Details for: PLN

Gene ID: 5350

Symbol: PLN

Ensembl ID: ENSG00000198523

Description: phospholamban

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 6.43
    Marker Score: 18754
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 5.97
    Marker Score: 17716
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 5.05
    Marker Score: 4837
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 4
    Marker Score: 89494
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.49
    Marker Score: 1148
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.73
    Marker Score: 36256
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.66
    Marker Score: 4994
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.57
    Marker Score: 9128
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.52
    Marker Score: 1789
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.36
    Marker Score: 6778
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.35
    Marker Score: 3063
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.22
    Marker Score: 2114
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.03
    Marker Score: 575
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.86
    Marker Score: 705
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.75
    Marker Score: 513
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.68
    Marker Score: 3181
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.6
    Marker Score: 9626
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.56
    Marker Score: 1029
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169381
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2
    Marker Score: 18748
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251809
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48052
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1
    Marker Score: 2025
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.98
    Marker Score: 3795
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.96
    Marker Score: 2450
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5324
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.89
    Marker Score: 532
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.89
    Marker Score: 447
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 614
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: fibrocyte (CL0000135)
    Fold Change: 0.73
    Marker Score: 225
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.72
    Marker Score: 342
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.67
    Marker Score: 834
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.67
    Marker Score: 170
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.66
    Marker Score: 1452
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.63
    Marker Score: 201
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.58
    Marker Score: 163
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.58
    Marker Score: 976
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 453
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.54
    Marker Score: 154
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.53
    Marker Score: 139
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.52
    Marker Score: 239
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.51
    Marker Score: 133
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.47
    Marker Score: 3131
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.46
    Marker Score: 202
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 395
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.38
    Marker Score: 205
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.37
    Marker Score: 209
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.37
    Marker Score: 218
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.37
    Marker Score: 207
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.36
    Marker Score: 120
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.33
    Marker Score: 447
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.32
    Marker Score: 136
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.31
    Marker Score: 95
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.31
    Marker Score: 316.5
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.31
    Marker Score: 84
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.29
    Marker Score: 100
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.28
    Marker Score: 117
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.27
    Marker Score: 330
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.25
    Marker Score: 577
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.24
    Marker Score: 158.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.24
    Marker Score: 100
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.24
    Marker Score: 477
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.23
    Marker Score: 362
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.23
    Marker Score: 113.5
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.23
    Marker Score: 367
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.22
    Marker Score: 694
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.22
    Marker Score: 58
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.2
    Marker Score: 122
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.2
    Marker Score: 190
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.19
    Marker Score: 831
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.19
    Marker Score: 171
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.19
    Marker Score: 99
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.18
    Marker Score: 74
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.17
    Marker Score: 71
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.17
    Marker Score: 324
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.16
    Marker Score: 75
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.16
    Marker Score: 143
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.16
    Marker Score: 456
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.16
    Marker Score: 309
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.15
    Marker Score: 89
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.15
    Marker Score: 87
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.14
    Marker Score: 97
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.14
    Marker Score: 48
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.14
    Marker Score: 159
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.13
    Marker Score: 40
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.13
    Marker Score: 76.5
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.12
    Marker Score: 24
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.12
    Marker Score: 33
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.12
    Marker Score: 57

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Other Information

**Key characteristics:** * The PLN gene is located on chromosome 17q21.1. * It is a large gene with a complex structure, encoding for a protein with multiple domains. * The protein is a key regulator of cardiac function, influencing processes such as heart contraction, heart rate, and blood circulation. **Pathways and functions:** * PLN is involved in the assembly and function of the heart's contractile apparatus. * It is a key regulator of cardiac contraction through its effects on the heart's ion channels. * It also plays a role in regulating heart rate by controlling the heart rate-determining center in the central nervous system. * PLN is also involved in blood circulation by regulating the release of calcium ions into the cardiac cells, which is essential for cardiac contraction. * It also regulates the transport of small molecules into and out of the cardiac cells. **Clinical significance:** * Mutations in the PLN gene have been linked to several heart conditions, including cardiomyopathy, heart failure, and arrhythmias. * These mutations can disrupt the proper functioning of the heart's contractile apparatus, leading to abnormal heart function. * Understanding the role of PLN in heart health is important for the development of new diagnostic tools and therapeutic strategies for cardiovascular diseases. **Additional information:** * PLN is a calcium-binding protein that undergoes conformational changes upon calcium binding. * It is a key regulator of cardiac excitability and contractility. * Mutations in the PLN gene have been shown to be associated with a variety of heart diseases, underscoring its critical role in cardiovascular health.

Genular Protein ID: 3223660932

Symbol: PPLA_HUMAN

Name: N/A

UniProtKB Accession Codes:

P26678

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 4 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 41 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 2 PANTHER 2 PDB 9 PDBsum 7 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1828805

Title: Structure of the rabbit phospholamban gene, cloning of the human cDNA, and assignment of the gene to human chromosome 6.

PubMed ID: 1828805

DOI: 10.1016/s0021-9258(18)99009-5

PubMed ID: 10198197

Title: The human phospholamban gene: structure and expression.

PubMed ID: 10198197

DOI: 10.1006/jmcc.1998.0904

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12705874

Title: Mutation of the phospholamban promoter associated with hypertrophic cardiomyopathy.

PubMed ID: 12705874

DOI: 10.1016/s0006-291x(03)00526-6

PubMed ID: 12804600

Title: Ca2+ -dependent interaction of S100A1 with the sarcoplasmic reticulum Ca2+ -ATPase2a and phospholamban in the human heart.

PubMed ID: 12804600

DOI: 10.1016/s0006-291x(03)00987-2

PubMed ID: 15598648

Title: Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum.

PubMed ID: 15598648

DOI: 10.1074/jbc.m412845200

PubMed ID: 16690701

Title: Ca2+-calmodulin-dependent protein kinase expression and signalling in skeletal muscle during exercise.

PubMed ID: 16690701

DOI: 10.1113/jphysiol.2006.111757

PubMed ID: 17241641

Title: Phospholamban interacts with HAX-1, a mitochondrial protein with anti-apoptotic function.

PubMed ID: 17241641

DOI: 10.1016/j.jmb.2006.10.057

PubMed ID: 22707725

Title: Lethal, hereditary mutants of phospholamban elude phosphorylation by protein kinase A.

PubMed ID: 22707725

DOI: 10.1074/jbc.m112.382713

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28890335

Title: The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation.

PubMed ID: 28890335

DOI: 10.1016/j.molcel.2017.08.005

PubMed ID: 7779806

Title: Solution structure of the cytoplasmic domain of phospholamban: phosphorylation leads to a local perturbation in secondary structure.

PubMed ID: 7779806

DOI: 10.1021/bi00023a006

PubMed ID: 7749920

Title: Computational searching and mutagenesis suggest a structure for the pentameric transmembrane domain of phospholamban.

PubMed ID: 7749920

DOI: 10.1038/nsb0295-154

PubMed ID: 9512019

Title: Using experimental information to produce a model of the transmembrane domain of the ion channel phospholamban.

PubMed ID: 9512019

DOI: 10.1016/s0006-3495(98)77835-x

PubMed ID: 16043693

Title: The structure of phospholamban pentamer reveals a channel-like architecture in membranes.

PubMed ID: 16043693

DOI: 10.1073/pnas.0504920102

PubMed ID: 16897780

Title: Structure determination of symmetric homo-oligomers by a complete search of symmetry configuration space, using NMR restraints and van der Waals packing.

PubMed ID: 16897780

DOI: 10.1002/prot.21091

PubMed ID: 12610310

Title: Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban.

PubMed ID: 12610310

DOI: 10.1126/science.1081578

PubMed ID: 16432188

Title: A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy.

PubMed ID: 16432188

DOI: 10.1073/pnas.0510519103

PubMed ID: 22137083

Title: Mutations in the human phospholamban gene in patients with heart failure.

PubMed ID: 22137083

DOI: 10.1016/j.ahj.2011.07.028

PubMed ID: 22427649

Title: Hydrophobic imbalance in the cytoplasmic domain of phospholamban is a determinant for lethal dilated cardiomyopathy.

PubMed ID: 22427649

DOI: 10.1074/jbc.m112.360859

Sequence Information:

  • Length: 52
  • Mass: 6109
  • Checksum: 0766304A76A854D3
  • Sequence:
    • MEKVQYLTRS AIRRASTIEM PQQARQKLQN LFINFCLILI CLLLICIIVM LL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.