Details for: GPX4

Gene ID: 2879

Symbol: GPX4

Ensembl ID: ENSG00000167468

Description: glutathione peroxidase 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 4.12
    Marker Score: 14634.5
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.05
    Marker Score: 8542.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4
    Marker Score: 136191
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.87
    Marker Score: 7067
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.68
    Marker Score: 9873
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.53
    Marker Score: 30674
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.49
    Marker Score: 195112
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.46
    Marker Score: 25760
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.46
    Marker Score: 8713
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.45
    Marker Score: 8420
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.44
    Marker Score: 22449.5
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.43
    Marker Score: 18004
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.36
    Marker Score: 39077
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.29
    Marker Score: 113987
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.24
    Marker Score: 3710
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.23
    Marker Score: 5350
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.22
    Marker Score: 1109.5
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.22
    Marker Score: 3884
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.19
    Marker Score: 1165
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.18
    Marker Score: 3399.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.17
    Marker Score: 5206
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.11
    Marker Score: 2935
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.11
    Marker Score: 2771.5
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.11
    Marker Score: 2648
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.1
    Marker Score: 7057.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 3.09
    Marker Score: 3138.5
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.08
    Marker Score: 11884
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.07
    Marker Score: 4889
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 3.04
    Marker Score: 1271
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.04
    Marker Score: 1443.5
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 3.03
    Marker Score: 1208.5
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.02
    Marker Score: 994
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.97
    Marker Score: 2970
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.97
    Marker Score: 3095.5
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.96
    Marker Score: 75812
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.94
    Marker Score: 5720
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.93
    Marker Score: 699
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.92
    Marker Score: 28896
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.9
    Marker Score: 5452
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.9
    Marker Score: 1208
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.89
    Marker Score: 3378
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.89
    Marker Score: 4094
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.89
    Marker Score: 2276.5
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.89
    Marker Score: 2053
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.88
    Marker Score: 1678
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.87
    Marker Score: 37823
  • Cell Name: platelet (CL0000233)
    Fold Change: 2.85
    Marker Score: 1290
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.84
    Marker Score: 1471
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.8
    Marker Score: 5694
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.8
    Marker Score: 2967
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.8
    Marker Score: 3375
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.78
    Marker Score: 1266
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.77
    Marker Score: 1856
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.77
    Marker Score: 13312
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.77
    Marker Score: 4456.5
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.77
    Marker Score: 3923
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.77
    Marker Score: 1426
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.76
    Marker Score: 1187
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 2.76
    Marker Score: 1892
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.76
    Marker Score: 3321
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.75
    Marker Score: 11809
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.75
    Marker Score: 4918
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.75
    Marker Score: 145336
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.75
    Marker Score: 1122
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.74
    Marker Score: 7109
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.73
    Marker Score: 30756.5
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.71
    Marker Score: 7084
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.69
    Marker Score: 2109
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.69
    Marker Score: 1275
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.69
    Marker Score: 1120
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.69
    Marker Score: 11587
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.68
    Marker Score: 7648
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.68
    Marker Score: 4598
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.65
    Marker Score: 1190
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.65
    Marker Score: 7324
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.63
    Marker Score: 4060
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.63
    Marker Score: 697
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.62
    Marker Score: 1742
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.61
    Marker Score: 4558.5
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.61
    Marker Score: 645
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.61
    Marker Score: 8957
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.59
    Marker Score: 822
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.59
    Marker Score: 3029
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.58
    Marker Score: 10560
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.56
    Marker Score: 909.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.56
    Marker Score: 5339
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 2.55
    Marker Score: 891
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.55
    Marker Score: 34301
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.55
    Marker Score: 1495
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.55
    Marker Score: 1454.5
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.53
    Marker Score: 4808
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.53
    Marker Score: 3263
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.53
    Marker Score: 1262
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.53
    Marker Score: 2748
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 2.52
    Marker Score: 711
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.52
    Marker Score: 609
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.51
    Marker Score: 1173
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 2.5
    Marker Score: 659
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.5
    Marker Score: 15210
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.5
    Marker Score: 2807

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Other Information

**Key characteristics:** - GPX4 is a single-pass membrane protein with a molecular weight of approximately 500 kDa. - It is a member of the glutathione peroxidase family, which are enzymes that catalyze the reduction of glutathione, a reduced form of glutathione. - GPX4 is a key enzyme in the biosynthesis of eicosanoids, a class of lipid mediators involved in inflammation and immune responses. - It is also involved in the metabolism of fatty acids and the synthesis of specialized proresolving mediators (spms). **Pathways and functions:** - GPX4 is involved in the biosynthesis of eicosanoids, including 5-eicosatetraenoic acid, 12-eicosatetraenoic acid derivatives, and 15-eicosatetraenoic acid derivatives. - It is also involved in the metabolism of fatty acids, including the synthesis of eicosanoids from linoleic acid and arachidonic acid. - It plays a role in the regulation of inflammation and immune responses by controlling the production and release of eicosanoids. **Clinical significance:** - Mutations in GPX4 have been linked to the development of several chronic diseases, including asthma, arthritis, and cancer. - GPX4 inhibitors are being investigated as potential therapeutic agents for these diseases. **Additional notes:** - GPX4 is a highly conserved protein with a similar sequence in mammals and humans. - It is a key enzyme in the innate immune response and is upregulated in response to injury or infection. - It is also involved in the regulation of inflammation and tissue repair.

Genular Protein ID: 4084921338

Symbol: GPX4_HUMAN

Name: N/A

UniProtKB Accession Codes:

P36969 O43381 Q6PJ59 Q9UPK2

Database IDs:

ABCD 1 AGR 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 79 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 2 EMBL 10 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 24 PDBsum 19 PIR 1 PIRSF 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PeroxiBase 3 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 7 RefSeq 2 Rhea 32 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8039723

Title: Cloning and sequencing of the cDNA encoding a human testis phospholipid hydroperoxide glutathione peroxidase.

PubMed ID: 8039723

DOI: 10.1016/0378-1119(94)90400-6

PubMed ID: 9705830

Title: Structural organization of the human selenium-dependent phospholipid hydroperoxide glutathione peroxidase gene (GPX4): chromosomal localization to 19p13.3.

PubMed ID: 9705830

DOI: 10.1006/bbrc.1998.9086

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11115402

Title: Evidence for the presence of phospholipid hydroperoxide glutathione peroxidase in human platelets: implications for its involvement in the regulatory network of the 12-lipoxygenase pathway of arachidonic acid metabolism.

PubMed ID: 11115402

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24439385

Title: Regulation of ferroptotic cancer cell death by GPX4.

PubMed ID: 24439385

DOI: 10.1016/j.cell.2013.12.010

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 36608588

Title: Side-by-side comparison of recombinant human glutathione peroxidases identifies overlapping substrate specificities for soluble hydroperoxides.

PubMed ID: 36608588

DOI: 10.1016/j.redox.2022.102593

PubMed ID: 17630701

Title: Structural basis for catalytic activity and enzyme polymerization of phospholipid hydroperoxide glutathione peroxidase-4 (GPx4).

PubMed ID: 17630701

DOI: 10.1021/bi700840d

PubMed ID: 27836545

Title: Discovery of GPX4 inhibitory peptides from random peptide T7 phage display and subsequent structural analysis.

PubMed ID: 27836545

DOI: 10.1016/j.bbrc.2016.11.035

PubMed ID: 12606444

Title: Genetic variations of gpx-4 and male infertility in humans.

PubMed ID: 12606444

DOI: 10.1095/biolreprod.102.007500

PubMed ID: 24706940

Title: Mutations in the enzyme glutathione peroxidase 4 cause Sedaghatian-type spondylometaphyseal dysplasia.

PubMed ID: 24706940

DOI: 10.1136/jmedgenet-2013-102218

Sequence Information:

  • Length: 197
  • Mass: 22175
  • Checksum: 1AE3BC7AE42FDDB1
  • Sequence:
    • MSLGRLCRLL KPALLCGALA APGLAGTMCA SRDDWRCARS MHEFSAKDID GHMVNLDKYR 
GFVCIVTNVA SQUGKTEVNY TQLVDLHARY AECGLRILAF PCNQFGKQEP GSNEEIKEFA 
AGYNVKFDMF SKICVNGDDA HPLWKWMKIQ PKGKGILGNA IKWNFTKFLI DKNGCVVKRY 
GPMEEPLVIE KDLPHYF

Genular Protein ID: 3687320844

Symbol: Q6PI42_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6PI42

Database IDs:

ARBA 7 BRENDA 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 10 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 4 RuleBase 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 197
  • Mass: 22164
  • Checksum: F7556DFE719C6199
  • Sequence:
    • MSLGRLCRLL KPALLCGALA APGLAGTMCA SRDDWRCARS MHEFSAKDID GHMVNLDKYR 
GFVCIVTNVA SQXGKTEVNY TQLVDLHVRY AECGLRILAF PCNQFGKQEP GSNEEIKEFA 
AGYNVKFDMF SKICVNGDDA HPLWKWMKIQ PKGKGILGNA IKWNFTKFLI DKNGCVVKRY 
GPMEEPLVIE KDLPHYF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.