Details for: LBP

Gene ID: 3929

Symbol: LBP

Ensembl ID: ENSG00000129988

Description: lipopolysaccharide binding protein

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.82
    Marker Score: 9,801
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.77
    Marker Score: 794
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.73
    Marker Score: 7,448
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.65
    Marker Score: 10,595
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.61
    Marker Score: 3,328
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.28
    Marker Score: 484
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.09
    Marker Score: 2,568
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.05
    Marker Score: 1,120
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.02
    Marker Score: 494
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,052
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.99
    Marker Score: 2,508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.94
    Marker Score: 1,780
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,352
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.8
    Marker Score: 5,336
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.77
    Marker Score: 529
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.61
    Marker Score: 1,241
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.61
    Marker Score: 9,486
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 460
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.57
    Marker Score: 266
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.49
    Marker Score: 242
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.45
    Marker Score: 448
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.38
    Marker Score: 119
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.3
    Marker Score: 143
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.29
    Marker Score: 174
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.28
    Marker Score: 104
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.24
    Marker Score: 105
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.23
    Marker Score: 124
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.22
    Marker Score: 68
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.21
    Marker Score: 59
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.21
    Marker Score: 120
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.2
    Marker Score: 73
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.19
    Marker Score: 616
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.19
    Marker Score: 112
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.19
    Marker Score: 49
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.17
    Marker Score: 53
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.16
    Marker Score: 289
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.16
    Marker Score: 91
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.16
    Marker Score: 42
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.16
    Marker Score: 50
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.13
    Marker Score: 119
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.13
    Marker Score: 201
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.13
    Marker Score: 71
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.12
    Marker Score: 49
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.12
    Marker Score: 42
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.1
    Marker Score: 99
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.1
    Marker Score: 22
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.1
    Marker Score: 106
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.09
    Marker Score: 98
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.09
    Marker Score: 102
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.09
    Marker Score: 160
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.09
    Marker Score: 20
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.09
    Marker Score: 43
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.09
    Marker Score: 50
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.08
    Marker Score: 33
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.08
    Marker Score: 179
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.08
    Marker Score: 49
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.08
    Marker Score: 63
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: brush cell of trachebronchial tree (CL0002075)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.07
    Marker Score: 90
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.07
    Marker Score: 958
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.07
    Marker Score: 93
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.07
    Marker Score: 67
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.07
    Marker Score: 222
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.07
    Marker Score: 188
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.07
    Marker Score: 45
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.06
    Marker Score: 1,017
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.06
    Marker Score: 39
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.06
    Marker Score: 153
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.06
    Marker Score: 51
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.06
    Marker Score: 97
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.06
    Marker Score: 24

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** LBP is a 18-kDa protein composed of four β-sheets and two α-helices. Its structure allows it to bind to LPS and LTA, facilitating their recognition by PRRs. 2. **Function:** LBP plays a central role in the recognition and response to bacterial components, including LPS and LTA. It binds to these components, which are then recognized by TLR4 and other PRRs, triggering a signaling cascade that activates immune cells. 3. **Cellular Expression:** LBP is expressed in various tissues, including the liver, lungs, kidneys, and endothelial cells. It is also found in epithelial cells and macrophages, where it plays a role in the recognition and response to bacterial components. 4. **Signaling Pathways:** LBP triggers a variety of signaling pathways, including the TLR4 cascade, which activates immune cells and leads to the production of pro-inflammatory cytokines and chemokines. **Pathways and Functions:** 1. **TLR4 Cascade:** LBP binds to LPS and LTA, which are then recognized by TLR4. This recognition triggers a signaling cascade that activates immune cells, including macrophages and neutrophils. 2. **Innate Immunity:** LBP plays a critical role in the innate immune response, which provides the first line of defense against pathogens. It helps to recognize and respond to bacterial components, including LPS and LTA. 3. **Pro-inflammatory Cytokines and Chemokines:** LBP triggers the production of pro-inflammatory cytokines and chemokines, which are essential for the elimination of pathogens. 4. **Macrophage Activation:** LBP activates macrophages, which are key immune cells involved in the phagocytosis and killing of pathogens. 5. **Neutrophil Chemotaxis:** LBP also triggers the production of chemokines that recruit neutrophils, which are essential for the elimination of pathogens. **Clinical Significance:** 1. **Infections:** LBP plays a critical role in the recognition and response to bacterial components, including LPS and LTA. Dysregulation of LBP has been implicated in various infections, including sepsis and pneumonia. 2. **Inflammatory Disorders:** LBP has been implicated in various inflammatory disorders, including rheumatoid arthritis and atherosclerosis. 3. **Cancer:** LBP has been shown to promote cancer progression by suppressing the immune response. 4. **Immunotherapy:** LBP has been identified as a potential target for immunotherapy, as it plays a critical role in the recognition and response to bacterial components. In conclusion, LBP is a critical component of the innate immune system that plays a pivotal role in the recognition and response to bacterial components. Its dysregulation has been implicated in various infections, inflammatory disorders, and cancer. Further research is needed to fully understand the role of LBP in the regulation of innate immunity and its potential as a therapeutic target.

Genular Protein ID: 3623877261

Symbol: LBP_HUMAN

Name: Lipopolysaccharide-binding protein

UniProtKB Accession Codes:

P18428 B2R938 O43438 Q92672 Q9H403 Q9UD66

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CPTAC 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 31 Ensembl 1 GO 35 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2402637

Title: Structure and function of lipopolysaccharide binding protein.

PubMed ID: 2402637

DOI: 10.1126/science.2402637

PubMed ID: 7517398

Title: Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS-mediated cell activation.

PubMed ID: 7517398

DOI: 10.1016/s0021-9258(17)32454-7

PubMed ID: 9240454

Title: The genomic organization of the genes for human lipopolysaccharide binding protein (LBP) and bactericidal permeability increasing protein (BPI) is highly conserved.

PubMed ID: 9240454

DOI: 10.1006/bbrc.1997.6970

PubMed ID: 9441745

Title: Similar organization of the lipopolysaccharide-binding protein (LBP) and phospholipid transfer protein (PLTP) genes suggests a common gene family of lipid-binding proteins.

PubMed ID: 9441745

DOI: 10.1006/geno.1997.5030

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 1698311

Title: CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein.

PubMed ID: 1698311

DOI: 10.1126/science.1698311

PubMed ID: 17481951

Title: Structural biology of the LPS recognition.

PubMed ID: 17481951

DOI: 10.1016/j.ijmm.2007.04.001

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 20133493

Title: Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells.

PubMed ID: 20133493

DOI: 10.1093/intimm/dxq005

PubMed ID: 24120359

Title: The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity.

PubMed ID: 24120359

DOI: 10.1016/j.immuni.2013.09.005

Sequence Information:

  • Length: 481
  • Mass: 53384
  • Checksum: 5A0E4B9E5E604C72
  • Sequence:
    • MGALARALPS ILLALLLTST PEALGANPGL VARITDKGLQ YAAQEGLLAL QSELLRITLP 
DFTGDLRIPH VGRGRYEFHS LNIHSCELLH SALRPVPGQG LSLSISDSSI RVQGRWKVRK 
SFFKLQGSFD VSVKGISISV NLLLGSESSG RPTVTASSCS SDIADVEVDM SGDLGWLLNL 
FHNQIESKFQ KVLESRICEM IQKSVSSDLQ PYLQTLPVTT EIDSFADIDY SLVEAPRATA 
QMLEVMFKGE IFHRNHRSPV TLLAAVMSLP EEHNKMVYFA ISDYVFNTAS LVYHEEGYLN 
FSITDDMIPP DSNIRLTTKS FRPFVPRLAR LYPNMNLELQ GSVPSAPLLN FSPGNLSVDP 
YMEIDAFVLL PSSSKEPVFR LSVATNVSAT LTFNTSKITG FLKPGKVKVE LKESKVGLFN 
AELLEALLNY YILNTFYPKF NDKLAEGFPL PLLKRVQLYD LGLQIHKDFL FLGANVQYMR 
V

Genular Protein ID: 1681281381

Symbol: Q8TCF0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8TCF0

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 4 Genevisible 1 GenomeRNAi 1 InterPro 6 KEGG 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PROSITE 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 4 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 477
  • Mass: 52934
  • Checksum: 03D5E9D55A3BA6D0
  • Sequence:
    • MGALARALPS ILLALLLTST PEALGANPGL VARITDKGLQ YAAQEGLLAL QSELLRITLP 
DFTGDLRIPH VGRGRYEFHS LNIHSCELLH SALRPVPGQG LSLSISDSSI RVQGRWKVRK 
SFFKLQGSFD VSVKGISISV NLLLGSESSG RPTVTASSCS SDIADVEVDM SGDLGWLLNL 
FHNQIESKFQ KVLESRICEM IQKSVSSDLQ PYLQTLPVTT EIDSFADIDY SLVEAPRATA 
QMLEVMFKGE IFHRNHRSPV TLLAAVMSLP EEHNKMVYFA ISDYVFNTAS LVYHEEGYLN 
FSITDDMIPP DSNIRLTTKS FRPFVPRLAR LYPNMNLELQ GSVPSAPLLN FSPGNLSVDP 
YMEIDAFVLL PSSSKEPVFR LSVATNVSAT LTFNTSKITG FLKPGKVKVE LKESKVGLFN 
AELLEALLNY YILNTFYPKF NDKLAEGFPL PLLKRVQLYD LGLQIHKDFP SRRDHPP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.