKRVQLYD LGLQIHKDFL FLGANVQYMR 
    V

Genular Protein ID: 1681281381

Symbol: Q8TCF0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 477
  • Mass: 52934
  • Checksum: 03D5E9D55A3BA6D0
  • Sequence:
  • MGALARALPS ILLALLLTST PEALGANPGL VARITDKGLQ YAAQEGLLAL QSELLRITLP 
    DFTGDLRIPH VGRGRYEFHS LNIHSCELLH SALRPVPGQG LSLSISDSSI RVQGRWKVRK 
    SFFKLQGSFD VSVKGISISV NLLLGSESSG RPTVTASSCS SDIADVEVDM SGDLGWLLNL 
    FHNQIESKFQ KVLESRICEM IQKSVSSDLQ PYLQTLPVTT EIDSFADIDY SLVEAPRATA 
    QMLEVMFKGE IFHRNHRSPV TLLAAVMSLP EEHNKMVYFA ISDYVFNTAS LVYHEEGYLN 
    FSITDDMIPP DSNIRLTTKS FRPFVPRLAR LYPNMNLELQ GSVPSAPLLN FSPGNLSVDP 
    YMEIDAFVLL PSSSKEPVFR LSVATNVSAT LTFNTSKITG FLKPGKVKVE LKESKVGLFN 
    AELLEALLNY YILNTFYPKF NDKLAEGFPL PLLKRVQLYD LGLQIHKDFP SRRDHPP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.