Details for: THRSP

Gene ID: 7069

Symbol: THRSP

Ensembl ID: ENSG00000151365

Description: thyroid hormone responsive

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 7.2204
    Cell Significance Index: 9.3400
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 5.3974
    Cell Significance Index: 23.2100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.7957
    Cell Significance Index: 57.5200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.2256
    Cell Significance Index: 20.9500
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.9947
    Cell Significance Index: 4.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9259
    Cell Significance Index: 20.0600
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.6477
    Cell Significance Index: 2.4800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3813
    Cell Significance Index: 22.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3720
    Cell Significance Index: 16.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3658
    Cell Significance Index: 59.5000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.3127
    Cell Significance Index: 2.4100
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.2895
    Cell Significance Index: 1.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2484
    Cell Significance Index: 47.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2362
    Cell Significance Index: 5.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0956
    Cell Significance Index: 5.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0840
    Cell Significance Index: 2.2500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0832
    Cell Significance Index: 1.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0709
    Cell Significance Index: 5.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0688
    Cell Significance Index: 3.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0624
    Cell Significance Index: 6.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0548
    Cell Significance Index: 5.9600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0414
    Cell Significance Index: 0.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0314
    Cell Significance Index: 4.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0272
    Cell Significance Index: 1.2800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.0238
    Cell Significance Index: 0.3000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0231
    Cell Significance Index: 0.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0191
    Cell Significance Index: 3.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0135
    Cell Significance Index: 0.8500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0068
    Cell Significance Index: 4.6700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0067
    Cell Significance Index: 0.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0042
    Cell Significance Index: 0.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0017
    Cell Significance Index: 0.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0007
    Cell Significance Index: 0.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0000
    Cell Significance Index: -0.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0000
    Cell Significance Index: 0.0200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0009
    Cell Significance Index: -0.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0012
    Cell Significance Index: -2.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0014
    Cell Significance Index: -2.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0015
    Cell Significance Index: -2.3400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0018
    Cell Significance Index: -2.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0023
    Cell Significance Index: -0.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0032
    Cell Significance Index: -0.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0037
    Cell Significance Index: -2.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0042
    Cell Significance Index: -3.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0043
    Cell Significance Index: -2.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0043
    Cell Significance Index: -2.3400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0044
    Cell Significance Index: -3.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0054
    Cell Significance Index: -3.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0059
    Cell Significance Index: -2.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0087
    Cell Significance Index: -0.8900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0105
    Cell Significance Index: -0.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0114
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0126
    Cell Significance Index: -2.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0142
    Cell Significance Index: -2.5600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0142
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0148
    Cell Significance Index: -3.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0173
    Cell Significance Index: -2.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0179
    Cell Significance Index: -2.4600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0185
    Cell Significance Index: -0.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0193
    Cell Significance Index: -1.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0207
    Cell Significance Index: -2.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0210
    Cell Significance Index: -2.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0225
    Cell Significance Index: -2.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0271
    Cell Significance Index: -2.0800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0299
    Cell Significance Index: -0.4500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0321
    Cell Significance Index: -1.9700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0329
    Cell Significance Index: -0.3500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0357
    Cell Significance Index: -2.4000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0392
    Cell Significance Index: -3.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0432
    Cell Significance Index: -2.4300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0434
    Cell Significance Index: -0.9500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0443
    Cell Significance Index: -1.4100
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: -0.0454
    Cell Significance Index: -0.5300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0469
    Cell Significance Index: -1.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0471
    Cell Significance Index: -2.0900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0491
    Cell Significance Index: -0.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0491
    Cell Significance Index: -1.8600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0494
    Cell Significance Index: -1.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0508
    Cell Significance Index: -1.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0518
    Cell Significance Index: -2.6200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0541
    Cell Significance Index: -2.8200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0583
    Cell Significance Index: -1.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0602
    Cell Significance Index: -1.9700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0630
    Cell Significance Index: -1.0100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0633
    Cell Significance Index: -0.6900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0652
    Cell Significance Index: -1.5900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0679
    Cell Significance Index: -0.9900
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.0699
    Cell Significance Index: -1.4600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0707
    Cell Significance Index: -0.9700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0728
    Cell Significance Index: -0.6900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0734
    Cell Significance Index: -1.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0746
    Cell Significance Index: -2.6200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0751
    Cell Significance Index: -0.9700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0768
    Cell Significance Index: -0.7600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0788
    Cell Significance Index: -1.8200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0791
    Cell Significance Index: -1.1100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0812
    Cell Significance Index: -1.6500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0816
    Cell Significance Index: -1.0300
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0816
    Cell Significance Index: -0.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** THRSP is a protein-coding gene that is significantly expressed in various tissues, including the retina, epicardial adipocytes, erythrocytes, enterocytes, and megakaryocytes. Its expression is induced by thyroid hormones, which suggests a regulatory role in the thyroid hormone signaling pathway. THRSP is also involved in the regulation of lipid metabolism, fatty acid metabolism, and the biosynthesis of triglycerides. **Pathways and Functions:** THRSP is involved in several metabolic pathways, including: 1. **Carnitine metabolism**: THRSP regulates the transport of carnitine across cell membranes, which is essential for the transport of fatty acids into mitochondria for beta-oxidation. 2. **Fatty acid metabolism**: THRSP modulates the expression of genes involved in fatty acid synthesis and degradation, influencing the overall energy balance of the cell. 3. **Lipid metabolic process**: THRSP regulates the biosynthesis of triglycerides, which is critical for energy storage and cellular homeostasis. 4. **Metabolism of lipids**: THRSP is involved in the regulation of lipid metabolism, including the synthesis and degradation of lipids. 5. **Regulation of lipid biosynthetic process**: THRSP modulates the expression of genes involved in lipid biosynthesis, influencing the production of lipids. 6. **Regulation of triglyceride biosynthetic process**: THRSP regulates the biosynthesis of triglycerides, which is critical for energy storage and cellular homeostasis. **Clinical Significance:** Dysregulation of THRSP has been implicated in various diseases, including: 1. **Thyroid disorders**: THRSP expression is influenced by thyroid hormones, and alterations in THRSP expression have been observed in thyroid disorders, such as hypothyroidism and hyperthyroidism. 2. **Metabolic disorders**: THRSP is involved in lipid metabolism and fatty acid metabolism, and alterations in THRSP expression have been linked to metabolic disorders, such as obesity and type 2 diabetes. 3. **Cardiovascular disease**: THRSP is involved in the regulation of lipid metabolism and fatty acid metabolism, and alterations in THRSP expression have been linked to cardiovascular disease. In conclusion, THRSP is a key regulator of metabolic pathways and cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of THRSP in maintaining normal physiological function. Further research is needed to fully understand the mechanisms by which THRSP regulates metabolic pathways and to explore its potential as a therapeutic target for disease prevention and treatment.

Genular Protein ID: 1854594101

Symbol: THRSP_HUMAN

Name: Thyroid hormone-inducible hepatic protein

UniProtKB Accession Codes:

Q92748 B2R4W7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 9003802

Title: Cloning and initial characterization of human and mouse Spot 14 genes.

PubMed ID: 9003802

DOI: 10.1016/s0014-5793(96)01433-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17418816

Title: Human spot 14 protein interacts physically and functionally with the thyroid receptor.

PubMed ID: 17418816

DOI: 10.1016/j.bbrc.2007.03.103

PubMed ID: 18299245

Title: Human Spot 14 protein is a p53-dependent transcriptional coactivator via the recruitment of thyroid receptor and Zac1.

PubMed ID: 18299245

DOI: 10.1016/j.biocel.2008.01.014

Sequence Information:

  • Length: 146
  • Mass: 16561
  • Checksum: 5135FB8EE380DF8F
  • Sequence:
    • MQVLTKRYPK NCLLTVMDRY AAEVHNMEQV VMIPSLLRDV QLSGPGGQAQ AEAPDLYTYF 
TMLKAICVDV DHGLLPREEW QAKVAGSEEN GTAETEEVED ESASGELDLE AQFHLHFSSL 
HHILMHLTEK AQEVTRKYQE MTGQVW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.