Details for: THRSP

Gene ID: 7069

Symbol: THRSP

Ensembl ID: ENSG00000151365

Description: thyroid hormone responsive

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 4.2
    Marker Score: 5241
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 3.72
    Marker Score: 1808
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 2.1
    Marker Score: 1166
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 1999
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1174
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 859
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 489
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7690
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4820
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.13
    Marker Score: 640
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 505
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.03
    Marker Score: 1418
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71832
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48056
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.98
    Marker Score: 2036
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.98
    Marker Score: 936
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.95
    Marker Score: 533
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.88
    Marker Score: 464
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.83
    Marker Score: 480
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.75
    Marker Score: 275
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 464
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.66
    Marker Score: 1062.5
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.64
    Marker Score: 2744
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 465
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 228
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.5
    Marker Score: 3238
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.5
    Marker Score: 159
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.5
    Marker Score: 2670
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.47
    Marker Score: 7320
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.47
    Marker Score: 249
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.47
    Marker Score: 1802
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4
    Marker Score: 805
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.35
    Marker Score: 133
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.34
    Marker Score: 565
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.28
    Marker Score: 173
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.22
    Marker Score: 637
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.22
    Marker Score: 149
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.22
    Marker Score: 204
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.21
    Marker Score: 51
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.2
    Marker Score: 116
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.2
    Marker Score: 210.5
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.2
    Marker Score: 84
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.19
    Marker Score: 58
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.18
    Marker Score: 348
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.18
    Marker Score: 405
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.17
    Marker Score: 182
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.17
    Marker Score: 204
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.17
    Marker Score: 395
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.17
    Marker Score: 168.5
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.16
    Marker Score: 43
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.16
    Marker Score: 102.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.15
    Marker Score: 77
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.14
    Marker Score: 54
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.14
    Marker Score: 51
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.14
    Marker Score: 401
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.13
    Marker Score: 34
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.13
    Marker Score: 260
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.12
    Marker Score: 135
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.11
    Marker Score: 441
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.1
    Marker Score: 31
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.09
    Marker Score: 112
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.09
    Marker Score: 97
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.08
    Marker Score: 36
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.08
    Marker Score: 47
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.08
    Marker Score: 65
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.07
    Marker Score: 33
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.07
    Marker Score: 130
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.07
    Marker Score: 112
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.07
    Marker Score: 14
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.07
    Marker Score: 64
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.07
    Marker Score: 34
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.07
    Marker Score: 118
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.06
    Marker Score: 60
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.06
    Marker Score: 18

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Other Information

**Key Characteristics:** THRSP is a protein-coding gene that is significantly expressed in various tissues, including the retina, epicardial adipocytes, erythrocytes, enterocytes, and megakaryocytes. Its expression is induced by thyroid hormones, which suggests a regulatory role in the thyroid hormone signaling pathway. THRSP is also involved in the regulation of lipid metabolism, fatty acid metabolism, and the biosynthesis of triglycerides. **Pathways and Functions:** THRSP is involved in several metabolic pathways, including: 1. **Carnitine metabolism**: THRSP regulates the transport of carnitine across cell membranes, which is essential for the transport of fatty acids into mitochondria for beta-oxidation. 2. **Fatty acid metabolism**: THRSP modulates the expression of genes involved in fatty acid synthesis and degradation, influencing the overall energy balance of the cell. 3. **Lipid metabolic process**: THRSP regulates the biosynthesis of triglycerides, which is critical for energy storage and cellular homeostasis. 4. **Metabolism of lipids**: THRSP is involved in the regulation of lipid metabolism, including the synthesis and degradation of lipids. 5. **Regulation of lipid biosynthetic process**: THRSP modulates the expression of genes involved in lipid biosynthesis, influencing the production of lipids. 6. **Regulation of triglyceride biosynthetic process**: THRSP regulates the biosynthesis of triglycerides, which is critical for energy storage and cellular homeostasis. **Clinical Significance:** Dysregulation of THRSP has been implicated in various diseases, including: 1. **Thyroid disorders**: THRSP expression is influenced by thyroid hormones, and alterations in THRSP expression have been observed in thyroid disorders, such as hypothyroidism and hyperthyroidism. 2. **Metabolic disorders**: THRSP is involved in lipid metabolism and fatty acid metabolism, and alterations in THRSP expression have been linked to metabolic disorders, such as obesity and type 2 diabetes. 3. **Cardiovascular disease**: THRSP is involved in the regulation of lipid metabolism and fatty acid metabolism, and alterations in THRSP expression have been linked to cardiovascular disease. In conclusion, THRSP is a key regulator of metabolic pathways and cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of THRSP in maintaining normal physiological function. Further research is needed to fully understand the mechanisms by which THRSP regulates metabolic pathways and to explore its potential as a therapeutic target for disease prevention and treatment.

Genular Protein ID: 1854594101

Symbol: THRSP_HUMAN

Name: Thyroid hormone-inducible hepatic protein

UniProtKB Accession Codes:

Q92748 B2R4W7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 9003802

Title: Cloning and initial characterization of human and mouse Spot 14 genes.

PubMed ID: 9003802

DOI: 10.1016/s0014-5793(96)01433-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17418816

Title: Human spot 14 protein interacts physically and functionally with the thyroid receptor.

PubMed ID: 17418816

DOI: 10.1016/j.bbrc.2007.03.103

PubMed ID: 18299245

Title: Human Spot 14 protein is a p53-dependent transcriptional coactivator via the recruitment of thyroid receptor and Zac1.

PubMed ID: 18299245

DOI: 10.1016/j.biocel.2008.01.014

Sequence Information:

  • Length: 146
  • Mass: 16561
  • Checksum: 5135FB8EE380DF8F
  • Sequence:
    • MQVLTKRYPK NCLLTVMDRY AAEVHNMEQV VMIPSLLRDV QLSGPGGQAQ AEAPDLYTYF 
TMLKAICVDV DHGLLPREEW QAKVAGSEEN GTAETEEVED ESASGELDLE AQFHLHFSSL 
HHILMHLTEK AQEVTRKYQE MTGQVW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.