Details for: GPX4
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 922.3041
Cell Significance Index: -143.4600 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 526.3689
Cell Significance Index: -133.5100 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 370.2655
Cell Significance Index: -152.5300 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 311.9699
Cell Significance Index: -126.7400 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 311.1586
Cell Significance Index: -146.9100 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 276.7187
Cell Significance Index: -142.3400 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 220.1306
Cell Significance Index: -147.7100 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 135.0625
Cell Significance Index: -128.9500 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 122.9160
Cell Significance Index: -151.5500 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 40.2174
Cell Significance Index: -158.7000 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 36.5566
Cell Significance Index: -97.9300 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 35.9537
Cell Significance Index: -110.4300 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 18.1807
Cell Significance Index: -39.7900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 5.5310
Cell Significance Index: 257.8800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 5.2882
Cell Significance Index: 248.5400 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 5.0258
Cell Significance Index: 30.9300 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 4.8169
Cell Significance Index: 340.6700 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.5909
Cell Significance Index: 131.6000 - Cell Name: cell in vitro (CL0001034)
Fold Change: 4.5194
Cell Significance Index: 2468.1400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 4.2412
Cell Significance Index: 582.4300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 4.0278
Cell Significance Index: 300.1900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.6757
Cell Significance Index: 192.9900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 3.5672
Cell Significance Index: 438.6300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 3.4569
Cell Significance Index: 623.1700 - Cell Name: lactocyte (CL0002325)
Fold Change: 3.3810
Cell Significance Index: 436.8000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 3.3267
Cell Significance Index: 1470.8100 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.2154
Cell Significance Index: 59.4300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.9683
Cell Significance Index: 80.8000 - Cell Name: odontoblast (CL0000060)
Fold Change: 2.4460
Cell Significance Index: 313.5600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.0978
Cell Significance Index: 135.3400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.5817
Cell Significance Index: 186.5300 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.4767
Cell Significance Index: 51.3200 - Cell Name: granulosa cell (CL0000501)
Fold Change: 1.2735
Cell Significance Index: 33.4900 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.2491
Cell Significance Index: 14.1900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.1599
Cell Significance Index: 30.9700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.1346
Cell Significance Index: 23.7500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.7132
Cell Significance Index: 141.5400 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6641
Cell Significance Index: 65.6900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.6062
Cell Significance Index: 121.6100 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4570
Cell Significance Index: 86.9600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4417
Cell Significance Index: 398.7900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.3863
Cell Significance Index: 292.3700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3518
Cell Significance Index: 126.1800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.2749
Cell Significance Index: 201.5900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1306
Cell Significance Index: 4.5900 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.1159
Cell Significance Index: 3.4100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1003
Cell Significance Index: 5.2100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0370
Cell Significance Index: 69.6400 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0101
Cell Significance Index: 1.6500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0135
Cell Significance Index: -1.3800 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0445
Cell Significance Index: -0.7500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0871
Cell Significance Index: -160.6900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0906
Cell Significance Index: -57.5300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.1138
Cell Significance Index: -175.2200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.1414
Cell Significance Index: -192.2000 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.1428
Cell Significance Index: -1.3200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1497
Cell Significance Index: -9.4400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1622
Cell Significance Index: -120.1800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.2140
Cell Significance Index: -148.0300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.2398
Cell Significance Index: -135.2500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.2728
Cell Significance Index: -123.8000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.2902
Cell Significance Index: -181.2100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.3585
Cell Significance Index: -61.2200 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.3873
Cell Significance Index: -4.2100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3977
Cell Significance Index: -31.5000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.4469
Cell Significance Index: -128.6000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.4963
Cell Significance Index: -25.8500 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.5953
Cell Significance Index: -10.5200 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -0.6293
Cell Significance Index: -3.9100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.6508
Cell Significance Index: -29.5000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.6891
Cell Significance Index: -100.1700 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.7617
Cell Significance Index: -19.4600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.8214
Cell Significance Index: -173.0000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.8383
Cell Significance Index: -97.6900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.9810
Cell Significance Index: -112.3900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -1.0524
Cell Significance Index: -29.4100 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -1.0606
Cell Significance Index: -63.6700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.0950
Cell Significance Index: -35.0700 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.3194
Cell Significance Index: -19.7700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.4143
Cell Significance Index: -30.6400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.4695
Cell Significance Index: -90.3200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.5131
Cell Significance Index: -157.5500 - Cell Name: kidney cell (CL1000497)
Fold Change: -1.5543
Cell Significance Index: -12.4100 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.6935
Cell Significance Index: -23.1100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.8296
Cell Significance Index: -123.0200 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -1.9136
Cell Significance Index: -14.7500 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.9159
Cell Significance Index: -51.2500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.9514
Cell Significance Index: -149.7500 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -2.0191
Cell Significance Index: -113.3000 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -2.0222
Cell Significance Index: -34.8600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -2.0507
Cell Significance Index: -125.7300 - Cell Name: preadipocyte (CL0002334)
Fold Change: -2.1827
Cell Significance Index: -42.6000 - Cell Name: helper T cell (CL0000912)
Fold Change: -2.1950
Cell Significance Index: -31.1900 - Cell Name: peg cell (CL4033014)
Fold Change: -2.3594
Cell Significance Index: -54.5100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -2.6469
Cell Significance Index: -70.9300 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -2.8606
Cell Significance Index: -34.1000 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -2.9099
Cell Significance Index: -85.7100 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -2.9561
Cell Significance Index: -17.8600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -3.2198
Cell Significance Index: -142.4200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -3.4562
Cell Significance Index: -88.8400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4084921338
Symbol: GPX4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8039723
Title: Cloning and sequencing of the cDNA encoding a human testis phospholipid hydroperoxide glutathione peroxidase.
PubMed ID: 8039723
PubMed ID: 9705830
Title: Structural organization of the human selenium-dependent phospholipid hydroperoxide glutathione peroxidase gene (GPX4): chromosomal localization to 19p13.3.
PubMed ID: 9705830
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11115402
Title: Evidence for the presence of phospholipid hydroperoxide glutathione peroxidase in human platelets: implications for its involvement in the regulatory network of the 12-lipoxygenase pathway of arachidonic acid metabolism.
PubMed ID: 11115402
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24439385
Title: Regulation of ferroptotic cancer cell death by GPX4.
PubMed ID: 24439385
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 36608588
Title: Side-by-side comparison of recombinant human glutathione peroxidases identifies overlapping substrate specificities for soluble hydroperoxides.
PubMed ID: 36608588
PubMed ID: 36828120
Title: FUNDC1 interacts with GPx4 to govern hepatic ferroptosis and fibrotic injury through a mitophagy-dependent manner.
PubMed ID: 36828120
PubMed ID: 17630701
Title: Structural basis for catalytic activity and enzyme polymerization of phospholipid hydroperoxide glutathione peroxidase-4 (GPx4).
PubMed ID: 17630701
DOI: 10.1021/bi700840d
PubMed ID: 27836545
Title: Discovery of GPX4 inhibitory peptides from random peptide T7 phage display and subsequent structural analysis.
PubMed ID: 27836545
PubMed ID: 12606444
Title: Genetic variations of gpx-4 and male infertility in humans.
PubMed ID: 12606444
PubMed ID: 24706940
Title: Mutations in the enzyme glutathione peroxidase 4 cause Sedaghatian-type spondylometaphyseal dysplasia.
PubMed ID: 24706940
Sequence Information:
- Length: 197
- Mass: 22175
- Checksum: 1AE3BC7AE42FDDB1
- Sequence:
MSLGRLCRLL KPALLCGALA APGLAGTMCA SRDDWRCARS MHEFSAKDID GHMVNLDKYR GFVCIVTNVA SQUGKTEVNY TQLVDLHARY AECGLRILAF PCNQFGKQEP GSNEEIKEFA AGYNVKFDMF SKICVNGDDA HPLWKWMKIQ PKGKGILGNA IKWNFTKFLI DKNGCVVKRY GPMEEPLVIE KDLPHYF
Genular Protein ID: 3687320844
Symbol: Q6PI42_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 197
- Mass: 22164
- Checksum: F7556DFE719C6199
- Sequence:
MSLGRLCRLL KPALLCGALA APGLAGTMCA SRDDWRCARS MHEFSAKDID GHMVNLDKYR GFVCIVTNVA SQXGKTEVNY TQLVDLHVRY AECGLRILAF PCNQFGKQEP GSNEEIKEFA AGYNVKFDMF SKICVNGDDA HPLWKWMKIQ PKGKGILGNA IKWNFTKFLI DKNGCVVKRY GPMEEPLVIE KDLPHYF
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.