Details for: CL0000135

Cell ID: CL0000135

Cell Name: fibrocyte

Marker Score Threshold: 309
(Derived using integrated single-cell and genomic data)

Description: An inactive fibroblast; cytoplasm is sparse, endoplasmic reticulum is scanty with flattened nucleus. Term used by some histologists; when fibroblasts become relatively inactive in fiber formation. However, this cell has the potential for fibrogenesis in quiescent connective tissue of the adult, as well as during development, other histologists prefer to use the term fibroblast in all circumstances. These cells represent ~0.5% of peripheral blood leukocytes.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.75
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.74
    Ensembl ID: ENSG00000075624
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.43
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.38
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.36
    Ensembl ID: ENSG00000172757
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.34
    Ensembl ID: ENSG00000099622
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.31
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.26
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.17
    Ensembl ID: ENSG00000070831
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.12
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.06
    Ensembl ID: ENSG00000179218
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 2.03
    Ensembl ID: ENSG00000067082
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.99
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.99
    Ensembl ID: ENSG00000152518
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.96
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.84
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.79
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.78
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.7
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.67
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.66
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.65
    Ensembl ID: ENSG00000127022
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.64
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.61
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.6
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.59
    Ensembl ID: ENSG00000117410
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.59
    Ensembl ID: ENSG00000122545
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.59
    Ensembl ID: ENSG00000013441
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.58
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.58
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.58
    Ensembl ID: ENSG00000213719
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.56
    Ensembl ID: ENSG00000128272
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.55
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.54
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.52
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.52
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.52
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.51
    Ensembl ID: ENSG00000163399
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.51
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.48
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.48
    Ensembl ID: ENSG00000173575
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.47
    Ensembl ID: ENSG00000122705
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.44
    Ensembl ID: ENSG00000196776
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.41
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.38
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.36
    Ensembl ID: ENSG00000141522
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.35
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.34
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.34
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.34
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.32
    Ensembl ID: ENSG00000070961
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.32
    Ensembl ID: ENSG00000053254
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.31
    Ensembl ID: ENSG00000182718
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.31
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.3
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.3
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.3
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.29
    Ensembl ID: ENSG00000154723
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.29
    Ensembl ID: ENSG00000042753
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.28
    Ensembl ID: ENSG00000153922
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.27
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.27
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.26
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.25
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.24
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.24
    Ensembl ID: ENSG00000110651
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.23
    Ensembl ID: ENSG00000161203
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.22
    Ensembl ID: ENSG00000112576
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.2
    Ensembl ID: ENSG00000146731
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.19
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.17
    Ensembl ID: ENSG00000143727
  • Gene Symbol: COPA (ENSG00000122218)
    Fold Change: 1.16
    Ensembl ID: ENSG00000122218
  • Gene Symbol: CLTC (ENSG00000141367)
    Fold Change: 1.16
    Ensembl ID: ENSG00000141367
  • Gene Symbol: CLNS1A (ENSG00000074201)
    Fold Change: 1.15
    Ensembl ID: ENSG00000074201
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.14
    Ensembl ID: ENSG00000134480
  • Gene Symbol: CTSC (ENSG00000109861)
    Fold Change: 1.14
    Ensembl ID: ENSG00000109861
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.14
    Ensembl ID: ENSG00000122359
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.13
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.13
    Ensembl ID: ENSG00000072778
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.13
    Ensembl ID: ENSG00000108561
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.12
    Ensembl ID: ENSG00000115307
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.12
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.12
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.1
    Ensembl ID: ENSG00000164111
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.1
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.09
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.08
    Ensembl ID: ENSG00000126247
  • Gene Symbol: CHD4 (ENSG00000111642)
    Fold Change: 1.08
    Ensembl ID: ENSG00000111642
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.07
    Ensembl ID: ENSG00000130303
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.07
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.04
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.04
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.04
    Ensembl ID: ENSG00000241837
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.04
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.03
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ACTG2 (ENSG00000163017)
    Fold Change: 1.02
    Ensembl ID: ENSG00000163017
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.01
    Ensembl ID: ENSG00000104763
  • Gene Symbol: COPB1 (ENSG00000129083)
    Fold Change: 1.01
    Ensembl ID: ENSG00000129083
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.01
    Ensembl ID: ENSG00000164615
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: N/A
    Ensembl ID: ENSG00000183255
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Cell Type**: Fibrocyte, a type of inactive fibroblast. 2. **Cytoplasmic Characteristics**: Sparse cytoplasm. 3. **Endoplasmic Reticulum**: Scant endoplasmic reticulum. 4. **Nuclear Characteristics**: Flattened nucleus. 5. **Gene Symbol**: B2M. 6. **Cellular Functions**: Potential for fibrogenesis in quiescent connective tissue, antigen presentation. 7. **Frequency**: Approximately 0.5% of peripheral blood leukocytes. **Clinical Significance** 1. **Fibrogenesis**: Fibrocytes have the potential to undergo fibrogenesis, particularly in adult tissues and during development, which can lead to various fibrotic diseases. 2. **Antigen Presentation**: Fibrocytes are involved in antigen presentation, which is crucial for the adaptive immune response. 3. **Amyloid Fiber Formation**: Fibrocytes are implicated in amyloid fiber formation, which is associated with various diseases, including Alzheimer's disease and amyloidosis. 4. **Peripheral Blood Leukocytes**: Fibrocytes are relatively rare in peripheral blood leukocytes, but their presence can indicate tissue damage or fibrosis. 5. **Disease Association**: Fibrocytes have been associated with various diseases, including cancer, fibrosis, and autoimmune disorders. In conclusion, the fibrocyte, CL0000135, is a unique cell type with characteristics that distinguish it from other fibroblasts. Its potential for fibrogenesis, antigen presentation, and involvement in amyloid fiber formation make it an important cell type in understanding various diseases and disorders.