Details for: AOC3

Gene ID: 8639

Symbol: AOC3

Ensembl ID: ENSG00000131471

Description: amine oxidase copper containing 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 23.7144
    Cell Significance Index: -6.0200
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 15.3409
    Cell Significance Index: 94.9100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 11.0141
    Cell Significance Index: -5.2000
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 6.7561
    Cell Significance Index: 77.8100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.1631
    Cell Significance Index: 84.7600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.2614
    Cell Significance Index: 36.2800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.2005
    Cell Significance Index: 38.8900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.5180
    Cell Significance Index: -5.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.1687
    Cell Significance Index: 71.6500
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.9103
    Cell Significance Index: 4.7900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.8847
    Cell Significance Index: 11.1400
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.4411
    Cell Significance Index: 1.9200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.2452
    Cell Significance Index: 3.5600
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.2446
    Cell Significance Index: 2.6200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2143
    Cell Significance Index: 193.4600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2042
    Cell Significance Index: 2.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1957
    Cell Significance Index: 19.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1693
    Cell Significance Index: 32.2100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1619
    Cell Significance Index: 3.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1356
    Cell Significance Index: 86.1000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0833
    Cell Significance Index: 0.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0589
    Cell Significance Index: 1.2800
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.0195
    Cell Significance Index: 0.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0152
    Cell Significance Index: 1.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0141
    Cell Significance Index: 6.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0124
    Cell Significance Index: 1.4500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0100
    Cell Significance Index: 1.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0065
    Cell Significance Index: 0.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0022
    Cell Significance Index: 0.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0021
    Cell Significance Index: 0.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0011
    Cell Significance Index: 0.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0001
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0006
    Cell Significance Index: -1.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0036
    Cell Significance Index: -6.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0045
    Cell Significance Index: -6.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0047
    Cell Significance Index: -0.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0051
    Cell Significance Index: -6.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0056
    Cell Significance Index: -0.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0062
    Cell Significance Index: -4.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0071
    Cell Significance Index: -3.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0073
    Cell Significance Index: -1.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0075
    Cell Significance Index: -2.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0075
    Cell Significance Index: -5.6700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0086
    Cell Significance Index: -6.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0086
    Cell Significance Index: -3.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0108
    Cell Significance Index: -0.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0112
    Cell Significance Index: -6.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0204
    Cell Significance Index: -2.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0250
    Cell Significance Index: -3.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0339
    Cell Significance Index: -2.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0363
    Cell Significance Index: -6.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0388
    Cell Significance Index: -8.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0392
    Cell Significance Index: -2.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0406
    Cell Significance Index: -1.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0408
    Cell Significance Index: -4.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0409
    Cell Significance Index: -5.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0468
    Cell Significance Index: -2.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0488
    Cell Significance Index: -2.4600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0496
    Cell Significance Index: -5.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0529
    Cell Significance Index: -5.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0538
    Cell Significance Index: -6.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0626
    Cell Significance Index: -3.2500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0699
    Cell Significance Index: -5.5400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0710
    Cell Significance Index: -5.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0748
    Cell Significance Index: -5.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0759
    Cell Significance Index: -5.8300
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0812
    Cell Significance Index: -0.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0884
    Cell Significance Index: -5.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0991
    Cell Significance Index: -6.0900
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0994
    Cell Significance Index: -1.2100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0996
    Cell Significance Index: -0.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1002
    Cell Significance Index: -4.7100
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.1108
    Cell Significance Index: -1.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1135
    Cell Significance Index: -6.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1141
    Cell Significance Index: -1.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1175
    Cell Significance Index: -6.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1202
    Cell Significance Index: -3.0900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1311
    Cell Significance Index: -5.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1384
    Cell Significance Index: -6.1200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1419
    Cell Significance Index: -1.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1428
    Cell Significance Index: -3.9900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1444
    Cell Significance Index: -4.1400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1448
    Cell Significance Index: -3.0300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1456
    Cell Significance Index: -2.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1472
    Cell Significance Index: -5.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1600
    Cell Significance Index: -5.2400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1606
    Cell Significance Index: -5.5800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1632
    Cell Significance Index: -5.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1637
    Cell Significance Index: -6.2000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1642
    Cell Significance Index: -5.2300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1643
    Cell Significance Index: -3.5000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1716
    Cell Significance Index: -4.2800
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1792
    Cell Significance Index: -2.1300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1804
    Cell Significance Index: -3.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1865
    Cell Significance Index: -4.9800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1901
    Cell Significance Index: -5.6000
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.1925
    Cell Significance Index: -1.8300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1958
    Cell Significance Index: -5.3300
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.1965
    Cell Significance Index: -2.0800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1989
    Cell Significance Index: -6.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Copper-Containing Amine Oxidase:** AOC3 is a member of the amine oxidase family, which contains a copper ion cofactor essential for catalyzing the oxidation of primary amines to aldehydes or ketones. 2. **Biological Oxidations:** AOC3 is involved in various biological oxidations, including the metabolism of primary amines, which play a crucial role in maintaining cellular homeostasis. 3. **Cellular Localizations:** The gene is expressed in multiple cell types, including the plasma membrane, endoplasmic reticulum, and Golgi apparatus, highlighting its diverse roles in cellular processes. 4. **Regulatory Mechanisms:** AOC3 is subject to negative regulation of primary amine oxidase activity, suggesting a fine-tuned mechanism to control its enzymatic activity. **Pathways and Functions:** 1. **Amine Metabolic Process:** AOC3 plays a pivotal role in the metabolism of primary amines, which is essential for maintaining cellular homeostasis and regulating various physiological processes. 2. **Biological Oxidations:** The gene is involved in various biological oxidations, including the oxidation of primary amines, which is crucial for cellular energy production and redox balance. 3. **Cell Adhesion:** AOC3 has been implicated in cell adhesion processes, suggesting its role in maintaining tissue integrity and regulating cellular interactions. 4. **Inflammatory Response:** The gene's expression is modulated in response to inflammatory stimuli, highlighting its involvement in regulating the inflammatory response. **Clinical Significance:** 1. **Neurological Disorders:** Alterations in AOC3 expression have been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease, underscoring its potential role in neurodegenerative processes. 2. **Cancer:** The gene's expression has been found to be altered in certain types of cancer, including colon cancer, suggesting its potential as a biomarker or therapeutic target. 3. **Cardiovascular Diseases:** AOC3's involvement in vascular biology and its expression in endothelial cells highlight its potential role in cardiovascular diseases, including atherosclerosis and hypertension. 4. **Immunological Disorders:** The gene's expression is modulated in response to inflammatory stimuli, suggesting its potential role in immunological disorders, including autoimmune diseases and allergic reactions. In conclusion, the AOC3 gene is a multifaceted gene with diverse roles in cellular processes, including metabolism, cell adhesion, and inflammatory response. Its clinical significance extends to various diseases, including neurological disorders, cancer, cardiovascular diseases, and immunological disorders. Further research is necessary to fully elucidate the complex mechanisms underlying AOC3's functions and its potential applications in human disease.

Genular Protein ID: 566616213

Symbol: AOC3_HUMAN

Name: Copper amine oxidase

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8972912

Title: Cloning and sequencing of a copper-containing, topaquinone-containing monoamine oxidase from human placenta.

PubMed ID: 8972912

DOI: 10.1016/s0378-1119(96)00387-3

PubMed ID: 9653080

Title: Cloning of vascular adhesion protein 1 reveals a novel multifunctional adhesion molecule.

PubMed ID: 9653080

DOI: 10.1084/jem.188.1.17

PubMed ID: 14585497

Title: Characterization of AOC2 gene encoding a copper-binding amine oxidase expressed specifically in retina.

PubMed ID: 14585497

DOI: 10.1016/s0378-1119(03)00753-4

PubMed ID: 23349812

Title: Functional modulation of vascular adhesion protein-1 by a novel splice variant.

PubMed ID: 23349812

DOI: 10.1371/journal.pone.0054151

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15242332

Title: Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.

PubMed ID: 15242332

DOI: 10.1042/bj20040647

PubMed ID: 9254657

Title: Vascular adhesion protein 1 (VAP-1) mediates lymphocyte subtype-specific, selectin-independent recognition of vascular endothelium in human lymph nodes.

PubMed ID: 9254657

DOI: 10.1084/jem.186.4.589

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 17400359

Title: Adipogenesis-related increase of semicarbazide-sensitive amine oxidase and monoamine oxidase in human adipocytes.

PubMed ID: 17400359

DOI: 10.1016/j.biochi.2007.02.013

PubMed ID: 19588076

Title: The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase.

PubMed ID: 19588076

DOI: 10.1007/s00018-009-0076-5

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 16046623

Title: Crystal structure of the human vascular adhesion protein-1: unique structural features with functional implications.

PubMed ID: 16046623

DOI: 10.1110/ps.051438105

PubMed ID: 24304424

Title: Novel pyridazinone inhibitors for vascular adhesion protein-1 (VAP-1): old target-new inhibition mode.

PubMed ID: 24304424

DOI: 10.1021/jm401372d

Sequence Information:

  • Length: 763
  • Mass: 84622
  • Checksum: 58AD55605EC9D228
  • Sequence:
  • MNQKTILVLL ILAVITIFAL VCVLLVGRGG DGGEPSQLPH CPSVSPSAQP WTHPGQSQLF 
    ADLSREELTA VMRFLTQRLG PGLVDAAQAR PSDNCVFSVE LQLPPKAAAL AHLDRGSPPP 
    AREALAIVFF GRQPQPNVSE LVVGPLPHPS YMRDVTVERH GGPLPYHRRP VLFQEYLDID 
    QMIFNRELPQ ASGLLHHCCF YKHRGRNLVT MTTAPRGLQS GDRATWFGLY YNISGAGFFL 
    HHVGLELLVN HKALDPARWT IQKVFYQGRY YDSLAQLEAQ FEAGLVNVVL IPDNGTGGSW 
    SLKSPVPPGP APPLQFYPQG PRFSVQGSRV ASSLWTFSFG LGAFSGPRIF DVRFQGERLV 
    YEISLQEALA IYGGNSPAAM TTRYVDGGFG MGKYTTPLTR GVDCPYLATY VDWHFLLESQ 
    APKTIRDAFC VFEQNQGLPL RRHHSDLYSH YFGGLAETVL VVRSMSTLLN YDYVWDTVFH 
    PSGAIEIRFY ATGYISSAFL FGATGKYGNQ VSEHTLGTVH THSAHFKVDL DVAGLENWVW 
    AEDMVFVPMA VPWSPEHQLQ RLQVTRKLLE MEEQAAFLVG SATPRYLYLA SNHSNKWGHP 
    RGYRIQMLSF AGEPLPQNSS MARGFSWERY QLAVTQRKEE EPSSSSVFNQ NDPWAPTVDF 
    SDFINNETIA GKDLVAWVTA GFLHIPHAED IPNTVTVGNG VGFFLRPYNF FDEDPSFYSA 
    DSIYFRGDQD AGACEVNPLA CLPQAAACAP DLPAFSHGGF SHN

Genular Protein ID: 2427574101

Symbol: Q9UEU7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8619474

Title: A "double adaptor" method for improved shotgun library construction.

PubMed ID: 8619474

DOI: 10.1006/abio.1996.0138

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

Sequence Information:

  • Length: 64
  • Mass: 6893
  • Checksum: A7A0F2972EAF3210
  • Sequence:
  • GVGFFLRPYN FFDEDPSFYS ADSIYFRGDQ DAGACEVNPL ACLPQAAACA PDLPAFSHGG 
    FSHN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.